Bedaquiline in multidrug-resistant tuberculosis treatment: Safety and efficacy in a Korean subpopulation
ConclusionsBedaquiline showed similar efficacy and safety in Korean patients with MDR-TB, despite their advanced drug-resistance profiles, possibly due to other concomitant drugs such as linezolid. (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 20, 2019 Category: Respiratory Medicine Source Type: research

The impact of obstructive sleep apnea and PAP therapy on all-cause and cardiovascular mortality based on age and gender – a literature review
ConclusionThere is a debate in the literature regarding the impact of OSA on all-cause and cardiovascular mortality in both genders and in different age groups. However, the variation in results might be related to different study designs and significant epidemiological prevalence of OSA in males and females. (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 18, 2019 Category: Respiratory Medicine Source Type: research

Should pulmonologists be gatekeepers or supporters for preoperative patients?
Publication date: Available online 16 October 2019Source: Respiratory InvestigationAuthor(s): Satoshi Hokari, Toshiaki KikuchiAbstractPostoperative pulmonary complications (PPCs) are considered as a leading cause of poor surgical outcomes, and occur frequently even in non-cardiothoracic surgery. Several multifactorial risk indices show potential effectiveness in identification of patients at high risk of developing PPCs. In preoperative consultation from surgeons, pulmonologists often act as gatekeepers for indication of surgery. With regard to preventive strategy for PPCs, recent reports have suggested the usefulness of p...
Source: Respiratory Investigation - October 16, 2019 Category: Respiratory Medicine Source Type: research

Clinical features of chronic summer-type hypersensitivity pneumonitis and proposition of diagnostic criteria
ConclusionsClinical features could be useful for distinguishing C-SHP from IPF and other etiologies of ILDs. (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 13, 2019 Category: Respiratory Medicine Source Type: research

Mesalazine-induced airway obstruction: Utility of pulmonary function testing in drug-induced lung diseases
Publication date: Available online 8 October 2019Source: Respiratory InvestigationAuthor(s): Haruki Hirakawa, Hiroki Tashiro, Koichiro Takahashi, Masahide Tanaka, Hironori Sadamatsu, Shinya Kimura, Naoko Sueoka-AraganeAbstractMesalazine is a standard therapeutic agent for the treatment of inflammatory bowel diseases. A rare case of mesalazine-induced airway obstruction documented by pulmonary function testing is reported herein. The patient had Crohn's disease and was treated with mesalazine; she subsequently developed a high fever, cough, and chest pain with centrilobular nodular shadows on chest computed tomography (CT)....
Source: Respiratory Investigation - October 10, 2019 Category: Respiratory Medicine Source Type: research

Current state and future prospect of the therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma
Publication date: Available online 4 October 2019Source: Respiratory InvestigationAuthor(s): Takayuki Yamamoto, Jun Miyata, Makoto Arita, Koichi Fukunaga, Akihiko KawanaAbstractAsthma is an allergic disorder with dominant type 2 airway inflammation, and its prevalence is increasing worldwide. Inhalation of corticosteroids is the primary treatment for asthma along with add-on drugs, including long-acting β2 agonists and/or cysteinyl leukotriene (cys-LT) receptor antagonists, in patients with poorly controlled asthma. Cys-LTs are composed of leukotriene C4 (LTC4), LTD4, and LTE4, which are enzymatically metabolized from...
Source: Respiratory Investigation - October 5, 2019 Category: Respiratory Medicine Source Type: research

Clinical and radiological features of pulmonary tuberculosis in patients with idiopathic pulmonary fibrosis
ConclusionsIncidental radiological findings were the most common presenting manifestations in TB-IPF patients, who were more likely to present with atypical PTB manifestations on CT scan and who experienced poorer treatment outcomes. (Source: Respiratory Investigation)
Source: Respiratory Investigation - September 27, 2019 Category: Respiratory Medicine Source Type: research

Spontaneous pneumothorax and air travel in Pulmonary Langerhans cell histiocytosis: A patient survey
ConclusionsSP is a common manifestation of PLCH, can be seen in approximately one-fourth of the patients, and has a high recurrence risk. Surgical pleurodesis leads to a substantial reduction in the SP recurrence risk. The risk of an air travel-related SP in patients with PLCH is about 2–3 per thousand flights.Trial registry clinicaltrials.govNCT03052101. (Source: Respiratory Investigation)
Source: Respiratory Investigation - September 27, 2019 Category: Respiratory Medicine Source Type: research

The role of molecular diagnosis in acute respiratory tract infection
Publication date: Available online 7 September 2019Source: Respiratory InvestigationAuthor(s): Katsunori Yanagihara (Source: Respiratory Investigation)
Source: Respiratory Investigation - September 7, 2019 Category: Respiratory Medicine Source Type: research

Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone
This study aimed to investigate the prognostic factors in IPF patients treated with PFD and clarify the clinical significance of marginal physiological changes after PFD therapy.MethodsWe retrospectively reviewed 96 consecutive IPF patients treated with PFD. The physiological evaluation was performed at 3–6 months after PFD therapy, and the findings were classified into three groups based on the presence of a 5% change in %forced vital capacity (%FVC): improved, stable, and worsened. The clinical characteristics and prognostic outcomes were compared among groups, and the prognostic factors were evaluated by Cox propo...
Source: Respiratory Investigation - August 31, 2019 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: September 2019Source: Respiratory Investigation, Volume 57, Issue 5Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 29, 2019 Category: Respiratory Medicine Source Type: research

Polymicrobial etiology as a prognostic factor for empyema in addition to the renal, age, purulence, infection source, and dietary factors score
ConclusionsMembers of the S. anginosus group and anaerobes were frequent pathogens in empyema, and polymicrobial etiology was independently associated with mortality in addition to the RAPID score. Surgery may be one option for preventing mortality. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 17, 2019 Category: Respiratory Medicine Source Type: research

Solitary pulmonary nodules caused by Mycobacterium avium complex
ConclusionsMAC should be considered in the differential diagnosis of SPNs in asymptomatic patients. To overcome the difficulties in diagnosing MAC-SPN, this study underscores the importance of diagnostic interventions and identification of MAC by culture and/or NAAT in biopsied specimens. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 10, 2019 Category: Respiratory Medicine Source Type: research

Variation in interferon-γ production between QFT-Plus and QFT-GIT assays in TB contact investigation
Publication date: Available online 8 August 2019Source: Respiratory InvestigationAuthor(s): Mizue Tsuyuzaki, Hidetoshi Igari, Nao Okada, Kiminori SuzukiAbstractBackgroundIndividuals with recent contact with active tuberculosis (TB) patients were screened for latent tuberculosis infection (LTBI) considering their greater relative risk for developing active TB. QuantiFERON®-TB Gold Plus (QFT-Plus) assay offers two TB-specific antigen tubes (TB1 and TB2). TB2 is designed to elicit both CD4 and CD8 T-cell responses. This mechanism could lead to increased sensitivity as compared to the QuantiFERON®-TB Gold In-Tube (QFT-...
Source: Respiratory Investigation - August 10, 2019 Category: Respiratory Medicine Source Type: research

Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia
Publication date: Available online 1 August 2019Source: Respiratory InvestigationAuthor(s): Takashi Ogura, Nagio Takigawa, Keisuke Tomii, Kazuma Kishi, Yoshikazu Inoue, Eiki Ichihara, Sakae Homma, Kazuhisa Takahashi, Hiroaki Akamatsu, Satoshi Ikeda, Naohiko Inase, Tae Iwasawa, Yuichiro Ohe, Hiromitsu Ohta, Hiroshi Onishi, Isamu Okamoto, Kazumasa Ogawa, Kazuo Kasahara, Hiroki Karata, Takumi KishimotoAbstractDramatic progress in targeted therapy and immunotherapy has been changing clinical practices in lung cancer. With the accumulation of clinical practice, it has become clear that pre-existing interstitial pneumonia (IP) c...
Source: Respiratory Investigation - August 1, 2019 Category: Respiratory Medicine Source Type: research

Probe-based optical fiberscopy for the direct observation of peripheral pulmonary lesions
ConclusionsThese results suggest that the findings of direct observation using probe-based optical fiberscopy are useful for differentiating malignant from benign peripheral pulmonary lesions.Trial registryUMIN-CTR; UMIN000018796; URL: https://www.umin.ac.jp/ctr/index.htm. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 26, 2019 Category: Respiratory Medicine Source Type: research

Association of specific metastatic organs with the prognosis and chemotherapeutic response in patients with advanced lung cancer
ConclusionsMuscle and liver metastases were associated with poor outcomes. Muscle and skin metastases were associated with a lower response rate to treatment. For patients with advanced lung cancer, oncologists should select treatment strategies considering the patients’ metastatic statuses as well as other clinical characteristics. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 19, 2019 Category: Respiratory Medicine Source Type: research

Objective measurement of nocturnal cough in infants with acute bronchiolitis
The objective measurement of the cough severity and the assessment of the pattern of nocturnal coughing could be useful in the treatment of respiratory diseases in children.Study designIn children with respiratory syncytial virus (RSV)-induced acute bronchiolitis, coughs were recorded using our original system with a microphone and accelerometer, and analyzed using our customized software program. The number of coughs in every 30-minute interval was measured in patients with acute bronchiolitis (n = 20), and their results were compared with those of infants with asthma exacerbation (n = 16).ResultsThe cough count in childr...
Source: Respiratory Investigation - July 19, 2019 Category: Respiratory Medicine Source Type: research

Outcomes of prolonged mechanical ventilation in patients who underwent bedside percutaneous dilatation tracheostomy in intermediate care units – A single center study
ConclusionThe prognosis of CCI patients in intermediate care units is generally poor. Identified risk factors for complications and survival should be presented to patients and their surrogates when discussing courses of action and future treatments. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 18, 2019 Category: Respiratory Medicine Source Type: research

Interstitial pneumonitis associated with dasatinib: two case reports and literature review
Publication date: Available online 13 July 2019Source: Respiratory InvestigationAuthor(s): Yuhei Ito, Motoaki Tanigawa, Keisuke Iwamoto, Akina Nigi, Hidetoshi Itani, Shigeto Kondo, Toshiya Tokui, Eiji Usui, Shigehisa TamakiAbstractDasatinib has increasingly been used to treat chronic myeloid leukemia (CML), although interstitial pneumonitis has been found as a complication in large clinical trials. In the present study, 23 patients received dasatinib for CML between 2012 and 2017 at our institution, of whom 2 developed symptomatic interstitial pneumonitis. Notably, the first patient developed interstitial pneumonitis five ...
Source: Respiratory Investigation - July 15, 2019 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: July 2019Source: Respiratory Investigation, Volume 57, Issue 4Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 5, 2019 Category: Respiratory Medicine Source Type: research

Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer
This study retrospectively investigated whether any patient characteristics, including ILA, were risk factors for ICI-ILD in patients with NSCLC.MethodsNSCLC patients who received anti-programmed death (PD)-1 antibody treatment at our hospital between September 2015 and December 2017 were enrolled. Information on patient characteristics before anti-PD-1 antibody administration, including chest CT findings and laboratory data, were obtained.ResultsAmong 83 enrolled patients, the incidence of ICI-ILD was 16.9% (14/83). All ICI-ILD cases developed by the third line of treatment. The incidence of ICI-ILD was significantly high...
Source: Respiratory Investigation - June 25, 2019 Category: Respiratory Medicine Source Type: research

Acute or subacute progressive interstitial pneumonia
Publication date: Available online 24 June 2019Source: Respiratory InvestigationAuthor(s): Tomoo Kishaba (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 24, 2019 Category: Respiratory Medicine Source Type: research

Clinical features of interstitial pneumonia associated with systemic lupus erythematosus
ConclusionIn SLE cases, IP primarily occurred in male and elderly patients. In addition to the NSIP pattern, the UIP pattern was evident on HRCT scans of IP-related SLE. The survival of SLE patients was unrelated to IP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 22, 2019 Category: Respiratory Medicine Source Type: research

Sex-specific differences in the association between birth weight and lung volume in Japanese young adults
ConclusionsBirth weight is significantly associated with pulmonary function in Japanese young adults. The associations are especially significant in males. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 15, 2019 Category: Respiratory Medicine Source Type: research

Programmed cell death-ligand 1 expression and efficacy of cisplatin-based chemotherapy in lung cancer: A sub-analysis of data from the two Okayama Lung Cancer Study Group prospective feasibility studies
ConclusionPD-L1 expression was negatively correlated with survival in patients receiving cisplatin-based chemotherapy. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 9, 2019 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: May 2019Source: Respiratory Investigation, Volume 57, Issue 3Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 24, 2019 Category: Respiratory Medicine Source Type: research

Patients with unresectable stage III non-small cell lung cancer eligible to receive consolidation therapy with durvalumab in clinical practice based on PACIFIC study criteria
ConclusionIn clinical practice, approximately 70% of patients with unresectable stage III NSCLC would be eligible to receive consolidation therapy with durvalumab. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 17, 2019 Category: Respiratory Medicine Source Type: research

The updated classification of PVOD/PCH: A slight but meaningful change
Publication date: Available online 15 May 2019Source: Respiratory InvestigationAuthor(s): Seiichiro Sakao (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 16, 2019 Category: Respiratory Medicine Source Type: research

Development of a CT image case database and content-based image retrieval system for non-cancerous respiratory diseases: Method and preliminary assessment
ConclusionsAlthough this was a preliminary small-scale assessment, the results suggest that this system may contribute to an improved interpretation of CT findings and differential diagnosis of non-cancerous respiratory diseases, which are difficult to diagnose for inexperienced physicians. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 16, 2019 Category: Respiratory Medicine Source Type: research

Diagnostic difficulty in idiopathic pulmonary fibrosis
Publication date: Available online 14 May 2019Source: Respiratory InvestigationAuthor(s): Yasuhiro Kondoh (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 14, 2019 Category: Respiratory Medicine Source Type: research

Four-meter gait speed predicts daily physical activity in patients with chronic respiratory diseases
Publication date: Available online 13 May 2019Source: Respiratory InvestigationAuthor(s): Chieko Yoshida, Hidenori Ichiyasu, Hideharu Ideguchi, Susumu Hirosako, Aiko Masunaga, Keisuke Kojima, Sho Saeki, Kazuhiko Fujii, Takuro Sakagami, Hirotsugu KohrogiAbstractBackgroundPhysical activity measures are valuable for assessing the progression of chronic respiratory diseases. The 4-m gait speed (4MGS) test is an established functional assessment in the elderly. However, the relationship between the 4MGS and daily activity in patients with chronic respiratory diseases has not been fully understood. The present study aimed to inv...
Source: Respiratory Investigation - May 13, 2019 Category: Respiratory Medicine Source Type: research

Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity
The objective of this study was to determine the predictors of the 6MWT distance (6MWD) in patients with COPD.MethodsThis retrospective observational study enrolled 133 Japanese patients with COPD. All patients underwent the 6MWT, COPD assessment test (CAT), spirometry, respiratory muscle strength evaluation, body composition assessment, and handgrip strength (HGS) measurement. We examined the associations between the 6MWD and evaluated parameters.ResultsFrom single regression analysis, the 6MWD was significantly correlated with age, CAT score, several spirometric measurements (e.g., percentages of forced vital capacity, f...
Source: Respiratory Investigation - May 12, 2019 Category: Respiratory Medicine Source Type: research

Cause of pleuroparenchymal fibroelastosis following allogeneic hematopoietic stem cell transplantation
Publication date: Available online 9 May 2019Source: Respiratory InvestigationAuthor(s): Hisao Higo, Nobuaki Miyahara, Akihiko Taniguchi, Yoshinobu Maeda, Katsuyuki KiuraAbstractLate-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications after hematopoietic stem cell transplantation (HSCT). Pleuroparenchymal fibroelastosis (PPFE) is a LONIPC, but its etiology remains elusive. Chronic graft-versus-host disease (cGVHD) and alkylating agents used for conditioning have been considered possible causes of PPFE. Therefore, to investigate the primary cause of PPFE in allogeneic HSCT, we compared t...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research

Application of a commercial serodiagnostic kit that measures the serum anti-glycopeptidolipid core IgA antibody in Mycobacterium avium complex pulmonary disease
Publication date: Available online 10 May 2019Source: Respiratory InvestigationAuthor(s): Seigo KitadaAbstractThe diagnosis of Mycobacterium avium complex (MAC) pulmonary disease is occasionally cumbersome and time-consuming because the MAC species is ubiquitous, and therefore its detection is not necessarily indicative of a definitive diagnosis. A serodiagnostic method specific for MAC pulmonary disease that measures the serum anti-glycopeptidolipid core antigen IgA has been developed and is commercially available. Meta-analysis revealed that the test showed a good diagnostic accuracy. The estimated sensitivity and specif...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research

Chronic obstructive pulmonary disease and the early stage of cor pulmonale: A perspective in treatment with pulmonary arterial hypertension-approved drugs
Publication date: Available online 10 May 2019Source: Respiratory InvestigationAuthor(s): Seiichiro SakaoAbstractCor pulmonale is right ventricular hypertrophy and/or dilation caused by pulmonary hypertension (PH) due to diseases affecting the lung function and structure. Recently, the definition of PH was revised from a mean pulmonary arterial pressure (mPAP)>25 mmHg to an mPAP>20 mmHg based on the Nice statement; this might expedite the detection of cor pulmonale. However, the only treatment for cor pulmonale for the past 3 decades has been to maintain the lung function and oxygen saturation.Chronic obstr...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research

Diagnostic utility of transbronchial lung cryobiopsy: Two cases of anti-aminoacyl-tRNA synthetase syndrome with respiratory failure
Publication date: Available online 1 May 2019Source: Respiratory InvestigationAuthor(s): Hanako Yoshimura, Nobuyasu Awano, Minoru Inomata, Naoyuki Kuse, Mari Tone, Tatsunori Jo, Tamiko Takemura, Toshio Kumasaka, Takehiro IzumoAbstractTransbronchial lung cryobiopsy (TBLC) is a useful and safe method for the diagnosis of interstitial lung disease (ILD). Herein, we describe the cases of two patients who developed ILD from anti-aminoacyl-tRNA synthetase syndrome with respiratory failure. TBLC was performed instead of surgical lung biopsy. There were no complications, and sufficient specimens were harvested to make the precise ...
Source: Respiratory Investigation - May 2, 2019 Category: Respiratory Medicine Source Type: research

Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks
Publication date: Available online 28 April 2019Source: Respiratory InvestigationAuthor(s): Yuri Tachibana, Hiroyuki Taniguchi, Yasuhiro Kondoh, Kensuke Kataoka, Naoki Hamada, Toshihiro Hashiguchi, Kazuya Ichikado, Tomoo Kishaba, Shuntaro Sato, Emiko Udo, Mikiko Hashisako, Junya FukuokaAbstractBackgroundPulmonary interstitial emphysema is a rare, abnormal condition in which air pressure from the alveolar airspace tears the adjacent interstitial tissues of the lung and causes the formation of cystic spaces. Pulmonary interstitial emphysema is a known indication for mechanical ventilation in premature infants with neonatal r...
Source: Respiratory Investigation - April 29, 2019 Category: Respiratory Medicine Source Type: research

Serum amyloid A in patients with idiopathic pulmonary fibrosis
ConclusionsSAA is a promising marker of disease severity in patients with IPF. Our preliminary data suggest a potential pathogenetic role of alteration in lipid metabolism in this rare disease. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 26, 2019 Category: Respiratory Medicine Source Type: research

HIRA-TAN detects pathogens of pneumonia with a progressive course despite antibiotic treatment
ConclusionsThe result warrants a larger clinical trial to confirm the clinical efficacy of the HIRA-TAN in patients with progressive pneumonia despite previous antibiotic treatment. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 26, 2019 Category: Respiratory Medicine Source Type: research

Possible pathogenic roles of nitric oxide in asthma
Publication date: Available online 22 April 2019Source: Respiratory InvestigationAuthor(s): Kazuhiro Yatera, Hiroshi MukaeAbstractNitric oxide (NO) has broad physiologic functions, including vasodilation, bronchodilatation, neurotransmission, inflammation, and host defense. Fraction of exhaled NO (FeNO) is used as a biomarker of eosinophilic airway inflammation for asthma control. However, the role of NO in the pathogenesis and progression of asthma is not well understood. Additionally, the absence of bronchial eosinophilic inflammation, mucus hypersecretion, and increased Th2 cytokine levels in mice lacking NO synthase is...
Source: Respiratory Investigation - April 23, 2019 Category: Respiratory Medicine Source Type: research

Characteristics and association with survival of respiratory-related hospitalization in Japanese idiopathic pulmonary fibrosis patients
ConclusionsPneumonia is the most frequent cause of respiratory-related hospitalization in Japanese IPF patients. Furthermore, respiratory-related hospitalization is significantly associated with subsequent poor survival. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 17, 2019 Category: Respiratory Medicine Source Type: research

Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia
ConclusionsChanges in serum KL-6 and SP-D levels over time may provide useful predictive information on disease behavior during treatment in patients with idiopathic f-NSIP and especially in those with non-IPAF f-NSIP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 17, 2019 Category: Respiratory Medicine Source Type: research

Recent trends in the treatment of unresectable stage III non-small-cell lung cancer
Publication date: Available online 15 April 2019Source: Respiratory InvestigationAuthor(s): Go Makimoto, Katsuyuki Hotta, Katsuyuki KiuraAbstractApproximately 20–25% of non-small-cell lung cancer (NSCLC) is diagnosed when the disease has progressed to clinical stage III. At this stage, and even if the cancer is considered unresectable, the treatment strategy should aim to achieve a cure. At the time of the initial diagnosis, it is necessary for medical oncologists to devise the best treatment strategy for each patient by composing a multidisciplinary treatment team including thoracic surgeons and radiation oncologist...
Source: Respiratory Investigation - April 16, 2019 Category: Respiratory Medicine Source Type: research

Microdeletion in Xq28 with a polymorphic inversion in a patient with FLNA-associated progressive lung disease
We report the first Japanese case of FLNA-associated progressive lung disease caused by a microdeletion in Xq28 encompassing the FLNA gene with a polymorphic inversion. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 14, 2019 Category: Respiratory Medicine Source Type: research

Criteria for the diagnosis of idiopathic pleuroparenchymal fibroelastosis: A proposal
ConclusionsWe have proposed diagnostic criteria for IPPFE in patients with and without SLB. Both imaging criteria and physiological criteria using RV/TLC and BMI successfully discriminate IPPFE from chronic IIPs when SLB cannot be performed. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 11, 2019 Category: Respiratory Medicine Source Type: research

Our obligation to find treatable and untreatable traits in patients with chronic airway diseases
Publication date: Available online 6 April 2019Source: Respiratory InvestigationAuthor(s): Hisako Matsumoto (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 6, 2019 Category: Respiratory Medicine Source Type: research

A difference in the effects of a comorbidity of allergic rhinitis on asthma symptoms between obese and non-obese patients
Publication date: Available online 27 March 2019Source: Respiratory InvestigationAuthor(s): Masako To, Ryuta Tsuzuki, Otohiro Katsube, Satoshi Yamawaki, Seiko Soeda, Yuta Kono, Natsue Honda, Ichino Kano, Kosuke Haruki, Yasuo To (Source: Respiratory Investigation)
Source: Respiratory Investigation - March 28, 2019 Category: Respiratory Medicine Source Type: research

Meteorological effects on severe hemoptysis: A hospital-based observational study
ConclusionsLower relative humidity was a significant risk factor for the development of hemoptysis. Clinicians should be aware of the potential for increases in hemoptysis events on days with low ambient humidity. (Source: Respiratory Investigation)
Source: Respiratory Investigation - March 21, 2019 Category: Respiratory Medicine Source Type: research

Treatment outcome of patients with unresectable stage III non-small cell lung cancer and interstitial pneumonia
ConclusionsCRT was the only predictive factor for longer survival in LC patients; however, no LC-IP patients received CRT, possibly because of the underlying IP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - March 19, 2019 Category: Respiratory Medicine Source Type: research