GSE252291 Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome
Contributors : H. Nayanga Thirimanne ; Sonali Arora ; Damian Almiron Bonnin ; Carolina Parada ; Manuel Ferreira ; Eric C HollandSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMeningiomas are the most common primary intracranial tumors in humans. While most of these tumors are benign, some are malignant, rapidly recur after multimodal treatment with surgery and radiotherapy, and can ultimately be fatal. The current WHO grade system does not always identify high risk meningiomas, therefore better characterizations of the biology of aggressive tumors are needed. In order to address...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE264477 Transcriptional effects of co-culture on the spatiotemporal dynamics of T cell motility and cancer-T cell interactions [RNA-seq]
Contributors : Xinyue Li ; Taoli Jin ; Lisha Wang ; Ming Li ; Weijing Han ; Xuefei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInsufficient infiltration of cytotoxic T cells into solid tumors poses a major challenge in cancer immunotherapy, largely due to the intricate tumor microenvironment. To address this, we co-cultured mouse cancer cell lines (B16-WT or B16-OVA) with cancer-specific cytotoxic T cells (activated OT-1) in vitro to uncover the impact of cancer-T cell interactions on T cell motility, pivotal for effective tumor infiltration. To investigate the potential m...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE264478 Transcriptional effects of co-culture on the spatiotemporal dynamics of T cell motility and cancer-T cell interactions [scRNA-seq]
Contributors : Xinyue Li ; Taoli Jin ; Lisha Wang ; Ming Li ; Weijing Han ; Xuefei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInsufficient infiltration of cytotoxic T cells into solid tumors poses a major challenge in cancer immunotherapy, largely due to the intricate tumor microenvironment. To address this, we co-cultured mouse cancer cell lines (B16-WT or B16-OVA) with cancer-specific cytotoxic T cells (activated OT-1) in vitro to uncover the impact of cancer-T cell interactions on T cell motility, pivotal for effective tumor infiltration. To investigate the potential m...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE262500 DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Contributors : Ya Wen ; Xiwang Yang ; Yifei Li ; Xueqing Zhao ; Liqiang Duan ; Shuwen Chenge ; Bo Peng ; Xiaofeng Zhua ; Xiaoli Chang ; Chang Zhang ; Tianyou Cheng ; He Wang ; Yibi Zhang ; Shan GaoSeries Type : OtherOrganism : Homo sapiensBoth N6-methyladenosine (m6A) mediates RNA fates and ubiquitin mediates protein fates play an important role in either physiology or pathology including cancer, yet how long noncoding RNAs (lncRNAs) are involved in a link of molecular fate between m6A and ubiquitin remains unknown. Here, we reveal a role for a lncRNA Downregulated RNA in Cancer (DRAIC) to suppress tumor grow...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE230700 Lipid droplet-mediated danger signaling balances Trem2+ macrophage induction and NLRP3 inflammasome activation in NASH
Contributors : Linkang Zhou ; Xiaoxue Qiu ; Tongyu Liu ; You Lu ; Siming Li ; Jiandie D LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages are exquisitely capable of sensing danger-associated molecular patterns (DAMPs) and orchestrating inflammatory response during tissue injury. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of metabolic fatty liver disease that increases the risk for cirrhosis and liver cancer. Pathogenic mechanisms of NASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment. However, the n...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Disrupting the interaction between a p53 gain ‐of‐function mutant and the transcriptional co‐activator PC4 reverses drug resistance in cancer cells
In a tumor cell harboring the gain-of-function mutant R273Hp53, the mutant p53 protein is recruited to the promoters of theMDR1 andUBE2C multidrug resistance-associated genes, assisted by the chromatin-associated protein PC4. This recruitment upregulates both genes. A peptide designed to disrupt the R273Hp53 –PC4 interaction, downregulatesMDR1 andUBE2C expression, sensitizing the cells to doxorubicin. This suggests that the PC4 –R273Hp53 interaction is a promising target for reducing drug resistance. PC4 is a chromatin-associated protein and transcriptional coactivator whose role in gene regulation by wild-type p53 is ...
Source: FEBS Letters - April 26, 2024 Category: Biochemistry Authors: Priya Mondal,
Kumar Singha Roy,
Supriya Varsha Bhagat,
Siddharth Singh,
Anupa Chattopadhyay,
Damayanti Das Ghosh,
Tapas K. Kundu,
Susanta Roychoudhury,
Siddhartha Roy Tags: Research Article Source Type: research
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma
Through bioinformatic analysis of transcriptomes in the cancer genome atlas (TCGA), we identified a new role for the transcription factor THAP domain-containing 3 (THAP3) in the expression of oxidative phosphorylation (OXPHOS) genes and mitochondrial respiration. Mechanistically, THAP3 cooperated with the histone methyltransferase SET and MYND domain-containing protein 3 (SMYD3) to upregulate H3K4me3 and promote OXPHOS gene expression. These actions of THAP3 support liver cancer cell proliferation and contribute to tumor development. Mitochondria harbor the oxidative phosphorylation (OXPHOS) system to sustain cellular resp...
Source: FEBS Letters - April 26, 2024 Category: Biochemistry Authors: Zi ‐Hao Wang,
Jingyi Wang,
Fuchen Liu,
Sijun Sun,
Quan Zheng,
Xiaotian Hu,
Zihan Yin,
Chengmei Xie,
Haiyan Wang,
Tianshi Wang,
Shengjie Zhang,
Yi‐Ping Wang Tags: Research Article Source Type: research
Ewing ’s sarcoma of kidney extending into IVC and RA: resection using modified cannulation strategy for CPB
AbstractEwing ’s sarcoma of the kidney is a rare tumor. Although renal carcinomas are known to involve the inferior cava, extension of the tumor up to the right atrium is not common. In the majority of cases when the tumor extends into the infrahepatic part of the inferior vena cava, it can be removed from the abdominal approach. Few patients require the use of cardiopulmonary bypass for removal of the tumor in the inferior vena cava and right atrium. The management of patients requiring resection of kidney tumors and right atrial mass is more complicated and requires a team approach consisting of oncosu rgeons, cardiac ...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - April 26, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
Crystallography, Charge Transfer, and Two ‐Photon Absorption Relations in Molecular Cocrystals for Two‐Photon Excited Fluorescence Imaging (Small 17/2024)
Fluorescence ImagingIn article number2308470, Zheshuai Lin, Weigang Zhu, and co-workers develop cocrystal micro nanoscale particles based on an intermolecular charge transfer collaborative strategy. These particles exhibit excellent two-photon excited fluorescence imaging capabilities of human hepatocarcinoma cells under near infrared excitation, while simultaneously showing low toxicity, excellent biocompatibility and strong stability. This approach shows promise for applications in deep tissue imaging, cancer monitoring, and diagnosis. (Source: Small)
Source: Small - April 26, 2024 Category: Nanotechnology Authors: Liangmeng Hao,
Fan Liu,
Xu Wang,
Lei Kang,
Yucheng Wang,
Lingsong Wang,
Zheshuai Lin,
Weigang Zhu Tags: Frontispiece Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
Viruses, Vol. 16, Pages 690: Challenges in Treating Pediatric Cancer Patients during the COVID-19 Pandemic: Balancing Risks and Care
es-Espíndola
The COVID-19 pandemic has resulted in millions of fatalities worldwide. The case of pediatric cancer patients stands out since, despite being considered a population at risk, few studies have been carried out concerning symptom detection or the description of the mechanisms capable of modifying the course of the COVID-19 disease, such as the interaction and response between the virus and the treatment given to cancer patients. By synthesizing existing studies, this paper aims to expose the treatment challenges for pediatric patients with COVID-19 in an oncology context. Additionally, this updated review i...
Source: Viruses - April 26, 2024 Category: Virology Authors: Ch ávez-Pacheco Castillejos-L ópez Laura M. Hern ández-Regino Velasco-Hidalgo Zapata-Tarres Correa-Carranza Rosario-M éndez Barrientos-R íos Aquino-G álvez Torres-Esp índola Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2010: Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
asmané Semde
A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence the immune system’s effectiveness, potentially leading to immune system failure. This review aims to provide an overview of the structure and action of immunomodulators isolated from African medicinal plants. The research was conducted according to PRISMA guidelines. Full-text access research articles published in English up to December 2023, including plant characteristics, isolated phytochemicals, and immuno-modulatory activities, were screened. The chemical structures of the isolated ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wendwaoga Ars ène Nikiema Moussa Ou édraogo Windbedma Prisca Ou édraogo Souleymane Fofana Boris Honor é Amadou Ouédraogo Talwendpanga Edwige Delma Belem Amad é Gambo Moustapha Abdoulaye Aim é Serge Sawadogo Raogo Ou édraogo Rasman é Semde Tags: Systematic Review Source Type: research
Neoadjuvant low-dose radiotherapy plus durvalumab and chemotherapy for potentially resectable stage III NSCLC: A phase Ib dose-escalation study
Non-small-cell lung cancer (NSCLC) accounts for 80 –85 % of all lung cancer cases. Approximately 30 % of patients with NSCLC are diagnosed with stage III disease [1], which is usually associated with a higher risk of recurrences (about one-third of patients) and poorer outcomes compared to other early stages [2]. Owing to an inherent heterogen eity, treatment approaches for stage III NSCLC vary depending on patients' distinct characteristics. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 26, 2024 Category: Radiology Authors: Juan Li, Shun Lu, Yuke Tian, Lan Jiang, Lu Li, Shao-Hua Xie, Qiang Li Tags: Original Article Source Type: research
Dose-effect Relationship of Kidney Function After Stereotactic Ablative Body Radiotherapy for Primary Renal Cell Carcinoma: Trog 15.03 Fastrack Ii
This study investigates the dose-effect relationship of kidney SABR with posttreatment renal function. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 26, 2024 Category: Radiology Authors: Mathieu Gaudreault, Nicholas Hardcastle, Price Jackson, Lachlan McIntosh, Braden Higgs, David Pryor, Mark Sidhom, Rachael Dykyj, Alisha Moore, Tomas Kron, Shankar Siva Tags: Clinical Investigation Source Type: research
IJERPH, Vol. 21, Pages 552: Clinical Outcomes from the Alaska Native Tribal Health Consortium Colorectal Cancer Control Program: 2009 & ndash;2015
IJERPH, Vol. 21, Pages 552: Clinical Outcomes from the Alaska Native Tribal Health Consortium Colorectal Cancer Control Program: 2009–2015
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph21050552
Authors:
Nash
Verhage
Flanagan
Haverkamp
Roik
Zimpelman
Redwood
The Alaska Native Tribal Health Consortium (ANTHC) participated in the United States Centers for Disease Control and Prevention Colorectal Cancer Control Program (CRCCP) from 2009 to 2015. We conducted a descriptive evaluation of ANTHC CRCCP demographics, quality measures, and clinical outcomes,...
Source: International Journal of Environmental Research and Public Health - April 26, 2024 Category: Environmental Health Authors: Nash Verhage Flanagan Haverkamp Roik Zimpelman Redwood Tags: Article Source Type: research
