Recommencement of atezolizumab with associated pulmonary sarcoid ‐like reaction
An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab was identified as the likely culprit. He was treated with prednisolone, resul ting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab. AbstractAn 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atez...
Source: Respirology Case Reports - April 27, 2024 Category: Respiratory Medicine Authors: Khai Tam,
Michael Wallace,
Siobhain Mulrennan Tags: CASE REPORT Source Type: research
Genes, Vol. 15, Pages 556: The Relationship between miR-5682 and Nutritional Status of Radiotherapy-Treated Male Laryngeal Cancer Patients
Conclusions: analysis of miR-5682 expression demonstrates a potential clinical utility in selection of LC patients suffering from nutritional deficiencies developing as a consequence of RT-based therapy. (Source: Genes)
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Marcin Mazurek Anna Brzozowska Miros ław Maziarz Teresa Ma łecka-Massalska Tomasz Powr ózek Tags: Article Source Type: research
Genes, Vol. 15, Pages 559: Optical Genome Mapping as a New Tool to Overcome Conventional Cytogenetics Limitations in Patients with Bone Marrow Failure
ez
Julián Sevilla
Cytogenetic studies are essential in the diagnosis and follow up of patients with bone marrow failure syndromes (BMFSs), but obtaining good quality results is often challenging due to hypocellularity. Optical Genome Mapping (OGM), a novel technology capable of detecting most types chromosomal structural variants (SVs) at high resolution, is being increasingly used in many settings, including hematologic malignancies. Herein, we compared conventional cytogenetic techniques to OGM in 20 patients with diverse BMFSs. Twenty metaphases for the karyotype were only obtained in three subjects (15%), and no...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: June Iriondo Ana G ómez Josune Zubicaray Jorge Garcia-Martinez Lorea Abad Carmen Matesanz Reyes Gim énez Almudena Gal án Alejandro Sanz Elena Sebasti án Jes ús Gonzalez de Pablo Ana de la Cruz Manuel Ram írez Juli án Sevilla Tags: Article Source Type: research
Genes, Vol. 15, Pages 560: Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling
Conclusions: The impacted genes primarily play roles in governing gene transcription, mRNA processing, and regulation of translation. Understanding these mechanisms offers valuable insights into the process of HPV-induced oncogenesis. (Source: Genes)
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Alina Fudulu Carmen Cristina Diaconu Iulia Virginia Iancu Adriana Plesa Adrian Albulescu Marinela Bostan Demetra Gabriela Socolov Irina Liviana Stoian Raluca Balan Gabriela Anton Anca Botezatu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1698: Identifying the Trends of Urinary microRNAs within Extracellular Vesicles for Esophageal Cancer
Conclusions: The current study identified the urinary microRNAs which were significantly expressed in ESCC patients. Validation study is warranted to evaluate whether these microRNAs could reflect tumor burden during multidisciplinary treatment for ESCC. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Kazuhiko Hisaoka Satoru Matsuda Kodai Minoura Hiroki Yamaguchi Yuki Ichikawa Mika Mizunuma Ryota Kobayashi Yosuke Morimoto Masashi Takeuchi Kazumasa Fukuda Rieko Nakamura Shutaro Hori Taigi Yamazaki Takehiko Sambe Hirofumi Kawakubo Yuko Kitagawa Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1696: Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions
abbro
Despite a better understanding of the mechanisms causing cancer cachexia (CC) and development of promising pharmacologic and supportive care interventions, CC persists as an underdiagnosed and undertreated condition. CC contributes to fatigue, poor quality of life, functional impairment, increases treatment related toxicity, and reduces survival. The core elements of CC such as weight loss and poor appetite should be identified early. Currently, addressing contributing conditions (hypothyroidism, hypogonadism, and adrenal insufficiency), managing nutrition impact symptoms leading to decreased oral intake (nausea,...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Sudeep Pandey Lauren Bradley Egidio Del Fabbro Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1697: A Review of the Paradigmatic Role of Adipose Tissue in Renal Cancer: Fat Measurement and Tumor Behavior Features
Conclusions: Methodological variations and limitations, such as retrospective designs and sample size constraints, pose challenges to standardization and generalizability. Further research is needed to understand these associations better and establish standardized approaches for adiposity assessment in RCC patients, which could inform clinical practice and therapeutic decision-making. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Eliodoro Faiella Elva Vergantino Federica Vaccarino Amalia Bruno Gloria Perillo Rosario Francesco Grasso Bruno Beomonte Zobel Domiziana Santucci Tags: Review Source Type: research
GSE265893 RNA-seq of E0771-Vector control and E0771-Malt1-WT at basal condition
Contributors : Yuwei Tao ; Chen Tian ; Hanqiu ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo reveal the downstream signal change induced by Malt1, we collected mRNA samples from Vector control- and WT-Malt1-expressing E0771 cancer cells, and performed RNA-seq analysis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Impact of blood salvage therapy during oncologic liver surgeries on allogenic transfusion events, survival, and recurrence, an ambidirectional cohort study
CONCLUSION: The use of Cell Saver® should not be avoided in oncologic surgeries of the liver. Use of Cell Saver® for major hepatectomies might be more beneficial as OS was significantly lower for the Cell Saver® group for patients who underwent minor hepactomies. Further research is needed to explain this conflicting result. Nonetheless, the use of Cell Saver® in autologous blood transfusions can reduce the use of valuable resources and the risks associated with allogenic blood transfusions.PMID:38666789 | DOI:10.1097/JS9.0000000000001458 (Source: Hand Surgery)
Source: Hand Surgery - April 26, 2024 Category: Surgery Authors: Liav Lugassy Samuel Marion Fr édéric Balthazar Sonia Gabriela Cheng Oviedo Yves Collin Source Type: research
From Bytes to Best Practices: Tracing ChatGPT-3.5's Evolution and Alignment With the National Comprehensive Cancer Network ® Guidelines in Pancreatic Adenocarcinoma Management
CONCLUSION: ChatGPT-3.5 represents an interesting but limited tool for assistance in clinical decision-making. We demonstrate that the platform evolved, and its responses to our standardized questions improved over a relatively short period (3-months). Future research is needed to determine the validity of this tool for this clinical application.PMID:38666297 | DOI:10.1177/00031348241248801 (Source: The American Surgeon)
Source: The American Surgeon - April 26, 2024 Category: Surgery Authors: Tamir E Bresler Shivam Pandya Ryan Meyer Zin Htway Manabu Fujita Source Type: research
Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial
CONCLUSIONS: To the best of our knowledge, this was the first placebo-controlled, randomized clinical trial exploring NALL's potential effects for treating AT. Despite improvements in some symptomss, NALL intervention failed to improve motor function significantly. However, patients' nausea and constipation were improved by NALL, which can be a relevant benefit clinically.PMID:38669738 | DOI:10.1016/j.ejpn.2024.04.009 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - April 26, 2024 Category: Neurology Authors: Mehran Beyraghi-Tousi Amirhosein Sahebkar Mahsa Houra Pooria Sarvghadi Tannaz Jamialahmadi Reza Bagheri Shima Tavallaie Eric Gumpricht Maryam Saberi-Karimian Source Type: research
Oncology Nursing for the Future: Multisector Planning Is Needed
Oncol Nurs Forum. 2024 Apr 18;51(3):196-197. doi: 10.1188/24.ONF.196-197.ABSTRACTAssessing the landscape for oncology nursing of the future, the biggest problem that faces the specialty is that of workforce shortages. On the practice side, nursing turnover, resignations, and early retirements have contrib.PMID:38668913 | DOI:10.1188/24.ONF.196-197 (Source: Oncology Nursing Forum)
Source: Oncology Nursing Forum - April 26, 2024 Category: Nursing Authors: Debra Lyon Source Type: research
Causal effect of sarcopenia-related traits on the occurrence and prognosis of breast cancer - A bidirectional and multivariable Mendelian randomization study
CONCLUSIONS: several sarcopenia-related traits were genetically associated with the occurrence and prognosis of breast cancer. It is crucial for elderly women to increase their strength and muscle mass to help prevent breast cancer.PMID:38666335 | DOI:10.20960/nh.05139 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Zhijian He Lujia Zhu Jie He Xinwei Chen Xiaoyang Li Jian Yu Source Type: research
Individualized nutritional intervention improves the nutritional status of liver cancer patients after transcatheter arterial chemoembolization
Conclusion Individualized nutritional intervention can effectively improve nutritional status, improve liver function, and reduce the incidence of postoperative complications in liver cancer patients after TACE. It was worth promoting.PMID:38666338 | DOI:10.20960/nh.05136 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Qian Sun Huixi Yu Tao You Dong Zhang Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
