Knowledge and attitudes of family doctors, dermatologists and endocrinologists on sun exposure and vitamin D.
The objective is to evaluate and compare the attitudes and recommendations of family doctors, dermatologists, and endocrinologists on exposure to the sun and vitamin D. METHODS: In a cross-sectional study, a questionnaire was completed by personal interview in a study population of 78 family doctors, 21 dermatologists, and 22 endocrinologists. RESULTS: On a scale of 1-10, the mean score for recommendations to reduce sun exposure was 4.7 for dermatologists, 4.2 for endocrinologists, and 6.4 for family doctors (P
Source: Postgraduate Medicine - May 28, 2018 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Molecules, Vol. 23, Pages 1288: Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer
hen-Zhong Zhang We designed a series of novel phenothiazine-1,2,3-triazole hybrids by the molecular hybridization strategy and evaluated their antiproliferative activity against three cancer cell lines (MDA-MB-231, MDA-MB-468 and MCF-7). For the structure-activity relationships, the importance of 1,2,3-triazole and substituents on phenyl ring was explored. Among these phenothiazine-1,2,3-triazole hybrids, compound 9f showed the most potent inhibitory effect against MCF-7 cells, with an IC50 value of 0.8 μM. Importantly, compound 9f could induce apoptosis against MCF-7 cells by regulating apoptosis-related pr...
Source: Molecules - May 28, 2018 Category: Chemistry Authors: Jun-Xia Zhang Jiao-Mei Guo Ting-Ting Zhang Hong-Jun Lin Nai-Song Qi Zhen-Guo Li Ji-Chun Zhou Zhen-Zhong Zhang Tags: Article Source Type: research

The Effect of Shift Work on Urogenital Disease: a Systematic Review
AbstractPurpose of ReviewNon-standard shift work schedules negatively impact the overall health of shift workers, and several studies have shown that shift work, specifically, is detrimental to urogenital health. The aims of this study are to systematically review the literature and determine the effect of shift work on the outcomes of hypogonadism, male infertility, lower urinary tract symptoms, and urogenital cancers.Recent FindingsRecent evidence supports associations between non-standard shift work and an increase in the frequency of prostate cancer and the severity of erectile dysfunction, lower urinary tract symptoms...
Source: Current Urology Reports - May 28, 2018 Category: Urology & Nephrology Source Type: research

Giant intrascrotal embryonal rhabdomyosarcoma in an adult: a case report and review of the  literature
ConclusionsIntrascrotal embryonal rhabdomyosarcoma is a rare but highly aggressive tumor. Clinical and imaging manifestations of this tumor are nonspecific, so the definitive diagnosis depends on postoperative pathology and immunohistochemistry. Early suspicion, radical orchiectomy, accurate pathologic diagnosis, and adjuvant chemotherapy and/or radiotherapy are the keys to optimal prognosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 28, 2018 Category: General Medicine Source Type: research

Long non-coding RNA-mediated regulation of signaling pathways in gastric cancer
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - May 27, 2018 Category: Laboratory Medicine Source Type: research

Celgene to pay Evotec $65 million in cancer drug pact
(Source: NanoFocus)
Source: NanoFocus - May 27, 2018 Category: Nanotechnology Authors: Ryan Cross Source Type: research

Celgene to pay Evotec $65 million in cancer drug pact
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - May 27, 2018 Category: Chemistry Authors: Ryan Cross Source Type: research

Immediate breast reconstruction following nipple-sparing mastectomy in an Asian population: Aesthetic outcomes and mitigating nipple-areolar complex necrosis.
Authors: Pek WS, Tan BK, Ru Ng YY, Kiak Mien Tan V, Rasheed MZ, Kiat Tee Tan B, Ong KW, Ong YS Abstract BACKGROUND: Nipple-sparing mastectomies (NSMs) are increasingly performed to obtain the best aesthetic and psychological outcomes in breast cancer treatment. However, merely preserving the nipple-areolar complex (NAC) does not guarantee a good outcome. Darkly pigmented NACs and a tendency for poor scarring outcomes are particular challenges when treating Asian patients. Herein, we review the reconstructive outcomes following NSM at Singapore General Hospital. METHODS: All breasts reconstructed following NSM o...
Source: Archives of Plastic Surgery - May 27, 2018 Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research

The lateral intercostal artery perforator as an alternative donor vessel for free vascularized lymph node transplantation.
Authors: Kwak MD, Machens HG Abstract Chronic lymphedema is caused by an impairment of the lymphatic system due to primary or secondary causes. Vascularized lymph node transplantation (VLNT) is currently the most promising and frequently used technique besides lymphaticovenous anastomosis. However, the vessel anatomy in the lateral thoracic region is sometimes quite variable. Based on our experiences with vascular anatomical inconstancy in the lateral thoracic region, we planned a lateral intercostal artery perforator flap for VLNT in a female patient with chronic stage II lymphedema of both legs after cervical can...
Source: Archives of Plastic Surgery - May 27, 2018 Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research

Trends in breast reconstruction: Implications for the National Health Insurance Service.
This study aimed to investigate trends in mastectomy and breast reconstruction over the past 10 years and to evaluate the impact of NHIS coverage on breast reconstruction. METHODS: Nationwide data regarding mastectomy and breast reconstruction were collected from the Korean Breast Cancer Society registry database. Multiple variables were analyzed in the records of patients who underwent breast reconstruction from January 2005 to March 2017 at a single institution. RESULTS: At Seoul National University Hospital, the total number of reconstruction cases increased 13-fold from 2005 to 2016. The proportion of immediate...
Source: Archives of Plastic Surgery - May 27, 2018 Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research

Utility of topical epinephrine for determining the resection range of eyelid sebaceous carcinoma with dermatitis.
Authors: Kiuchi T, Shimizu Y, Yamazaki S, Awazawa T, Kishi K PMID: 29788677 [PubMed] (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - May 27, 2018 Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research

GSE97326 Resetting the Epigenetic Balance of Polycomb/COMPASS Function at Enhancers for Cancer Therapy
This study provides a molecular mechanism to explain the role of MLL3 PHD mutations in cancer pathogenesis. Therefore, based on these observations, we propose a potential therapeutic strategy for cancers harboring MLL3/COMPASS mutations by resetting the Polycomb/COMPASS epigenetic balanced state of gene expression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 27, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Salvage high-dose-rate brachytherapy for prostate cancer persistence after brachytherapy: repeated use of a polyethylene glycol hydrogel spacer.
Conclusions: The use of a hydrogel prior to salvage HDR-BT in a patient previously treated with HDR-BT is feasible and could help reduce the rectal exposure in the salvage setting. PMID: 29789766 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Successful salvage treatment of refractory recurrence of maxillary sinus carcinoma using image-guided high-dose-rate interstitial brachytherapy.
Authors: Zhang Y, Wu N, Zhao Z, Chen Q, Cheng G Abstract This case report illustrates a treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of maxillary sinus carcinoma. A 61-year-old male was previously admitted to another hospital and received surgery because of left maxillary sinus squamous cell carcinoma (SCC) 6 years ago. Tumor regrowth was noted 2 years after the initial radical surgery. The patient accepted local excision again for the recurrence, followed by external beam radiotherapy. Despite salvage treatment with surgery and external irradiation...
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A single institution analysis of low-dose-rate brachytherapy: 5-year reported survival and late toxicity outcomes.
Conclusions: LDR brachytherapy is an effective treatment option in low- to intermediate-risk prostate cancer patients. We observed low biochemical relapse rates and minimal GU toxicities several years after treatment in patients with or without TURP. However, a small risk of urinary retention was observed in some patients. PMID: 29789764 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Percutaneous computed tomography-guided permanent 125I implantation as therapy for pulmonary metastasis.
Authors: Huo X, Huo B, Wang H, Wang L, Cao Q, Zheng G, Wang J, Chai S, Zhang Z, Yang K, Niu Y, Wang H Abstract Purpose: To evaluate intermediate-term outcomes after computed tomography (CT)-guided radioactive 125I seed implantation (CTRISI), and to determine prognostic variables associated with outcomes in patients with pulmonary metastases. Material and methods: Thoracic surgeons evaluated and performed implantation of 125I radioactive seeds under CT guidance or combined with surgical resection. Patients were monitored in the thoracic surgery clinic for recurrence and survival. Results: Fifty patients (31 ...
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

High-dose-rate brachytherapy in treatment of non-melanoma skin cancer of head and neck region: preliminary results of a prospective single institution study.
Conclusions: With appropriate patient selection and choosing as lowest dose per fraction as possible, HDR brachytherapy with customized surface molds yields good oncological and cosmetic results for the treatment of localized skin BCC and SCC. PMID: 29789760 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Combined external beam radiotherapy and vaginal brachytherapy versus vaginal brachytherapy in stage I, intermediate- and high-risk cases of endometrium carcinoma.
Conclusions: VBT alone is as effective as EBRT+VBT in ensuring loco-regional control and achieving comparable survival rates, with fewer toxic effects for patients with stage I intermediate- and high-risk endometrial carcinoma. The dose escalation did not make a difference in the survival rates and was like in the other major trials (PORTEC-2). PMID: 29789759 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer.
Conclusions: This technique, although time-consuming, achieves good local disease control with a satisfactory toxicity profile in both early-stage and local recurrent breast cancer patients. It may be especially suitable for frail patients. PMID: 29789758 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - May 27, 2018 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Should omega-3 fatty acids be used for adjuvant treatment of cancer cachexia?
CONCLUSIONS: Future cachexia trials would likely benefit from studying a single tumour type with earlier stage disease, with probably different dosage depending on the cancer type and its inflammatory profile. PMID: 29779814 [PubMed - in process] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 27, 2018 Category: Cancer & Oncology Authors: Lavriv DS, Neves PM, Ravasco P Tags: Clin Nutr ESPEN Source Type: research

Chest wall reconstruction after tumor resection
Pediatric chest wall tumors and rare. Malignancies predominate of which sarcomas are the most common. Their resection and the subsequent reconstruction of the chest wall has been a surgical challenge since Dr Frederick W Parham published his first comprehensive account on the subject in 1898. Chest wall reconstruction is age, site and pathology dependent, must preserve long term function and cosmesis, must accommodate future growth and development, and must not be a hindrance to adjuvant radiotherapy. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - May 27, 2018 Category: Pediatrics Authors: Dr. Gideon Sandler, Dr. Andrea Hayes-Jordan Source Type: research

Quality Improvement Initiative to Improve HPV Vaccine Initiation at Nine Years of Age,,
Conclusion This QI project used multiple interventions to increase HPV vaccination at nine years of age in a large primary care network serving a diverse low-income population. (Source: Academic Pediatrics)
Source: Academic Pediatrics - May 27, 2018 Category: Pediatrics Source Type: research

The Standardized Korean Red Ginseng Extract and Its Ingredient Ginsenoside Rg3 Inhibit Manifestation of Breast Cancer Stem Cell-like Properties through Modulation of Self-renewal Signaling
Conclusions This study suggests that Rg3 has a therapeutic potential targeting breast CSCs. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 27, 2018 Category: Complementary Medicine Source Type: research

Red Ginseng Monograph
Publication date: Available online 26 May 2018 Source:Journal of Ginseng Research Author(s): Seung-Ho So, Jong Won Lee, Young-Sook Kim, Sun Hee Hyun, Chang-Kyun Han Ginseng has been traditionally used for several millennia in Asian countries including Korea, China, and Japan, not only as a nourishing and tonifying agent but also as a therapeutic agent for a variety of diseases. In recent years, the various effects of red ginseng including immunity improvement, fatigue relief, memory improvement, blood circulation improvement, anti-oxidation, mitigation of menopausal women’s symptoms, and anti-cancer have been report...
Source: Journal of Ginseng Research - May 27, 2018 Category: Complementary Medicine Source Type: research

Ginsenoside compound K inhibits nuclear factor-kappa B by targeting Annexin A2
Conclusion This study for the first time revealed a cellular target of C-K and the molecular mechanism for its anticancer activity. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 27, 2018 Category: Complementary Medicine Source Type: research

Ginsenoside Rg1 activates ligand-independent estrogenic effects via  rapid estrogen receptor signaling pathway
Conclusion Ginsenoside Rg1 exerted estrogenic actions by rapidly inducing the formation of ER containing signalosome in MCF-7 cells. Additionally, Rg1 could activate EGFR and c-Src ER-independently and exert estrogenic effects via rapid activation of membrane-associated ER and G protein-coupled estrogen receptor. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 27, 2018 Category: Complementary Medicine Source Type: research

Problems and solutions in IGRT for cervical cancer
Publication date: Available online 26 May 2018 Source:Reports of Practical Oncology & Radiotherapy Author(s): Iván Ríos, Ilse Vásquez, Elsa Cuervo, Óscar Garzón, Johnny Burbano The contribution of Image-guided Radiotherapy (IGRT) to modern radiotherapy is undeniable, being the way to bring into daily practice the dosimetric benefits of Intensity-Modulated Radiotherapy (IMRT). Organ and target motion is constant and unpredictable at the pelvis, thus posing a challenge to the safe execution of IMRT. There are potential benefits of IMRT in the radical treatment of cervical cancer pa...
Source: Reports of Practical Oncology and Radiotherapy - May 27, 2018 Category: Cancer & Oncology Source Type: research

Breast and cervical cancer incidence and mortality trends in Russia 1980 –2013
Conclusion The temporal patterns of breast cancer incidence and mortality in Russia are in line with other countries in Europe, although cervical cancer rates and the risk of occurrence in recent generations is rapidly increasing; these trends underscore the need to place immediate priority in national cervical vaccination and screening programs. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 27, 2018 Category: Cancer & Oncology Source Type: research

Enhancing the therapeutic effect via elimination of hepatocellular carcinoma stem cells using Bmi1 siRNA delivered by cationic cisplatin Nanocapsules
Publication date: Available online 26 May 2018 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Tan Yang, Yuyuan Chen, Pengxuan Zhao, Huiying Xue, Jia You, Bin Li, Yong Liu, Chuanchuan He, Xiaojuan Zhang, Lingling Fan, Robert J. Lee, Lei Li, Xiang Ma, Chuanrui Xu, Guangya Xiang Resistance of hepatocellular carcinoma (HCC) to systemic chemotherapy is partially due to presence of drug-resistant cancer stem cells. Bmi1 protein is essential for survival and proliferation of HCC cancer stem cells (CSCs). Here, we report that Bmi1 siRNA (Bmi1siR) loaded in cationic nanocapsules of cisplatin (NPC) eliminated ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 27, 2018 Category: Nanotechnology Source Type: research

Observations of Mortality in Farmed Bison in the Canadian Prairies: 2103 - 2016
Publication date: Available online 26 May 2018 Source:Preventive Veterinary Medicine Author(s): Tasha Epp, Fabienne D. Uehlinger, Chris Wojnarowicz, Pritpal S. Malhi, Soraya Sayi, Murray R. Woodbury The present study is a continuation of a previous mortality study on Saskatchewan bison farms with special emphasis on Malignant Catarrhal Fever. The updated objective of the study was to estimate the most common causes of mortality in farmed bison herds in Western Canada. Results were compared to the previous Saskatchewan study to assess the similarities and differences in the etiology associated with farmed bison deaths acro...
Source: Preventive Veterinary Medicine - May 27, 2018 Category: Veterinary Research Source Type: research

Calcium signaling and the therapeutic targeting of cancer cells
Publication date: Available online 26 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Alice H.L. Bong, Gregory R. Monteith The calcium signal is implicated in a variety of processes important in tumor progression (e.g. proliferation and invasiveness). The calcium signal has also been shown to be important in other processes important in cancer progression including the development of resistance to current cancer therapies. In this review, we discuss how Ca2+ channels, pumps and exchangers may be drug targets in some cancer types. We consider what factors should be taken into accoun...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 27, 2018 Category: Molecular Biology Source Type: research

Singlet oxygen probes made simple: Anthracenylmethyl substituted fluorophores as reaction-based probes for detection and imaging of cellular 1O2
We report herein that anthracenylmethyl modified non-fluorescent derivatives of fluorescein and rhodamine-6G can reacts with 1O2, which resulted in CC bond cleavage that detach anthracene unit from the fluorophores resulting in strong fluorescence enhancement. These probes exhibit high selectivity and sensitivity in detection and imaging of 1O2 in chemical and in living cells. Our approach makes it simple and flexible for development of reaction-based 1O2 fluorescent probes for broad application in chemical, biomedical, and environmental sciences. Graphical abstract (Source: Sensors and Actuators B: Chemical)
Source: Sensors and Actuators B: Chemical - May 27, 2018 Category: Chemistry Source Type: research

Association of polymorphism in P16 and myeloperoxidase genes with susceptibility to oral lesions in North Indian population
Conclusion Our results suggest that single nucleotide polymorphisms in P16 genes may affect the susceptibility to oral lesions; while genotype of MPO showed no association with the development of oral lesions. (Source: Meta Gene)
Source: Meta Gene - May 27, 2018 Category: Genetics & Stem Cells Source Type: research

The challenge of HPV vaccination uptake and opportunities for solutions: Lessons learned from Alabama
Publication date: August 2018 Source:Preventive Medicine, Volume 113 Author(s): Sarah E. Dilley, Sylvia Peral, J. Michael Straughn, Isabel C. Scarinci The human papillomavirus (HPV) vaccine is an important tool for cancer prevention. However, vaccination rates in Alabama, a state with high rates of HPV-related cancers, remain below the national average. Our objective was to develop a comprehensive assessment of HPV vaccination in our state, with the goal to make recommendations for tailored multilevel interventions. A multimodal approach with quantitative and qualitative data was used to determine barriers and facilitator...
Source: Preventive Medicine - May 27, 2018 Category: International Medicine & Public Health Source Type: research

Radioembolization for Hepatocellular Carcinoma: A Nationwide 10-Year Experience
Conclusions Use of TARE in patients with HCC has been increasing. Several factors are significantly associated with a less favorable outcome after TARE, including male sex, large tumors, and extrahepatic disease. These data can be used for designing future radioembolization trials. (Source: Journal of Vascular and Interventional Radiology)
Source: Journal of Vascular and Interventional Radiology - May 27, 2018 Category: Radiology Source Type: research

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract (Source: Molecular and Cellular Endocrinology)
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research

Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC –MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice
In this study, a sensitive, rapid and specific LC–MS/MS method for quantification of PX, VX and OH-VX in the plasma of tumor bearing mouse was developed and validated. After protein precipitation, all the analytes were separated on an Agilent ZORBAX Extend-C18 HPLC column (2.1 × 100 mm, 3.5 μm) with gradient elution. The analytes were detected by an electrospray negative ionization mass spectrometry in the multiple reaction monitoring mode. The transition m/z 369.0 → 119.0, m/z 312.9 → 117.9, m/z 329.0 → 196.0, and m/z 307.1 → 161.3 were used for monitoring PX, V...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 27, 2018 Category: Drugs & Pharmacology Source Type: research

Taxifolin binds with LXR ( α & amp; β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway
Conclusion These results validate the anti-cancer potential of TAX in DMBA-induced MC through LXR-mTOR/Maf1/PTEN axis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 27, 2018 Category: Drugs & Pharmacology Source Type: research

Drug metabolizing enzymes and their inhibitors' role in cancer resistance
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Shelly Pathania, Rohit Bhatia, Ashish Baldi, Randhir Singh, Ravindra K. Rawal Despite continuous research on chemotherapeutic agents, different mechanisms of resistance have become a major pitfall in cancer chemotherapy. Although, exhaustive efforts are being made by several researchers to target resistance against chemotherapeutic agents, there is another class of resistance mechanism which is almost carrying on unattended. This class of resistance includes pharmacokinetics resistance such as efflux by ABC transporters an...
Source: Biomedicine and Pharmacotherapy - May 27, 2018 Category: Drugs & Pharmacology Source Type: research

Definitive Local Therapy is Associated with Improved Overall Survival in Metastatic Cervical Cancer
Conclusions Definitive local therapy is associated with improved OS in patients with metastatic cervical cancer. These findings suggest a novel setting for the use of definitive local therapy in the metastatic setting. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - May 27, 2018 Category: Cancer & Oncology Source Type: research

Androgen blockade based clinical trials landscape in triple negative breast cancer
Publication date: Available online 25 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Author(s): Yaqin Shi, Fang Yang, Doudou Huang, Xiaoxiang Guan Androgen receptor (AR) targeted treatment has shown promising preliminary results in triple negative breast cancer (TNBC). Identification of AR-associated signaling pathways is of great significance for in-depth understanding of their roles in pathogenesis of TNBC. To meet this objective, preclinical and clinical studies were conducted to clarify the biological interactions of AR signaling and combination strategies based on AR-targeted therapy. Biologi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 27, 2018 Category: Cancer & Oncology Source Type: research

Mitochondria in Cancer metabolism, an organelle whose time has come?
Publication date: Available online 26 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Author(s): Rebecca G. Anderson, Lais P. Ghiraldeli, Timothy S. Pardee Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being studied a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 27, 2018 Category: Cancer & Oncology Source Type: research

Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA
Publication date: July 2018 Source:Molecular Immunology, Volume 99 Author(s): Jessica L. Shannon, Molly S. Murphy, Uma Kantheti, Jordan M. Burnett, Marina G. Hahn, Tyler J. Dorrity, Constantinos J. Bacas, Ethan B. Mattice, Kathryna D. Corpuz, Brianne R. Barker Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both pathogen and host origin. We aimed to examine the role of DNA sensors interferon-γ-inducible protein 16 (IFI16) and cyclic GMP-AMP synthase (cGAS) in responding to cytosolic DNA. We show IFI16 and cGAS can synergistically induce IFNb transcriptional activity in response t...
Source: Molecular Immunology - May 27, 2018 Category: Allergy & Immunology Source Type: research

TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression
Publication date: July 2018 Source:Molecular Immunology, Volume 99 Author(s): Gang Chi, Xin-Xia Feng, Ying-Xia Ru, Ting Xiong, Yuan Gao, Han Wang, Zhen-Long Luo, Ran Mo, Fang Guo, Yong-Pei He, Gui-Mei Zhang, De-An Tian, Zuo-Hua Feng Autoimmune hepatitis (AIH), a serious autoimmune liver disease, can be a lifelong illness, leading to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). So far the mechanisms for disease initiation are largely unknown. Here we report that the amplified non-AIH liver inflammation could promote the initiation of AIH due to the sustained increase of IL-6, IL-12, IL-4, and IL-25 in the liver...
Source: Molecular Immunology - May 27, 2018 Category: Allergy & Immunology Source Type: research

Affinity Network Fusion and Semi-supervised Learning for Cancer Patient Clustering
Publication date: Available online 26 May 2018 Source:Methods Author(s): Tianle Ma, Aidong Zhang Defining subtypes of complex diseases such as cancer and stratifying patient groups with the same disease but different subtypes for targeted treatments is important for personalized and precision medicine. Approaches that incorporate multi-omic data are more advantageous to those using only one data type for patient clustering and disease subtype discovery. However, it is challenging to integrate multi-omic data as they are heterogeneous and noisy. In this paper, we present Affinity Network Fusion (ANF) to integrate multi-omi...
Source: Methods - May 27, 2018 Category: Molecular Biology Source Type: research

Synthesis, characterization and anticancer studies of bis(1-phenylpiperazine dithiocarbamato) Cu(II), Zn(II) and Pt(II) complexes: Crystal structures of 1-phenylpiperazine dithiocarbamato-S,S ′ zinc(II) and Pt(II)
Publication date: 15 October 2018 Source:Journal of Molecular Structure, Volume 1170 Author(s): Fartisincha P. Andrew, Peter A. Ajibade Copper(II), zinc(II) and platinum(II) complexes of phenylpiperazine dithiocarbamate formulated as [CuL2], [PtL2] and [Zn2(μ-L)2(L)2], where L = phenylpiperazine dithiocarbamate were prepared and characterized by elemental analysis IR, UV–Visible, 1H and 13C NMR spectroscopy. Single crystal X-ray structures of the Zn(II) and Pt(II) complexes are also reported. The FTIR spectra of the complexes confirm the bidentate coordination of the ligand to the metal ions by the single ban...
Source: Journal of Molecular Structure - May 27, 2018 Category: Molecular Biology Source Type: research

Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression
AbstractTaraxasterol has potent anti-inflammatory and anti-tumor activity. However, the effect and potential mechanisms of Taraxasterol on the growth of human liver cancer have not been clarified. Histidine triad nucleotide-binding protein 1 (Hint1) is a tumor suppressor and its downregulated expression is associated with the development of cancer. Here, we report that Taraxasterol treatment significantly suppressed cell proliferation and induced cell cycle arrest at G0/G1 phase and apoptosis in liver cancer cells, but not in non-tumor hepatocytes. Furthermore, Taraxasterol upregulated Hint1 and Bax, but downregulated Bcl2...
Source: Journal of Molecular Medicine - May 27, 2018 Category: Molecular Biology Source Type: research

Multi-branched ionic liquid-chitosan as a smart and biocompatible nano-vehicle for combination chemotherapy with stealth and targeted properties
In this study, a smart, biocompatible, magnetic nanocarrier composed of multi-branched ionic liquid-chitosan grafted mPEG was designed and used for targeted multidrug delivery of DOX and MTX as model anticancer agents to MCF7 breast cancer cells. The results of hemolysis assay on human red blood cells and cytotoxicity studies indicated that blank nanocarrier has no significant hemolytic and cytotoxic effects in MCF7 cells as observed in the results of MTT assay, however, drugs-loaded nanocarrier could decrease the viability of MCF7 cells in a dose-dependent manner. To further simulate the interaction of nanocarrier with pl...
Source: Carbohydrate Polymers - May 27, 2018 Category: Biomedical Science Source Type: research

Dual docking robotic surgical staging for high risk endometrial cancer
Conclusion Robotic surgical staging with dual docking in women with high risk endometrial cancer seems to be feasible with few complications. More studies are required to assess the safety of robotic surgery and its impact on survival. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - May 27, 2018 Category: OBGYN Source Type: research

Sclerosing odontogenic carcinoma in the mandible
We report a case of an asymptomatic sclerosing odontogenic carcinoma in a 68-year-old woman. A bulge was noted in the anterior mandibular region, and it increased rapidly without clinical symptoms. On computed tomography, a radiolucent osteolytic lesion was identified in the central incisor apex of the mandible, and the labial cortical bone disappeared. Magnetic resonance imaging showed an internal heterogeneous circular mass outside the alveolar region. Pathological assessment of a biopsy specimen did not lead to a definitive diagnosis, but a benign odontogenic tumor was suspected. The tumor was resected en bloc with 4 in...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - May 27, 2018 Category: ENT & OMF Source Type: research