Tuning conductivity and roughness of diselenide polymer dot-coated surface for ROS-mediated selective real-time wireless detection of cancer cells
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Seul Gi Kim, Benny Ryplida, Nguyen Ngan Giang, Gibaek Lee, Kang Dae Lee, Sung Young Park (Source: Chemical Engineering Journal)
Source: Chemical Engineering Journal - June 22, 2021 Category: Chemistry Source Type: research

pH-responsive core-shell nanogels induce in situ antigen production for cancer treatment
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Ting Fan, Wenping Ye, Pengxuan Zhao, Weixin Zhou, Yan Chen, Chuanchuan He, Xiaojuan Zhang, Ruicong Yan, Chen Chen, Jun Luo, Tan Yang, Xiang Ma, Guangya Xiang, Yao Lu (Source: Chemical Engineering Journal)
Source: Chemical Engineering Journal - June 22, 2021 Category: Chemistry Source Type: research

Decorated of Au NPs over L-arginine-modified Fe3O4 nanoparticles as a novel nanomagnetic composite for the treatment of human ovarian cancer
Publication date: Available online 20 June 2021Source: Arabian Journal of ChemistryAuthor(s): Jing Xu, Li Li, Jun Zhang, Yifei Min (Source: Arabian Journal of Chemistry)
Source: Arabian Journal of Chemistry - June 22, 2021 Category: Chemistry Source Type: research

Reply to Wei Liu, Katherine Zukotynski, and Glenn Bauman’s Letter to the Editor re: Rachel M. Glicksman, Ur Metser, Douglass Vines, et al. Curative-intent Metastasis-directed Therapies for Molecularly-defined Oligorecurrent Prostate Cancer: A Prospective Phase II Trial Testing the Oligometastasis Hypothesis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.02.031
Publication date: Available online 20 June 2021Source: European UrologyAuthor(s): Rachel M. Glicksman, Alejandro Berlin (Source: European Urology)
Source: European Urology - June 21, 2021 Category: Urology & Nephrology Source Type: research

Contextual factors associated with cancer screening uptake: A systematic review of observational studies.
Publication date: Available online 21 June 2021Source: Preventive MedicineAuthor(s): Quentin Rollet, Laure Tron, Rémy De Mil, Guy Launoy, Élodie Guillaume (Source: Preventive Medicine)
Source: Preventive Medicine - June 21, 2021 Category: International Medicine & Public Health Source Type: research

Targeting PLA2G16, a lipid metabolism gene, by Ginsenoside Compound K to suppress the malignant progression of colorectal cancer
Publication date: Available online 12 June 2021Source: Journal of Advanced ResearchAuthor(s): Li Yang, Lingjie Zheng, Xiaonv Xie, Junjia Luo, Jing Yu, Lihua Zhang, Wenhui Meng, Yingen Zhou, Ling Chen, Dongsheng Ouyang, Honghao Zhou, Zhirong Tan (Source: Journal of Advanced Research)
Source: Journal of Advanced Research - June 21, 2021 Category: Research Source Type: research

MUC5AC expression is linked to mucinous/endometroid subtype, absence of nodal metastasis and mismatch repair deficiency in ovarian cancer
Publication date: Available online 21 June 2021Source: Pathology - Research and PracticeAuthor(s): Sebastian Dwertmann Rico, Barbara Schmalfeldt, Volkmar Müller, Linn Wölber, Isabell Witzel, Peter Paluchowski, Ingo von Leffern, Uwe Heilenkötter, Frank Jacobsen, Christian Bernreuther, Till Clauditz, Ronald Simon, Stefan Steurer, Eike Burandt, Andreas H Marx, Till Krech (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - June 21, 2021 Category: Pathology Source Type: research

HER2 positive mucinous carcinoma of breast with micropapillary features: Report of a case and review of literature
Publication date: September 2021Source: Human Pathology: Case Reports, Volume 25Author(s): Dinesh Chandra Doval, Rupal Tripathi, Sunil Pasricha, Pankaj Goyal, Chaturbhuj Agrawal, Anurag Mehta (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 21, 2021 Category: Pathology Source Type: research

Lingual primary tuberculosis mimicking malignancy
Publication date: Available online 20 June 2021Source: Annals of Medicine and SurgeryAuthor(s): Bahaa Razem, Sami El Hamid, Iro Salissou, Mohammed Raiteb, Faiçal Slimani (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - June 21, 2021 Category: General Medicine Source Type: research

Clarifying Progress on the Genomic Landscape of Actinic Keratosis
Most cutaneous squamous cell carcinomas (cSCCs) arise from actinic keratoses (AKs), making these premalignant lesions attractive targets for therapeutic intervention before transformation. In a new article of the Journal of Investigative Dermatology, Thomson et  al. (2021) characterize the genetic alterations in AKs and identify significantly mutated drivers associated with risk factors such as UVR or azathioprine along with signaling pathways that may regulate the progression from AK to cSCC. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 21, 2021 Category: Dermatology Authors: Matthew Hedberg, John T. Seykora Tags: Commentary Source Type: research

Clinical Snippets
Actinic keratoses (AKs) are considered to be the precursors of squamous cell carcinoma (SCC) because nearly 66% of SCCs arise from AKs, but whole-genome molecular analysis of the genomic landscapes of these lesions is lacking. Thomson et  al. performed whole-exome sequencing studies of AKs from 37 patients and compared these data with previously compiled sequencing data from SCCs from a subset of these patients. These sequencing data revealed that AKs are similar to SCCs at the genomic level and that these lesions exhibit similar t umor mutational burdens, patterns of driver genes, and copy number alterations. (Source...
Source: Journal of Investigative Dermatology - June 21, 2021 Category: Dermatology Tags: Clinical Snippets Source Type: research

Hypofractionated Intensity Modulated Radiation Therapy With Concurrent Chemotherapy in Locally Advanced Non-Small Cell Lung Cancer: A Phase II Prospective Clinical Trial (GASTO1011)
Publication date: Available online 20 June 2021Source: Practical Radiation OncologyAuthor(s): Bo Qiu, Mai Xiong, YiFeng Luo, QiWen Li, NaiBin Chen, Li Chen, SuPing Guo, Bin Wang, XiaoYan Huang, MaoSheng Lin, Nan Hu, JinYu Guo, Ying Liang, Yi Fang, JiBin Li, YunPeng Yang, Yan Huang, Li Zhang, SiYu Wang, Hui Liu (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - June 21, 2021 Category: Cancer & Oncology Source Type: research

Treatment of Adults and Young Adults with Acute Lymphoblastic Leukemia: Real Life Data from Two Centers in Slovakia
Publication date: Available online 20 June 2021Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Iveta Oravcova, Jozef Lukas, Silvia Cingelova, Ludmila Demitrovicova, Eva Mikuskova, Lubos Drgona, Ladislav Sopko, Balazs Galffy, Alzbeta Batorova, Martin Mistrik (Source: Clinical Lymphoma Myeloma and Leukemia)
Source: Clinical Lymphoma Myeloma and Leukemia - June 21, 2021 Category: Cancer & Oncology Source Type: research

Chylothorax associated with lymphatic reflux in a thoracic duct tributary after lung cancer surgery
Chylothorax after lung cancer surgery can be associated with lymphatic reflux into the damaged tributary from the thoracic duct. Catheter lymphangiography proved useful in detecting the location and direction of flow of lymphatic leakages as well as that in subsequent embolization. AbstractChyle leaks are attributed to damage to the thoracic duct itself or its tributaries during surgery. Chylothorax after lung cancer surgery can occur due to damaged thoracic duct tributaries; however, little is known of the mechanism involved. A 71-year-old female underwent a left upper lobectomy with hilar and mediastinal lymphadenectomy ...
Source: Thoracic Cancer - June 21, 2021 Category: Cancer & Oncology Authors: Hironori Ishida, Ken Nakazawa, Akitoshi Yanagihara, Tetsuya Umesaki, Ryo Taguchi, Akiko Yamada, Hiroyuki Nitanda, Hirozo Sakaguchi Tags: CASE REPORT Source Type: research

Mutational Spectrum of BRAF gene in colorectal cancer patients in Saudi Arabia
Publication date: Available online 20 June 2021Source: Saudi Journal of Biological SciencesAuthor(s): Mahmood Rasool, Peter Natesan Pushparaj, Abdelbaset Buhmeida, Sajjad Karim (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - June 21, 2021 Category: Biology Source Type: research

Parosteal lipoma of the rib: A rare condition in an uncommon location
SummaryA 36-year-old female patient was diagnosed with a parosteal lipoma arising from the left 3rd rib. This was preluded by a 5-year history of an asymptomatic and stable mass at the medial aspect of the left scapula. It had displayed an interval enlargement in the preceding 3  months which prompted investigation to rule out an aggressive lesion. The patient was investigated with CT, MRI and PET scan which demonstrated a well-circumscribed juxtacortical fatty mass with osseous excrescence and no enhancing soft tissue components or FDG avidity in the fatty component, in k eeping with a parosteal lipoma. CT-guided bio...
Source: Journal of Medical Imaging and Radiation Oncology - June 21, 2021 Category: Radiology Authors: Roland Z White, John Au, Thi Nguyen, Matthew J Sampson Tags: Medical Imaging —Case Letter Source Type: research

LNG-IUS combined with progesterone ameliorates endometrial thickness and pregnancy outcomes of patients with early-stage endometrial cancer or atypical hyperplasia
Am J Transl Res. 2021 May 15;13(5):5412-5419. eCollection 2021.ABSTRACTOBJECTIVE: To determine the positive effect of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with progesterone on endometrial thickness and pregnancy outcomes of patients with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer (EEC).METHODS: Patients with AEH or EEC admitted to our hospital were enrolled, and assigned to a control group (con group) and a combination group (com group). Patients in the con group were treated with LNG-IUS, while those in the com group were treated with LNG-IUS combined with progester...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Fang Fang Hao Xu Ling Wu Linyi Hu Ying Liu Yinnan Li Chunhua Zhang Source Type: research

Effects of high quality nursing in patients with lung cancer undergoing chemotherapy and related influence on self-care ability and pulmonary function
Am J Transl Res. 2021 May 15;13(5):5476-5483. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effects of high quality nursing in patients with lung cancer undergoing chemotherapy and related influence on self-care ability and pulmonary function.METHODS: 108 patients with lung cancer were grouped as the control group (54 cases, received routine nursing) and the observation group (54 cases, received high quality nursing including health education, psychological nursing, diet intervention, pain nursing and complication nursing). The psychology, self-care ability, pulmonary function, quality of life and complications before...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Jing Miao Shuo Ji Sue Wang Han Wang Source Type: research

The effect of comprehensive nursing on the recovery speed and prognosis of elderly colon cancer patients
Am J Transl Res. 2021 May 15;13(5):5491-5497. eCollection 2021.ABSTRACTTo explore the effect of comprehensive nursing on the recovery speed and prognosis of elderly colon cancer patients. A total of 110 elderly patients undergoing colon cancer surgery in our hospital from January 2018 to January 2020 were selected and divided into a control group (n=55, routine care) and an observation group (n=55, comprehensive nursing) according to the random number table method. The post-care stress state index score, surgical tolerance, postoperative recovery, postoperative complications, satisfaction, gastrointestinal quality of life ...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Jingjing Wu Chuanling Wei Fengxia Li Xiling Wang Fang Sun Source Type: research

Effect of comprehensive nursing on the appearance and recovery effect of oral squamous cell carcinoma patients
Am J Transl Res. 2021 May 15;13(5):5519-5525. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effect of comprehensive nursing on the appearance and recovery of oral squamous cell carcinoma.METHODS: 52 patients with oral squamous cell carcinoma admitted to our hospital from February 2019 to February 2020 were selected and divided into a control group (n = 26, conventional nursing care) and an observation group (n = 26, comprehensive nursing). The postoperative hospital stay and postoperative intravenous infusion time, quality of life score, postoperative complications, nursing satisfaction, shape recovery, SAS score,...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Junli Lu Dailing Xiao Junjie Sun Junqian Huang Source Type: research

Expression of miR-92a, miR-224 and miR-25 in non-small cell lung cancer and their correlation with clinical characteristics
Am J Transl Res. 2021 May 15;13(5):5561-5567. eCollection 2021.ABSTRACTOBJECTIVE: To analyze the correlation of the expression of microRNA-92a (miR-92a), microRNA-224 (miR-224), and microRNA-25 (miR-25) in non-small cell lung cancer with its clinical characteristics.METHODS: This prospective study was performed in 125 non-small cell lung cancer patients admitted to our hospital between January 2019 and January 2020. All patients' cancer and adjacent tissue were collected and the expression of miR-92a, miR-224, and miR-25 were detected using real-time fluorescence quantitative RT-PCR. Data were analyzed using SPSS statistic...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Hao Yuan Jiajia Su Siqin Hu Peng Wei Source Type: research

The effect of TACE in combination with thalidomide-mediated adjuvant therapy on the levels of VEGF and bFGF in patients with hepatocellular carcinoma
Am J Transl Res. 2021 May 15;13(5):5575-5581. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the efficacy of transcatheter arterial chemoembolization (TACE) combined with thalidomide-mediated adjuvant therapy on the expression levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in hepatocellular carcinoma (HCC) patients.METHODS: A prospective study was designed, by which 134 HCC patients from our hospital who underwent treatment were selected and randomly divided into an observation group and a control group, 67 participants per group. The control group was administered hepatic...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Chao Tong Hui Liu Rihui Chen Fengting Zhu Source Type: research

Effect of traditional Chinese medicine nursing on postoperative patients with gastric cancer and its impact on quality of life
Am J Transl Res. 2021 May 15;13(5):5589-5595. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effect of traditional Chinese medicine (TCM) nursing on postoperative patients with gastric cancer and its impact on quality of life.METHODS: According to the random number table method, 103 patients with gastric cancer were divided into observation group (n=52, TCM nursing) and control group (n=51, routine nursing). The postoperative recovery of gastrointestinal function, the scores of mental states, inflammatory index, self-esteem scale (SES) and quality of life score (generic quality of life inventory-74 scale, GQOLI-74 scal...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Yi Zhang Xueyan Wang Haixia Yang Source Type: research

Evaluation of the effect of ultrasound interventional injection of cisplatin in the treatment of liver cancer
Am J Transl Res. 2021 May 15;13(5):5603-5609. eCollection 2021.ABSTRACTOBJECTIVE: To evaluate the effect of ultrasound interventional injection of cisplatin in the treatment of hepatocellular carcinoma (HCC).METHODS: 68 patients with HCC admitted to our hospital from February 2016 to February 2018 were enrolled. According to the different treatment methods, they were divided into a study group and a control group. The control group was treated with hepatic artery embolization chemotherapy (n=34), the study group adopted interventional ultrasound injection of cisplatin (n=34). The clinical treatment effects of the two group...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Tao Zhang Shengkai Cheng Jianbo Li Yangyang Shang Mingyou Zheng Source Type: research

Integrated analysis identifies S100A16 as a potential prognostic marker for pancreatic cancer
CONCLUSION: S100A16 is a potential independent prognostic marker and immunotherapy target for PC. Mechanistically, S100A16 potentially affects prognosis by extensive immunosuppression, including the inhibition of the anti-tumor immune response of CD8+ T cells.PMID:34150181 | PMC:PMC8205789 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Tian Chen De-Meng Xia Chao Qian Shan-Rong Liu Source Type: research

The value of LncRNA SNHG5 as a marker for the diagnosis and prognosis of gastric cancer
Am J Transl Res. 2021 May 15;13(5):5420-5427. eCollection 2021.ABSTRACTOBJECTIVE: To elucidate the value of serum lncRNA SNHG5 as a marker for the diagnosis and prognosis in gastric cancer.METHODS: From January 2017 to January 2018, serum samples were collected from 50 cases of gastric cancer patients and 50 cases of benign gastrosia who underwent operations in our hospital, and 50 cases of healthy person. We detected the expression level of serum lncRNA SNHG5 in all research targets and the expression levels of LncRNA SNHG5 in the cancer adjacent tissues and cancer tissues of gastric cancer patients to analyze the relatio...
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Xiangying Li Yaqing Du Yunfang Wang Source Type: research

Factors related to spiritual well-being in the last days of life in three East Asian countries: An international multicenter prospective cohort study
CONCLUSIONS: This study found novel factors related to spiritual well-being in the last days of life, several of which differed according to country. Recognition of factors associated with spiritual well-being can improve the quality of palliative care.PMID:34148395 | DOI:10.1177/02692163211022179 (Source: Palliative Medicine)
Source: Palliative Medicine - June 21, 2021 Category: Palliative Care Authors: Yusuke Hiratsuka Sang-Yeon Suh Sun-Hyun Kim Shao-Yi Cheng Seok-Joon Yoon Su-Jin Koh Shin Ae Park Ji-Yeon Seo Jung Hye Kwon Jeanno Park Youngmin Park Sun Wook Hwang Eon Sook Lee Hong-Yup Ahn David Hui Ping-Jen Chen Takashi Yamaguchi Tatsuya Morita Satoru T Source Type: research

Reducing variability among treatment machines using knowledge-based planning for head and neck, pancreatic, and rectal cancer
CONCLUSIONS: Dosimetric indices of RapidPlan model-based plans appear to be comparable to the ones based on clinical plans regardless of energies, MLC types, and disease sites. The results suggest that the RapidPlan model can generate treatment plans independent of the type of treatment machine.PMID:34151503 | DOI:10.1002/acm2.13316 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - June 21, 2021 Category: Physics Authors: Hideaki Hirashima Mitsuhiro Nakamura Nobutaka Mukumoto Ryo Ashida Kota Fujii Kiyonao Nakamura Aya Nakajima Katsuyuki Sakanaka Michio Yoshimura Takashi Mizowaki Source Type: research

Improving symptom burden and quality of life in patients with myelofibrosis: current strategies and future directions
Expert Rev Hematol. 2021 Jun 21. doi: 10.1080/17474086.2021.1944096. Online ahead of print.ABSTRACTINTRODUCTION: Myelofibrosis (MF) is a complex and aggressive hematologic malignancy resulting from JAK/STAT-driven myeloproliferation and abnormal fibrogenesis. The clinical manifestations are heterogeneous and include splenomegaly, constitutional symptoms, cytopenias, impaired quality of life, and shortened survival. JAK inhibitors improve symptoms and splenomegaly to a variable degree in a proportion of patients, but the effects for many patients are insufficient or short-lived.AREAS COVERED: This review examines the conste...
Source: Expert Review of Hematology - June 21, 2021 Category: Hematology Authors: James Yoon Kristen Pettit Source Type: research

Chronic psychological stress attenuates the efficacy of anti-PD-L1 immunotherapy for bladder cancer in immunocompetent mice
Cancer Invest. 2021 Jun 19:1-28. doi: 10.1080/07357907.2021.1943746. Online ahead of print.ABSTRACTWe aimed to explore whether chronic psychological stress affected the efficacy of immune checkpoint inhibitors (ICIs) immunotherapy in bladder cancer. The chronic unpredictable mild stress (CUMS) process was applied during the administration of anti-PD-L1 for subcutaneous tumors in mice. Tumor regression was obviously shown in anti-PD-L1 therapy groups, while this effect was notably attenuated by CUMS. Additionally, increased infiltration of regulatory T cells, decreased amount of CD8+ lymphocytes, and reduced levels of tumor...
Source: Cancer Investigation - June 21, 2021 Category: Cancer & Oncology Authors: Qidong Zhou Zhiyu Qian Weihong Ding Guangliang Jiang Chuanyu Sun Ke Xu Source Type: research

Glioma associated microglia/macrophages distribution is conserved in glioblastoma regrowth: a morphometric study
Cancer Invest. 2021 Jun 21:1-14. doi: 10.1080/07357907.2021.1944179. Online ahead of print.ABSTRACTWe compared the morphological aspect of glioblastoma associated microglia/macrophages cells in 15 paired recurrent glioblastomas to check the ability of glioblastoma to recreate its microenvironment. The absolute number of GAMs is lower in normal tissue (21/mm2) than in the isolated tumor cells area (100-112/mm2) than in the solid tumor area (212-220/mm2) (p
Source: Cancer Investigation - June 21, 2021 Category: Cancer & Oncology Authors: Arnaud Pautrat Fran çois Vassal Fran çois Casteillo Nicolas Magn é Michel P éoc'h Fabien Forest Source Type: research

The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma
Cancer Invest. 2021 Jun 21:1-18. doi: 10.1080/07357907.2021.1944178. Online ahead of print.ABSTRACTUnderstanding dexamethasone's effect on the immune microenvironment in glioma patients is of key importance. We performed a comprehensive literature review using the NCBI PubMed database for all articles meeting the following search criteria. ((dexamethasone[All Fields]) AND (glioma or glioblastoma)[Title/Abstract]) AND (immune or T cell or B cell or monocyte or neutrophil or macrophage). Forty-three manuscripts were deemed relevant to the topic at hand. Multiple clinical studies have linked dexamethasone use to decreased ove...
Source: Cancer Investigation - June 21, 2021 Category: Cancer & Oncology Authors: Pavan S Upadhyayula Dominique M Higgins Michael G Argenziano Eleonora F Spinazzi Cheng-Chia Wu Peter Canoll Jeffrey N Bruce Source Type: research

ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma
CONCLUSIONS: Our work suggests that ROBO2 inhibits tumor progression in PDAC and may serve as a predictive biomarker and therapeutic target in PDAC.PMID:34148491 | DOI:10.1080/00365521.2021.1930144 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Cheng Ding Yatong Li Shunda Wang Cheng Xing Lixin Chen Hanyu Zhang Yizhi Wang Menghua Dai Source Type: research

Screening, clinical features and prognostic analysis of liver cirrhosis-related hepatocellular carcinoma
Scand J Gastroenterol. 2021 Jun 19:1-7. doi: 10.1080/00365521.2021.1938208. Online ahead of print.ABSTRACTOBJECTIVE: To explore the impact of the screening interval and methods on cirrhosis-related hepatocellular carcinoma (HCC) detection and to analyse the clinical features and prognosis of HCC.MATERIALS AND METHODS: We recruited 3000 patients diagnosed with liver cirrhosis, who had been treated at the First Affiliated Hospital of Anhui Medical University from January 2016 to January 2020. The time of admission was divided into 3- (group A, 539 cases), 6- (group B, 1012 cases), and 12-month screening groups (group C, 1449...
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Zhengwei Zha Wenyue Wu Qianqian Zhang Xi Wang Xuecan Mei Yi Xiang Derun Kong Source Type: research

MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer
CONCLUSION: In short, MALAT1 might be a potential biomarker and therapeutic target for HER2-positive breast cancer therapy.PMID:34148540 | DOI:10.2174/1568009621666210618164300 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - June 21, 2021 Category: Cancer & Oncology Authors: Chuansheng Yang Hongbo Zhu Yeru Tan Renjie Zhu Xiaoping Wu Yuehua Li Cunchuan Wang Source Type: research

Fungal infection in immunocompromised children
Rev Iberoam Micol. 2021 Jun 18:S1130-1406(21)00031-0. doi: 10.1016/j.riam.2021.04.005. Online ahead of print.ABSTRACTIn recent years, immunodeficiency condition has experienced a rise among children, who are at risk of invasive fungal infections (IFI) due to their health condition. Cancer, non-malignant hematological diseases, as primary immunodeficiencies, hematopoietic stem cell transplantation (HSCT), extreme prematurity, or critically ill condition in Pediatric Intensive Care Unit (PICU) are some immunosuppressive situations in children. The use of oncologic therapies, including immunotherapy and monoclonal antibodies,...
Source: Revista Iberoamericana de Micologia - June 21, 2021 Category: Biology Authors: Marta Gonz ález-Vicent Jos é Tomás Ramos-Amador Source Type: research

Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR-20a expression
Exp Ther Med. 2021 Aug;22(2):846. doi: 10.3892/etm.2021.10278. Epub 2021 Jun 7.ABSTRACTOsteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and a major regulatory factor in osteoclast development. OPG has been previously associated with the malignant behavior of various types of cancer, particularly that of cancer metastasis. However, information on the link between the expression profile of OPG and lung cancer metastasis remained elusive. In the present study, the expression levels of OPG in the serum samples of patients with non-small cell lung cancer (NSCLC) was measured using ELISA. The e...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Ke Wan Ziwei Tu Zhentian Liu Yun Cai Yinglan Chen Chunhua Ling Source Type: research

STK10 knockout inhibits cell migration and promotes cell proliferation via modulating the activity of ERM and p38 MAPK in prostate cancer cells
Exp Ther Med. 2021 Aug;22(2):851. doi: 10.3892/etm.2021.10283. Epub 2021 Jun 8.ABSTRACTProstate cancer (PCa) is one of the most common types of cancer and is a serious threat to men's health due to the high rate of incidence and metastasis. However, the exact underlying pathology of this malignant disease has yet to be fully elucidated. The ezrin-radixin-moesin (ERM) family of proteins are associated with the development and metastasis of various types of cancer. Serine threonine kinase 10 (STK10) is an ERM kinase that is involved in the activation of ERM proteins and serves essential roles in the aggregation and adhesion ...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Lu Zhang Shun-Yuan Lu Rui Guo Jin-Xia Ma Ling-Yun Tang Jin-Jin Wang Chun-Ling Shen Li-Ming Lu Jie Liu Zhu-Gang Wang Hong-Xin Zhang Source Type: research

miR-125b-5p inhibits cell proliferation by targeting ASCT2 and regulating the PI3K/AKT/mTOR pathway in an LPS-induced intestinal mucosa cell injury model
Exp Ther Med. 2021 Aug;22(2):838. doi: 10.3892/etm.2021.10270. Epub 2021 Jun 6.ABSTRACTIntestinal barrier injury is an important cause of death in patients with acquired immune deficiency syndrome (AIDS). Therefore, it is of great significance to identify a therapeutic target for intestinal barrier injury to delay the progression of AIDS. microRNA (miRNA/miR)-125b-5p has an extensive role in cancer and controlling intestinal epithelial barrier function, but its role in human immunodeficiency virus-related intestinal mucosal damage remains unknown. The present study was designed to explore the effects of miR-125b-5p on lipo...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Huiming Guo Jianyuan Gao Yuan Qian Huawei Wang Jiang Liu Qingyan Peng Yong Zhou Kunhua Wang Source Type: research

Molecular markers associated with potentially malignant oral lesions (Review)
Exp Ther Med. 2021 Aug;22(2):834. doi: 10.3892/etm.2021.10266. Epub 2021 Jun 4.ABSTRACTAccording to literature data, potentially premalignant oral lesions are the basis of over 85% of cell carcinomas. Despite multiple advances achieved during the last few decades in the diagnosis and treatment of oral squamous cell carcinomas, there has not been a significant change in the prognosis and 5-year survival rate. The prevention of malignant transformation of these tumors by diagnosis and targeted treatment would be the ideal scenario. These potentially premalignant oral lesions represent an important subject for either the clin...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Oana Mihaela Condurache Hritcu Ana Emanuela Botez Doinita Temelie Olinici P Onofrei Laura Stoica V B Grecu Paula Mihaela Toader Laura Gheuc ă-Solovăstru Elena Carmen Cotrutz Source Type: research

Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G < sub > 1 < /sub > /S cell cycle arrest in human colorectal cancer cells via ROS generation
Exp Ther Med. 2021 Aug;22(2):829. doi: 10.3892/etm.2021.10261. Epub 2021 Jun 3.ABSTRACTColorectal cancer (CRC) is one of the most common cancer types and a leading cause of cancer-associated mortality in China. Increased thioredoxin reductase 1 (TrxR1) levels have been previously identified as possible target for CRC. The present study revealed that the natural product hydroxytyrosol (HT), which exhibits a polyphenol scaffold, is a potent inhibitor of TrxR1. Inhibition of TrxR1 was indicated to result in accumulation of reactive oxygen species, inhibit proliferation and induce apoptosis and G1/S cell cycle arrest of CRC ce...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Sheng-Peng Zhang Ji Zhou Qing-Zhu Fan Xiao-Mei Lv Tian Wang Fan Wang Yang Chen Sen-Yan Hong Xiao-Ping Liu Bing-Song Xu Lei Hu Chao Zhang Ye-Ming Zhang Source Type: research

PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data
J Biosci. 2021;46:56.ABSTRACTTo promote diligent analysis of the progression of a disease, it is important to identify interesting biomarkers for the disease. Biclustering has already been established as an effective technique to help identify such biomarkers of high biological significance. Although in the recent past, a good number of biclustering techniques have been introduced, most of them fail to perform consistently across multiple domains or datasets. To choose a single biclustering technique that can help the accomplishment of such a critical task for multiple diseases with high precision is extremely difficult. H...
Source: Journal of Biosciences - June 21, 2021 Category: Biomedical Science Authors: Pallabi Patowary Dhruba K Bhattacharyya Source Type: research

Hypomethylation of < em > LIMD1 < /em > and < em > P16 < /em > by downregulation of < em > DNMT1 < /em > results in restriction of liver carcinogenesis by amarogentin treatment
J Biosci. 2021;46:53.ABSTRACTAmarogentin (active component of Chirata) was found to prevent CCl4/NDEA-induced liver carcinogenesis at mild dysplastic stage through modulation of cell cycle, apoptosis, self-renewal pathways. The cell cycle regulatory genes LIMD1, P16 and RBSP3 were found to be upregulated in restricted liver lesions. To understand the mechanism of upregulation during restriction of cacinogenesis, the effect of amarogentin on epigenetic modification was evaluated in this study. It was also validated in vitro. Hypermethylation of LIMD1 and P16 was seen in mouse hepatocellular carcinoma (30th week carcinogen c...
Source: Journal of Biosciences - June 21, 2021 Category: Biomedical Science Authors: Debolina Pal Subhayan Sur Rituparna Roy Suvra Mandal Chinmay Kumar Panda Source Type: research

Relationship of intracellular proteolysis with CAP1 and cofilin1 in non-small-cell lung cancer
J Biosci. 2021;46:55.ABSTRACTThe main cause of death in non-small-cell lung cancer (NSCLC) is tumor progression, in which metastasis and invasion play an important role. The metastatic cascade is marked by a change in morphological, biological, biochemical and functional characteristics, including the acquisition of cellular mobility. The migration activity of tumor cells determines the work of actin-binding proteins that cause their functional partners CAP1 and cofilin. Of interest is the study of the regulation of working tandem CAP1/cofilin in NSCLC. The mechanism that regulates the level of proteins in cells is proteol...
Source: Journal of Biosciences - June 21, 2021 Category: Biomedical Science Authors: E S Kolegova G V Kakurina E E Shashova N V Yunusova L V Spirina E A Sidenko D N Kostromitskiy A Yu Dobrodeev I V Kondakova Source Type: research

Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
Intern Med. 2021 Jun 19. doi: 10.2169/internalmedicine.4456-20. Online ahead of print.ABSTRACTA 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, leptomeningeal carcinomatosis from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabin...
Source: Internal Medicine - June 21, 2021 Category: Internal Medicine Authors: Kunio Iwatsuka Daiichiro Kikuta Hitoshi Shibuya Masahiro Ogawa Takuji Gotoda Mitsuhiko Moriyama Hiroshi Nakagawara Akihiro Hemmi Kenji Yamao Source Type: research

A Case of Adrenocortical Carcinoma Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
Intern Med. 2021 Jun 19. doi: 10.2169/internalmedicine.7555-21. Online ahead of print.ABSTRACTAdrenocortical carcinoma (ACC) is a rare malignancy with a very poor prognosis. A 77-year-old man underwent imaging studies due to poorly controlled hypertension, which revealed a mass measuring 43 mm in diameter near the left adrenal gland. There were no findings indicative of pheochromocytoma. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) was performed for the preoperative pathological evaluation, and the findings indicated a possibility of ACC. Based on these results, curative surgery was performed. If the diagn...
Source: Internal Medicine - June 21, 2021 Category: Internal Medicine Authors: Hiromune Katsuda Shomei Ryozawa Yuki Tanisaka Akashi Fujita Tomoya Ogawa Masahiro Suzuki Yoichi Saito Mei Hamada Masanori Yasuda Koshiro Nishimoto Masafumi Mizuide Source Type: research

Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea
Intern Med. 2021 Jun 19. doi: 10.2169/internalmedicine.7190-21. Online ahead of print.ABSTRACTThe spontaneous regression (SR) of cancer is defined as either partial or complete, and temporary or permanent, disappearance without appropriate treatment for the disease, and this phenomenon is rare in the case of small cell lung carcinoma (SCLC). We herein report an 83-year-old woman who presented with left-sided hemichorea associated with anti-SOX1 (SOX1-Ab) and -CV2/CRMP5 (CV2/CRMP5-Ab) antibodies with SR following a 7-year interval free of disease progression of SCLC. Hemichorea can present with the coexistence of anti-SOX1 ...
Source: Internal Medicine - June 21, 2021 Category: Internal Medicine Authors: Koichi Shibata Yoshiko Nishimura Hiroshi Sakura Source Type: research

New and topics: enfortumab vedotin mechanisms of response and resistance in urothelial cancer - What do we understand so far?
Urol Oncol. 2021 Jun 17:S1078-1439(21)00219-2. doi: 10.1016/j.urolonc.2021.05.013. Online ahead of print.ABSTRACTEnfortumab vedotin (EV) was FDA approved in December 2019 for platinum- and checkpoint-refractory urothelial cancer based on an exceptional 44% response rate, and is currently approved for use after platinum and checkpoint inhibitor therapy. Enfortumab is an antibody-drug conjugate that targets Nectin-4, which is widely expressed in urothelial cancer. Despite this ample target, clinical benefit is not achieved by all patients, and mechanisms of treatment resistance are undescribed. Herein we summarize what is kn...
Source: Urologic Oncology - June 21, 2021 Category: Urology & Nephrology Authors: Jean Hoffman-Censits Kara Lombardo David McConkey Noah M Hahn Babar Bashir Wm Kevin Kelly Burles Johnson Andres Matoso Source Type: research

Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking
This study aims to analyze the targets of the effective active ingredients of Scutellariae radix-Coptidis rhizoma drug pair (SCDP) in ulcerative colitis (UC) by network pharmacology and molecular docking and to explore the associated therapeutic mechanism. The effective active ingredients and targets of SCDP were determined from the TCMSP database, and the drug ingredient-target network was constructed using the Cytoscape software. The disease targets related to UC were searched in GeneCards, DisGeNET, OMIM, and DrugBank databases. Then, the drug ingredient and disease targets were intersected to construct a protein-protei...
Source: Evidence-based Complementary and Alternative Medicine - June 21, 2021 Category: Complementary Medicine Authors: Kai Niu Qifang Li Yuan Liu Yi Qiao Bingbing Li Chao Wei Kunrui Wang Lu'an Cui Canlei Zheng Rong Wang Li Zhang Honghua Zhang Bing Sun Bin Yu Source Type: research

Sonographic risk factors of aggressive behaviors in medullary thyroid carcinomas
CONCLUSION: High frequency ultrasound and TI-RADS were effective methods for preoperative diagnosis of MTC. Sex of the patients and margin of the nodule are common risk factors for both metastasis and perithyroidal invasion. Focality of the tumor is another independent risk factor for metastasis.PMID:34148749 | DOI:10.1016/j.asjsur.2021.05.036 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 21, 2021 Category: Surgery Authors: Chun-Ping Ning Eun-Kyung Kim Source Type: research