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An overview on hepatoprotective effects of thymoquinone.
Authors: Farkhondeh T, Noorbakhsh MF, Hayati F, Samarghandian S, Shaterzadeh-Yazdi H Abstract Liver as an essential organ has an important function in metabolism and waste secretion from the body. Disorders of this organ may caused by several reasons such as high alcoholic consumption, various chemical or microbial agents and various hepatic cancers. Reactive and oxidative stress and oxygen species (ROS) are introduced the main mechanisms of these hepatic injuries. The seeds of Nigella sativa (Family Ranunculaceae) which is known as black seed, is widely used as a medicinal herb for cure or prevention of many of di...
Source: Recent Patents on Food, Nutrition and Agriculture - February 24, 2018 Category: Food Science Tags: Recent Pat Food Nutr Agric Source Type: research

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.
Authors: Dayot S, Speisky D, Couvelard A, Bourgoin P, Gratio V, Cros J, Rebours V, Sauvanet A, Bedossa P, Paradis V, Ruszniewski P, Couvineau A, Voisin T Abstract Pancreatic ductal adenocarcinoma (PDAC) is still the poorest prognostic tumor of the digestive system. We investigated the antitumoral role of orexin-A and almorexant in PDAC. We analyzed the orexin receptor type 1 (OX1R) expression by immunohistochemistry in human normal pancreas, PDAC and its precursor dysplastic intraepithelial lesions. We used PDAC-derived cell lines and fresh tissue slices to study the apoptotic role of hypocretin-1/orexin-A and almo...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Milk/dairy products consumption and gastric cancer: an update meta-analysis of epidemiological studies.
In conclusion, we found adverse effect of dairy consumption associated with gastric cancer. PMID: 29467955 [PubMed] (Source: Oncotarget)
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Vitamin D receptor Taq I polymorphism and the risk of prostate cancer: a meta-analysis.
Authors: Kang S, Zhao Y, Wang L, Liu J, Chen X, Liu X, Shi Z, Gao W, Cao F Abstract Numerous previous studies reported the association of Vitamin D receptor gene Taq Ipolymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs. ...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Gemcitabine-based chemotherapy as a viable option for treatment of advanced breast cancer patients: a meta-analysis and literature review.
Authors: Xie Z, Zhang Y, Jin C, Fu D Abstract This meta-analysis was designed to compare the efficacy and safety of gemcitabine-based regimens for the treatment advanced breast cancer (ABC). Altogether 15 studies involving 8195 ABC patients were retrieved for analysis. Compared with non-gemcitabine-based chemotherapies, patients receiving gemcitabine-based therapy exhibited better overall survival (OS), progression free survival (PFS), and objective response rate (ORR) (HR = 1.12, 95% CI 1.05 to 1.19; HR = 1.16, 95% CI 1.03 to 1.30; HR = 1.14, 95% CI 1.04 to 1.24). Grade 3/4 hematologic toxicity was significantly h...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pharmacokinetic properties of radiolabeled mutant Interleukin-2v: a PET imaging study.
Authors: Hartimath SV, Manuelli V, Zijlma R, Signore A, Nayak TK, Freimoser-Grundschober A, Klein C, Dierckx RAJO, de Vries EFJ Abstract Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious immune-related toxicity. Recently, a mutant of IL2 (IL2v) with abolished CD25 binding, increased plasma half-life and less toxicity was engineered. Unlike wild-type IL2 (wt-IL2), mutant IL2v does not bind to the α-subunit (CD25) of the high affinity IL2αβγ receptor, but only to its β and γ su...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Socioeconomic status is inversely associated with esophageal squamous cell carcinoma risk: results from a population-based case-control study in China.
Authors: Gao P, Yang X, Suo C, Yuan Z, Cheng H, Zhang Y, Jin L, Lu M, Chen X, Ye W Abstract Socioeconomic status (SES) is suspected to influence the risk of esophageal squamous-cell carcinoma (ESCC) in China, however, the evidence is still inconclusive and the selection of SES indicators remains inconsistent. In current study, we examined the association between SES and risk of ESCC based on a population-based case-control study in Taixing, China, with 1298 histopathology-confirmed cases and 1900 controls recruited between October 2010 and September 2013. Data on SES indicators was collected using a structured ques...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

A liquid biopsy for bronchopulmonary/lung carcinoid diagnosis.
Authors: Kidd M, Modlin IM, Drozdov I, Aslanian H, Bodei L, Matar S, Chung KM Abstract No effective blood biomarker exists to detect and clinically manage bronchopulmonary (BP) neuroendocrine tumors (NET). We developed a blood-based 51 NET-specific transcript set for diagnosis and monitoring and evaluated clinical performance metrics. It accurately diagnosed the tumor and differentiated stable from progressive disease as determined by RECIST criteria. Gene expression was evaluated in: a) publicly available BPNET transcriptomes (GSE35679); b) two BPNET cell-lines; and c) BPNET tissue with paired blood (n = 7). Blood...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.
Authors: Korbecki J, Gutowska I, Kojder I, Jeżewski D, Goschorska M, Łukomska A, Lubkowska A, Chlubek D, Baranowska-Bosiacka I Abstract Recent years have seen considerable progress in understanding the biochemistry of cancer. For example, more significance is now assigned to the tumor microenvironment, especially with regard to intercellular signaling in the tumor niche which depends on many factors secreted by tumor cells. In addition, great progress has been made in understanding the influence of factors such as neurotensin, growth differentiation factor-15 (GDF-15), sphingosine-1-phosphate (S1P), and infection...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Correction: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Authors: Li X, Li M, Ruan H, Qiu W, Xu X, Lin Z, Yu J Abstract [This corrects the article DOI: 10.18632/oncotarget.14063.]. PMID: 29467964 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Meta-analysis of a 10-plex urine-based biomarker assay for the detection of bladder cancer.
Authors: Masuda N, Ogawa O, Park M, Liu AY, Goodison S, Dai Y, Kozai L, Furuya H, Lotan Y, Rosser CJ, Kobayashi T Abstract A 10-plex urine-based bladder cancer (BCa) diagnostic signature has the potential to non-invasively predict the presence of BCa in at-risk patients, as reported in various case-control studies. The present meta-analysis was performed to re-evaluate and demonstrate the robustness and consistency of the diagnostic utility of the 10-plex urine-based diagnostic assay. We re-analyzed primary data collected in five previously published case-control studies on the 10-plex diagnostic assay. Studies rep...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Diffusion-weighted imaging in identifying breast cancer pathological response to neoadjuvant chemotherapy: A meta-analysis.
Conclusions: DWI may be an accurate and nonradioactive imaging technique for identifying pCRs to NAC in breast cancer. Nonetheless, there are a variety of issues when assessing DWI techniques for estimating breast cancer responses to NAC, and large scale and well-designed clinical trials are needed to assess the technique's diagnostic value. PMID: 29467952 [PubMed] (Source: Oncotarget)
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughput NIS (sodium iodide symporter) enhancer screening platform using dual reporter gene system.
In conclusion, we successfully established a novel high-throughput NIS enhancer screening platform to excavate a NIS enhancer and identified K905-0266 TKI among TKI candidates and it's proven to increase the endogenous NIS expression and therapeutic efficacy of RAI in ATC. These findings suggest that a novel high-throughput NIS enhancer screening platform is useful for selecting of NIS promoter enhancers. In addition, K905-0266 TKI can be used to re-induce endogenous NIS expression and recover RAI therapy in ATC. PMID: 29467951 [PubMed] (Source: Oncotarget)
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Identification and characterisation of NANOG+/ OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines.
In this study, we report the presence of previously unknown populations of trophoblastic stem-like cells (SLCs) that are resistant to the chemotherapeutic drug doxorubicin. We demonstrate that these populations express the stem cell markers NANOG and Sox2 and higher levels of OCT-4 (NANOG+/OCT-4high/SOX2+). Although chemoresistant, we show that the invasive capacity of these trophoblastic SLCs is significantly inhibited by doxorubicin treatment. To better characterise these populations, we also identified cellular pathways that are involved in SLCs-chemoresistance to doxorubicin. In summary, we provide evidence of the pres...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Challenges in using liquid biopsies for gene expression profiling.
Authors: Porras TB, Kaur P, Ring A, Schechter N, Lang JE Abstract Circulating tumor cells (CTCs) have potential utility as a surrogate biomarker of tumor biology via a liquid biopsy. The aim of this study was to evaluate if the nCounter NanoString assay could be used for accurate gene expression profiling of CTCs using the PAM50 research-use-only CodeSet. Analysis was performed on CTCs isolated by the ANGLE Parsortix system from healthy blood spiked with the breast cancer cell lines Hs578T, SkBr3, MDA-MB-231 or MCF7. Using cell lines as gold standard positive controls and Parsortix processed blood without spiking (...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer.
Authors: Rasmussen SL, Krarup HB, Sunesen KG, Johansen MB, Stender MT, Pedersen IS, Madsen PH, Thorlacius-Ussing O Abstract Epigenetic alterations in colorectal cancer (CRC) cause important differences in the underlying tumor biology and aggressiveness. DNA hypermethylation is central for the development of CRC but the prognostic impact remains elusive. We aimed to assess the association between cell-free hypermethylated DNA and stage and survival in colorectal cancer (CRC). We analyzed pre-treatment plasma samples from 193 patients with CRC. Thirty gene-promoter regions were analyzed using methylation specific PCR...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Metformin inhibits TGF- β1-induced epithelial-to-mesenchymal transition-like process and stem-like properties in GBM via AKT/mTOR/ZEB1 pathway.
In this study, we confirmed that metformin inhibited TGF-β1-induced EMT-like process and EMT-associated migration and invasion in LN18 and U87 GBM cells. Our results also showed that metformin significantly suppressed self-renewal capacity of glioblastoma stem cells (GSCs), and expression of stem cell markers Bmi1, Sox2 and Musashi1, indicating that metformin can inhibit cancer stem-like properties of GBM cells. We further clarified that metformin specifically inhibited TGF-β1 activated AKT, the downstream molecular mTOR and the leading transcription factor ZEB1. Taken together, our data demonstrate that metformi...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma.
Authors: Sakane T, Murase T, Okuda K, Takino H, Masaki A, Oda R, Watanabe T, Kawano O, Haneda H, Moriyama S, Saito Y, Yamada T, Nakanishi R, Inagaki H Abstract Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays. The cases of 53 patients were reviewed and their specimens were subjected to four PD-L1 assays with different antibodies (SP142, SP263, 22C3, and 28-8). The PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was evaluated. I...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient.
Authors: Phan NN, Wang CY, Li KL, Chen CF, Chiao CC, Yu HG, Huang PL, Lin YC Abstract Breast cancer is a dangerous disease that results in high mortality rates for cancer patients. Many methods have been developed for the treatment and prevention of this disease. Determining the expression patterns of certain target genes in specific subtypes of breast cancer is important for developing new therapies for breast cancer. In the present study, we performed a holistic approach to screening the mRNA expression of six members of the cell division cycle-associated gene family (CDCA) with a focus on breast cancer using the...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The modified glasgow prognostic score is an independent prognostic indicator in neoadjuvantly treated adenocarcinoma of the esophagogastric junction.
Authors: Jomrich G, Hollenstein M, John M, Baierl A, Paireder M, Kristo I, Ilhan-Mutlu A, Asari R, Preusser M, Schoppmann SF Abstract The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. mGPS wa...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer.
Authors: Guo X, Zhao W, Liu Z, Wang J Abstract Ras-targeted therapy represents a 'holy grail' in oncology. Based on our model prediction, Spiclomazine freezing the intermediate conformation of activated Ras is central to cancer therapeutics. We show here that Spiclomazine leads to an effective suppression in Ras-mediated signaling through abrogating the KRas-GTP level in the KRas-driven pancreatic cancer. The Ras-mediated signaling inhibition leads to dramatically reduced survivals of five KRas-driven pancreatic cancer cell lines with IC50 ranging 19.7~74.2 μM after 48 hours of treatment. However, no significant...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.
In this study, we examined the binding details of ZB716 to the estrogen receptor alpha (ERα) by computer modeling to reveal its interactions with the ligand binding domain as a steroidal molecule. We also found that ZB716 modulates ERα-coregulator interactions in nearly identical manner to fulvestrant. The ability of ZB716 to inhibit cell growth and downregulate ER expression in endocrine resistant, ERα mutant breast cancer cells was demonstrated. Moreover, in both the MCF-7 xenograft and a patient derived xenograft model, orally administered ZB716 showed superior efficacy in blocking tumor growth when co...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SMAD4-independent activation of TGF- β signaling by MUC1 in a human pancreatic cancer cell line.
We report that overexpression of MUC1 in BxPC3 human PDA cells (BxPC3.MUC1) enhances the induction of epithelial to mesenchymal transition leading to increased invasiveness in response to exogenous TGF-β1. Simultaneously, these cells resist TGF-β induced apoptosis by downregulating levels of cleaved caspases. We show that mutating the tyrosines in MUC1-CT to phenylalanine reverses the TGF-β induced invasiveness. This suggests that the tyrosine residues in MUC1-CT are required for TGF-β induced invasion. Some of these tyrosines are phosphorylated by the tyrosine kinase c-Src. Thus, treatment of BxPC3.MUC...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer.
Authors: Yamauchi T, Espinosa Fernandez JR, Imamura CK, Yamauchi H, Jinno H, Takahashi M, Kitagawa Y, Nakamura S, Lim B, Krishnamurthy S, Reuben JM, Liu D, Tripathy D, Chen H, Takebe N, Saya H, Ueno NT Abstract Chemotherapy has been reported to increase the proportion of cancer stem cells (CSCs) and to promote epithelial-mesenchymal transition (EMT) phenotype changes. Anti-HER2 therapy may provide a strategy for eliminating CSC and EMT, which contribute to therapeutic resistance. No study has determined the changes in the quantity or characteristics of CSCs or circulating tumor cells (CTCs) with EMT phenotype durin...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Effects of STC1 overexpression on tumorigenicity and metabolism of hepatocellular carcinoma.
In this study, using a metastatic HCC cell-line (MHCC-97L, P) and lentiviral vector mediated-STC1 overexpression, the inoculation of STC1-overexpressing MHCC-97L (S1) cells in a nude mice xenograft model demonstrated reductions in tumor mass and volume. As compared with P cells, S1 cells exhibited epithelial phenotype with significantly lower plating efficiency and reduced migratory and proliferative potential. Using coulter counter for cell-sizing, S1 cells (17.6 μm) were significantly smaller than P cells (19.6 μm). Western blot analysis revealed that S1 cells exhibited reduced expression level of phosphorylated ri...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Determinants of variability of five programmed death ligand-1 immunohistochemistry assays in non-small cell lung cancer samples.
Authors: Soo RA, Yun Lim JS, Asuncion BR, Fazreen Z, Herrera MC, Mohd Omar MF, Diem Phuong NH, Seet JE, Amanuel B, Iacopetta B, Byrne D, Hendry S, Fox S, Soong R Abstract Programmed death ligand-1 (PD-L1) expression as determined by immunohistochemistry (IHC) is potentially predictive of clinical outcome. The aim of this study was to assess the concordance of reported PD-L1 IHC assays and investigate factors influencing variability. Consecutive sections from 20 non-small cell lung cancers (NSCLCs) comprising resection, core biopsy, cytology and pleural fluid samples underwent IHC with 5 different antibody/autostain...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Characterization of aptamer-mediated gene delivery system for liver cancer therapy.
Authors: Liu Z, Sun X, Xiao S, Lin Y, Li C, Hao N, Zhou M, Deng R, Ke S, Zhong Z Abstract Liver cancer is a fatal disease with limited therapy options. The recombinant adenovirus expressing tumor-suppressor gene of PTEN (Ad5-PTEN) showed effective antitumor activity against liver cancer. However, its disadvantages produced great limitation on its application, especially its nonspecific and toxicity to normal cells and tissues. The epithelial cell adhesion molecule (EpCAM) is over-expressed in some liver cancer cells and an RNA aptamer EpDT3 could specially target to EpCAM-positive cells. Based on this founding, we ...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Toll-like receptor 2 induces adenosine receptor A2a and promotes human squamous carcinoma cell growth via extracellular signal regulated kinases ½.
Toll-like receptor 2 induces adenosine receptor A2a and promotes human squamous carcinoma cell growth via extracellular signal regulated kinases ½. Oncotarget. 2018 Jan 23;9(6):6814-6829 Authors: Palani CD, Ramanathapuram L, Lam-Ubol A, Kurago ZB Abstract Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 path...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Identification of the potential crucial genes in invasive ductal carcinoma using bioinformatics analysis.
In conclusion, the present study identified DEGs between normal and IDC samples, which could improve our understanding of the molecular mechanisms in the development of IDC, and these candidate genes might be used as therapeutic targets for IDC. PMID: 29467930 [PubMed] (Source: Oncotarget)
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients.
Authors: Mao Y, Zou C, Meng F, Kong J, Wang W, Hua D Abstract The single nucleotide polymorphisms (SNPs) in the microRNA precursor (pre-miRNA) may modulate the posttranscriptional regulation of gene expression and explain individual sensitivity to chemotherapy. Here we investigated the correlation between 23 SNPs in the pre-miRNA and the efficacy of capecitabine-based chemotherapy in 274 advanced colon cancer patients. Statistical analysis indicated that much more patients with rs744591 A/C(48.03%), C/C (53.45%) or C allele (49.73%) responded to the chemotherapy than those with the A/A genotype (33.71%). The respon...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor- β receptor type I inhibitor.
Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor. Oncotarget. 2018 Jan 23;9(6):6659-6677 Authors: Yingling JM, McMillen WT, Yan L, Huang H, Sawyer JS, Graff J, Clawson DK, Britt KS, Anderson BD, Beight DW, Desaiah D, Lahn MM, Benhadji KA, Lallena MJ, Holmgaard RB, Xu X, Zhang F, Manro JR, Iversen PW, Iyer CV, Brekken RA, Kalos MD, Driscoll KE Abstract Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target ...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Synthetic analysis of associations between IL-10 polymorphisms and skin cancer risk.
Authors: Zhao H, Yang J, Yu Z, Shen H, Huang X, Zhang M, Long T, Cailing A, Wang W Abstract The current study was designed to quantitatively summarize the evidence for the strength of the associations between common IL-10 functional polymorphisms and skin cancer risk. Relevant publications concerning the associations between common IL-10 functional polymorphisms(-1082G>A, -819C>T and -592C>A) and skin cancer were retrieved by a comprehensive electronic literature search in PubMed, Web of Science, EBSCO, Embase, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Database (CBM). The odds ra...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients.
CONCLUSIONS: VEGF-A mRNA and CHD4 mRNA were up-regulated in CK20-positive pN0 lymph nodes and they may have prognostic significance in pN0 CRC patients. METHODS: Two cohorts of lymph node specimens from pN0 CRC patients of each with and without CK20-positive cells were recruited. In the first cohort, tumor metastasis genes were profiled using gene expression arrays. Differential expressed genes were validated in the second cohort. Moreover, their prognostic significance was examined by following-up the second cohort of patients with CK20-positive cells for 60 months and all histopathological findings were correlated to...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Inferring modes of evolution from colorectal cancer with residual polyp of origin.
In this study, we analyzed patterns of somatic single nucleotide variations (SNVs) and copy number aberrations (CNAs) in CRC with residual polyp of origin from 13 patients in order to determine this relationship. For each MOE we defined an expected pattern with characteristic features of allele frequency distributions for SNVs in cancers and their matching adenomas. From these distinct patterns, we then assigned an MOE to each CRC case and found that stepwise progression was the most common (70% of cases). We found that CRC with the same MOE may exhibit different mutational spectra, suggesting that different mutational mec...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Kanglaite inhibits EMT caused by TNF- α via NF-κΒ inhibition in colorectal cancer cells.
Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells. Oncotarget. 2018 Jan 23;9(6):6771-6779 Authors: Shi G, Zheng X, Zhang S, Wu X, Yu F, Wang Y, Xing F Abstract Tumor necrosis factor-alpha is a critical pro-inflammatory cytokine produced by macrophages and was once considered an anti-tumor agent. However, a low dose of tumor necrosis factor-alpha can cause epithelial mesenchymal transition, angiogenesis and metastasis. NF-κΒ contributes to epithelial mesenchymal transition induced by tumor necrosis factor-alpha. Kanglaite, an extract from ...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pectoral nerve block and persistent pain following breast cancer surgery: an observational cohort study.
Authors: Besch G, Lagrave-Safranez C, Ecarnot F, de Larminat V, Gay C, Berthier F, Samain E, Pili-Floury S PMID: 29469548 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - February 24, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Access to Anti-Cancer Drugs in India: Is There a Need to Revise Reimbursement Policies?
CONCLUSIONS: Policy makers should consider addition of newer treatments, exclusion of sub-optimal treatments, increments in per patient budget and optimization of supportive care, which may contribute to improvements in survival and quality of life for Indian cancer patients. PMID: 29466887 [PubMed - as supplied by publisher] (Source: Expert Review of Pharmacoeconomics and Outcomes Research)
Source: Expert Review of Pharmacoeconomics and Outcomes Research - February 24, 2018 Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research

Setting the IMPACT (IMProve Access to Clinical Trial data) Observatory baseline.
Conclusions: Our findings indicate that the year 2000 could be used as a baseline for monitoring the evolution of CT data sharing as basic prerequisites were set in place, including greater understanding that CT data sharing is essential for decision making and the advancements of the Internet. PMID: 29472799 [PubMed - in process] (Source: Biochemia Medica)
Source: Biochemia Medica - February 24, 2018 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Diagnostic value of tumour markers in pleural effusions.
Authors: Volarić D, Flego V, Žauhar G, Bulat-Kardum L Abstract Introduction: We investigated whether tumour markers carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cancer antigen 125 (CA-125), and cytokeratin 19 fragment (CYFRA 21-1) in pleural effusions and serum can be used to distinguish pleural effusion aetiology. Materials and methods: During the first thoracentesis, we measured pleural fluid and serum tumour marker concentrations and calculated the pleural fluid/serum ratio for patients diagnosed with pleural effusion, using electrochemiluminescence immunoassays. Receiver operating charac...
Source: Biochemia Medica - February 24, 2018 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Gamma heavy-chain disease accompanied with follicular lymphoma: a case report.
We describe a case of a challenging diagnosis of γ-HCD due to the absence of clinical signs frequently reported in the disease (anaemia and palatal oedema among others). Haematological malignancy was the first suspicion but bone marrow examination was negative. In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient. A thoracoabdominal computed tomography reported many small adenopathies whose pathological and immunohystochemical study revealed a follicular lymphoma. Shortly after, serum inmunofixation secondary to an abnormal electrophoretic p...
Source: Biochemia Medica - February 24, 2018 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

The Role of Pregnancy, Perinatal Factors, and Hormones in Maternal Cancer Risk: A review of the evidence
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - February 24, 2018 Category: Internal Medicine Authors: Rebecca Troisi, Tone Bj ørge, Mika Gissler, Tom Grotmol, Cari M. Kitahara, Solbjørg Makalani Myrtveit Sæther, Anne Gulbech Ording, Camilla Sköld, Henrik Toft Sørensen, Britton Trabert, Ingrid Glimelius Tags: Review ‐Symposium Source Type: research

FDG-PET Assessment of Other Gynecologic Cancers
PET and PET/computed tomography play a role in the staging, monitoring of response to therapy, and surveillance for cervical and ovarian cancers. Currently, it is also an integral part of the assessment of patients with endometrial cancer and other gynecologic malignancies, such as vaginal and vulvar cancers and uterine sarcomas. In this article, we discuss in detail and highlight the potential role of PET and PET/computed tomography in evaluating these gynecologic malignancies using illustrative cases with relevant imaging findings. (Source: PET Clinics)
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Silvana Faria, Catherine Devine, Chitra Viswanathan, Sanaz Javadi, Brinda Rao Korivi, Priya R. Bhosale Source Type: research

Imaging in Gynecologic Oncology
PET CLINICS (Source: PET Clinics)
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Drew A. Torigian, Domenico Rubello Source Type: research

The Role of PET Imaging in Gynecologic Radiation Oncology
The goal of this review is to discuss the current utility of fluorine-18 –fluorodeoxyglucose (FDG)–PET for radiation oncologists who treat gynecologic malignancies. FDG-PET/computed tomography (CT) is recommended for baseline assessment in cervical cancer and for staging in vulvar and vaginal cancer. The authors use FDG-PET/CT in definitive radiation treatment planni ng for cervical, vulvar, and vaginal cancer. PET may be helpful for salvage radiation treatment planning for any recurrent gynecologic malignancy. There are published data to support the use of PET in posttreatment evaluation of cervical and vulvar...
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Yuan James Rao, Perry W. Grigsby Source Type: research

Non –18F-2-Fluoro-2-Deoxy-d-Glucose PET/Computed Tomography in Gynecologic Oncology
The current status and future potential targets of non –18F-2-fluoro-2-deoxy-d-glucose (FDG) PET/computed tomography (CT) in 3 major gynecologic malignancies are discussed. Estrogen receptor–based 16alpha-18F-fluoro-17beta-estradiol (18F-FES) PET/CT has been investigated in (a) Uterine malignancies (both endometrial and myometrial pathologies) and ( b) ovarian carcinoma. For uterine tumors, FDG/FES standardized uptake value and/or uptake ratio showed a positive correlation with malignant transformation (ie, endometrial carcinoma and uterine sarcoma) and higher malignant grades, whereas higher 18F-FES uptake was...
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Ashwini Kalshetty, Sandip Basu Source Type: research

Normal Variants and Pitfalls Encountered in PET Assessment of Gynecologic Malignancies
This article reviews normal variants and potential pitfalls encountered in PET assessment of gynecologic malignancies to provide useful information for the referring and reporting physicians. (Source: PET Clinics)
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Jian Q. Yu, Mohan Doss, R. Katherine Alpaugh Source Type: research

Imaging in Gynecologic Oncology
Gynecologic malignancies account for a significant proportion of disease-related morbidity and mortality in women throughout the world. Multimodality imaging, predominantly with PET, ultrasonography (US), computed tomography (CT), and MR imaging, plays an essential role in the diagnosis, staging, pretreatment planning, response assessment, and surveillance assessment of patients with such conditions. Therefore, in this issue of PET Clinics, we provide a series of state-of-the-art articles regarding the application of multimodality imaging to various gynecologic malignancies. (Source: PET Clinics)
Source: PET Clinics - February 24, 2018 Category: Radiology Authors: Drew A. Torigian, Domenico Rubello Tags: Preface Source Type: research

Forthcoming Issues
Breast Cancer (Source: PET Clinics)
Source: PET Clinics - February 24, 2018 Category: Radiology Source Type: research

RCR Meetings
(Source: Clinical Oncology)
Source: Clinical Oncology - February 24, 2018 Category: Radiology Source Type: research

Cancer development in Korean patients with ANCA-associated vasculitis: a single centre study.
CONCLUSIONS: The risk of cancer is low in Korean patients with AAV. PMID: 29465366 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research