Identification of 10 differentially expressed and cuproptosis-related genes in immune infiltration and prognosis of thyroid carcinoma
We presented the expression profiles of dysregulated genes in thyroid carcinoma. The findings of our study highlighted the potential of cuproptosis-related genes as prognostic biomarkers for thyroid carcinoma.PMID:38650151 | DOI:10.14715/cmb/2024.70.3.13 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Weixuan Yu Haiping Liu Yunda Zhang Ming Liu Weicong Li Libin Wang Dongwei Li Source Type: research
Chelerythrine induces apoptosis and ferroptosis through Nrf2 in ovarian cancer cells
In this study, we investigated the cytotoxic mechanism and potential targets of CHE on in vitro cultures of A2780 and SKOV3 cells derived from ovarian cancer. Additionally, in vivo experiments were conducted to confirm the suppressive impact of CHE on tumor growth in nude mice. The findings revealed that CHE impeded the growth of A2780 and SKOV3 cells in a concentration-time-dependent manner and significantly suppressed the development of tumors in nude mice. CHE elevated the level of oxidative stress in tumor cells, prompted cell cycle halt in the S phase, and increased their mitochondrial membrane potential. Western blot...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jia Zhou Yuchen Wang Yangxin Fu Zhe Lin He Lin Guangfu Lv Ning Kong Guo Xin Fang Zhou Zhidong Qiu Xiaowei Huang Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis
This study aimed to investigate the roles of circ_0006743 (circ_JMJD1C) in breast cancer. The downstream of circ_JMJD1C and their interaction network was determined by bioinformatic analyses. Gene expression were analyzed through western blot and qRT-PCR assays. Functional assays were conducted in vitro and in vivo to verify circ_JMJD1C role in BC. FISH and confocal analysis indicated the cellular distribution of circ_JMJD1C. Luciferase reporter, RNA immune-precipitation (RIP) assays, as well as Pearson's correlation analysis, were implemented to test the relation of miR-182-5p, JMJD1C and circ_JMJD1C. Circ_JMJD1C and JMJD...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Renyuan Xu Haomiao Lan Li Zhang Sisi Yang Yu Mao Hongying Che Source Type: research
The therapeutic effects of ADSCs on photoaging of skin induced by UVB irradiation
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):233-240. doi: 10.14715/cmb/2024.70.3.35.ABSTRACTSkin photoaging affects appearance and is associated with a variety of skin diseases, even skin cancer. Therefore, the prevention and treatment of skin photoaging is very important. However, there is a lack of effective evaluation methods, so it is an urgent problem to explore a comprehensive, non-invasive and in vivo evaluation method. Adipose-derived mesenchymal stem cells (ADSCs) are widely used to improve skin conditions as easier to obtain and positive effects. Recently, as the development of ultrasound technology, skin u...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jing Wang Xiaochen Zhou Di Cao Ying Meng Yingchun Wang Debin Yang Source Type: research
Importin 7 enhances protective autophagy induced by nuclear translocation of homeobox A10 in oral squamous cell carcinoma
This study aimed to explore the function and mechanism of IPO7 in OSCC. IPO7 expression in tissues and cells was determined by RT-qPCR. Cell proliferative, migratory, and invasive capabilities were detected through transwell assay and colony formation assay. Mice xenograft models were established for evaluating tumor growth. Autophagy was estimated by the LC3 levels in cells through western blot and immunofluorescence (IF). Western blot was utilized to detect the key proteins in PERK/EIF2AK3/ATF4 pathway for assessing the endoplasmic reticulum stress (ERS). The interaction of IPO7 and homeobox A10 (HOXA10) was tested by GS...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Shanshan Chen Jianbo Pan Source Type: research
Shanghai Gynecologic Oncology Group's Consensus on the academic and industry's clinical trial types
Chin Med J (Engl). 2024 Apr 24. doi: 10.1097/CM9.0000000000003146. Online ahead of print.NO ABSTRACTPMID:38654409 | DOI:10.1097/CM9.0000000000003146 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 23, 2024 Category: General Medicine Authors: Tingyan Shi Jihong Liu Jianqing Zhu Xipeng Wang Wei Jiang Xin Lu Weiwei Feng Shengtao Zhou Yang Shen Gang Chen Zhenyu Wu Dongling Zou Peng Wu Huijuan Yang Sufang Wu Tao Zhu Huaying Wang Yingli Zhang Lihua Qiu Xiaoqing Guo Libing Xiang Wei Zhang Yulan Ren Source Type: research
Brystkreft hos menn – histopatologi og biomarkører
Tidsskr Nor Laegeforen. 2024 Mar 27;144(5). doi: 10.4045/tidsskr.23.0438. Print 2024 Apr 23.ABSTRACTBACKGROUND: Breast cancer in men accounts for around 1 % of all cases of the disease. The study aimed to identify histopathological parameters and selected biomarkers in men with breast cancer.MATERIAL AND METHOD: Retrospective study of archival material from 53 men diagnosed with breast cancer at the department of pathology, Haukeland University Hospital, in the period 1996-2020. The prevalence of the oestrogen receptor (ER), progesterone receptor (PGR) and Human Epidermal Growth Factor (HER2) biomarkers was examined.RESULT...
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Ingvild Kathrin Lok øy Inga Sofie Bakken Elisabeth Wik Ingunn Marie Stefansson Source Type: research
A woman in her fifties with a post-operative infection, generalised rash and organ failure
This article presents a case of a middle-aged woman who developed symptoms of toxic shock syndrome five days after elective breast cancer surgery, with high fever, multiorgan failure and a characteristic desquamation of the palms.INTERPRETATION: Toxic shock syndrome is a potentially lethal, toxin-mediated disease. Symptoms develop quickly, within hours. Early recognition and appropriate surgical management, intensive care and antibiotics are therefore important to reduce mortality and sequelae.PMID:38651709 | DOI:10.4045/tidsskr.23.0623 (Source: Tidsskrift for den Norske Laegeforening)
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Naima Borg Tahri Berit Gravdehaug Nazli Bahrami Laurens Reitsma Source Type: research
Discordance between pain specialists and patients on the perception of dependence on pain medication: A multi-centre cross-sectional study
CONCLUSION: Medical shared-decision for changing pain treatment could be improved by taking into account the perception of patient dependence on medications for pain relief and or psychoactive effects, particularly in nociplastic pain for which the treatment is challenging.PMID:38653623 | DOI:10.1016/j.therap.2024.01.008 (Source: Therapie)
Source: Therapie - April 23, 2024 Category: Psychiatry & Psychology Authors: Anne Roussin Z énab Cissé Vanessa Rousseau Guillaume Roche C écile Lestrade Alexandre Cauchie No émie Delage Anne Donnet Elise Van Obberghen Chantal Wood Maryse Lapeyre-Mestre Nathalie Cantagrel Source Type: research
The Landsteiner lung cancer research platform (LALUCA) : Objectives, methodology and implementation of a real-world clinical lung cancer registry
CONCLUSION: The LALUCA registry is a web-based platform for the collection of real-world clinical data of lung cancer patients. Combining a large number of patients with a focus on gathering comprehensive data on diagnosis and treatment, the LALUCA registry provides a tool for investigation, evaluation, and improvement of the clinical management, survival and quality of care of Austrian lung cancer patients.PMID:38652311 | DOI:10.1007/s00508-024-02351-3 (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 23, 2024 Category: General Medicine Authors: Anna Lang-St öberl Hannah Fabikan Maximilan Hochmair Klaus Kirchbacher Vikaela Mania Rodriguez Leya Ay Christoph Weinlinger David Rosenthaler Oliver Illini Nino M üser Georg-Christian Funk Arschang Valipour Source Type: research
Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research
Predictors of treatment response in lymphogenic metastasized papillary thyroid cancer: a histopathological study
CONCLUSIONS: Detailed re-examination of lymph nodes revealed that only the presence of more than 5 lymph node metastases was an independent predictor of failure to achieve a complete response to treatment. No predictive value was found for other histopathological features, including the diameter of the lymph node metastases. These findings have the potential to improve risk stratification in patients with PTC and clinically evident lymph node metastases.PMID:38652802 | DOI:10.1093/ejendo/lvae048 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Caroline M J van Kinschot Lindsey Oudijk Charlotte van Noord Tim I M Korevaar Francien H van Nederveen Robin P Peeters Folkert J van Kemenade W Edward Visser Source Type: research
Medullary Thyroid Cancer: Single Institute Experience over Three Decades and Risk Factors for Recurrence
CONCLUSION: One of 4 patients undergoing surgery for MTC will recur. Risk factors associated with recurrence are male gender, lateral LN metastasis and high/highest MTC risk level mutations, but not necessarily surgery type. Preoperative calcitonin>2,175 pg/mL is suggestive of advanced disease and should prompt further evaluation.PMID:38651609 | DOI:10.1210/clinem/dgae279 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sara Abou Azar Joseph Tobias Megan Applewhite Peter Angelos Xavier M Keutgen Source Type: research
