Co-delivery of fucoxanthin and Twist siRNA using hydroxyethyl starch-cholesterol self-assembled polymer nanoparticles for triple-negative breast cancer synergistic therapy
CONCLUSION: Systematic studies revealed that this dual-functional nanomedicine that targets both tumor cells and tumor microenvironment significantly alleviates TNBC orthotopic tumor burden and inhibits lung metastasis, establishing a new paradigm for TNBC therapy.PMID:38636588 | DOI:10.1016/j.jare.2024.04.017 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Zeliang Wu Yuxiang Tang Yuanhui Liu Zhaozhao Chen Yuao Feng Hang Hu Hui Liu Gang Chen Youming Lu Yu Hu Rong Xu Source Type: research
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: L éo Pio-Lopez Michael Levin Source Type: research
CD58 alterations govern antitumor immune responses by inducing PD-L1 and IDO in diffuse large B-cell lymphoma
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2874. Online ahead of print.ABSTRACTRecurrent abnormalities in immune surveillance-related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate the response to therapeutic interventions. CD58 interacts with the CD2 receptor on T cells and natural killer (NK) cells and is recurrently mutated and deleted in DLBCL, suggesting it may play a role in regulating antitumor immunity. Herein, we comprehensively analyzed the genomic characteristics of CD58 through targeted next-generation sequencing, RNA-sequencing, whole-exome sequencing, and single...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Xiyue Xu Yidan Zhang Yaxiao Lu Xiaoyan Zhang Cuicui Zhao Jiesong Wang Qingpei Guan Yingfang Feng Meng Gao Jingwei Yu Zheng Song Xia Liu Zahra Golchehre Lanfang Li Weicheng Ren Qiang Pan-Hammarstr öm Huilai Zhang Xianhuo Wang Source Type: research
Fc-silent anti-TIGIT antibodies potentiate anti-tumor immunity without depleting regulatory T cells
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2455. Online ahead of print.ABSTRACTTIGIT is an inhibitory receptor on immune cells that outcompetes an activating receptor, CD226, for shared ligands. Tumor-infiltrating lymphocytes express TIGIT and CD226 on regulatory T cells (Treg) and on CD8+ T cells with tumor-reactive or exhausted phenotypes, supporting the potential of therapeutically targeting TIGIT to enhance anti-tumor immunity. To optimize the efficacy of therapeutic antibodies against TIGIT, it is necessary to understand whether there is therapeutic benefit from Fcγ receptor (FcγR) binding. Here, we show...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Dana Piovesan Amber E de Groot Soonweng Cho Amy E Anderson Rebecca D Ray Amita Patnaik Paul G Foster Casey G Mitchell Alejandra Y Lopez Espinoza Wandi S Zhu Carlo E Stagnaro Hema Singh Xiaoning Zhao Lisa Seitz Nigel P Walker Matthew J Walters Kelsey E Siv Source Type: research
CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-0453. Online ahead of print.ABSTRACTT cell exhaustion is a major contributor to immunosuppression in the tumor microenvironment (TME). Blockade of key regulators of T cell exhaustion, such as PD-1, can reinvigorate tumor-specific T cells and activate anti-tumor immunity in various types of cancer. Here, we identified that CD106 was specifically expressed in exhausted CD8+ T cells in the TME using single-cell RNA-sequencing. High CD106 expression in the TME in clinical samples corresponded to improved response to cancer immunotherapy. CD106 in tumor-specific T cells sup...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Yuto Naoi Takao Morinaga Joji Nagasaki Ryo Ariyasu Youki Ueda Kazuo Yamashita Wenhao Zhou Shusuke Kawashima Katsushige Kawase Akiko Honobe-Tabuchi Takehiro Ohnuma Tatsuyoshi Kawamura Yoshiyasu Umeda Yu Kawahara Yasuhiro Nakamura Yukiko Kiniwa Osamu Yamasa Source Type: research
Omental preadipocytes stimulate matrix remodeling and IGF signaling to support ovarian cancer metastasis
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2613. Online ahead of print.ABSTRACTOvarian cancer can metastasize to the omentum, which is associated with a complex tumor microenvironment. Omental stromal cells facilitate ovarian cancer colonization by secreting cytokines and growth factors. Improved understanding of the tumor supportive functions of specific cell populations in the omentum could identify strategies to prevent and treat ovarian cancer metastasis. Here, we showed that omental preadipocytes enhance the tumor initiation capacity of ovarian cancer cells. Secreted factors from preadipocytes supported ca...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Jennifer A Waters Mikella Robinson Omar Lujano-Olazaba Cassidy Lucht Samuel F Gilbert Carrie D House Source Type: research
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2552. Online ahead of print.ABSTRACTMetabolic subtypes of glioblastoma have different prognoses and responses to treatment. Deuterium metabolic imaging with 2H-labeled substrates is a potential approach to stratify patients into metabolic subtypes for targeted treatment. Here, we used 2H magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) measurements of [6,6'-2H2]glucose metabolism to identify metabolic subtypes and their responses to chemoradiotherapy in patient-derived glioblastoma xenografts in vivo. The metabolism of patient-derived cells was fi...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Jacob Chen Ming Low Jianbo Cao Friederike Hesse Alan J Wright Anastasia Tsyben Islam Alshamleh Richard Mair Kevin M Brindle Source Type: research
Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & amp; Heck coupling on cytotoxicity
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2342558. Online ahead of print.ABSTRACTSclareol, a bioactive diterpene alcohol isolated from Salvia sclarea, was subjected to structural modification and cytotoxic evaluation. Boron-Heck-coupled analogs of manoyl oxide were prepared from sclareol in a two-step reaction scheme. In the first step manoyl oxide was prepared from sclareol using cerium (IV) ammonium nitrate. Further the structural modification of manoyl oxide via Palladium (II) catalysed Boron-Heck coupling reaction produced a new series of compounds. All the synthesised compounds were screened for in vi...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Ifshana Gani Zahidul Islam Sofi Gursimar Kaur Anindya Goswami Khursheed Ahmad Bhat Source Type: research
Comprehensive characterization of β-alanine metabolism-related genes in HCC identified a novel prognostic signature related to clinical outcomes
In conclusion, this study uncovers β-alanine's significant role in HCC for the first time, suggesting new research targets and directions for diagnosis and treatment.PMID:38637116 | DOI:10.18632/aging.205744 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Yi Jia Xu Chen Hui Guo Biao Zhang Bin Liu Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
Autophagy cooperates with PDGFRA to support oncogenic growth signaling
Autophagy. 2024 Apr 18:1-2. doi: 10.1080/15548627.2024.2338572. Online ahead of print.ABSTRACTMacroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been shown to be involved in various aspects of tumor development by engaging with multiple cellular substrates. We recently uncovered a novel role for autophagy in regulating the signaling and levels of PDGFRA, a receptor tyrosine kinase amplified in several cancers. We discovered that PDGFRA can be targeted to autophagic degradation by bin...
Source: Autophagy - April 18, 2024 Category: Cytology Authors: Joanne E Simpson Noor Gammoh Source Type: research
Gallbladder cancer: surgical treatment, immunotherapy, and targeted therapy
Postgrad Med. 2024 Apr 18. doi: 10.1080/00325481.2024.2345585. Online ahead of print.ABSTRACTGallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, rad...
Source: Postgraduate Medicine - April 18, 2024 Category: Internal Medicine Authors: Yanjun Sun Junfeng Gong Zhuang Li Lin Han Dengqun Sun Source Type: research
Therapeutic Targeting of Thioredoxin Reductase 1 Causes Ferroptosis while Potentiating Anti-PD-1 Efficacy in Head and Neck Cancer
This study is the first to highlight TXNRD1 as a crucial factor contributing to resistance to anti-PD-1 treatment in HNSCC. In this study, we identified targetable regulators of resistance to immunotherapy-induced ferroptosis in HNSCC. We observed a link of thioredoxin reductase 1 (TXNRD1) with tumoral PD-L1 expression and ferroptosis suppression in HNSCC. Moreover, HNSCC tumors with aberrant TXNRD1 expression exhibited a lack of PD-1 response, NRF2 overexpression, and PD-L1 upregulation. TXNRD1 inhibition promoted ferroptosis in HNSCC cells with NRF2 activation and in organoid tumors derived from patients lacking a PD-1 r...
Source: Chemico-Biological Interactions - April 18, 2024 Category: Molecular Biology Authors: Ming-Shou Hsieh Hang Huong Ling Syahru Agung Setiawan Mardiah Suci Hardianti Iat-Hang Fong Chi-Tai Yeh Jia-Hong Chen Source Type: research
Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?
CONCLUSION: FDG-PET/CT detects residual and metastatic disease in patients with IGBC, enabling the institution of appropriate management and acting as a tool for prognostication of survival.PMID:38633288 | PMC:PMC11018561 | DOI:10.1007/s13139-024-00841-w (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Venkata Subramanian Krishnaraju Rajender Kumar Bhagwant Rai Mittal Harjeet Singh Piyush Aggarwal Harmandeep Singh Thakur Deen Yadav Ritambhra Nada Vikas Gupta Rajesh Gupta Source Type: research
Hepatic Superscan in Medullary Thyroid Carcinoma: A Rare Presentation in [ < sup > 18 < /sup > F]FDG PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):147-149. doi: 10.1007/s13139-023-00836-z. Epub 2024 Jan 18.NO ABSTRACTPMID:38633289 | PMC:PMC11018564 | DOI:10.1007/s13139-023-00836-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ahmed Saad Abdlkadir Dhuha Al-Adhami Baraa Alsyouf Raghad Alhouwari Ula Al-Rasheed Omar Jaber Issa Mohamad Akram Al-Ibraheem Source Type: research
