Implementing a Clinical Pathway for Malignant Bowel Obstruction in Patients with Gynecologic Malignancies
1. Recognize key aspects of care for hospitalized patients with malignant bowel obstruction.2. Describe opportunities and challenges in implementing a clinical pathway to improve quality of care among patients with malignant bowel obstruction. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Helen P. Knight, Caroline G. Hollahan, Shuk On Annie Leung, Isaac Chua, Janet L. Abrahm, Colleen M. Feltmate Source Type: research
Intranasal Esketamine for Treatment Resistant Depression with Suicidal Ideation in Cancer Patients: A Case Series
1. Participants will self-report the ability to discuss TRD and SI as significant psychiatric comorbidities associated with cancer.2. Participants will self-report the ability to discuss applications of IN esketamine for TRD and SI in patients with cancer. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: William Alexander, Mercy Tomy, AmyAllen Case, Sanjay Gupta Source Type: research
Pilot of a Telehealth Hospice Transition Intervention for Children and Young Adults with Cancer
1. Participants will be able to evaluate the feasibility and acceptability of a hospice telehealth home-based intervention for pediatric and young adult patients with cancer at the end of life using data obtained from the Technology Acceptable Model 2 survey.2. Participants will be able to assess the self-reported partnership, collaboration, and care coordination between the patient's hospice and hospital providers using the Assessment of Interprofessional Team Collaboration Scale II survey. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Nicholas DeGroote, Ebonee N. Harris, Shaheen Rana, Anna Lange, Karen Wasilewski-Masker, James L. Klosky, Katharine E. Brock Source Type: research
GSE248167 Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model
In conclusion, our novel TIDE-based subtyping method can serve as a powerful clinical tool for BC and pan-cancer patients, and potentially guiding personalized therapy decisions for selecting potential beneficiaries and excluding resistant patients of ICB therapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE173195 Roles of LTBP1 in the gastric cancer cells
We report the effect of LTBP1 on the RNA expression profiling in MKN28 gastric cancer cells (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE172334 Fusobacterium nucleatum Induces PD-L1 Expression by Tumor-Associated Macrophages and Inhibits Anti-Tumor Immunity in Colorectal Cancer.
Contributors : Yz Yang ; Yl MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFusobacterium nucleatum (Fn) infection has been linked to the initiation and development of colorectal cancer (CRC). However, the underlying mechanisms remains unexplored. Tissues from Fn-infected mice were first collected for single-cell RNA sequencing. we investigated the correlation between Fn infection and accumulations of tumor associated macrophages (TAMs) in tissues from human CRC or AOM/DSS treated mice. The impact of Fn on biological function of TAMs were interrogated. We deciphered the mechanis...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE255251 Integrative transcriptomic and proteomic profiling of subconfluent and confluent cancer cells
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a measure of cell confluency, we observed a profound translocation of AGO2 into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA s...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE255499 Replication-attenuated r3LCMV vectors potentiate tumor control via IFN-I
We report striking antitumoral effects by a nonlytic viral vector based on attenuated lymphocytic choriomeningitis virus (r3LCMV). We show in multiple tumor models that injection of tumor-bearing mice with this novel vector results in improved tumor control and survival. Importantly, r3LCMV also improved tumor control in immunodeficient Rag1-/- mice. Single cell RNA-Seq analyses, antibody blockade experiments, and KO models revealed a critical role for host IFN-I in the antitumoral efficacy of r3LCMV vectors. Collectively, these data demonstrate potent antitumoral effects by a replication-attenuated LCMV vector and unveil ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE262306 TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies
Contributors : Simone Minnie ; Olivia Waltner ; Geoffrey Hill ; Scott FurlanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusChronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (TPHEX), expressed granzymes, perforin, and IFN γ. Concurrent gene expression and DNA accessibility revealed that genes encoding these functional proteins correlated with BATF expression and motif accessibility. IFNγ+ TPHEX effectively kil...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
GSE249290 Integrative transcriptomic and proteomic profiling of the effects of cell confluency on gene expression
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a consequence of cell confluency, AGO2 protein translocates into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA sequencing, reve...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
A gastric sarcoma from 3000 years ago: paleopathological diagnosis at the field
ConclusionsMalignant diseases are seldom described in Paleopathology; to our knowledge, this is the oldest and most unique case of this type of pathology in mummies worldwide. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Correction: Predictive progression outcomes and risk stratification in patients with recurrent or metastatic nasopharyngeal carcinoma who received first ‑line immunochemotherapy
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Biologically effective dose (BED) value lower than 120 Gy improve outcomes in lung SBRT
ConclusionOur data suggest that mean total dose lower 54 and a calculated BED < 120 Gy is the optimal. Further prospective data are needed to confirm these results and determine the optimal dose fractionation scheme as a function of tumor size and location of volume. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Impact of 18F-FDG PET/CT in the management decisions of breast cancer board on early-stage breast cancer
ConclusionsIn conclusion, this study highlights the importance of adherence to the guidelines and appropriate use of PET/CT in early-stage breast cancer management. PET/CT should be reserved for cases where it is clinically warranted, considering the potential economic burden and minimal impact on treatment decisions of breast cancer tumor board in this patient population. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
