Dendritic cell-derived exosome (DEX) therapy for digestive system cancers: Recent advances and future prospect
Pathol Res Pract. 2024 Apr 6;257:155288. doi: 10.1016/j.prp.2024.155288. Online ahead of print.ABSTRACTTumor-mediated immunosuppression is a fundamental obstacle to the development of dendritic cell (DC)-based cancer vaccines, which despite their ability to stimulate host anti-tumor CD8 T cell immunity, have not been able to generate meaningful therapeutic responses. Exosomes are inactive membrane vesicles that are nanoscale in size and are produced by the endocytic pathway. They are essential for intercellular communication. Additionally, DC-derived exosomes (DEXs) contained MHC class I/II (MHCI/II), which is frequently c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Sulieman Ibraheem Shelash Al-Hawary Yasir Qasim Almajidi Pooja Bansal Irfan Ahmad Harpreet Kaur Ahmed Hjazi Mahamedha Deorari Ahmed Hussein Zwamel Hamza Fadhel Hamzah Bahira Abdulrazzaq Mohammed Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
Prognostic value of Geriatric-8 for adverse outcomes within 30 days of surgery in older adults with colorectal cancer: A retrospective cohort study
CONCLUSION: This study confirms that G8 scores have no prognostic value for adverse outcomes, complications and mortality within 30 days of surgery among older adults with CRC. Therefore, the G8 should not be the tool for short-term risk prediction of adverse outcomes in these patients.PMID:38652933 | DOI:10.1016/j.ejon.2024.102591 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 23, 2024 Category: Nursing Authors: A M Winters J Bakker J Ten Hoor H J G Bilo P F Roodbol M A Edens E J Finnema Source Type: research
Use of a wearable device to compare subjective and objective fatigue in lung cancer patients and cancer-free controls
CONCLUSIONS: Utilizing wearable smart bands for HRV-based analysis is feasible for objectively assess CRF levels in cancer patients, especially during sleep. By distinguishing between LF/HF ratios and LF/HF disorder ratios, our findings suggest that wearable technology and detailed HRV analysis offer promising avenues for real-time fatigue monitoring. This approach has the potential to significantly improve cancer care by providing new methods for managing and intervening in CRF, particularly with a focus on autonomic dysregulation as a crucial factor.PMID:38652934 | DOI:10.1016/j.ejon.2024.102587 (Source: European Journal...
Source: European Journal of Oncology Nursing - April 23, 2024 Category: Nursing Authors: Ting-Ling Chou Chi-Huang Shih Pai-Chien Chou Jun-Hung Lai Tsai-Wei Huang Source Type: research
The tumor suppressor effect of miRNA 200-c-3p on A549 non-small cell lung cancer cell line is associated with down-regulation of programmed cell death ligand 1; an immune-check point mechanism
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):13-21. doi: 10.14715/cmb/2024.70.3.3.ABSTRACTMiRNA 200-c-3p has varying functions in different tumor types, whether tumor suppression or promotion. Comprehensive assessment of its function in non-small cell lung cancer (NSCLC) together with its effect on antitumor immune response have not been declared before. We aimed to explore the effect of replacement and suppression of miRNA 200-c-3p on non-small cell lung cancer and its impact on immune checkpoint function and subsequently antitumor immunity. MiRNA 200-c-3p mimic/inhibitor was transfected into the A549 cells. A 549 no...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Sara Ezzat None Magda I Mohamad None Manal Basyouni Ahmed None Sara Elsayed Abdelrahman None Nesma Hussein Abdel Hay None Nashwa El-Khazragy None Maha Imam Ismail Source Type: research
Clinical value of KiSS-1 and MMP-2 expression levels in breast cancer tissue in evaluating prognosis of elderly breast cancer patients after modified radical mastectomy
In conclusion, KiSS-1 and MMP-2 levels in BC tissue possess relation to adverse prognosis of MCM. KiSS-1 and MMP-2 levels in elderly BC patients before surgery may be detected in the future to assist in prognosis evaluation of elderly BC patients after MCM.PMID:38650158 | DOI:10.14715/cmb/2024.70.3.38 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jiyang Lv Junya Zhang Fangfang Wu Source Type: research
MiR-4319 targets tuftelin 1 to reduce malignancy of cervical cancer cells
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):54-60. doi: 10.14715/cmb/2024.70.3.8.ABSTRACTCervical cancer (CC) is the most common malignant tumor of female reproductive system. MiR-4319 has been identified as an anti-oncogene in various cancers. In the present study, role of miR-4319 in CC was identified. Colony formation, flow cytometer, wound healing, and transwell assays were used to detect CC cell proliferation, apoptosis, migration, and invasion. The expression of miR-4319 was decreased in clinical CC tissues and CC cell lines. Upregulation of miR-4319 suppressed cell viability, proliferation, migration, and inva...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lijun Zheng Qiongzhen Ren Weipei Zhu Xiaomin Tao Liangsheng Guo Source Type: research
Development of a novel six DNA damage response-related prognostic signature in osteosarcoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):110-115. doi: 10.14715/cmb/2024.70.3.16.ABSTRACTDNA damage response (DDR) plays a vital role in the development of cancer. Nevertheless, in osteosarcoma, the potential of DDR-related genes (DDRGs) remains unclear. Thus, the current research is intended to investigate the mechanisms of DDRGs in the development of osteosarcoma and to explore potential DDR-related biomarkers in forecasting the prognosis of osteosarcoma patients. The osteosarcoma genomic data from TCGA, GEO and cBioPortal databases were utilized for screening and identification of differentially expressed DDRGs...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Tianyang Li Zhenzhou Tang Sucheng Li Minhua Lu Source Type: research
Lactoferrin mediates epithelial-mesenchymal transformation by regulating the PI3K/AKT/mTOR pathway to inhibit nasopharyngeal carcinoma metastasis
This study suggests that LTF is a potential biomarker of NPC and that LTF-mediated EMT progression plays a tumor-suppressive role in the progression of NPC metastasis.PMID:38650146 | DOI:10.14715/cmb/2024.70.3.19 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Min Xu Ye Fan Guoying Zou Qi Yang Fei Xu Source Type: research
Comprehensive bioinformatics analysis of KIF20A as a prognosis biomarker for clear cell renal cell carcinoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):116-124. doi: 10.14715/cmb/2024.70.3.17.ABSTRACTIt has been shown that kinesin family member 20A (KIF20A) is involved in the development of several cancers. However, research on clear cell renal cell carcinoma (ccRCC) and KIF20A is still exploratory. The current research was carried out to determine whether KIF20A expression has any prognosis value in ccRCC. Data were downloaded from The Cancer Genome Atlas (TCGA) database to validate the KIF20A mRNA expression and to perform clinicopathological analysis. Receiver operating characteristic (ROC) curves were used in evaluatin...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Cankun Xie Wingkeung Yiu Yijiang Mo Source Type: research
Identification of 10 differentially expressed and cuproptosis-related genes in immune infiltration and prognosis of thyroid carcinoma
We presented the expression profiles of dysregulated genes in thyroid carcinoma. The findings of our study highlighted the potential of cuproptosis-related genes as prognostic biomarkers for thyroid carcinoma.PMID:38650151 | DOI:10.14715/cmb/2024.70.3.13 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Weixuan Yu Haiping Liu Yunda Zhang Ming Liu Weicong Li Libin Wang Dongwei Li Source Type: research
Chelerythrine induces apoptosis and ferroptosis through Nrf2 in ovarian cancer cells
In this study, we investigated the cytotoxic mechanism and potential targets of CHE on in vitro cultures of A2780 and SKOV3 cells derived from ovarian cancer. Additionally, in vivo experiments were conducted to confirm the suppressive impact of CHE on tumor growth in nude mice. The findings revealed that CHE impeded the growth of A2780 and SKOV3 cells in a concentration-time-dependent manner and significantly suppressed the development of tumors in nude mice. CHE elevated the level of oxidative stress in tumor cells, prompted cell cycle halt in the S phase, and increased their mitochondrial membrane potential. Western blot...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jia Zhou Yuchen Wang Yangxin Fu Zhe Lin He Lin Guangfu Lv Ning Kong Guo Xin Fang Zhou Zhidong Qiu Xiaowei Huang Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis
This study aimed to investigate the roles of circ_0006743 (circ_JMJD1C) in breast cancer. The downstream of circ_JMJD1C and their interaction network was determined by bioinformatic analyses. Gene expression were analyzed through western blot and qRT-PCR assays. Functional assays were conducted in vitro and in vivo to verify circ_JMJD1C role in BC. FISH and confocal analysis indicated the cellular distribution of circ_JMJD1C. Luciferase reporter, RNA immune-precipitation (RIP) assays, as well as Pearson's correlation analysis, were implemented to test the relation of miR-182-5p, JMJD1C and circ_JMJD1C. Circ_JMJD1C and JMJD...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Renyuan Xu Haomiao Lan Li Zhang Sisi Yang Yu Mao Hongying Che Source Type: research
