Cervical Cancer Cell-derived Tie1 Expression Via PI3K/AKT Signaling Pathway Promotes Tumour Progression
CONCLUSIONS: Our research indicates that Tie1 is highly connected to CC progression as it may play a role in the EMT process through the PI3K/AKT signaling pathway.PMID:38719173 | DOI:10.1016/j.yexcr.2024.114060 (Source: Experimental Cell Research)
Source: Experimental Cell Research - May 8, 2024 Category: Cytology Authors: Yan Wei Panpan Yu None Zouyu Zhao Chongfeng Sun Qianyu Sun Rui Bai Weirui Gao Ping Yang Source Type: research
Prognostic value and immunological role of MMRN1: a rising star in cancer
CONCLUSION: Our analysis demonstrated a significant relationship between MMRN1 and prognosis, tumor immunity, and drug sensitivity of several tumors. As a rising star in cancer, it needs further research.PMID:38715238 | DOI:10.1080/15257770.2024.2335680 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - May 8, 2024 Category: Biochemistry Authors: Qing Zhou Ying Liu Jieyu Zhou Wenling Zhang Source Type: research
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPAR α and PCK1
Cell Metab. 2024 May 2:S1550-4131(24)00135-9. doi: 10.1016/j.cmet.2024.04.015. Online ahead of print.ABSTRACTThe role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well as ameliorates established NASH and fibrosis without affecting total calorie intake. Furthermore, the IF 5:2 regimen blunted NASH-HCC transition when applied therapeutically. The timing, length, and number of fasting cycles as well as the type of NASH diet were critical para...
Source: Cell Metabolism - May 8, 2024 Category: Cytology Authors: Suchira Gallage Adnan Ali Jose Efren Barragan Avila Nogayhan Seymen Pierluigi Ramadori Vera Joerke Laimdota Zizmare David Aicher Indresh K Gopalsamy Winnie Fong Jan Kosla Enrico Focaccia Xin Li Suhail Yousuf Tjeerd Sijmonsma Mohammad Rahbari Katharina S K Source Type: research
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer
Cell Metab. 2024 May 7;36(5):886-888. doi: 10.1016/j.cmet.2024.04.009.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.PMID:38718754 | DOI:10.1016/j.cmet.2024.04.009 (Source: Cell Metabolism)
Source: Cell Metabolism - May 8, 2024 Category: Cytology Authors: Shane J F Cronin Source Type: research
Co-delivery of Plinabulin and Tirapazamine boosts anti-tumor efficacy by simultaneously destroying tumor blood vessels and killing tumor cells
In this study, we employed methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (mPEG-b-PDLLA) to co-deliver Plinabulin and TPZ to the tumor site, concurrently disrupting blood vessels and eliminating tumor cells, addressing both symptoms and the root cause of tumor progression. Plinabulin was converted into a prodrug with esterase response (PSM), and TPZ was synthesized into a hexyl chain-containing derivative (TPZHex) for effective co-delivery. PSM and TPZHex were co-encapsulated with mPEG-b-PDLLA, forming nanodrugs (PT-NPs). At the tumor site, PT-NPs responded to esterase overexpression, releasing Plinabulin, disrupting bl...
Source: Biomaterials - May 8, 2024 Category: Materials Science Authors: Jianlin Lv Yajun Xu Ya Liu Kazuo Sakurai Haiyang Yu Zhaohui Tang Source Type: research
Correlation of NAT10 expression with clinical data and survival profiles in esophageal squamous cell carcinoma patients, and its impact on cell proliferation and apoptosis
CONCLUSION: The observed overexpression of NAT10 in ESCC tissues is associated with larger tumor diameters and reduced patient survival. NAT10 appears to play a pivotal role in the progression of esophageal cancer by influencing cell proliferation and apoptosis. These findings suggest potential clinical implications, with Ki67 and Caspase3 potentially participating in this intricate molecular biological process.PMID:38716745 | DOI:10.14670/HH-18-752 (Source: Histology and Histopathology)
Source: Histology and Histopathology - May 8, 2024 Category: Cytology Authors: Wei Sun Xiaoying Shen Xinyi Wang Xiaoyan Zhang Yongling Ji Jin Wang Source Type: research
Cystatin SA attenuates gastric cancer cells growth and increases sensitivity to oxaliplatin via PI3K/AKT signaling pathway
CONCLUSION: These findings indicate that CST2 is downregulated at the protein level in gastric cancer tissues and cell lines. Additionally, CST2 was found to attenuate the growth of gastric cancer cells and to enhance sensitivity to Oxaliplatin through the PI3K/AKT signaling pathway, specific to gastric cancer cell lines. CST2 may serve as a tumor suppressor gene increasing sensitivity to Oxaliplatin in gastric cancer.PMID:38717526 | DOI:10.1007/s00432-024-05780-9 (Source: Cell Research)
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Yida Lu Huizhen Wang Sihan Chen Bo Yang Yaxian Li Yongxiang Li Source Type: research
Left ventricular global longitudinal strain is worse in BRCA mutation positive breast cancer patients prior to cancer treatment and premature menopause
CONCLUSION: In women with newly diagnosed breast cancer and prior to treatment, LV-GLS was worse in BRCA1 and BRCA2 mutation carriers compared to those with BRCA wildtype. These findings suggest that BRCA mutations may be associated with subtle changes in cardiac function. Whether differences in GLS translate to increased cardiovascular risk in women with BRCA mutations needs to be further characterized.PMID:38717528 | DOI:10.1007/s10549-024-07344-4 (Source: Cell Research)
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Billy Lin Alexis LeVee Louie Cao Reva Basho Balaji Tamarappoo Janet Wei Chrisandra Shufelt Source Type: research
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis
In conclusion, altersolanol A exhibited potential reproductive cytotoxicity against human trophoblasts via promoting mitochondrial-mediated apoptosis and inhibiting the MAPK signaling pathway.PMID:38717551 | DOI:10.1007/s12550-024-00539-0 (Source: Cell Research)
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Ting Gu Yuting Wen Qian Zhou Wei Yuan Haichun Guo Wen-Lin Chang Qing Yang Source Type: research
LAMP2A regulates cisplatin resistance in colorectal cancer through mediating autophagy
CONCLUSION: In summary, LAMP2A boosted malignant progression and DDP resistance in CRC/DDP cells through mediating autophagy. Clarifying LAMP2A function in DDP resistance is promising to seek cancer therapies biomarkers targeting LAMP2A activity.PMID:38717639 | DOI:10.1007/s00432-024-05775-6 (Source: Cell Research)
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Zhiliang Shi Shuting Yang Chenglong Shen Jiazhe Shao Fang Zhou Haichen Liu Guoqiang Zhou Source Type: research
CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition
CONCLUSIONS: IDH-mutant gliomas with deletion of CDKN2A/B are sensitized to CDK4/6 inhibitors. These results support investigation of the use of these agents in a clinical setting.PMID:38718141 | DOI:10.1158/1078-0432.CCR-24-0562 (Source: Cell Research)
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Ali M Nasser Lisa Melamed Ethan Wetzel Chia-Chen Chang Hiroaki Nagashima Yosuke Kitagawa Logan Muzyka Hiroaki Wakimoto Daniel P Cahill Julie J Miller Source Type: research
The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression
Cancer Res. 2024 May 8. doi: 10.1158/0008-5472.CAN-23-3942. Online ahead of print.ABSTRACTCircadian clock perturbation frequently occurs in cancer and facilitates tumor progression by regulating malignant growth and shaping the immune microenvironment. Emerging evidence has indicated that clock genes are disrupted in melanoma and linked to immune escape. Here, we found that the expression of retinoic acid receptor-related orphan receptor-α (RORA) is downregulated in melanoma patients and that patients with higher RORA expression have a better prognosis after immunotherapy. Additionally, RORA was significantly positively c...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Dandan Liu Benliang Wei Long Liang Yue Sheng Shengjie Sun Xing Sun Maohua Li Haobo Li Chaoying Yang Yuanliang Peng Yifang Xie Chengcai Wen Lu Chen Xionghao Liu Xiang Chen Hong Liu Jing Liu Source Type: research
Estrogen induces LCAT to maintain cholesterol homeostasis and suppress hepatocellular carcinoma development
Cancer Res. 2024 May 8. doi: 10.1158/0008-5472.CAN-23-3966. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is an aggressive disease that occurs predominantly in men. Estrogen elicits protective effects against HCC development. Elucidation of the estrogen-regulated biological processes that suppress HCC could lead to improved prevention and treatment strategies. Here, we performed transcriptomic analyses on mouse and human liver cancer and identified LCAT as the most highly estrogen-upregulated gene and a biomarker of favorable prognosis. LCAT upregulation inhibited HCC in vitro and in vivo and mediated estrog...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Wenzhi He Min Wang Xuechun Zhang Yilan Wang Dongli Zhao Wenhua Li Fang Lei Min Peng Zhonglin Zhang Yufeng Yuan Zan Huang Source Type: research
HDAC Inhibition Increases CXCL12 Secretion to Recruit Natural Killer Cells in Peripheral T Cell Lymphoma
Cancer Res. 2024 May 8. doi: 10.1158/0008-5472.CAN-23-3250. Online ahead of print.ABSTRACTPeripheral T cell lymphoma (PTCL) is a heterogeneous and aggressive disease with a poor prognosis. Histone deacetylase (HDAC) inhibitors have shown inhibitory effects on PTCL. A better understanding of the therapeutic mechanism underlying the effects of HDAC inhibitors could help improve treatment strategies. Here, we found that high expression of HDAC3 is associated with poor prognosis in PTCL. HDAC3 inhibition suppressed lymphoma growth in immunocompetent mice but not in immunodeficient mice. HDAC3 deletion delayed the progression o...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Jiayan Zhu Feng Wang Lining Wang Bo Dai Guilin Xu Luyao Zhao Huimin Jiang Wenhui Gao Tingting Zhang Chenxi Zhao Yun-Xuan Li Jiong Hu Ke Li Source Type: research
A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors
Cancer Res. 2024 May 8. doi: 10.1158/0008-5472.CAN-23-3414. Online ahead of print.ABSTRACTPulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy to enhance antitumor immunity by promoting type I interferon secretion. However, following pulmonary delivery, poly(I:C) suffers from rapid degradation and poor endosomal escape, thus limiting its potency. Inspired by the structure of a virus that utilizes internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, we...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Junyao Li Lanqing Luo Jia He Jinchao Yu Xinyan Li Xueying Shen Junxia Zhang Sai Li Jeffrey M Karp Rui Kuai Source Type: research
