GSE265829 Mutant IDH1 inhibition activates tumor immunity via endogenous reverse transcriptase and dsDNA sensing
Contributors : Yi Xiao ; Diana Shi ; Samuel McBrayerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIsocitrate Dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores anti-tumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. IDH1-mutant solid tumors show striking...
Source: GEO: Gene Expression Omnibus - April 25, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants
AbstractThe investigation of perinatal transmission of HPV is vital for early screening of cervical/oral cancers. Here, transmission of HPV from the pregnant women to their infants was studied. p53 and Bcl-2 expressions and their correlations with HPV infection were examined. HPV infection was detected in the cervical and oral swabs of 135 mother-baby pairs employing both PCR and HC-II methods. 1 year follow-up with an interim visit at 3 months for mothers and 6 months for babies was performed. Immunocytochemistry of p53 and Bcl-2 using the streptavidin–biotin peroxidase method was performed. Prevalence of HPV infect...
Source: Virus Genes - April 25, 2024 Category: Genetics & Stem Cells Source Type: research
Challenges and Strategies in Colorectal Surgery among Patients with Morbid Obesity
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786391This chapter explores the interplay between morbid obesity and the challenges encountered in colorectal surgery. Understanding the unique considerations in preoperative and intraoperative management along with weight optimization tools such as bariatric surgery emerges as potential mitigators, demonstrating benefits in reducing colorectal cancer risk and improving perioperative outcomes. Furthermore, the pervasive stigma associated with morbid obesity further complicates patient care, emphasizing the need for empathetic and nuanced approaches. Recommendations for minimizing...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Dualeh, Shukri H.A. Howard, Ryan Tags: Review Article Source Type: research
Considerations for the Treatment of Sexual and Gender Minority Individuals in Colon and Rectal Surgery
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786375Sexual and gender minorities (SGMs) experience critical barriers to health care access and have unique health care needs that are often overlooked. Given the rise in individuals identifying as lesbian, gay, bisexual, transgender, and queer, colorectal surgeons are likely to care for increasing numbers of such individuals. Here, we discuss key barriers to health care access and research among SGM populations and outline approaches to address these barriers in clinical practice. We also highlight two specific topics relevant to SGM populations that colorectal surgeons should ...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Roblee, Cole V. Jacobson, Clare Lane, Megan Morrison, Shane D. Tags: Review Article Source Type: research
Screening for those at risk for anxiety and depression warranting further clinical evaluation among patients presenting to breast services: a single-centre, cross-sectional study
Conclusions
There is a high prevalence of being at risk for anxiety and depression among patients who seek breast services warranting further clinical evaluation. The predictors of being at risk for anxiety were higher age and postmenopausal status, and for those at risk for depression were young age and residing in rural areas. (Source: BMJ Open)
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Husain, S., Rao, S., Suresh, S., Jesudoss, K. V. A., Krishna, B., Raj, J. P. Tags: Open access, Surgery Source Type: research
Malignancy Risk Associated with the Use of Systemic Immunomodulatory Therapy in the Management of Non-infectious Uveitis
Patients with non-infectious uveitis (NIU) can require treatment with systemic immunomodulatory therapy (IMT), but it is unclear whether IMT drug categories increase the risk of malignancy in NIU patients. The purpose of this study is to determine if the use of systemic IMT in patients with NIU is associated with an increased risk of malignancy. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: George N. Papaliodis, Yinxi Yu, Daniel A. Brill, Lucia Sobrin, Brian VanderBeek Tags: Original Articles Source Type: research
FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F ‑FDG‑PET/CT
ConclusionsIncreased postoperative uptakes in the cervical muscles were observed on the dissected side in approximately half of the patients after neck dissection. The SUVmax in the trapezius and sternocleidomastoid muscles decreased after surgery over time. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Access to innovative anticancer medicines in China: a national survey on availability, price and affordability
Conclusions
The overall accessibility of 33 nationally negotiated innovative anticancer medicines improved from 2020 to 2022. However, the overall availability of most anticancer medicines in China remained at a low level (less than 50%). Further efforts should be made to sufficiently and equally benefit patients with cancer. (Source: BMJ Open)
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Li, W., Lu, W., Chen, H., Zhang, C., Wang, M., Zheng, F., Wu, H.-H., Wan, G.-W., Yang, Q., Ye, L. Tags: Open access, Health services research Source Type: research
Neoadjuvant and/or adjuvant chemotherapy for gastric cancer patients with microsatellite instability or deficient mismatch repair: a systematic review and meta-analysis study protocol
This study protocol is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols-P guideline. PubMed, Embase, Cochrane (CENTRAL), and the Web of Science databases will be searched, supplemented by a secondary screening of relevant records. Both randomised controlled trials and non-randomised studies will be included in this study. The primary and secondary outcomes under scrutiny will be overall survival, disease-free survival and progression-free survival. Two reviewers will independently screen studies, extract data and assess the risk of bias. We will analyse different treatm...
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Liu, B., Yin, X., Cai, Z., Shen, C., Jiang, T., Han, Y., Yin, Y., Zhang, B. Tags: Open access, Surgery Source Type: research
Deep learning-accelerated T2WI: image quality, efficiency, and staging performance against BLADE T2WI for gastric cancer
ConclusionsDLSB-T2WI demonstrated shorter acquisition time, better image quality, and comparable staging accuracy, which could be an alternative to BLADE-T2WI for gastric cancer imaging.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 25, 2024 Category: Radiology Source Type: research
Association between interstitial lung abnormality and mortality in patients with esophageal cancer
ConclusionILAs were significantly associated with shorter survival in patients with esophageal cancer. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity. NIR-PIT selectively targets cancer cells for destruction and activates a strong anticancer host immunity. The fluorescent signal emitted by IR700 enables the visualization of the APC in vivo using fluorescence imagi ng. Similarly, the activation of IR700 during therapy can be...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Longitudinal assessment of tumor-infiltrating lymphocytes in primary breast cancer following neoadjuvant radiotherapy
Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast. Despite interest in combining radiotherapy with immunotherapy, little is known about the effect of radiotherapy itself on the tumor-immune microenvironment, including TILs. Here, we interrogated longitudinal dynamics of tumor-infiltrating and systemic lymphocytes in patient samples taken before, during, and after neoadjuvant radiotherapy (NART), from XXX and XXX breast clinical trials. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 25, 2024 Category: Radiology Authors: Miki Yoneyama, Konstantinos Zormpas-Petridis, Ruth Robinson, Faranak Sobhani, Elena Provenzano, Harriet Steel, Sara Lightowlers, Catherine Towns, Simon P. Castillo, Selvakumar Anbalagan, Tom Lund, Erik Wennerberg, Alan Melcher, Charlotte E. Coles, Ioannis Tags: Biology Contribution Source Type: research
Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy
AbstractEndometriosis is a benign, common, but controversial disease due to its enigmatic etiopathogenesis and biological behavior. Recent studies suggest multiple genetic, and environmental factors may affect its onset and development. Genomic analysis revealed the presence of cancer-associated gene mutations, which may reflect the neoplastic aspect of endometriosis. The management has changed dramatically with the development of fertility-preserving, minimally invasive therapies. Diagnostic strategies based on these recent basic and clinical findings are reviewed. With a focus on the presentation of clinical cases, we di...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
The research trends and future prospects of nanomaterials in breast cancer
ConclusionOur findings predict that the use of nanomaterials in medication delivery will become a significant research area in the future, and provide valuable references for scholars investigating the role of nanotechnology in breast cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 25, 2024 Category: Cancer & Oncology Source Type: research
