Novel nanoformulation of disulfiram with bacterially synthesized copper oxide nanoparticles for augmenting anticancer activity: an in vitro study
ConclusionAll of the aforementioned findings verified that this novel nanocomplex was capable of improving the therapeutic index of the conventional DS –Cu complex. The potent selective anticancer activity of this promising nanomedicine merits further investigation, as a separate future study, using animal models as preliminary step before its clinical application.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 6, 2021 Category: Cancer & Oncology Source Type: research

Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo
In this study, Ber, noncovalently bound to a carbon nanostructure C60 fullerene (C60) at various molar ratios of the components, was explored against Lewis lung carcinoma (LLC).MethodsC60–Ber noncovalent nanocomplexes were synthesized in 1:2, 1:1 and 2:1 molar ratios. Ber release from the nanocomplexes was studied after prolonged incubation at different pH with the liquid chromatography–mass spectrometry analysis of free Ber content. Biological effects of the free and C60-complaxated Ber were studied in vitro towards LLC cells with phase-contrast and fluorescence microscopy, flow cytometry, MTT reduction, caspa...
Source: Cancer Nanotechnology - August 23, 2021 Category: Cancer & Oncology Source Type: research

Montmorillonite colloid plates with adsorbed cytochrome c: in vitro cytotoxic effect on colon cancer cell culture
ConclusionThe in vitro experiments with colon cancer cell culture disclose that cytC-MM composite particles have potential for application in anticancer therapy of superficial neoplasms of the skin and the alimentary system (mouth cavity, esophagus, stomach, jejunum and colon).Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 23, 2021 Category: Cancer & Oncology Source Type: research

Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial –mesenchymal transition
ConclusionE-PLNs inhibit EMT to enhance the sensitivity of breast cancer to DOX. The combination of E-PLNs and DOX can improve the efficacy of DOX in the treatment of breast cancer, which provides a new method to prevent or delay clinical drug resistance. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 11, 2021 Category: Cancer & Oncology Source Type: research

Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model
ConclusionIn contrast to gCSNP, the CSNP not only demonstrated inhibitory effect on the expression of genes coding for the NLRP3 inflammasome complex (signal 1 —priming), but also decreased relative expression of gene involved in the activation of NLRP3 inflammasome complex (signal 2—activation). Conjugation of gallic acid reversed the immunosuppressor mimicking action of CSNP in cervical cancer cell line. Future research can reveal the immunomodulator y mechanism of CSNP may have its translational significance as potential treatment strategies targeting immune evasion as an important hallmark of cancer.Graphic...
Source: Cancer Nanotechnology - August 11, 2021 Category: Cancer & Oncology Source Type: research

Synthesis of gold nanorods and their performance in the field of cancer cell imaging and photothermal therapy
AbstractCancer is one of the most common incident in the world, with malignant tumors having a death rate of up to 19%. A new method of treating cancer cells effectively with minimal cytotoxicity is needed. In the field of biomedicine with unique shape-dependent optical properties, gold nanorods (GNRs) have attracted worldwide interest. These nanorods have two distinct plasmon bands. One is transverse plasmon band in the area of visible light, and the other is longitudinal band of plasmons in near infrared region. These specific characters provide promise for the design of new optically active reagents that simultaneously ...
Source: Cancer Nanotechnology - July 23, 2021 Category: Cancer & Oncology Source Type: research

Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells
ConclusionsThis work highlights the potential application of designed GNSs@Dox-Pol in a combinational chemo-PTT to treat breast cancer cells.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 23, 2021 Category: Cancer & Oncology Source Type: research

Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment
ConclusionsFinally, the conclusions and perspectives on further advancing the graphene oxide-based multifunctional nanomaterials toward potential and versatile development for fundamental researches and nanomedicine are proposed.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 12, 2021 Category: Cancer & Oncology Source Type: research

Ultrasound-activated nano-TiO2 loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme
ConclusionWe found this nanomedicine-based ultrasound modality highly efficient in GBM treatment and is of future clinical application value due to the employment of already FDA-approved techniques and nanomedicine. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 10, 2021 Category: Cancer & Oncology Source Type: research

Radiolabeling and PET –MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer
ConclusionOur results demonstrate that PET –MRI following a microdose injection of the agent will accurately reflect the innate biodistribution of the therapeutic. The tools developed in the present study lay the groundwork for the clinical testing of MN-anti-miR10b and other similar therapeutics in patients with cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 8, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles
ConclusionOwing to the results achieved from this study, the novel drug-loaded nanoparticles are compatible to be used for breast cancer treatment and could potentially be used for further in vivo studies. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 8, 2021 Category: Cancer & Oncology Source Type: research

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
ConclusionsOur study successfully declares that melittin-loaded niosome had more anti-cancer effects than free melittin. This project has demonstrated that niosomes are suitable vesicle carriers for melittin, compare to the free form. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 22, 2021 Category: Cancer & Oncology Source Type: research

Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood –brain barrier model
ConclusionTJ-modulating peptide-modified LPN could be a prospective platform for the delivery of chemotherapeutics across the BBB to the brain for the potential treatment of the BM of NSCLC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 7, 2021 Category: Cancer & Oncology Source Type: research

Development of Fe3O4 core –TiO2 shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization
ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles ...
Source: Cancer Nanotechnology - May 14, 2021 Category: Cancer & Oncology Source Type: research

Development of Fe 3 O 4 core –TiO 2 shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization
ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles ...
Source: Cancer Nanotechnology - May 14, 2021 Category: Cancer & Oncology Source Type: research

Methylene blue associated with maghemite nanoparticles has antitumor activity in breast and ovarian carcinoma cell lines
ConclusionsTreatment with MAGCIT –MB induces the death of cancer cells but not normal cells. These results highlight the importance of the maghemite core for drug delivery and for increasing methylene blue activity, aiming at the treatment of breast and ovarian cancer.Graphic Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 11, 2021 Category: Cancer & Oncology Source Type: research

Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform
ConclusionsAs a proof of concept, the designed immunosensor was desirably applied for the quantification of HER-2 protein in breast cancer suffering patients. As a result, the designed ECL-based immunosensor has the capability of being used as a conventional test method in biomedical laboratories for early detection of HER-2 protein in biological fluids.Graphic Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 1, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 11, 2021 Category: Cancer & Oncology Source Type: research

Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells
ConclusionQD –MUA–FA–DOX nanoconjugates can thus be considered as a potential drug delivery system for the effective treatment of adenocarcinomic human alveolar basal epithelial cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research

Investigating the effect of outer layer of magnetic particles on cervical cancer cells HeLa by magnetic fluid hyperthermia
ConclusionThe preliminary analysis of this study shows significant cell death due to hyperthermia, wherein MFWI revealed higher cytotoxicity compared to MFWL. Additional analysis into the role of the outer stabilizing layer on nanoparticle ’s surface, concentration of nanoparticles, and hyperthermic duration is desirable to utilize MFH as a futuristic anti-cancer therapeutic tool. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research

Quantum dots as targeted doxorubicin drug delivery nanosystems
ConclusionQD –MUA–FA–DOX nanoconjugates can thus be considered as a potential drug delivery system for the effective treatment of adenocarcinomic human alveolar basal epithelial cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research

Targeting BMI-1 with PLGA –PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells
AbstractDespite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential novel therapeutic target for GBM. To enhance the efficacy and reduce the toxicity, PTC209, a BMI-1 inhibitor, was loaded into a PLGA –PEG nanoparticle conjugated with CD133 antibody (Nano-PTC209) and its effect on the behavior of human GBM stem-like cells (GSCs) and the human glioblastoma cell line (U87MG) was assessed. Nano-PTC209 has a diameter of ~ 75 nm with efficient drug loading and cont...
Source: Cancer Nanotechnology - February 6, 2021 Category: Cancer & Oncology Source Type: research

Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles
ConclusionCorrectly formulated superparamagnetic iron oxide nanoparticles can facilitate the chemotherapeutic effectiveness of cytotoxic drugs on skin tumors by both increasing their transdermal penetration and ameliorating host –tumor interactions. This enhancement of skin penetration occurs without the need for conjugation or encapsulation of the co-administered drugs, and so will likely be applicable to other drugs, also. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 6, 2021 Category: Cancer & Oncology Source Type: research

Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization
ConclusionThese biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 5, 2021 Category: Cancer & Oncology Source Type: research

Excretable, ultrasmall hexagonal NaGdF 4 :Yb50% nanoparticles for bimodal imaging and radiosensitization
ConclusionThese biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 5, 2021 Category: Cancer & Oncology Source Type: research

Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro
AbstractBackgroundHere, we examined the tumoricidal effect of Gemini surfactant nanoparticles enriched with curcumin on 3D spheroid HT-29 cells. The delivery of curcumin and other phytocompounds to the tumor niche is an important challenge.MethodsSpheroid HT-29 cells were generated by using a conventional hanging drop method and exposed to different concentrations of Gemini-curcumin nanoparticles. The changes in spheroid integrity and cell viability were evaluated by measuring the spheroid diameter and LDH release, respectively. The uptake of Gemini-curcumin nanoparticles was detected by flow cytometry assay. Flow cytometr...
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research

Experimental conditions influence the formation and composition of the corona around gold nanoparticles
ConclusionThe current study showed that the pre-processing conditions modulate PC composition and can be used to enhance identification of NMTPs. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research

Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells
ConclusionsStudies have shown that both the GO surface structure on which the cells are grown as well as the presence of a multi-component natural cocktail of regulatory proteins, can modify the expression of integrins, increase adhesion and, as a consequence, proliferation and the cell cycle —entering the resting phase. For the first time, it has been documented that hepatic cancer cells of the HepG2 line under the influence of stimuli derived from mimic ECM (graphene oxide) in interaction with a unique protein complex derived from chicken liver embryo decreased of the invasiveness of cancer cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research

Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy
ConclusionTaken together, NPDOX/siPD-L1 showed significant anti-tumor effects on HCC by the induction of ICD and inhibition of PD-L1 overexpression. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 14, 2020 Category: Cancer & Oncology Source Type: research

Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro
ConclusionsThis study highlights the opportunity to exploit pluronic-based nanomicelles for the delivery of compounds that regulate epigenetic processes, thus inhibiting cancer development and progression. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 25, 2020 Category: Cancer & Oncology Source Type: research

Synthesis and analysis of silver –copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells
ConclusionThe data suggest that the AgCu-NP alloy imposes preferential toxicity in breast cancer MCF-7 cells and thus could be exploited as a new candidate for further anticancer investigation (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 25, 2020 Category: Cancer & Oncology Source Type: research

Nanotechnology approaches to addressing HER2-positive breast cancer
AbstractBreast cancer is a major cause of cancer-associated deaths in the United States. It was estimated that 12% of women in the U.S. will develop invasive breast cancer in their lifetime. The human epidermal growth factor receptor (HER2/neu) is a growth-promoting protein that is overexpressed in 15 –20% of breast cancers (HER2-positive breast cancer). HER2-positive breast cancer generally grows and spreads more quickly than other breast cancers, but it can be targeted therapeutically. Targeting drugs have been developed with a specific design to stop the growth and even the spread of cancer. These drugs include tr...
Source: Cancer Nanotechnology - October 17, 2020 Category: Cancer & Oncology Source Type: research

Algae-meditated route to cuprous oxide (Cu 2 O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer
This study was aimed to synthesize Cu2O nanoparticles from the cystoseira myrica algae (CM-Cu2O NPs) assess their antimicrobial activity against pathogenic bacteria and fungi. We evaluated the expression levels of lncRNAs (MALAT1 andGAS5) and apoptosis genes (p53, p27, bax, bcl2 andcaspase3), their prognostic roles.MethodsIn this study, CM-Cu2O NPs synthesized by cystoseira myrica algae extraction used to evaluate its cytotoxicity and apoptotic properties on MDA-MB-231, SKBR3 and T-47D BC cell lines compared to HDF control cell line. The CM-Cu2O NPs was characterized by UV –Vis spectroscopy, Fourier transform infrare...
Source: Cancer Nanotechnology - October 14, 2020 Category: Cancer & Oncology Source Type: research

Cockle shell-derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells
AbstractCockle shell-derived aragonite calcium carbonate nanoparticles (CACNP) have demonstrated prospect as nano-sized drug carriers for targeting cancer cells. CACNP is biocompatible, biodegradable and its biomaterial is readily available and is of low cost. In addition, CACNP is highly porous, has a large surface area which confer a high loading capacity. The pH-dependent release properties as well as its potential for surface functionalization with targeting agents make CACNP useful in passive and active targeting of cancer cells and cancer stem cells. In this article, we reviewed the current state of CACNP as nano-siz...
Source: Cancer Nanotechnology - October 6, 2020 Category: Cancer & Oncology Source Type: research

Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac
ConclusionsNovel nano-enhanced radiotherapy with gadolinium-containing nanoparticles is ideally suited for implementation on an MRI-linac, allowing a workflow with time-of-treatment imaging. Live irradiations using this treatment workflow, carried out for the first time at the Australian MRI-linac, confirm the safety and feasibility of performing MRI-guided radiotherapy with AGuIX® nanoparticles. Follow-up studies are needed to demonstrate on an MRI-linac the radiation enhancement effects previously shown with conventional radiotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 5, 2020 Category: Cancer & Oncology Source Type: research

Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology
AbstractSuccessful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical role: FBs suppress the tumor growth while CAFs promote it. It is not yet known how NPs interact with FBs and CAFs compared to cancer cells. Hence, our goal was to elucidate the extent of NP uptake, retention, and toxicity...
Source: Cancer Nanotechnology - August 17, 2020 Category: Cancer & Oncology Source Type: research

Cancer research, treatment, and COVID-19
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 5, 2020 Category: Cancer & Oncology Source Type: research

Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy
AbstractBackgroundDoxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of Dox@HAuNS followed by photothermal ablation (PTA) in a rabbit model of liver cancer. Adult New Zealand white rabbits (N = 25) were inoculated with VX2 tumors into the left lobe of the liver. The animals were then randomized to sham surgery (N = 5), PTA only (N = 3), Dox@HAuNS only (N = 5), HAuNS + PTA (N ...
Source: Cancer Nanotechnology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI
ConclusionThis study showed no significance difference in MRI contrast between Mag and Mag-Lnp pancreatic cancer PDX mouse models. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 13, 2020 Category: Cancer & Oncology Source Type: research

Preferential drug delivery to tumor cells than normal cells using a tunable niosome –chitosan double package nanodelivery system: a novel in vitro model
AbstractBackgroundWe previously described the properties of a targeted drug delivery system (DDS) in a cell-free system. Here, in this comparative cell-based study (normal and tumor cells), we provide a quantitative analysis of the extracellular diffusion and intracellular localization of this DDS. This DDS consists of fluorescence-labeled paclitaxel encapsulated in non-ionic surfactant vesicles/niosomes embedded in a thermo-sensitive cross-linked chitosan hydrogel with an affinity for the MUC1 mucin surface antigen overexpressed on tumor cells, and designed for a sustained and controlled, localized delivery of embedded dr...
Source: Cancer Nanotechnology - March 29, 2020 Category: Cancer & Oncology Source Type: research

Reducing the effective dose of cisplatin using gold nanoparticles as carriers
AbstractNanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanoparticles, functionalize them for the transportation of cisplatin and release them to the cancer-affected area. They have the same cytotoxicity as conventional treatments but with the smallest effective quantity of cisplatin. We synthesized spherical gold nanoparticles using the Turkevich method. We functionalized them with polyethylene glycol and cisplatin, adapting the method used by Sun. Using electronic transmis...
Source: Cancer Nanotechnology - March 29, 2020 Category: Cancer & Oncology Source Type: research

A [60]fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer
ConclusionIn this paper, we present a robust approach for synthesizing a highly water-soluble [60]fullerene nanoconjugate with gemcitabine. The performed biological assays on pancreatic cancer cell lines demonstrated cytotoxic effects of nanoC60GEM, which were enhanced by the generation of reactive oxygen species after blue LED irradiation of synthesized fullerene nanomaterial. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications
ConclusionsDye-doped silica nanoparticles have found success in the immunodiagnostics domain and have also shown promise as bioimaging agents in human clinical trials. Their use in cancer delivery has been restricted to murine models, as has been the case for the vast majority of nanomaterials intended for cancer therapy. This is hampered by the need for more human-like disease models and the lack of standardisation towards assessing nanoparticle toxicity. However, developments in the manipulation of the protein corona have improved the understanding of fundamental bio –nano interactions, and will undoubtedly assist ...
Source: Cancer Nanotechnology - January 8, 2020 Category: Cancer & Oncology Source Type: research

Nanomedicine review: clinical developments in liposomal applications
ConclusionLiposomal formulations are less toxic than drugs alone and have better pharmacological parameters. Although they seem to be the first choice for drug delivery systems for various diseases, further research about dosage regimen regarding dose and time needs to be carried out. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 18, 2019 Category: Cancer & Oncology Source Type: research

A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays
ConclusionsBeyond identifying promising metal oxide NP radiosensitisers and radioprotectors, our broad comparisons reveal unexpected differences that suggest the surface chemistry of NP radiosensitisers is an important criterion for their success. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 18, 2019 Category: Cancer & Oncology Source Type: research

Science vs. technology in radiation therapy from X-rays to ions
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 30, 2019 Category: Cancer & Oncology Source Type: research

Effects and side effects of plasmonic photothermal therapy in brain tissue
ConclusionsOur results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 23, 2019 Category: Cancer & Oncology Source Type: research

Comparison of the effect of rhodium citrate-associated iron oxide nanoparticles on metastatic and non-metastatic breast cancer cells
ConclusionMRC act at the nucleus, inhibiting DNA synthesis and proliferation and inducing cell death. These effects were verified in both tumor lines, but MDA-MB-231 cells seem to be more responsive to the effects of NPs. In addition, NPs may also disrupt the metastatic activity of remaining cells, by reducing their migratory capacity. Our results suggest that MRC nanoparticles are a promising nanomaterial that can provide a convenient route for tumor targeting and treatment, mainly in metastatic cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 10, 2019 Category: Cancer & Oncology Source Type: research

Multiscale modeling for cancer radiotherapies
ConclusionsMultiscale approach ’s predictive capabilities are based on the fundamental scientific knowledge. Their strength is in relation to actual physical, chemical, and biological processes that take place following the ions incidence on tissue. This makes the approach flexible and versatile to include various conditions, s uch as the degree of aeration or the presence of sensitizing nanoparticles, related to particular cases. The ideas for how the MSA can contribute to an improved optimization of therapy planning are summarized in the review. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 21, 2019 Category: Cancer & Oncology Source Type: research

The role of shock waves on the biodamage induced by ion beam radiation
ConclusionThe effects of shock waves on the scenario of radiation damage at different values of linear energy transfer are discussed in detail including the most recently simulated chemical effects. A number of ideas of experiments, in which the shock waves could be discovered, are presented, and ideas for the future developments in this field are conveyed. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 29, 2019 Category: Cancer & Oncology Source Type: research