A gastric sarcoma from 3000 years ago: paleopathological diagnosis at the field
ConclusionsMalignant diseases are seldom described in Paleopathology; to our knowledge, this is the oldest and most unique case of this type of pathology in mummies worldwide. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Endometrial cancer: predictors and oncological safety of tumor tissue manipulation
ConclusionWhilst performing common gynecological procedures, iatrogenic distention and manipulation of the uterine cavity are produced. Our study suggests that the use of uterine manipulator increases the rate of LVSI and, therefore, leads to poorer oncological results. Conversely, preoperative hysteroscopy does not show higher rates of LVSI involvement in the final surgical specimen and can be safely used. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Distribution of PD-L1, TROP2 and HER2- “lowness” in early triple-negative breast cancer: an opportunity for treatment de-escalation
ConclusionsEarly HER2-low, PD-L1-positive TNBC patients have a very good prognosis, particularly if treated with anthracycline/taxane- or carboplatin-containing regimes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Current status of fertility preservation in a Spanish tertiary public hospital: multidisciplinary approach and experience in over 1500 patients
ConclusionsThe increase in FP treatment reflects the implementation of reproductive counselling in oncology programmes. A multidisciplinary approach in a tertiary public hospital allows individualised FP treatment for each patient. In recent years, there has been a change in trend with the introduction of new indications for FP and a change in techniques due to their optimisation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Immunoradiotherapy for NSCLC: mechanisms, clinical outcomes, and future directions
AbstractNon-small-cell lung cancer (NSCLC) has an extremely low 5-year survival rate, with the only effective treatment being immunoradiotherapy (iRT). Here, we review the progress of clinical research on iRT for non-small-cell lung cancer (NSCLC) over 2018 –2023, as well as the future directions. We first discuss the synergistic mechanisms of iRT, reflected in three aspects: immune regulation of RT, RT-activated immune-related pathways, and RT-related immune sensitization. iRT may include either external-beam or stereotactic-body RT combined with ei ther immune checkpoint inhibitors (e.g., immunoglobulins against immune...
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Three-month life expectancy as inclusion criterion for clinical trials in advanced pancreatic cancer: is it really a valid tool for patient selection?
ConclusionsDespite the definition of a life expectancy of > 3 months as a standard inclusion criterion in clinical trials for advanced PC, a significant proportion of study patients does not survive > 3 months.Trial registration numbersNCT00440167 (AIO-PK0104), NCT01729481 (RASH), NCT01728818 (ACCEPT). (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Exploring the time-dependent regulatory potential of microRNAs in breast cancer cells treated with proteasome inhibitors
ConclusionsThe diversity of pathways predicted to be affected by the diversity in miRNA expression after treatment with PIs paves the way for the recognition of new regulatory axes in BrCa. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Sexual dysfunction in patients with cancer, a challenge in oncology practice: results of the CLARIFY project
ConclusionsOur population has a high prevalence of SD, which supports the need to increase awareness of this disorder among the medical oncology team and the importance of including sexual health assessment in oncological patient follow-up. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Overactive Bladder Linked to Depressive Symptoms
People who have been diagnosed with overactive bladder are nearly three times as likely to have depression than those without overactive bladder, astudy in theJournal of Affective Disorders has found.Xiansheng Zhang, M.D., Ph.D., of Anhui Medical University in Hefei, China, and colleagues examined responses from adults who participated in the National Health and Nutrition Examination Survey from 2005 to 2018 and who had complete data related to depression and urinary function. The researchers excluded adults who had conditions that could affect their urination, such as pregnancy, benign prostate issues, certain cancers, or...
Source: Psychiatr News - April 22, 2024 Category: Psychiatry Tags: depression Journal of Affective Disorders National Health and Nutrition Examination Survey nocturia overactive bladder risk factors social functioning urinary problems Source Type: research
Green synthesis for diverse bioactive benzo-fused spiroindolines through DBU-catalysed post-Ugi double cyclization
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00846D, CommunicationShuang Zhao, Mengxiao Chen, Wenlu Zhou, Dan Ni, Zhenghua Li, Shenyou Nie, Yi He A metal-free protocol utilizing DBU catalysis for post-Ugi amide-ester exchange and Conia-ene double cyclization has successfully developed, allowing the synthesis of diverse highly functionalized cycloimide-fused spiroindolines with anti-cancer activities under... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 22, 2024 Category: Chemistry Authors: Shuang Zhao Source Type: research
Precise prostate cancer diagnosis using fluorescent nanoprobes for detecting PSA and PSMA in serum
Chem. Commun., 2024, Advance Article DOI: 10.1039/D4CC00670D, CommunicationMingyi Ouyang, Ming Jia, Zixuan Chang, Yinian Wang, Keyi Wang, Xiaonan Gao, Bo Tang Novel Au –Se bond-based nanoprobes were designed for concurrent detection of PSA and PSMA in serum samples, aiming to enhance the early diagnosis of prostate cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 22, 2024 Category: Chemistry Authors: Mingyi Ouyang Source Type: research
Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2024 Category: Endocrinology Source Type: research
Metabolite signature of human malignant thyroid tissue: A systematic review and meta ‐analysis
ConclusionIt appears that the field of TC metabolomics will experience notable advancement, leading to the discovery of trustworthy diagnostic and prognostic biomarkers. (Source: Cancer Medicine)
Source: Cancer Medicine - April 22, 2024 Category: Cancer & Oncology Authors: S. Adeleh Razavi,
Babak Khorsand,
Pouya Salehipour,
Mehdi Hedayati Tags: REVIEW Source Type: research
Review of patient ‐reported outcomes (PROs) and non‐PROs in randomized controlled trials addressing head/neck cancers
ConclusionsThere has been a growth in the types of PROs in more recent years, and they were more frequently reported in RCTs. However, head/neck cancer trials with a combination of PROs and non-PROs were the most prevalent. (Source: Cancer Medicine)
Source: Cancer Medicine - April 22, 2024 Category: Cancer & Oncology Authors: Michelle Gode,
Clovis Mariano Faggion Jr Tags: REVIEW Source Type: research
