Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Int Rev Cell Mol Biol. 2024;385:211-226. doi: 10.1016/bs.ircmb.2024.01.002. Epub 2024 Feb 15.ABSTRACTBreast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.PMID:38663960 | DOI:10.1016/bs.ircmb.2024.01.0...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Anirban Ganguly Sumit Mukherjee Kaushiki Chatterjee Sheila Spada Source Type: research
Targeting signaling pathways in cancer stem cells: A potential approach for developing novel anti-cancer therapeutics
Int Rev Cell Mol Biol. 2024;385:157-209. doi: 10.1016/bs.ircmb.2024.01.001. Epub 2024 Feb 10.ABSTRACTCancer stem cells (CSCs) have emerged as prime players in the intricate landscape of cancer development, progression, and resistance to traditional treatments. These unique cellular subpopulations own the remarkable capability of self-renewal and differentiation, giving rise to the diverse cellular makeup of tumors and fostering their recurrence following conventional therapies. In the quest for developing more effective cancer therapeutics, the focus has now shifted toward targeting the signaling pathways that govern CSCs ...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Saptarshi Sinha Krushna Chandra Hembram Subhajit Chatterjee Source Type: research
Importance of targeting various cell signaling pathways in solid cancers
Int Rev Cell Mol Biol. 2024;385:101-155. doi: 10.1016/bs.ircmb.2024.02.002. Epub 2024 Feb 24.ABSTRACTMost adult human cancers are solid tumors prevailing in vital organs and lead to mortality all over the globe. Genetic and epigenetic alterations in cancer genes or genes of associated signaling pathways impart the most common characteristic of malignancy, that is, uncontrolled proliferation. Unless the mechanism of action of these cells signaling pathways (involved in cell proliferation, apoptosis, metastasis, and the maintenance of the stemness of cancer stem cells and cancer microenvironment) and their physiologic altera...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Chandrayee Ghosh Jiangnan Hu Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled
Int Rev Cell Mol Biol. 2024;385:227-261. doi: 10.1016/bs.ircmb.2023.11.005. Epub 2024 Jan 12.ABSTRACTCervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in prevention and treatment, the identification of novel therapeutic targets remains crucial for cervical cancer. Toll-like receptors (TLRs) play an essential role in innate immunity as pattern-recognition receptors. There are several types of pathogen-associated molecular patterns (PAMPs), including those present in cervical cancer cells, which have the ability to activate toll-like receptors (TLRs). Recent studie...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Mohini Agarwal Manish Kumar Rajiv Pathak Kumud Bala Anoop Kumar Source Type: research
Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression
Crit Rev Biochem Mol Biol. 2024 Apr 25:1-11. doi: 10.1080/10409238.2024.2344465. Online ahead of print.ABSTRACTTP53 encodes a transcription factor that is centrally-involved in several pathways, including the control of metabolism, the stress response, DNA repair, cell cycle arrest, senescence, programmed cell death, and others. Since the discovery of TP53 as the most frequently-mutated tumor suppressor gene in cancer over four decades ago, the field has focused on uncovering target genes of this transcription factor that are essential for tumor suppression. This search has been fraught with red herrings, however. Dozens o...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Alexandra Indeglia Maureen E Murphy Source Type: research
Analysis of the Complexity of Palliative Care for Cancer Patients
This study aims to describe the degree of complexity of cancer patients in palliative care, to determine which elements of complexity are most prevalent and to determine which other hospital clinical factors are associated with the level of complexity.METHODS: This study is a descriptive, observational, and cross-sectional analysis that included patients diagnosed with advanced oncological pathology undergoing palliative treatment who were admitted to the Medical Oncology ward of the Miguel Servet University Hospital between March and April 2023.RESULT: A total of 100 patients were selected for the study. According to the ...
Source: The American Journal of Hospice and Palliative Care - April 25, 2024 Category: Palliative Care Authors: F átima Mocha Campillo Ana Mar ía Comín Orce Mar ía Luna Monreal Cepero Pablo Trincado Cobos Pablo G ómez Mugarza Susana Barriendos Sanz Natalia Pascual de la Fuente Sofia Ruffini Egea Javier Mart ínez Trufero Source Type: research
A Genuinely Hybrid, Multiscale 3D Cancer Invasion and Metastasis Modelling Framework
Bull Math Biol. 2024 Apr 25;86(6):64. doi: 10.1007/s11538-024-01286-0.ABSTRACTWe introduce in this paper substantial enhancements to a previously proposed hybrid multiscale cancer invasion modelling framework to better reflect the biological reality and dynamics of cancer. These model updates contribute to a more accurate representation of cancer dynamics, they provide deeper insights and enhance our predictive capabilities. Key updates include the integration of porous medium-like diffusion for the evolution of Epithelial-like Cancer Cells and other essential cellular constituents of the system, more realistic modelling o...
Source: Bulletin of Mathematical Biology - April 25, 2024 Category: Bioinformatics Authors: Dimitrios Katsaounis Nicholas Harbour Thomas Williams Mark Aj Chaplain Nikolaos Sfakianakis Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Drugs & Pharmacology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Exploring the role of coagulation-related genes in renal cell carcinoma: Implications for tumor microenvironment and prognostic biomarkers
CONCLUSION: There is an obvious correlation between the coagulation and the tumor microenvironment in ccRCC. As a key coagulation-related gene, MMP9 may promote the progression of renal cell carcinoma by influencing immune infiltration of CD8+T cells and Treg cells. Additionally, the risk score could be used as a durable prognostic biomarker, which could assist in clinical decision making for ccRCC patients.PMID:38663187 | DOI:10.1016/j.compbiolchem.2024.108082 (Source: Computational Biology and Chemistry)
Source: Computational Biology and Chemistry - April 25, 2024 Category: Bioinformatics Authors: Yang Qiu Yuanpeng Liao Jianqiang Zhang Yuedian Ye Zhongshu Zhang Zheng Jiang Jiaai Zhang Jinghan Xin Shidong Lv Hongmei Peng Source Type: research
Bqt4 affects relative movement between SPB and nucleolus in fission yeast
Biochem Biophys Res Commun. 2024 Apr 23;714:149970. doi: 10.1016/j.bbrc.2024.149970. Online ahead of print.ABSTRACTMovement dynamics in the nucleus involve various biological processes, including DNA repair, which is crucial for cancer prevention. Changes in the movement of the components of the nucleus indicate the changes in movement dynamics in the nucleus. In Schizosaccharomyces pombe, the inner nuclear membrane protein Bqt4 plays an essential role in attaching telomeres to the nuclear envelope. We observed that the deletion of bqt4+ caused a significant decrease in the mean square displacement (MSD) calculated from th...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Kaiyu Wang Hiroaki Ito Junko Kanoh Masaru Ueno Source Type: research
The γ-glutamyl cycle serves as an amino acids supply system in colorectal cancer organoids under chronic hypoxia
Biochem Biophys Res Commun. 2024 Apr 22;714:149977. doi: 10.1016/j.bbrc.2024.149977. Online ahead of print.ABSTRACTMalignant tumors are characterized by a hypoxic microenvironment, and metabolic reprogramming is necessary to ensure energy production and oxidative stress resistance. Although the microenvironmental properties of tumors vary under acute and chronic hypoxia, studies on chronic hypoxia-induced metabolic changes are limited. In the present study, we performed a comprehensive metabolic analysis in a chronic hypoxia model using colorectal cancer (CRC) organoids, and identified an amino acid supply system through t...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sho Tabata Hiroko Endo Hideki Makinoshima Tomoyoshi Soga Masahiro Inoue Source Type: research
Galectin-9, a pro-survival factor inducing immunosuppression, leukemic cell transformation and expansion
Mol Biol Rep. 2024 Apr 25;51(1):571. doi: 10.1007/s11033-024-09563-w.ABSTRACTLeukemia is a malignancy of the bone marrow and blood originating from self-renewing cancerous immature blast cells or transformed leukocytes. Despite improvements in treatments, leukemia remains still a serious disease with poor prognosis because of disease heterogeneity, drug resistance and relapse. There is emerging evidence that differentially expression of co-signaling molecules play a critical role in tumor immune evasion. Galectin-9 (Gal-9) is one of the key proteins that leukemic cells express, secrete, and use to proliferate, self-renew, ...
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Cansu Y ıldırım Source Type: research
Research Progress and Prospect of Nitrogen-containing Heterocycle in Anti-gastric Cancer Drugs: A Review
Curr Med Chem. 2024 Apr 24. doi: 10.2174/0109298673296147240405113328. Online ahead of print.ABSTRACTGastric cancer was the fifth most common cancer, and its drug treatment mainly included chemotherapy, targeted therapy, and immunotherapy. With the rise of immunotherapy in gastric cancer, small-molecule anti-gastric cancer drugs still have irreplaceable places because of many advantages, such as high stability and mass-productivity, high efficiency, and low cost. At present, the small-molecule anti-gastric cancer drugs in the clinic are constrained by their side effects. So, developing more novel anti-gastric cancer drugs ...
Source: Current Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Yang Li Lizhi Jiang Junfeng Qu Xiaoyu Peng Kaiyue Wu Miaojia Chen Yuanyuan Peng Xuan Cao Source Type: research
