Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research

The necroptosis-related signature and tumor microenvironment immune characteristics associated with clinical prognosis and drug sensitivity analysis in stomach adenocarcinoma
CONCLUSIONS: This investigation provides a robust methodological advance in prognosticating and personalizing immunotherapy for STAD, leveraging quantitatively derived tumor cluster risk scores. It posits the use of necroptosis-related lncRNAs as pivotal molecular beacons for guiding therapeutic strategies and enhancing clinical outcomes in STAD.PMID:38546403 | DOI:10.18632/aging.205690 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Biao Yang Yingnan Wang Tao Liu Meijing Zhang Tianhang Luo Source Type: research

Identification of a novel disulfideptosis-related gene signature for prognostic implication in lower-grade gliomas
In conclusion, we discovered a gene signature associated with disulfideptosis that can effectively predict OS in GBMLGG patients. As a result, treating disulfideptosis may be a viable alternative for GBMLGG patients.PMID:38546389 | DOI:10.18632/aging.205688 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Fuqiang Zhang Meihong Lv Yi He Source Type: research

Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies
Aging (Albany NY). 2024 Mar 27;16. doi: 10.18632/aging.205689. Online ahead of print.ABSTRACTProgrammed death-1 and its ligand-1 (PD-1/PD-L1), immune checkpoints proteins, play a crucial role in anti-tumor responses. A large number of studies have evaluated the relationships of PD-1/PD-L1 polymorphisms with risk of cancer, but evidence for the associations remains inconsistent. Therefore, we performed a meta-analysis to examine the associations between PD-1/PD-L1 single nucleotide polymorphisms (SNPs) and cancer predisposition. Results showed that PD-1.3 and PD-L1 rs17718883 were significantly correlated with overall cance...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Maoquan Yang Yan Liu Shuangshuang Zheng Peizhen Geng Tianhao He Linan Lu Yikuan Feng Qiqi Jiang Source Type: research

Correction: Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis
J Cancer Res Clin Oncol. 2024 Mar 28;150(3):166. doi: 10.1007/s00432-024-05636-2.NO ABSTRACTPMID:38546886 | DOI:10.1007/s00432-024-05636-2 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Chenlu Wu Jiafei Ying Mei Dai Jing Peng Danhua Zhang Source Type: research

Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway
CONCLUSION: UCN-1 promotes migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.PMID:38546882 | DOI:10.1007/s00432-024-05693-7 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Xiaolan Guo Ya Li Xiangyu Chen Binghua Sun Xiaolan Guo Source Type: research

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
CONCLUSIONS: In vitro, RSV can exert anti-tumor effects on GBM and improve the inflammatory response in the GBM microenvironment by inhibiting the activation of the JAK2/STAT3 signaling pathway. These findings provide new insights into potential therapeutic targets for GBM.PMID:38546908 | DOI:10.1007/s00432-024-05625-5 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Chao Zhang Qian Peng Yuhang Tang Chengcheng Wang Shuai Wang Dong Yu Shiqiang Hou Yu Wang Lanlan Zhang Ning Lin Source Type: research

Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker
CONCLUSION: Our findings indicate that increased TPTE expression is associated with progression of disease. The ability of anti-TPTE-p2 antibody to recognize and target the TPTE protein makes it a potential biomarker to assess and/or target the PCa.PMID:38546751 | DOI:10.1007/s00432-024-05694-6 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Nahid Zainodini Maryam Abolhasani Monireh Mohsenzadegan Mohammad M Farajollahi Elham Rismani Source Type: research

Hepatitis B Virus-mediated m6A demethylation increases hepatocellular carcinoma stemness and immune escape
Mol Cancer Res. 2024 Mar 28. doi: 10.1158/1541-7786.MCR-23-0720. Online ahead of print.ABSTRACTHepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) in multiple cancers, while the regulatory mechanism in stemness maintenance of HBV persistent infection-related HCC remains elusive. Here, we demonstrated that the level of m6A modification was downregulated by HBV in HBV-positive HCC, through enhanced stability of ALKBH5 mRNA. More specifically, we also identified that ALKBH5 mRNA was funct...
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Yuting Meng Zheyue Shu Xueyao Wang Liang Hong Baohua Wang Jingjing Jiang Kangxin He Qingyi Cao Fan Shi Hai Wang Lan Gong Hongyan Diao Source Type: research

Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment
Cancer Res Commun. 2024 Mar 26;4(3):919-937. doi: 10.1158/2767-9764.CRC-23-0161.ABSTRACTLung cancer is the leading cause of cancer deaths. Lethal pulmonary adenocarcinomas (ADC) present with frequent mutations in the EGFR. Genetically engineered murine models of lung cancer expedited comprehension of the molecular mechanisms driving tumorigenesis and drug response. Here, we systematically analyzed the evolution of tumor heterogeneity in the context of dynamic interactions occurring with the intermingled tumor microenvironment (TME) by high-resolution transcriptomics. Our effort identified vulnerable tumor-specific epitheli...
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Giorgia Maroni Indira Krishnan Roberta Alfieri Valerie A Maymi Nicole Pandell Eva Csizmadia Junyan Zhang Marla Weetall Art Branstrom Giulia Braccini Eva Cabrera San Mill án Barbara Storti Ranieri Bizzarri Olivier Kocher Daniela S Daniela Sanchez Bass èr Source Type: research

Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial
CONCLUSIONS: TILT-123 was safe and able to produce anti-tumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, NCT06125197).PMID:38546220 | DOI:10.1158/1078-0432.CCR-23-3874 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Santeri A Pakola Katriina J Peltola James H A Clubb Elise Jirovec Lyna Haybout Tatiana V Kudling Tuomo Alanko Riitta Korpisaari Susanna Juteau Marjut Jaakkola Jorma Sormunen Jukka Kemppainen Annabrita Hemmes Teijo Pellinen Mirte van der Heijden Dafne C A Source Type: research

Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells
CONCLUSIONS: These results provided an important basis of DOX combination with RES analogues, especially Oxy-RES, for better therapeutic effect. Further studies in human should be performed on exploring combination of DOX and Oxy-RES.PMID:38546076 | DOI:10.31557/APJCP.2024.25.3.939 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Waraporn Yahayo Veerachai Pongkittiphan Roogntawan Supabphol Somrudee Saiyudthong Source Type: research

Development of injectable upconversion nanoparticle-conjugated doxorubicin theranostics electrospun nanostructure for targeted photochemotherapy in breast cancer
J Biomed Mater Res A. 2024 Mar 28. doi: 10.1002/jbm.a.37713. Online ahead of print.ABSTRACTNanotheranostic-based photochemotherapies with targeted drug delivery have considerably surfaced in cancer therapy. In the presented work, polyethyleneimine-coated upconversion nanoparticles were engineered to conjugate covalently with doxorubicin. Upconversion nanoparticles (UCNP)-Doxorubicin (DOX)/synthesized epidermal growth factor receptor-targeting peptide blended with polymer composite was electrospun and formulated as the injectable dosage form. The size of the UCNP and the nanofiber diameter were assessed as 26.75 ± 1.54 and...
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Amreen Khan Abhishek Tripathi Mayuri Gandhi Jayesh Bellare Rohit Srivastava Source Type: research

CDCA5 promoted cell invasion and migration by activating TGF-beta1 pathway in human ovarian cancer cells
CONCLUSIONS: CDCA5 may be a strong potential therapeutic target for the treatment and management of OC.PMID:38539247 | DOI:10.1186/s13048-024-01393-5 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Qingsong Zhang Rong Zhang Yuzhi Li Xiaojun Yang Source Type: research

Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology
CONCLUSIONS: CCR7 gene knockout can significantly inhibit the growth of mouse oral squamous cell carcinoma by promoting the polarization of M2 macrophages.PMID:38539232 | DOI:10.1186/s13046-024-03013-y (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Zengxu Wang Keith L Kirkwood Yao Wang Weidong Du Shanfeng Lin Wanhang Zhou Cong Yan Jiaxing Gao Zhenning Li Changfu Sun Fayu Liu Source Type: research