CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

CONCLUSIONS: IDH-mutant gliomas with deletion of CDKN2A/B are sensitized to CDK4/6 inhibitors. These results support investigation of the use of these agents in a clinical setting.PMID:38718141 | DOI:10.1158/1078-0432.CCR-24-0562

Source: Cell Research - May 8, 2024 Category: Cytology Authors: Ali M Nasser Lisa Melamed Ethan Wetzel Chia-Chen Chang Hiroaki Nagashima Yosuke Kitagawa Logan Muzyka Hiroaki Wakimoto Daniel P Cahill Julie J Miller Source Type: research