New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research
Investigating the shared genetic architecture between breast and ovarian cancers
Genet Mol Biol. 2024 Apr 15;47(2):e20230181. doi: 10.1590/1678-4685-GMB-2023-0181. eCollection 2024.ABSTRACTHigh heritability and strong correlation have been observed in breast and ovarian cancers. However, their shared genetic architecture remained unclear. Linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (ρ-HESS) were applied to estimate heritability and genetic correlations. Bivariate causal mixture model (MiXeR) was used to qualify the polygenic overlap. Then, stratified-LDSC (S-LDSC) was used to identify tissue and cell type specificity. Meanwhile, the adaptive assoc...
Source: Mol Biol Cell - April 16, 2024 Category: Molecular Biology Authors: Xuezhong Shi Anqi Bu Yongli Yang Yuping Wang Chenyu Zhao Jingwen Fan Chaojun Yang Xiaocan Jia Source Type: research
Pelvic target volume inter-fractional motion during radiotherapy for cervical cancer with daily iterative cone beam computed tomography
This study aimed to quantify inter-fractional movements of the uterus and cervix ... (Source: Radiation Oncology)
Source: Radiation Oncology - April 15, 2024 Category: Cancer & Oncology Authors: Zheng Zeng, Jiawei Zhu, Zhiqun Wang, Guangyu Wang, Junfang Yan and Fuquan Zhang Tags: Research Source Type: research
Fibroblast Growth Factor 23 is a Potential Prognostic Biomarker in Uterine Sarcoma
CONCLUSION: FGF23 was highly expressed in US and was promising as a novel potential biomarker for the diagnosis and prognosis of US.PMID:38613349 | DOI:10.1177/15330338241245924 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Ling Yang Ying Cai Yunjia Wang Yue Huang Chi Zhang Hu Ma Jian-Guo Zhou Source Type: research
Fibroblast Growth Factor 23 is a Potential Prognostic Biomarker in Uterine Sarcoma
CONCLUSION: FGF23 was highly expressed in US and was promising as a novel potential biomarker for the diagnosis and prognosis of US.PMID:38613349 | PMC:PMC11015760 | DOI:10.1177/15330338241245924 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Ling Yang Ying Cai Yunjia Wang Yue Huang Chi Zhang Hu Ma Jian-Guo Zhou Source Type: research
En Bloc Resection of Sentinel Lymph Nodes with the Hysterectomy Specimen in Endometrial Cancer
CONCLUSION: This novel surgical technique emphasizes the importance of anatomical knowledge and offers inspiration for studies with potential clinical benefit that should follow.PMID:38615152 | DOI:10.1245/s10434-024-15234-8 (Source: Ann Oncol)
Source: Ann Oncol - April 13, 2024 Category: Cancer & Oncology Authors: Manolis Nikolopoulos Vasileios Mitsopoulos Anni Innamaa Jonathan Lippiatt Ioannis Biliatis Source Type: research
Fibroblast Growth Factor 23 is a Potential Prognostic Biomarker in Uterine Sarcoma
CONCLUSION: FGF23 was highly expressed in US and was promising as a novel potential biomarker for the diagnosis and prognosis of US.PMID:38613349 | PMC:PMC11015760 | DOI:10.1177/15330338241245924 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Ling Yang Ying Cai Yunjia Wang Yue Huang Chi Zhang Hu Ma Jian-Guo Zhou Source Type: research
Outcomes after fertility ‐sparing surgery of early‐stage ovarian cancer: A nationwide population‐based study
ConclusionFSS can be a safe alternative procedure in selected young patients of Stage I EOC who have fertility desire. Endometrial biopsy before or during FSS and regular surveillance to detect recurrence are mandatory for ovarian cancer patients undergoing FSS. (Source: Cancer Medicine)
Source: Cancer Medicine - April 12, 2024 Category: Cancer & Oncology Authors: Chia ‐Yi Lee,
Chun‐Ju Chiang,
Yi‐Jou Tai,
Heng‐Cheng Hsu,
Yu‐Li Chen,
Ying‐Cheng Chiang,
Chia‐Ying Wu,
Wen‐Chung Lee,
Hsiao‐Lin Hwa,
Wen‐Fang Cheng Tags: RESEARCH ARTICLE Source Type: research
Prognostic values of tumor size and location in early stage endometrial cancer patients who received radiotherapy
CONCLUSION: Tumor size and LUSI are independent prognostic factors in early-stage EC patients who have received radiotherapy. Integrating these variables into prognostic models would improve predictive ability.PMID:38606825 | DOI:10.3802/jgo.2024.35.e84 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 12, 2024 Category: OBGYN Authors: Shuning Jiao Lichun Wei Lijuan Zou Tiejun Wang Ke Hu Fuquan Zhang Xiaorong Hou Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease †
In this study, we review the underlying principles of shear wave elastography and its current clinical uses outside the reproductive tract as well as its successful application of shear wave elastography to reproductive tissues, including the uterus and cervix. We also describe an emerging use of this technology in evaluation of human ovarian stiffness via transvaginal ultrasound. Establishing ovarian stiffness as a clinical biomarker of ovarian aging may have implications for predicting the ovarian reserve and outcomes of Assisted Reproductive Technologies as well as for the assessment of the efficacy of emerging therapeu...
Source: Biology of Reproduction - April 12, 2024 Category: Reproduction Medicine Authors: Emily J Zaniker Man Zhang Lydia Hughes Lizellen La Follette Tomiris Atazhanova Alexis Trofimchuk Elnur Babayev Francesca E Duncan Source Type: research
Prognostic values of tumor size and location in early stage endometrial cancer patients who received radiotherapy
CONCLUSION: Tumor size and LUSI are independent prognostic factors in early-stage EC patients who have received radiotherapy. Integrating these variables into prognostic models would improve predictive ability.PMID:38606825 | DOI:10.3802/jgo.2024.35.e84 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 12, 2024 Category: OBGYN Authors: Shuning Jiao Lichun Wei Lijuan Zou Tiejun Wang Ke Hu Fuquan Zhang Xiaorong Hou Source Type: research
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease †
In this study, we review the underlying principles of shear wave elastography and its current clinical uses outside the reproductive tract as well as its successful application of shear wave elastography to reproductive tissues, including the uterus and cervix. We also describe an emerging use of this technology in evaluation of human ovarian stiffness via transvaginal ultrasound. Establishing ovarian stiffness as a clinical biomarker of ovarian aging may have implications for predicting the ovarian reserve and outcomes of Assisted Reproductive Technologies as well as for the assessment of the efficacy of emerging therapeu...
Source: Reproductive Biology - April 12, 2024 Category: Reproduction Medicine Authors: Emily J Zaniker Man Zhang Lydia Hughes Lizellen La Follette Tomiris Atazhanova Alexis Trofimchuk Elnur Babayev Francesca E Duncan Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
