Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
CONCLUSION: Our analysis preliminarily describes the complex function of CMPK2 in cancer progression and immune microenvironment highlighting its potential as a diagnostic and therapeutic target for immunotherapy.PMID:38486392 | DOI:10.2174/0115680096281451240306062101 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - March 15, 2024 Category: Cancer & Oncology Authors: Jingyuan Luo Qianyue Zhang Shutong Wang Luojie Zheng Jie Liu Yuchen Zhang Yingchen Wang Ranran Wang Zhigang Xiao Zheng Li Source Type: research
The role and challenges of regulating endometrial microbiome in uterine health and diseases
Crit Rev Microbiol. 2024 Mar 15:1-18. doi: 10.1080/1040841X.2024.2320247. Online ahead of print.ABSTRACTThe uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance...
Source: Critical Reviews in Microbiology - March 15, 2024 Category: Microbiology Authors: Chongshan Yuan Kunyu Xie Lianjun Feng Shouyang Gao Lifu Cai Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
The immune microenvironment of cancer of the uterine cervix
Histol Histopathol. 2024 Mar 1:18727. doi: 10.14670/HH-18-727. Online ahead of print.ABSTRACTWhile several treatment choices exist for cervical cancer, such as surgical therapy, chemotherapy, and radiotherapy, some patients will still show poor prognosis. HPV infection is a principal factor for cervical cancer development, from early inflammation to proliferation, angiogenesis, and neoplastic growth. While HPV T-cell responses exist, the tumor seems to evade the immune system upon its tolerance. The latter suggests the existence of a confluent tumor microenvironment responsible for the evasion tactics employed by the neopl...
Source: Histology and Histopathology - March 14, 2024 Category: Cytology Authors: Michail Mastrogeorgiou Elena Chatzikalil Stamatios Theocharis Alexandra Papoudou-Bai Michel P éoc'h Mousa Mobarki Georgia Karpathiou Source Type: research
MiRNAs related in signaling pathways of women's reproductive diseases: an overview
CONCLUSIONS: This review focuses on the investigation of miRNAs and their involvement in various reproductive disorders in women, including their molecular targets. Additionally, it explores the role of miRNAs in the development and progression of these disorders.PMID:38472662 | DOI:10.1007/s11033-024-09357-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 13, 2024 Category: Molecular Biology Authors: Malihe Bagheri Behzad Khansarinejad Mahdieh Mondanizadeh Mohadeseh Azimi Shima Alavi Source Type: research
MiRNAs related in signaling pathways of women's reproductive diseases: an overview
CONCLUSIONS: This review focuses on the investigation of miRNAs and their involvement in various reproductive disorders in women, including their molecular targets. Additionally, it explores the role of miRNAs in the development and progression of these disorders.PMID:38472662 | DOI:10.1007/s11033-024-09357-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 13, 2024 Category: Molecular Biology Authors: Malihe Bagheri Behzad Khansarinejad Mahdieh Mondanizadeh Mohadeseh Azimi Shima Alavi Source Type: research
Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids
In conclusion, for the UCS1 patient-derived tumor cells, gemcitabine combinations were more effective than carboplatin/paclitaxel. Our data support the use of PDOs to predict responses to second-line chemotherapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1142: Performance of MRI for Detection of & ge;pT1b Disease in Local Staging of Endometrial Cancer
Cancers, Vol. 16, Pages 1142: Performance of MRI for Detection of ≥pT1b Disease in Local Staging of Endometrial Cancer
Cancers doi: 10.3390/cancers16061142
Authors:
Van Vynckt
Tummers
Denys
Göker
Hendrickx
Naert
Salihi
Van de Vijver
van Ramshorst
Van Weehaeghe
Vandecasteele
Villeirs
De Visschere
Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The presence of ≥pT1b disease (i.e., tumor invasion in ≥50% of the myometrium, into the cervical stroma or spread outside the uterus) has important pr...
Source: Cancers - March 13, 2024 Category: Cancer & Oncology Authors: Van Vynckt Tummers Denys G öker Hendrickx Naert Salihi Van de Vijver van Ramshorst Van Weehaeghe Vandecasteele Villeirs De Visschere Tags: Article Source Type: research
