Cancers, Vol. 16, Pages 1315: Detection and Classification of Hysteroscopic Images Using Deep Learning
Conclusion: Our DL model achieved a low diagnostic performance in the detection and classification of intracavitary uterine lesions from hysteroscopic images. Although the best diagnostic performance was obtained with the aid of clinical data, such an improvement was slight. (Source: Cancers)
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Diego Raimondo Antonio Raffone Paolo Salucci Ivano Raimondo Giampiero Capobianco Federico Andrea Galatolo Mario Giovanni Cosimo Antonio Cimino Antonio Travaglino Manuela Maletta Stefano Ferla Agnese Virgilio Daniele Neola Paolo Casadio Renato Seracchioli Tags: Article Source Type: research
Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer
AbstractPatient-derived organoids (PDOs) retain the original tumor ’s characteristics to a large degree and allow direct evaluation of the drug sensitivity, thereby emerging as a valuable resource for both basic and preclinical researches. Whereas most past studies stereotypically adopted a single PDO as an avatar of the patient, it remains to be investigated whe ther this assumption can be justified even for the tumor with spatial diversity. To address this issue, we established and characterized multiple PDOs originating from various sites of a patient with advanced uterine carcinosarcoma (UCS). Specifically, cancer ce...
Source: Human Cell - March 28, 2024 Category: Cytology Source Type: research
Ovarian Cancer in the Older Manitoban Population-Treatment Tolerance and Cancer-Related Outcomes: A Manitoba Ovarian Cancer Outcomes (MOCO) Group Study
CONCLUSIONS: Our study demonstrated a high rate of chemotherapy dose reduction and discontinuation in the elderly epithelial ovarian cancer population. Further research is needed to identify risk factors for treatment discontinuation and intolerance in this population.PMID:38534935 | DOI:10.3390/curroncol31030102 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Lesley F Roberts Pascal Lambert Mark W Nachtigal Alon D Altman Erin Dean Source Type: research
PFAS Modulate Osmotic Signaling Independent of Gravimetric Changes in the Rat Uterus
This study screened multiple PFAS in the rat uterotrophic assay to determine potential estrogenic effects on the uterus with PFAS exposure. This study also explored PFAS-dependent uterine signaling with an osmotic stress mRNA gene expression array. Briefly, Sprague-Dawley rats (26-39 days old) were ovariectomized, and uterine tissue was allowed to regress for a 3-week period of recovery. Animals were then exposed daily via oral gavage to PFAS for 4 days, and then uterine weight was determined. In contrast to the positive control estrogens, the PFAS tested (4:2, 6:2, and 8:2FTOH; perfluorooctanesulfonamide (PFOSA), perfluor...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Aaron Dixon Evelyn G Rowan Allison N Yackley Erin P Hines Source Type: research
Results of Definitive (Chemo)radiotherapy Using Computed Tomography-based Brachytherapy for Cervical Cancer
CONCLUSION: Combination of EBRT and CT-based IGBT with or without concurrent chemotherapy produced favorable LC with acceptable rates of late toxicities. However, extra-pelvic failures frequently occurred and PFS was less satisfactory in patients with stage III-IVA disease, which indicated the need for additional treatment in these patients.PMID:38537975 | DOI:10.21873/anticanres.16956 (Source: Cell Research)
Source: Cell Research - March 27, 2024 Category: Cytology Authors: Tomomi Aoshika Shin-Ei Noda Takanori Abe Y U Kumazaki Ryuta Hirai Mitsunobu Igari Satoshi Saito Yasuhiro Ryuno Misaki Iino Yuga Takeda Tomohiro Ohta Jun Watanabe Keita Tsukahara Shingo Kato Source Type: research
Ovarian Cancer in the Older Manitoban Population-Treatment Tolerance and Cancer-Related Outcomes: A Manitoba Ovarian Cancer Outcomes (MOCO) Group Study
CONCLUSIONS: Our study demonstrated a high rate of chemotherapy dose reduction and discontinuation in the elderly epithelial ovarian cancer population. Further research is needed to identify risk factors for treatment discontinuation and intolerance in this population.PMID:38534935 | PMC:PMC10969362 | DOI:10.3390/curroncol31030102 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Lesley F Roberts Pascal Lambert Mark W Nachtigal Alon D Altman Erin Dean Source Type: research
