A comparative study of mono-exponential and advanced diffusion-weighted imaging in differentiating stage IA endometrial carcinoma from benign endometrial lesions
ConclusionAdvanced diffusion-weighted imaging models have good performance for differentiating IAEC from EH and endometrial thickening. Among all of the diffusion parameters, K showed the best performance and was the only independent predictor. Diffusion kurtosis imaging was defined as the most valuable model in the current context. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 20, 2024 Category: Cancer & Oncology Source Type: research
The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers
Curr Pharm Des. 2024 Mar 18. doi: 10.2174/0113816128291955240306112558. Online ahead of print.ABSTRACTGynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved ...
Source: Current Pharmaceutical Design - March 19, 2024 Category: Drugs & Pharmacology Authors: Vahideh Keyvani Samaneh Mollazadeh Espanta Riahi Reihaneh Alsadat Mahmoudian Masoomeh Tabari Elmira Lagzian Elnaz Ghorbani Hamed Akbarzade Amir-Sadra Gholami Ibrahim Saeed Gataa Seyed Mahdi Hassanian Gordon A Ferns Majid Khazaei Amir Avan Kazem Anvari Source Type: research
The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers
Curr Pharm Des. 2024 Mar 18. doi: 10.2174/0113816128291955240306112558. Online ahead of print.ABSTRACTGynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved ...
Source: Current Pharmaceutical Design - March 19, 2024 Category: Drugs & Pharmacology Authors: Vahideh Keyvani Samaneh Mollazadeh Espanta Riahi Reihaneh Alsadat Mahmoudian Masoomeh Tabari Elmira Lagzian Elnaz Ghorbani Hamed Akbarzade Amir-Sadra Gholami Ibrahim Saeed Gataa Seyed Mahdi Hassanian Gordon A Ferns Majid Khazaei Amir Avan Kazem Anvari Source Type: research
The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers
Curr Pharm Des. 2024 Mar 18. doi: 10.2174/0113816128291955240306112558. Online ahead of print.ABSTRACTGynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved ...
Source: Current Pharmaceutical Design - March 19, 2024 Category: Drugs & Pharmacology Authors: Vahideh Keyvani Samaneh Mollazadeh Espanta Riahi Reihaneh Alsadat Mahmoudian Masoomeh Tabari Elmira Lagzian Elnaz Ghorbani Hamed Akbarzade Amir-Sadra Gholami Ibrahim Saeed Gataa Seyed Mahdi Hassanian Gordon A Ferns Majid Khazaei Amir Avan Kazem Anvari Source Type: research
Cancers, Vol. 16, Pages 1210: Clinical Workflow of Cone Beam Computer Tomography-Based Daily Online Adaptive Radiotherapy with Offline Magnetic Resonance Guidance: The Modular Adaptive Radiotherapy System (MARS)
Conclusion: This study describes the first workflow to date of a CBCT-based oART combined with a shuttle-based offline approach for MR guidance. The oART duration times reported resemble the range shown by previous publications for first clinical experiences with the Ethos system. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Ji-Young Kim Bouchra Tawk Maximilian Knoll Philipp Hoegen-Sa ßmannshausen Jakob Liermann Peter E. Huber Mona Lifferth Clemens Lang Peter H äring Regula Gnirs Oliver J äkel Heinz-Peter Schlemmer J ürgen Debus Juliane H örner-Rieber Fabian Weykamp Tags: Article Source Type: research
Impact of programmed cell death protein 1 inhibitor therapy on the survival of patients with advanced or recurrent uterine cancers: a meta-analysis
ConclusionSurvival was significantly better using PD-1 inhibitor therapy than variable non-PD-1 inhibitor chemotherapies among patients with advanced or recurrent uterine cancers. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research
Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
CONCLUSION: Our analysis preliminarily describes the complex function of CMPK2 in cancer progression and immune microenvironment highlighting its potential as a diagnostic and therapeutic target for immunotherapy.PMID:38486392 | DOI:10.2174/0115680096281451240306062101 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - March 15, 2024 Category: Cancer & Oncology Authors: Jingyuan Luo Qianyue Zhang Shutong Wang Luojie Zheng Jie Liu Yuchen Zhang Yingchen Wang Ranran Wang Zhigang Xiao Zheng Li Source Type: research
The role and challenges of regulating endometrial microbiome in uterine health and diseases
Crit Rev Microbiol. 2024 Mar 15:1-18. doi: 10.1080/1040841X.2024.2320247. Online ahead of print.ABSTRACTThe uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance...
Source: Critical Reviews in Microbiology - March 15, 2024 Category: Microbiology Authors: Chongshan Yuan Kunyu Xie Lianjun Feng Shouyang Gao Lifu Cai Source Type: research
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Cancer Control)
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research
Hand Foot Syndrome Induced by Lenvatinib - A Case Report
CONCLUSION: Hand-foot syndrome is one of the commonest ADRs due to the use of lenvatinib. Lenvatinib is an oral formulation that patients can take at their homes. Hence, educating patients regarding the HFS is important so that they report it to the treating physicians on time. It is also essential to educate patients regarding the precautions to be taken to avoid hand-foot syndrome. This will help the physicians with the early discontinuation and appropriate treatment with corticosteroids, which will help in improving the quality of life of the patients already suffering from cancer.PMID:38486391 | DOI:10.2174/01157488632...
Source: Current Drug Safety - March 15, 2024 Category: Drugs & Pharmacology Authors: Kiran Rangshahi Siddhartha Nanda Meenalotchini Prakash Gurunthalingam Vikas Katiyara Pugazhenthan Thangaraju Nitin R Gaikwad Source Type: research
Uterine body metastasis from rectal cancer: A case report
Asian J Surg. 2024 Mar 14:S1015-9584(24)00468-8. doi: 10.1016/j.asjsur.2024.03.041. Online ahead of print.NO ABSTRACTPMID:38490866 | DOI:10.1016/j.asjsur.2024.03.041 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 15, 2024 Category: Surgery Authors: Xing Wen Meng Wang Source Type: research
Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
CONCLUSION: Our analysis preliminarily describes the complex function of CMPK2 in cancer progression and immune microenvironment highlighting its potential as a diagnostic and therapeutic target for immunotherapy.PMID:38486392 | DOI:10.2174/0115680096281451240306062101 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - March 15, 2024 Category: Cancer & Oncology Authors: Jingyuan Luo Qianyue Zhang Shutong Wang Luojie Zheng Jie Liu Yuchen Zhang Yingchen Wang Ranran Wang Zhigang Xiao Zheng Li Source Type: research
The role and challenges of regulating endometrial microbiome in uterine health and diseases
Crit Rev Microbiol. 2024 Mar 15:1-18. doi: 10.1080/1040841X.2024.2320247. Online ahead of print.ABSTRACTThe uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance...
Source: Critical Reviews in Microbiology - March 15, 2024 Category: Microbiology Authors: Chongshan Yuan Kunyu Xie Lianjun Feng Shouyang Gao Lifu Cai Source Type: research
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
CONCLUSIONS: Compared to traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.PMID:38488807 | DOI:10.1158/1078-0432.CCR-24-0148 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Josephine K Dermawan Sarah Chiang Samuel Singer Bhumika Jadeja Martee L Hensley William D Tap Sujana Movva Robert G Maki Cristina R Antonescu Source Type: research
