Automatic segmentation of tumour and organs at risk in 3D MRI for cervical cancer radiation therapy with anatomical variations
Phys Eng Sci Med. 2024 Apr 24. doi: 10.1007/s13246-024-01415-y. Online ahead of print.ABSTRACTCervical cancer is a common cancer in women globally, with treatment usually involving radiation therapy (RT). Accurate segmentation for the tumour site and organ-at-risks (OARs) could assist in the reduction of treatment side effects and improve treatment planning efficiency. Cervical cancer Magnetic Resonance Imaging (MRI) segmentation is challenging due to a limited amount of training data available and large inter- and intra- patient shape variation for OARs. The proposed Masked-Net consists of a masked encoder within the 3D U...
Source: Health Physics - April 24, 2024 Category: Physics Authors: Sze-Nung Leung Shekhar S Chandra Karen Lim Tony Young Lois Holloway Jason A Dowling Source Type: research
Automatic segmentation of tumour and organs at risk in 3D MRI for cervical cancer radiation therapy with anatomical variations
AbstractCervical cancer is a common cancer in women globally, with treatment usually involving radiation therapy (RT). Accurate segmentation for the tumour site and organ-at-risks (OARs) could assist in the reduction of treatment side effects and improve treatment planning efficiency. Cervical cancer Magnetic Resonance Imaging (MRI) segmentation is challenging due to a limited amount of training data available and large inter- and intra- patient shape variation for OARs. The proposed Masked-Net consists of a masked encoder within the 3D U-Net to account for the large shape variation within the dataset, with additional dila...
Source: Australasian Physical and Engineering Sciences in Medicine - April 24, 2024 Category: Biomedical Engineering Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Cancers, Vol. 16, Pages 1621: P16/Ki67 Dual Staining in Glandular Cell Abnormalities of the Uterine Cervix
In this study, we investigated the diagnostic accuracy of p16/Ki67 dual staining for the detection of glandular and squamous lesions on the uterine cervix and for cancer of the upper reproductive tract. We performed a retrospective analysis of prospectively collected data on 96 patients with glandular cell abnormalities. We analyzed the diagnostic accuracy of p16/Ki67 dual staining for atypical glandular cells, not otherwise specified (AGC-NOS); atypical glandular cells, favor neoplastic (AGC-FN); adenocarcinoma in situ (AIS); and A-CA (cervical adenocarcinoma). A separate analysis for the detection of squamous precancerou...
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Sa ša Jeromel Alenka Rep še Fokter Andra ž Dovnik Tags: Article Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
AbstractProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system,progesterone contributes to the control ofluteinizing hormone andfollicle-stimulating hormone secretion and their pulsatility,via itsreceptors on thekisspeptin,neurokinin B, anddynorphin neurons in the hypothalamus.Progesterone together withestradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participate...
Source: Reviews in Endocrine and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Endometrial cancer: predictors and oncological safety of tumor tissue manipulation
ConclusionWhilst performing common gynecological procedures, iatrogenic distention and manipulation of the uterine cavity are produced. Our study suggests that the use of uterine manipulator increases the rate of LVSI and, therefore, leads to poorer oncological results. Conversely, preoperative hysteroscopy does not show higher rates of LVSI involvement in the final surgical specimen and can be safely used. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Novel targets and their functions in the prognosis of uterine corpus endometrial cancer patients
J Appl Genet. 2024 Apr 19. doi: 10.1007/s13353-024-00856-1. Online ahead of print.ABSTRACTAberrant mRNA expression is implicated in uterine corpus endometrial carcinoma (UCEC) oncogenesis and progression. However, effective prognostic biomarkers for UCEC remain limited. We aimed to construct a reliable multi-gene risk model using gene expression profiles. Utilizing TCGA data (543 UCEC samples, 35 controls), we identified 1517 differentially acting genes. Weighted gene co-expression complex analysis (WGCCA), hub gene screening, and risk regression analysis (RRA) were employed to determine prognosis-related genes and constru...
Source: J Appl Genet - April 19, 2024 Category: Genetics & Stem Cells Authors: Xin Sui Penghui Feng Jie Guo Xingtong Chen Rong Chen Yanmin Zhang Falin He Feng Deng Source Type: research
Endometrial cancer: predictors and oncological safety of tumor tissue manipulation
ConclusionWhilst performing common gynecological procedures, iatrogenic distention and manipulation of the uterine cavity are produced. Our study suggests that the use of uterine manipulator increases the rate of LVSI and, therefore, leads to poorer oncological results. Conversely, preoperative hysteroscopy does not show higher rates of LVSI involvement in the final surgical specimen and can be safely used. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1570: Machine Learning Applied to Pre-Operative Computed-Tomography-Based Radiomic Features Can Accurately Differentiate Uterine Leiomyoma from Leiomyosarcoma: A Pilot Study
Conclusions: CECT images integrated with radiomics have great potential in differentiating uterine leiomyomas from leiomyosarcomas. Such a tool can be used to mitigate the risks of eventual surgical spread in the case of leiomyosarcoma and allow for safer fertility-sparing treatment in patients with benign uterine lesions. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Miriam Santoro Vladislav Zybin Camelia Alexandra Coada Giulia Mantovani Giulia Paolani Marco Di Stanislao Cecilia Modolon Stella Di Costanzo Andrei Lebovici Gloria Ravegnini Antonio De Leo Marco Tesei Pietro Pasquini Luigi Lovato Alessio Giuseppe Morganti Tags: Article Source Type: research
New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research
Indicators of cure for women living after uterine and ovarian cancers: a population-based study
This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynaecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate Net Survival (NS), Cure Fraction, Time To Cure (5-year conditional NS>95%), Cure Prevalence (women who will not die of cancer), and Already Cured (living longer than Time to Cure). In 2018, 0.4% (121,704) of Italian women were alive after corpus uteri cancer, 0.2% (52,551) after cervical, and 0.2% (52,153) after ovarian cancer. More than 90% of ...
Source: Am J Epidemiol - April 17, 2024 Category: Epidemiology Authors: Fabiola Giudici Angela De Paoli Federica Toffolutti Stefano Guzzinati Silvia Francisci Lauro Bucchi Gemma Gatta Elena Demuru Sandra Mallone Antonella Dal Cin Adele Caldarella Francesco Cuccaro Enrica Migliore Maria Letizia Gambino Alessandra Ravaioli Anto Source Type: research
New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research
Investigating the shared genetic architecture between breast and ovarian cancers
Genet Mol Biol. 2024 Apr 15;47(2):e20230181. doi: 10.1590/1678-4685-GMB-2023-0181. eCollection 2024.ABSTRACTHigh heritability and strong correlation have been observed in breast and ovarian cancers. However, their shared genetic architecture remained unclear. Linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (ρ-HESS) were applied to estimate heritability and genetic correlations. Bivariate causal mixture model (MiXeR) was used to qualify the polygenic overlap. Then, stratified-LDSC (S-LDSC) was used to identify tissue and cell type specificity. Meanwhile, the adaptive assoc...
Source: Mol Biol Cell - April 16, 2024 Category: Molecular Biology Authors: Xuezhong Shi Anqi Bu Yongli Yang Yuping Wang Chenyu Zhao Jingwen Fan Chaojun Yang Xiaocan Jia Source Type: research
