Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease †
In this study, we review the underlying principles of shear wave elastography and its current clinical uses outside the reproductive tract as well as its successful application of shear wave elastography to reproductive tissues, including the uterus and cervix. We also describe an emerging use of this technology in evaluation of human ovarian stiffness via transvaginal ultrasound. Establishing ovarian stiffness as a clinical biomarker of ovarian aging may have implications for predicting the ovarian reserve and outcomes of Assisted Reproductive Technologies as well as for the assessment of the efficacy of emerging therapeu...
Source: Biology of Reproduction - April 12, 2024 Category: Reproduction Medicine Authors: Emily J Zaniker Man Zhang Lydia Hughes Lizellen La Follette Tomiris Atazhanova Alexis Trofimchuk Elnur Babayev Francesca E Duncan Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease †
In this study, we review the underlying principles of shear wave elastography and its current clinical uses outside the reproductive tract as well as its successful application of shear wave elastography to reproductive tissues, including the uterus and cervix. We also describe an emerging use of this technology in evaluation of human ovarian stiffness via transvaginal ultrasound. Establishing ovarian stiffness as a clinical biomarker of ovarian aging may have implications for predicting the ovarian reserve and outcomes of Assisted Reproductive Technologies as well as for the assessment of the efficacy of emerging therapeu...
Source: Biology of Reproduction - April 12, 2024 Category: Reproduction Medicine Authors: Emily J Zaniker Man Zhang Lydia Hughes Lizellen La Follette Tomiris Atazhanova Alexis Trofimchuk Elnur Babayev Francesca E Duncan Source Type: research
Prognostic values of tumor size and location in early stage endometrial cancer patients who received radiotherapy
CONCLUSION: Tumor size and LUSI are independent prognostic factors in early-stage EC patients who have received radiotherapy. Integrating these variables into prognostic models would improve predictive ability.PMID:38606825 | DOI:10.3802/jgo.2024.35.e84 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 12, 2024 Category: OBGYN Authors: Shuning Jiao Lichun Wei Lijuan Zou Tiejun Wang Ke Hu Fuquan Zhang Xiaorong Hou Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
The feasibility and outcomes of metabolic and bariatric surgery prior to neoplastic therapy
CONCLUSIONS: This study highlights the potential feasibility of employing MBS prior to neoplastic therapy in patients with low-grade, less aggressive neoplasms in the context of obesity. This underscores the importance of providing a personalized, case-to-case multidisciplinary approach in the management of these patients.PMID:38594091 | DOI:10.1016/j.soard.2024.02.008 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 9, 2024 Category: Surgery Authors: Chetan Parmar Kamal Abi Mosleh Pauline Aeschbacher Thorvardur R Halfdanarson Travis J McKenzie Raul J Rosenthal Omar M Ghanem BRIDGE Study Group Source Type: research
The feasibility and outcomes of metabolic and bariatric surgery prior to neoplastic therapy
CONCLUSIONS: This study highlights the potential feasibility of employing MBS prior to neoplastic therapy in patients with low-grade, less aggressive neoplasms in the context of obesity. This underscores the importance of providing a personalized, case-to-case multidisciplinary approach in the management of these patients.PMID:38594091 | DOI:10.1016/j.soard.2024.02.008 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 9, 2024 Category: Surgery Authors: Chetan Parmar Kamal Abi Mosleh Pauline Aeschbacher Thorvardur R Halfdanarson Travis J McKenzie Raul J Rosenthal Omar M Ghanem BRIDGE Study Group Source Type: research
Discovery of novel macrocyclic derivatives as potent and selective cyclin-dependent kinase 2 inhibitors
Bioorg Med Chem. 2024 Apr 3;104:117711. doi: 10.1016/j.bmc.2024.117711. Online ahead of print.ABSTRACTCyclin-dependent kinase 2 (CDK2) is a member of CDK family of kinases (CDKs) that regulate the cell cycle. Its inopportune or over-activation leads to uncontrolled cell cycle progression and drives numerous types of cancers, especially ovarian, uterine, gastric cancer, as well as those associated with amplified CCNE1 gene. However, developing selective lead compound as CDK2 inhibitors remains challenging owing to similarities in the ATP pockets among different CDKs. Herein, we described the optimization of compound 1, a no...
Source: Bioorganic and Medicinal Chemistry - April 7, 2024 Category: Chemistry Authors: Pengpeng Niu Yanxin Tao Qingyuan Meng Yixing Huang Shan Li Ke Ding Dawei Ma Zu Ye Mengyang Fan Source Type: research
Discovery of novel macrocyclic derivatives as potent and selective cyclin-dependent kinase 2 inhibitors
Bioorg Med Chem. 2024 Apr 3;104:117711. doi: 10.1016/j.bmc.2024.117711. Online ahead of print.ABSTRACTCyclin-dependent kinase 2 (CDK2) is a member of CDK family of kinases (CDKs) that regulate the cell cycle. Its inopportune or over-activation leads to uncontrolled cell cycle progression and drives numerous types of cancers, especially ovarian, uterine, gastric cancer, as well as those associated with amplified CCNE1 gene. However, developing selective lead compound as CDK2 inhibitors remains challenging owing to similarities in the ATP pockets among different CDKs. Herein, we described the optimization of compound 1, a no...
Source: Bioorganic and Medicinal Chemistry - April 7, 2024 Category: Chemistry Authors: Pengpeng Niu Yanxin Tao Qingyuan Meng Yixing Huang Shan Li Ke Ding Dawei Ma Zu Ye Mengyang Fan Source Type: research
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Biochimica et Biophysica Acta - April 5, 2024 Category: Biochemistry Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
