E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Biochimica et Biophysica Acta - April 5, 2024 Category: Biochemistry Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
Biochim Biophys Acta Mol Cell Res. 2024 Apr 3:119721. doi: 10.1016/j.bbamcr.2024.119721. Online ahead of print.ABSTRACTMetabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative and metabolic pathways, and acts, depending on the cellular and molecular context, as an oncogene or tumor suppressor. The latter is evident by the observation that E2f1-knockout mice develop spontaneous tumors, including uterine sarcomas. This dual role warrants a detailed investigation o...
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Katharina Huber Albert Giralt Ren é Dreos Helene Michenthaler Sarah Geller Valentin Barquissau Dorian V Ziegler Daniele Tavernari Hector Gallart-Ayala Katarina Krajina Katharina Jonas Giovanni Ciriello Julijana Ivanisevic Andreas Prokesch Martin Pichler Source Type: research
Immunomodulatory effects of Diospyros peregrina fruit preparation (DFP) in non-small cell lung cancer (NSCLC) by utilizing dendritic cell-mediated antigen presentation and T helper (TH) cell differentiation
AbstractDiospyros peregrina is a dioecious plant which is native to India. It belongs to the family of Ebenaceae and is extensively used to treat various ailments, such as leucorrhoea and other uterine-related problems. Though few studies have been onD. peregrina for their anti-tumour response, little is known. Therefore, this intrigued us to understand its immunomodulator capabilities on various types of cancer extensively. Our primary focus is on NSCLC (Non-Small Cell Lung Cancer), which is ranked as the second largest form of cancer in the world, and the treatments demand non-invasive agents to target NSCLC effectively....
Source: Medical Oncology - April 5, 2024 Category: Cancer & Oncology Source Type: research
Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID ‐19 pandemic in North Carolina
Conclusion and RelevanceIn women, the COVID-19 pandemic resulted in a significant reduction in the incidence of breast and uterine cancers, but not colon or pancreatic cancers. A change in the proportion of poor prognosis breast and uterine cancers suggests that some cancers that otherwise would have been diagnosed at an earlier stage will be detected in later years. Continued analysis of long-term trends is needed to understand the full impact of the pandemic on cancer incidence and outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Sarah J. Nyante,
Allison M. Deal,
Hillary M. Heiling,
Kyung Su Kim,
Cherie M. Kuzmiak,
Benjamin C. Calhoun,
Emily M. Ray Tags: RESEARCH ARTICLE Source Type: research
A vocal cord palsy caused by the uterine cancer metastatic tumor in the mediastinum revealed in a patient with a thyroid lesion: a case report and review of the literature
ConclusionA history of the disease should always be kept in mind when assessing a patient ’s complaints. VCP in case of thyroid pathology and previous secondary malignancy may be caused by metastatic tumor anywhere along the RLN pathway. Such a rare case shows the importance of additional methods of examination which may avoid unnecessary thyroid surgeries. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 4, 2024 Category: General Medicine Source Type: research
Comparative Analysis of Oncologic Outcomes in Patients with Squamous Cell Carcinoma of the Uterine Cervix with High-Risk Features for Para-Aortic Recurrence: Prophylactic Extended-Field versus Pelvic Chemoradiotherapy
(Source: Cancer Management and Research)
Source: Cancer Management and Research - April 3, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Reducing radicality in fertility-sparing surgery is associated with improved in vitro fertilization outcome in early-stage cervical cancer: A national retrospective study
CONCLUSION: This is the largest study to evaluate IVF outcomes in young cervical cancer survivors who have undergone FSS. The findings suggest that less radical procedures are associated with significantly better IVF outcomes. These results emphasize the importance of considering oncological safety and reproductive outcomes together when choosing FSS for early-stage cervical cancer patients. It also highlights the reproductive benefits of performing less radical surgery.PMID:38569327 | DOI:10.1016/j.ygyno.2024.03.024 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 3, 2024 Category: Cancer & Oncology Authors: D óra Vesztergom Gy öngyvér Téglás Kiarash Bahrehmand Attila T örök Levente Balla Vince Forg ács J ános Konc Zolt án Tándor Ákos Várnagy P éter Boga J ános Zádori Mikl ós Sipos Zolt án Mánfai Zolt án Novák Source Type: research
Reducing radicality in fertility-sparing surgery is associated with improved in vitro fertilization outcome in early-stage cervical cancer: A national retrospective study
CONCLUSION: This is the largest study to evaluate IVF outcomes in young cervical cancer survivors who have undergone FSS. The findings suggest that less radical procedures are associated with significantly better IVF outcomes. These results emphasize the importance of considering oncological safety and reproductive outcomes together when choosing FSS for early-stage cervical cancer patients. It also highlights the reproductive benefits of performing less radical surgery.PMID:38569327 | DOI:10.1016/j.ygyno.2024.03.024 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 3, 2024 Category: Cancer & Oncology Authors: D óra Vesztergom Gy öngyvér Téglás Kiarash Bahrehmand Attila T örök Levente Balla Vince Forg ács J ános Konc Zolt án Tándor Ákos Várnagy P éter Boga J ános Zádori Mikl ós Sipos Zolt án Mánfai Zolt án Novák Source Type: research
Reducing radicality in fertility-sparing surgery is associated with improved in vitro fertilization outcome in early-stage cervical cancer: A national retrospective study
CONCLUSION: This is the largest study to evaluate IVF outcomes in young cervical cancer survivors who have undergone FSS. The findings suggest that less radical procedures are associated with significantly better IVF outcomes. These results emphasize the importance of considering oncological safety and reproductive outcomes together when choosing FSS for early-stage cervical cancer patients. It also highlights the reproductive benefits of performing less radical surgery.PMID:38569327 | DOI:10.1016/j.ygyno.2024.03.024 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 3, 2024 Category: Cancer & Oncology Authors: D óra Vesztergom Gy öngyvér Téglás Kiarash Bahrehmand Attila T örök Levente Balla Vince Forg ács J ános Konc Zolt án Tándor Ákos Várnagy P éter Boga J ános Zádori Mikl ós Sipos Zolt án Mánfai Zolt án Novák Source Type: research
Risk of Secondary Malignancies After Pelvic Radiation: A Population-based Analysis
CONCLUSIONS AND CLINICAL IMPLICATIONS: Except for localized cervical cancer, when put in the context of median overall survival, the impact of radiation likely does not carry enough weight to change practice patterns. Radiation for pelvic malignancies increases the risk for several secondary malignancies, and more specifically, secondary pelvic malignancies, but with a relatively low absolute risk of secondary malignancies, the benefits of radiation warrant continued use for most pelvic malignancies. Practice changes should be considered for radiation utilization in malignancies with excellent cancer-specific survival such...
Source: Anal Sci - April 1, 2024 Category: Chemistry Authors: Connor McPartland Andrew Salib Joshua Banks James R Mark Costas D Lallas Edouard J Trabulsi Leonard G Gomella Hanan Goldberg Benjamin Leiby Robert Den Thenappan Chandrasekar Source Type: research
Risk of Secondary Malignancies After Pelvic Radiation: A Population-based Analysis
CONCLUSIONS AND CLINICAL IMPLICATIONS: Except for localized cervical cancer, when put in the context of median overall survival, the impact of radiation likely does not carry enough weight to change practice patterns. Radiation for pelvic malignancies increases the risk for several secondary malignancies, and more specifically, secondary pelvic malignancies, but with a relatively low absolute risk of secondary malignancies, the benefits of radiation warrant continued use for most pelvic malignancies. Practice changes should be considered for radiation utilization in malignancies with excellent cancer-specific survival such...
Source: Anal Sci - April 1, 2024 Category: Chemistry Authors: Connor McPartland Andrew Salib Joshua Banks James R Mark Costas D Lallas Edouard J Trabulsi Leonard G Gomella Hanan Goldberg Benjamin Leiby Robert Den Thenappan Chandrasekar Source Type: research
62. Gynecologic Management Practices of Adolescent and Young Adult Cancer Survivors after Pelvic and/or Total Body Irradiation
The objective of this study is assess if current practice patterns are consistent with recommended guidelines of care for adolescent cancer survivors and to identify gaps in the management and treatment of radiation-induced uterine injury. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Adeola Akapo, Leslie Appiah, Alejandro Varela, Karen Hampanda, Fatima Mustaffa Source Type: research
Long-Term Reproductive Health Outcomes in Women Veterans Exposed to Airborne Hazards and Open Burn Pits
To investigate airborne hazards and burn pits exposures, and recognize the impact of military exposures on long-term reproductive health outcomes among women Veterans such as breast, cervical, uterine and ovarian cancers. Describe the WRIISC Women health addendum and understand its development and implementation. Discuss the current and future use of WRIISC Women addendum, implications, and next steps. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Maheen Adamson, Mehret Assefa, Daya Grewal, Gladys Veltkamp, Jennifer Jennings, Dylan Jester Tags: Oral Presentation 2443303 Source Type: research
High-dose ascorbate exerts anti-tumor activities and improves inhibitory effect of carboplatin through the pro-oxidant function pathway in uterine serous carcinoma cell lines
CONCLUSIONS: Ascorbate has potent antitumor activity and acts synergistically with carboplatin through its pro-oxidant effects. Clinical trials of ascorbate combined with carboplatin as adjuvant treatment of uterine serous carcinoma are worth exploring.PMID:38555710 | DOI:10.1016/j.ygyno.2024.03.021 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 31, 2024 Category: Cancer & Oncology Authors: Xiaochang Shen Jiandong Wang Boer Deng Shuning Chen Catherine John Ziyi Zhao Nikita Sinha Jennifer Haag Wenchuan Sun Weimin Kong Ivan Spasojevic Ines Batinic-Haberle Angeles Alvarez Secord Chunxiao Zhou Victoria L Bae-Jump Source Type: research
