Risk of Secondary Malignancies After Pelvic Radiation: A Population-based Analysis

CONCLUSIONS AND CLINICAL IMPLICATIONS: Except for localized cervical cancer, when put in the context of median overall survival, the impact of radiation likely does not carry enough weight to change practice patterns. Radiation for pelvic malignancies increases the risk for several secondary malignancies, and more specifically, secondary pelvic malignancies, but with a relatively low absolute risk of secondary malignancies, the benefits of radiation warrant continued use for most pelvic malignancies. Practice changes should be considered for radiation utilization in malignancies with excellent cancer-specific survival such as cervical cancer.PATIENT SUMMARY: The use of radiation for the management of pelvic malignancies induces a risk of secondary malignancies to its recipients. However, the absolute risk being low, the benefits of radiation warrant its continued use, and a change in practice patterns is unlikely.PMID:38558762 | PMC:PMC10979055 | DOI:10.1016/j.euros.2024.02.013

Source: Anal Sci - April 1, 2024 Category: Chemistry Authors: Connor McPartland Andrew Salib Joshua Banks James R Mark Costas D Lallas Edouard J Trabulsi Leonard G Gomella Hanan Goldberg Benjamin Leiby Robert Den Thenappan Chandrasekar Source Type: research