High-dose ascorbate exerts anti-tumor activities and improves inhibitory effect of carboplatin through the pro-oxidant function pathway in uterine serous carcinoma cell lines

CONCLUSIONS: Ascorbate has potent antitumor activity and acts synergistically with carboplatin through its pro-oxidant effects. Clinical trials of ascorbate combined with carboplatin as adjuvant treatment of uterine serous carcinoma are worth exploring.PMID:38555710 | DOI:10.1016/j.ygyno.2024.03.021

Source: Gynecologic Oncology - March 31, 2024 Category: Cancer & Oncology Authors: Xiaochang Shen Jiandong Wang Boer Deng Shuning Chen Catherine John Ziyi Zhao Nikita Sinha Jennifer Haag Wenchuan Sun Weimin Kong Ivan Spasojevic Ines Batinic-Haberle Angeles Alvarez Secord Chunxiao Zhou Victoria L Bae-Jump Source Type: research