A landscape of patient-derived cancer-associated fibroblast signals in endometrial cancers
Am J Cancer Res. 2024 Feb 15;14(2):467-489. eCollection 2024.ABSTRACTIn conversation with endometrial tumor cells, the endometrial cancer-associated fibroblasts (CAFs) are the "partners in crime" of uterine neoplasm's highly heterogeneous tumor microenvironment (TME). We designed a laboratory-friendly method to culture endometrial CAFs on a patient-to-patient basis for studying the CAF-TME and CAF-tumor cell interaction(s). Here, we present a comprehensive characterization of endometrial CAFs derived from patients' tumor tissues (T) and tumor-adjacent normal tissues (N). We used more than 80 T and N from 53 consecutive con...
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Raed Sulaiman Nischal Koirala Jennifer C Aske Xiaoqian Lin Luis Rojas-Espaillat David Starks Adam Dale Kris Gaster Pradip De Nandini Dey Source Type: research
Quality of Life After Extended Pelvic Surgery with Neurovascular or Bony Resections in Gynecological Oncology: A Systematic Review
CONCLUSIONS: In this highly selected patient group, mortality and QoL seem to be acceptable, with a high morbidity rate. This comprehensive study will help to inform eligible patients about the outcomes of extended pelvic surgery with neurovascular or bony resections. Future collaborative studies can enable the collection of QoL data in a validated, uniform manner.PMID:38459419 | DOI:10.1245/s10434-023-14649-z (Source: Ann Oncol)
Source: Ann Oncol - March 8, 2024 Category: Cancer & Oncology Authors: Andreas Denys Sofie Thielemans Rawand Salihi Philippe Tummers Gabrielle H van Ramshorst Source Type: research
Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue
CONCLUSIONS: An important caveat for future liquid biopsy/DNA-based cancer diagnostics is the repertoire of shared and distinct mutation profiles between histologically unremarkable and EndoCA tissues. The lack of selection pressure between functional and non-functional mutations in histologically unremarkable uterine tissue may offer a glimpse into an unrecognized EndoCA protective mechanism.PMID:38452634 | DOI:10.1016/j.ygyno.2024.02.027 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 7, 2024 Category: Cancer & Oncology Authors: Deep Pandya Shannon Tomita Maria Padron Rhenals Sabina Swierczek Katherine Reid Olga Camacho-Vanegas Catalina Camacho Kelsey Engelman Stephanie Polukort Jordan RoseFigura Linus Chuang Vaagn Andikyan Samantha Cohen Paul Fiedler Steven Sieber Ie-Ming Shih J Source Type: research
Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue
CONCLUSIONS: An important caveat for future liquid biopsy/DNA-based cancer diagnostics is the repertoire of shared and distinct mutation profiles between histologically unremarkable and EndoCA tissues. The lack of selection pressure between functional and non-functional mutations in histologically unremarkable uterine tissue may offer a glimpse into an unrecognized EndoCA protective mechanism.PMID:38452634 | DOI:10.1016/j.ygyno.2024.02.027 (Source: Ann Oncol)
Source: Ann Oncol - March 7, 2024 Category: Cancer & Oncology Authors: Deep Pandya Shannon Tomita Maria Padron Rhenals Sabina Swierczek Katherine Reid Olga Camacho-Vanegas Catalina Camacho Kelsey Engelman Stephanie Polukort Jordan RoseFigura Linus Chuang Vaagn Andikyan Samantha Cohen Paul Fiedler Steven Sieber Ie-Ming Shih J Source Type: research
