Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies
Crit Rev Microbiol. 2021 Sep 3:1-24. doi: 10.1080/1040841X.2021.1962803. Online ahead of print.ABSTRACTFacing the increasing threat of multi-drug antimicrobial resistance (AMR), humans strive to search for antibiotic drug candidates and antibacterial alternatives from all possible places, from soils in remote areas to deep in the sea. In this "gold rush for antibacterials," researchers turn to the natural enemy of bacterial cells, bacteriophage (phages), and find them a rich source of weapons for AMR bacteria. Endolysins (lysins), the enzymes phages use to break the bacterial cells from within, have been shown to...
Source: Critical Reviews in Microbiology - September 3, 2021 Category: Microbiology Authors: Marco Kai Yuen Ho Pengfei Zhang Xi Chen Jiang Xia Sharon Shui Yee Leung Source Type: research

Bacterial survival strategies and responses under heavy metal stress: a comprehensive overview
Crit Rev Microbiol. 2021 Sep 2:1-29. doi: 10.1080/1040841X.2021.1970512. Online ahead of print.ABSTRACTHeavy metals bring long-term hazardous consequences and pose a serious threat to all life forms. Being non-biodegradable, they can remain in the food webs for a long period of time. Metal ions are essential for life and indispensable for almost all aspects of metabolism but can be toxic beyond threshold level to all living beings including microbes. Heavy metals are generally present in the environment, but many geogenic and anthropogenic activities has led to excess metal ion accumulation in the environment. To survive i...
Source: Critical Reviews in Microbiology - September 2, 2021 Category: Microbiology Authors: Ayon Pal Sukanya Bhattacharjee Jayanti Saha Monalisha Sarkar Parimal Mandal Source Type: research

Metal-organic frameworks for diagnosis and therapy of infectious diseases
Crit Rev Microbiol. 2021 Aug 25:1-36. doi: 10.1080/1040841X.2021.1950120. Online ahead of print.ABSTRACTInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review pr...
Source: Critical Reviews in Microbiology - August 25, 2021 Category: Microbiology Authors: Christian Rafael Quijia Renata Carolina Alves Gilmar Hanck-Silva Regina C élia Galvão Frem Guilherme Arroyos Marlus Chorilli Source Type: research

Metal-organic frameworks for diagnosis and therapy of infectious diseases
Crit Rev Microbiol. 2021 Aug 25:1-36. doi: 10.1080/1040841X.2021.1950120. Online ahead of print.ABSTRACTInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review pr...
Source: Critical Reviews in Microbiology - August 25, 2021 Category: Microbiology Authors: Christian Rafael Quijia Renata Carolina Alves Gilmar Hanck-Silva Regina C élia Galvão Frem Guilherme Arroyos Marlus Chorilli Source Type: research

Metal-organic frameworks for diagnosis and therapy of infectious diseases
Crit Rev Microbiol. 2021 Aug 25:1-36. doi: 10.1080/1040841X.2021.1950120. Online ahead of print.ABSTRACTInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review pr...
Source: Critical Reviews in Microbiology - August 25, 2021 Category: Microbiology Authors: Christian Rafael Quijia Renata Carolina Alves Gilmar Hanck-Silva Regina C élia Galvão Frem Guilherme Arroyos Marlus Chorilli Source Type: research

Metal-organic frameworks for diagnosis and therapy of infectious diseases
Crit Rev Microbiol. 2021 Aug 25:1-36. doi: 10.1080/1040841X.2021.1950120. Online ahead of print.ABSTRACTInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review pr...
Source: Critical Reviews in Microbiology - August 25, 2021 Category: Microbiology Authors: Christian Rafael Quijia Renata Carolina Alves Gilmar Hanck-Silva Regina C élia Galvão Frem Guilherme Arroyos Marlus Chorilli Source Type: research

Metal-organic frameworks for diagnosis and therapy of infectious diseases
Crit Rev Microbiol. 2021 Aug 25:1-36. doi: 10.1080/1040841X.2021.1950120. Online ahead of print.ABSTRACTInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review pr...
Source: Critical Reviews in Microbiology - August 25, 2021 Category: Microbiology Authors: Christian Rafael Quijia Renata Carolina Alves Gilmar Hanck-Silva Regina C élia Galvão Frem Guilherme Arroyos Marlus Chorilli Source Type: research

Applications of bacteriophages against intracellular bacteria
Crit Rev Microbiol. 2021 Aug 24:1-18. doi: 10.1080/1040841X.2021.1960481. Online ahead of print.ABSTRACTInfectious diseases pose a significant threat to both human and animal populations. Intracellular bacteria are a group of pathogens that invade and survive within the interior of eukaryotic cells, which in turn protect them from antibacterial drugs and the host immune system. Limited penetration of antibacterials into host cells results in insufficient bacterial clearance and treatment failure. Bacteriophages have, over the decades, been proved to play an important role in combating bacterial infections (phage therapy), ...
Source: Critical Reviews in Microbiology - August 24, 2021 Category: Microbiology Authors: Paulina Śliwka Marta Ochocka Aneta Skaradzi ńska Source Type: research

Applications of bacteriophages against intracellular bacteria
Crit Rev Microbiol. 2021 Aug 24:1-18. doi: 10.1080/1040841X.2021.1960481. Online ahead of print.ABSTRACTInfectious diseases pose a significant threat to both human and animal populations. Intracellular bacteria are a group of pathogens that invade and survive within the interior of eukaryotic cells, which in turn protect them from antibacterial drugs and the host immune system. Limited penetration of antibacterials into host cells results in insufficient bacterial clearance and treatment failure. Bacteriophages have, over the decades, been proved to play an important role in combating bacterial infections (phage therapy), ...
Source: Critical Reviews in Microbiology - August 24, 2021 Category: Microbiology Authors: Paulina Śliwka Marta Ochocka Aneta Skaradzi ńska Source Type: research

Water in bacterial biofilms: pores and channels, storage and transport functions
Crit Rev Microbiol. 2021 Aug 19:1-20. doi: 10.1080/1040841X.2021.1962802. Online ahead of print.ABSTRACTBacterial biofilms occur in many natural and industrial environments. Besides bacteria, biofilms comprise over 70 wt% water. Water in biofilms occurs as bound- or free-water. Bound-water is adsorbed to bacterial surfaces or biofilm (matrix) structures and possesses different Infra-red and Nuclear-Magnetic-Resonance signatures than free-water. Bound-water is different from intra-cellularly confined-water or water confined within biofilm structures and bacteria are actively involved in building water-filled structures by b...
Source: Critical Reviews in Microbiology - August 19, 2021 Category: Microbiology Authors: Kecheng Quan Jiapeng Hou Zexin Zhang Yijin Ren Brandon W Peterson Hans-Curt Flemming Christian Mayer Henk J Busscher Henny C van der Mei Source Type: research

Water in bacterial biofilms: pores and channels, storage and transport functions
Crit Rev Microbiol. 2021 Aug 19:1-20. doi: 10.1080/1040841X.2021.1962802. Online ahead of print.ABSTRACTBacterial biofilms occur in many natural and industrial environments. Besides bacteria, biofilms comprise over 70 wt% water. Water in biofilms occurs as bound- or free-water. Bound-water is adsorbed to bacterial surfaces or biofilm (matrix) structures and possesses different Infra-red and Nuclear-Magnetic-Resonance signatures than free-water. Bound-water is different from intra-cellularly confined-water or water confined within biofilm structures and bacteria are actively involved in building water-filled structures by b...
Source: Critical Reviews in Microbiology - August 19, 2021 Category: Microbiology Authors: Kecheng Quan Jiapeng Hou Zexin Zhang Yijin Ren Brandon W Peterson Hans-Curt Flemming Christian Mayer Henk J Busscher Henny C van der Mei Source Type: research

Water in bacterial biofilms: pores and channels, storage and transport functions
Crit Rev Microbiol. 2021 Aug 19:1-20. doi: 10.1080/1040841X.2021.1962802. Online ahead of print.ABSTRACTBacterial biofilms occur in many natural and industrial environments. Besides bacteria, biofilms comprise over 70 wt% water. Water in biofilms occurs as bound- or free-water. Bound-water is adsorbed to bacterial surfaces or biofilm (matrix) structures and possesses different Infra-red and Nuclear-Magnetic-Resonance signatures than free-water. Bound-water is different from intra-cellularly confined-water or water confined within biofilm structures and bacteria are actively involved in building water-filled structures by b...
Source: Critical Reviews in Microbiology - August 19, 2021 Category: Microbiology Authors: Kecheng Quan Jiapeng Hou Zexin Zhang Yijin Ren Brandon W Peterson Hans-Curt Flemming Christian Mayer Henk J Busscher Henny C van der Mei Source Type: research

Water in bacterial biofilms: pores and channels, storage and transport functions
Crit Rev Microbiol. 2021 Aug 19:1-20. doi: 10.1080/1040841X.2021.1962802. Online ahead of print.ABSTRACTBacterial biofilms occur in many natural and industrial environments. Besides bacteria, biofilms comprise over 70 wt% water. Water in biofilms occurs as bound- or free-water. Bound-water is adsorbed to bacterial surfaces or biofilm (matrix) structures and possesses different Infra-red and Nuclear-Magnetic-Resonance signatures than free-water. Bound-water is different from intra-cellularly confined-water or water confined within biofilm structures and bacteria are actively involved in building water-filled structures by b...
Source: Critical Reviews in Microbiology - August 19, 2021 Category: Microbiology Authors: Kecheng Quan Jiapeng Hou Zexin Zhang Yijin Ren Brandon W Peterson Hans-Curt Flemming Christian Mayer Henk J Busscher Henny C van der Mei Source Type: research

Modulating host gene expression via gut microbiome-microRNA interplay to treat human diseases
Crit Rev Microbiol. 2021 Sep;47(5):596-611. doi: 10.1080/1040841X.2021.1907739. Epub 2021 Apr 6.ABSTRACTThe human gastrointestinal (GI) tract hosts trillions of microbial inhabitants involved in maintaining intestinal homeostasis, dysbiosis of which provokes a motley of pathogenic and autoimmune disorders. While the mechanisms by which the microbiota modulates human health are manifold, their liberated metabolites from ingested dietary supplements play a crucial role by bidirectionally regulating the expression of micro-ribonucleic acids (miRNAs). miRNAs are small endogenous non-coding RNAs (ncRNAs) that have been confirme...
Source: Critical Reviews in Microbiology - August 18, 2021 Category: Microbiology Authors: Deepansh Mody Vedika Verma Vibha Rani Source Type: research

Modulating host gene expression via gut microbiome-microRNA interplay to treat human diseases
Crit Rev Microbiol. 2021 Sep;47(5):596-611. doi: 10.1080/1040841X.2021.1907739. Epub 2021 Apr 6.ABSTRACTThe human gastrointestinal (GI) tract hosts trillions of microbial inhabitants involved in maintaining intestinal homeostasis, dysbiosis of which provokes a motley of pathogenic and autoimmune disorders. While the mechanisms by which the microbiota modulates human health are manifold, their liberated metabolites from ingested dietary supplements play a crucial role by bidirectionally regulating the expression of micro-ribonucleic acids (miRNAs). miRNAs are small endogenous non-coding RNAs (ncRNAs) that have been confirme...
Source: Critical Reviews in Microbiology - August 18, 2021 Category: Microbiology Authors: Deepansh Mody Vedika Verma Vibha Rani Source Type: research

The role of membrane contact sites at the bacteria-host interface
Crit Rev Microbiol. 2021 Aug 17:1-13. doi: 10.1080/1040841X.2021.1961678. Online ahead of print.ABSTRACTMembrane contact sites (MCSs) refer to the areas of close proximity between heterologous membranes. A growing body of evidence indicates that MCSs are involved in important cellular functions, such as cellular material transfer, organelle biogenesis, and cell growth. Importantly, the study of MCSs at the bacteria-host interface is an emerging popular research topic. Intracellular bacterial pathogens have evolved a variety of fascinating strategies to interfere with MCSs by injecting effectors into infected host cells. Ba...
Source: Critical Reviews in Microbiology - August 17, 2021 Category: Microbiology Authors: Chen Jiang Xue Huang Jia Yao Lihua Yu Fujing Wei Aimin Yang Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge
Crit Rev Microbiol. 2021 Aug 6:1-25. doi: 10.1080/1040841X.2021.1950121. Online ahead of print.ABSTRACTBiofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infecti...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Maryam Roudbary Roya Vahedi-Shahandashti Andr é Luis Souza Dos Santos Shahla Roudbar Mohammadi Peyman Aslani Cornelia Lass-Fl örl C élia F Rodrigues Source Type: research

The role of influenza A virus-induced hypercytokinemia
Crit Rev Microbiol. 2021 Aug 5:1-17. doi: 10.1080/1040841X.2021.1960482. Online ahead of print.ABSTRACTInfluenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or "cytokine storm&...
Source: Critical Reviews in Microbiology - August 6, 2021 Category: Microbiology Authors: Fanhua Wei Chengjiang Gao Yujiong Wang Source Type: research

Lung-brain axis
Crit Rev Microbiol. 2021 Aug 4:1-13. doi: 10.1080/1040841X.2021.1960483. Online ahead of print.ABSTRACTThe appreciation of human microbiome is gaining strong grounds in biomedical research. In addition to gut-brain axis, is the lung-brain axis, which is hypothesised to link pulmonary microbes to neurodegenerative disorders and behavioural changes. There is a need for analysis based on emerging studies to map out the prospects for lung-brain axis. In this review, relevant English literature and researches in the field of 'lung-brain axis' is reported. We recommend all the highlighted prospective studies to be integrated wit...
Source: Critical Reviews in Microbiology - August 5, 2021 Category: Microbiology Authors: Ousman Bajinka Lucette Simbilyabo Yurong Tan John Jabang Shakeel Ahmed Saleem Source Type: research

< em > Burkholderia < /em > in the genomic era: from taxonomy to the discovery of new antimicrobial secondary metabolites
Crit Rev Microbiol. 2021 Aug 4:1-40. doi: 10.1080/1040841X.2021.1946009. Online ahead of print.ABSTRACTSpecies of Burkholderia are highly versatile being found not only abundantly in soil, but also as plants and animals' commensals or pathogens. Their complex multireplicon genomes harbour an impressive number of polyketide synthase (PKS) and nonribosomal peptide-synthetase (NRPS) genes coding for the production of antimicrobial secondary metabolites (SMs), which have been successfully deciphered by genome-guided tools. Moreover, genome metrics supported the split of this genus into Burkholderia sensu stricto (s.s.) and fiv...
Source: Critical Reviews in Microbiology - August 4, 2021 Category: Microbiology Authors: Evelise Bach Luciane Maria Pereira Passaglia Junjing Jiao Harald Gross Source Type: research

< em > Burkholderia < /em > in the genomic era: from taxonomy to the discovery of new antimicrobial secondary metabolites
Crit Rev Microbiol. 2021 Aug 4:1-40. doi: 10.1080/1040841X.2021.1946009. Online ahead of print.ABSTRACTSpecies of Burkholderia are highly versatile being found not only abundantly in soil, but also as plants and animals' commensals or pathogens. Their complex multireplicon genomes harbour an impressive number of polyketide synthase (PKS) and nonribosomal peptide-synthetase (NRPS) genes coding for the production of antimicrobial secondary metabolites (SMs), which have been successfully deciphered by genome-guided tools. Moreover, genome metrics supported the split of this genus into Burkholderia sensu stricto (s.s.) and fiv...
Source: Critical Reviews in Microbiology - August 4, 2021 Category: Microbiology Authors: Evelise Bach Luciane Maria Pereira Passaglia Junjing Jiao Harald Gross Source Type: research

< em > Acinetobacter < /em > defence mechanisms against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanisms against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research

< em > Acinetobacter < /em > defence mechanims against biological aggressors and their use as alternative therapeutic applications
Crit Rev Microbiol. 2021 Jul 21:1-21. doi: 10.1080/1040841X.2021.1939266. Online ahead of print.ABSTRACTSeveral Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously add...
Source: Critical Reviews in Microbiology - July 21, 2021 Category: Microbiology Authors: Mar ía Marcela Cameranesi Daniel Kurth Guillermo Daniel Repizo Source Type: research