Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii
Graphical Abstract (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 2562: Discovery of Bispecific Lead Compounds from Azadirachta indica against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations
i
Esam I. Azhar
Zika virus (ZIKV) has been characterized as one of many potential pathogens and placed under future epidemic outbreaks by the WHO. However, a lack of potential therapeutics can result in an uncontrolled pandemic as with other human pandemic viruses. Therefore, prioritized effective therapeutics development has been recommended against ZIKV. In this context, the present study adopted a strategy to explore the lead compounds from Azadirachta indica against ZIKV via concurrent inhibition of the NS2B-NS3 protease (ZIKVpro) and NS5 RNA dependent RNA polymerase (ZIKVRdRp) proteins using molecular simulation...
Source: Molecules - April 15, 2022 Category: Chemistry Authors: Sanjay Kumar Sherif A. El-Kafrawy Shiv Bharadwaj S. S. Maitra Thamir A. Alandijany Arwa A. Faizo Aiah M. Khateb Vivek Dhar Dwivedi Esam I. Azhar Tags: Article Source Type: research
Molecular Docking and Molecular Dynamics Simulation of Fisetin, Galangin, Hesperetin, Hesperidin, Myricetin, and Naringenin against Polymerase of Dengue Virus
J Trop Med. 2022 Mar 20;2022:7254990. doi: 10.1155/2022/7254990. eCollection 2022.ABSTRACTDengue fever is a disease spread by the DENV virus through mosquitoes. This disease is dangerous because there is no specific drug, vaccine, or antiviral against the DENV virus, insisting on drug discovery for dengue fever. RNA-dependent RNA polymerase (RdRp) enzyme in DENV can be a drug target because it has an important role in the virus replication process. In this research, in silico simulations were carried out on bioflavonoid compounds, namely, Fisetin, Galangin, Hesperetin, Hesperidin, Myricetin, and Naringenin with Quercetin a...
Source: Journal of Tropical Medicine - March 31, 2022 Category: Tropical Medicine Authors: Jaka Fajar Fatriansyah Raihan Kenji Rizqillah Muhammad Yusup Yandi Source Type: research
Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced
Hepatotoxicity through Targeting
NLRP3/NF- κB/Nrf2
In this study, we
evaluated the possible effect of isorhamnetin in prevention of APAP-induced ALI
and analyzed further the involvement of oxidative stress and
inflammation-associated factors. Male C57BL/6 mice were given
isorhamnetin (25 or 100 mg/kg b.w., p.o.) three times at
48, 24, and 1 h before APAP administration (300 mg/kg
b.w., i.p.). Functional indicators of liver injury were measured as well
as analysis of oxidative stress- and inflammation-associated indices and liver
histopathology was also conducted. Isorhamnetin at the highe...
Source: Drug Research - March 31, 2022 Category: Drugs & Pharmacology Authors: Rousta, Ali-Mohammad Mirahmadi, Seyed-Mohamad-Sadegh Shahmohammadi, Alireza Mehrabi, Zhila Fallah, Soudabeh Baluchnejadmojarad, Tourandokht Roghani, Mehrdad Tags: Original Article Source Type: research
Biological importance of a biflavonoids 'bilobetin' in the medicine: Medicinal importance, pharmacological activities and analytical aspects
CONCLUSION: Scientific data analysis revealed biological importance and pharmacological activities of bilobetin in the health sectors.PMID:35319397 | DOI:10.2174/1871526522666220321152036 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 23, 2022 Category: Infectious Diseases Authors: Dinesh Kumar Patel Source Type: research
Biological importance of a biflavonoids 'bilobetin' in the medicine: Medicinal importance, pharmacological activities and analytical aspects
CONCLUSION: Scientific data analysis revealed biological importance and pharmacological activities of bilobetin in the health sectors.PMID:35319397 | DOI:10.2174/1871526522666220321152036 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 23, 2022 Category: Infectious Diseases Authors: Dinesh Kumar Patel Source Type: research
Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress
AbstractAlzheimer ’s disease (AD) is presented as an age-related neurodegenerative disease with multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved factor in its development. Nobiletin is a bioflavonoid isolated from citrus fruits peels with anti-inflammatory and anti-oxidat ive activity as well as anti-dementia property that has shown potency to ameliorate intracellular and extracellular Ab. The aim of the present study was to assess protective effect of nobiletin against Aβ1 −40-induced cognitive impairment as a consistent model of AD. After bilateral intrahippocampal (CA1 su...
Source: Metabolic Brain Disease - March 16, 2022 Category: Neurology Source Type: research
Protective effect of Naringin ameliorates TNBS-induced colitis in rats via improving antioxidant status and pro-inflammatory cytokines
This study examined the effect of NG on 2, 4, 6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. 42 male Wistar rats were divided into seven groups like Normal Control (NC), Ethanol Control (EC), Disease Control (DC), NG 20 (20 mg/kg, p.o.), NG 40 (40 mg/kg, p.o.), NG 80 (80 mg/kg, p.o.) and Dexamethasone (DEX) (2 mg/kg, p.o.). Colitis was induced in Wistar albino rats by administering TNBS intra-rectally (in 50% ethanol). The rats were then given 14 days of NG (20, 40, and 80 mg/kg) and DEX (2 mg/kg) treatment. Several behavioural, biochemical, molecular, and histological analyses were performed. The treatmen...
Source: Immunopharmacology and Immunotoxicology - March 7, 2022 Category: Allergy & Immunology Authors: Vrushali R Hambardikar Deepa S Mandlik Source Type: research
The Bioflavonoids Rutin and Rutin Succinate Neutralize the Toxins of B. jararaca Venom and Inhibit its Lethality
In conclusion, RS has anticoagulant properties and is a novel SVMP inhibitor. Rutin and RS showed different mechanisms of action on hemostasis. Only RS inhibited directly BjV biological activities, even though both flavonoids neutralized B. jararaca toxicity in vivo. Our results showed clearly that rutin and RS show a great potential to be used as therapeutic compounds for snakebite envenomation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 21, 2022 Category: Drugs & Pharmacology Source Type: research
Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway
CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR-485-5p/YAP1 axis, which might provide a novel treatment strategy for DN.PMID:35129398 | DOI:10.1177/20587384211066440 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - February 7, 2022 Category: Allergy & Immunology Authors: Huan Wan Yaping Wang Qingyun Pan Xia Chen Sijun Chen Xiaohui Li Weiguo Yao Source Type: research
Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway
CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR-485-5p/YAP1 axis, which might provide a novel treatment strategy for DN.PMID:35129398 | PMC:PMC8832592 | DOI:10.1177/20587384211066440 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - February 7, 2022 Category: Allergy & Immunology Authors: Huan Wan Yaping Wang Qingyun Pan Xia Chen Sijun Chen Xiaohui Li Weiguo Yao Source Type: research
