Molecules, Vol. 28, Pages 417: Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats
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Recent evidences indicate that there is a substantial increase in worldwide cases of dementia. Alzheimer's disease is the leading cause of dementia and may contribute to 60–70% of cases. Quercetin is a unique bioflavonoid that has numerous therapeutic benefits such as anti-allergy, anti-ulcer, anti-inflammatory, anti-hypertensive, anti-cancer, immuno-modulatory, anti-infective, antioxidant, acetylcholinesterase inhibitory activity, neuroprotective effects, etc. In the present study, we evaluated the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats after...
Source: Molecules - January 3, 2023 Category: Chemistry Authors: Ratnakar Jadhav Yogesh A. Kulkarni Tags: Article Source Type: research
Normalization of HPA Axis, Cholinergic Neurotransmission, and Inhibiting Brain Oxidative and Inflammatory Dynamics Are Associated with The Adaptogenic-like Effect of Rutin Against Psychosocial Defeat Stress
In this study, we investigated the neuroprotective effect of rutin, a bioflavonoid with neuroprotective and anti-inflammatory functions on neurobehavioral and neuro-biochemical changes in mice exposed to SDS. Groups of mice named the intruder mice received normal saline (10 mL/kg), rutin (5, 10, and 20 mg/kg, i.p.), and ginseng (50 mg/kg, i.p.) daily for 14 days, and then followed by 10 min daily SDS (physical/psychological) exposures to aggressor mice from days 7-14. Investigations consisting of neurobehavioral (locomotion, memory, anxiety, and depression) phenotypes, neuro-biochemical (oxidative, nitrergic, chol...
Source: Journal of Molecular Neuroscience - December 29, 2022 Category: Neuroscience Source Type: research
Chemical Structures and Pharmacological Properties of Typical Bioflavonoids in < em > Polygonati Rhizoma < /em > (PGR)
J Environ Public Health. 2022 Sep 20;2022:4649614. doi: 10.1155/2022/4649614. eCollection 2022.ABSTRACTMost medicines are coming with toxic and detrimental side effects. In addition, microbials are resisting the medicine. Therefore, alternative drugs with low toxic and side effects and low microbial resistance are needed. Plants offer good potential candidates due to a broad range of chemicals they contain. These chemicals have been studied, and research is still going on to probe chemical properties of plant chemicals. In China, traditional Chinese medicine is practised, whereby plant extracts are obtained, and then sold ...
Source: Journal of Environmental and Public Health - December 26, 2022 Category: Environmental Health Authors: Min Luo Zongren Hu Zixuan Zhong Lumei Liu Chengxiong Lin Qinghu He Source Type: research
