Activating the Hippo pathway by nevadensin overcomes Yap-drived resistance to sorafenib in hepatocellular carcinoma
ConclusionsThe present study indicates that nevadensin could be a potential effective approach to treating HCC, and overcoming sorafeni resistance via inducing activation of Hippo signaling. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 27, 2023 Category: Cancer & Oncology Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research
A new class of layered Bi2O2S nanopetals by one-pot supercritical-CO2 approach: A reliable electrocatalyst for analgesic bioflavonoid detection
Chemosphere. 2023 Mar 31:138534. doi: 10.1016/j.chemosphere.2023.138534. Online ahead of print.ABSTRACTNanomaterials frequently draw a lot of interest in a variety of disciplines, including electrochemistry. Developing a reliable electrode modifier for the selective electrochemical detection of the analgesic bioflavonoid i.e., Rutinoside (RS) is a great challenge. Here in, we have explored the supercritical-CO2 (SC-CO2) mediated synthesis of bismuth oxysulfide (SC-BiOS) and reported it as a robust electrode modifier for the detection of RS. For a comparison study, the same preparation procedure was carried out in the conve...
Source: Chemosphere - April 2, 2023 Category: Chemistry Authors: Shobana Sebastin Mary Manickaraj Sabarison Pandiyarajan Ai-Ho Liao Angelin Rubavathi Panneer Selvam Sheng-Tung Huang J Rosaline Vimala Kuo-Yu Lee Ho-Chiao Chuang Source Type: research
A new class of layered Bi2O2S nanopetals by one-pot supercritical-CO2 approach: A reliable electrocatalyst for analgesic bioflavonoid detection
Chemosphere. 2023 Mar 31:138534. doi: 10.1016/j.chemosphere.2023.138534. Online ahead of print.ABSTRACTNanomaterials frequently draw a lot of interest in a variety of disciplines, including electrochemistry. Developing a reliable electrode modifier for the selective electrochemical detection of the analgesic bioflavonoid i.e., Rutinoside (RS) is a great challenge. Here in, we have explored the supercritical-CO2 (SC-CO2) mediated synthesis of bismuth oxysulfide (SC-BiOS) and reported it as a robust electrode modifier for the detection of RS. For a comparison study, the same preparation procedure was carried out in the conve...
Source: Chemosphere - April 2, 2023 Category: Chemistry Authors: Shobana Sebastin Mary Manickaraj Sabarison Pandiyarajan Ai-Ho Liao Angelin Rubavathi Panneer Selvam Sheng-Tung Huang J Rosaline Vimala Kuo-Yu Lee Ho-Chiao Chuang Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
