Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
Curr Issues Mol Biol. 2023 Mar 6;45(3):2136-2156. doi: 10.3390/cimb45030137.ABSTRACTThe KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant could be an efficient strategy. Therefore, in the present study, we targeted the switch I (residues 25-40) and switch II (residues 57-76) regions of KRAS G12D with dietary bioflavonoids in comparison with the reference KRAS SI/II inhibitor BI-2852. ...
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Prasanna Srinivasan Ramalingam Purushothaman Balakrishnan Senthilnathan Rajendran Arunachalam Jothi Rajasekaran Ramalingam Sivakumar Arumugam Source Type: research
