Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Hydroxyapatite microbeads containing BMP-2 and quercetin fabricated via electrostatic spraying to encourage bone regeneration
Hydroxyapatite (HAp) possesses osteoconductive properties, and its granular form can serve as an effective drug delivery vehicle for bone regeneration. Quercetin (Qct), a plant-derived bioflavonoid, is known t... (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - February 18, 2023 Category: Biomedical Engineering Authors: Seoyun Lee, Honghyun Park, Jeong-Seop Oh, Kyubin Byun, Dae-Yong Kim, Hui-suk Yun and Byung-Jae Kang Tags: Research Source Type: research
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most i...
Source: Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Haiyan Wang Yongyong Yan Janak L Pathak Wei Hong Jing Zeng Dongyang Qian Binwei Hao Haiqing Li Jinlan Gu Richard T Jaspers Gang Wu Ming Shao Gongyong Peng Haifeng Lan Source Type: research
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most i...
Source: J Cell Mol Med - February 1, 2023 Category: Molecular Biology Authors: Haiyan Wang Yongyong Yan Janak L Pathak Wei Hong Jing Zeng Dongyang Qian Binwei Hao Haiqing Li Jinlan Gu Richard T Jaspers Gang Wu Ming Shao Gongyong Peng Haifeng Lan Source Type: research
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most i...
Source: Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Haiyan Wang Yongyong Yan Janak L Pathak Wei Hong Jing Zeng Dongyang Qian Binwei Hao Haiqing Li Jinlan Gu Richard T Jaspers Gang Wu Ming Shao Gongyong Peng Haifeng Lan Source Type: research
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most i...
Source: J Cell Mol Med - February 1, 2023 Category: Molecular Biology Authors: Haiyan Wang Yongyong Yan Janak L Pathak Wei Hong Jing Zeng Dongyang Qian Binwei Hao Haiqing Li Jinlan Gu Richard T Jaspers Gang Wu Ming Shao Gongyong Peng Haifeng Lan Source Type: research
Molecules, Vol. 28, Pages 1354: Brain Targeting by Intranasal Drug Delivery: Effect of Different Formulations of the Biflavone & ldquo;Cupressuflavone & rdquo; from Juniperus sabina L. on the Motor Activity of Rats
Molecules, Vol. 28, Pages 1354: Brain Targeting by Intranasal Drug Delivery: Effect of Different Formulations of the Biflavone “Cupressuflavone” from Juniperus sabina L. on the Motor Activity of Rats
Molecules doi: 10.3390/molecules28031354
Authors:
El-Sayed Khafagy
Gamal A. Soliman
Ahmad Abdul-Wahhab Shahba
Mohammed F. Aldawsari
Khalid M. Alharthy
Maged S. Abdel-Kader
Hala H. Zaatout
The polar fractions of the Juniperus species are rich in bioflavonoid contents. Phytochemical study of the polar fraction of Juniperus sabina aerial parts resulted in the isolation of cupressuflavone (C...
Source: Molecules - January 31, 2023 Category: Chemistry Authors: El-Sayed Khafagy Gamal A. Soliman Ahmad Abdul-Wahhab Shahba Mohammed F. Aldawsari Khalid M. Alharthy Maged S. Abdel-Kader Hala H. Zaatout Tags: Article Source Type: research
Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles
This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) were separated into 12 groups of five rat each. Type 2 diabetes was induced following oral therapy with fructose solution and one-time injection of 45 mg/kg of streptozotocin (STZ). The DEP extract was administered by nasal instillation, whereas MH was administered via oral gavage. Biochemical assays were used to determine the effect of MH on diabetic rats and DEP-exposed diabetic rats with respect to liver function indices (AST and ALT), liver antioxidants (SOD, CAT,...
Source: Applied Biochemistry and Biotechnology - January 28, 2023 Category: Biochemistry Authors: Ibukun Mary Folorunso Akeem Olalekan Lawal Olusola Olalekan Elekofehinti Opeyemi Iwaloye Source Type: research
Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles
This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) were separated into 12 groups of five rat each. Type 2 diabetes was induced following oral therapy with fructose solution and one-time injection of 45 mg/kg of streptozotocin (STZ). The DEP extract was administered by nasal instillation, whereas MH was administered via oral gavage. Biochemical assays were used to determine the effect of MH on diabetic rats and DEP-exposed diabetic rats with respect to liver function indices (AST and ALT), liver antioxidants (SOD, CAT,...
Source: Applied Biochemistry and Biotechnology - January 28, 2023 Category: Biochemistry Authors: Ibukun Mary Folorunso Akeem Olalekan Lawal Olusola Olalekan Elekofehinti Opeyemi Iwaloye Source Type: research
Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles
This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) were separated into 12 groups of five rat each. Type 2 diabetes was induced following oral therapy with fructose solution and one-time injection of 45 mg/kg of streptozotocin (STZ). The DEP extract was administered by nasal instillation, whereas MH was administered via oral gavage. Biochemical assays were used to determine the effect of MH on diabetic rats and DEP-exposed diabetic rats with respect to liver function indices (AST and ALT), liver antioxidants (SOD, CAT,...
Source: Applied Biochemistry and Biotechnology - January 28, 2023 Category: Biochemistry Authors: Ibukun Mary Folorunso Akeem Olalekan Lawal Olusola Olalekan Elekofehinti Opeyemi Iwaloye Source Type: research
