Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling
Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects. Lonicerin is a kind of bioflavonoid isolated from the Chinese herb Lonicera japonica Thunb, which has anti-inflammatory and immunomodulatory effects. The aim of this study was to elucidate the effects of lonicerin on eosinophilic asthma and its potential mechanisms. Here, we established a house dust mite (house dust mite)-induced eosinophilic asthma model in BALB/c mouse, and evaluated the effects of lonicerin on it. Our results showed that lonicerin signif...
Source: Frontiers in Pharmacology - December 23, 2022 Category: Drugs & Pharmacology Source Type: research
[ASAP] Feature Selection Assists BLSTM for the Ultrasensitive Detection of Bioflavonoids in Different Biological Matrices Based on the 3D Fluorescence Spectra of Gold Nanoclusters
Analytical ChemistryDOI: 10.1021/acs.analchem.2c03814 (Source: Analytical Chemistry)
Source: Analytical Chemistry - December 6, 2022 Category: Chemistry Authors: Hamada A. A. Noreldeen, Kai-Yuan Huang, Gang-Wei Wu, Qi Zhang, Hua-Ping Peng, Hao-Hua Deng, and Wei Chen Source Type: research
Molecules, Vol. 27, Pages 8335: Isoginkgetin & mdash;A Natural Compound to Control U87MG Glioblastoma Cell Growth and Migration Activating Apoptosis and Autophagy
Molecules, Vol. 27, Pages 8335: Isoginkgetin—A Natural Compound to Control U87MG Glioblastoma Cell Growth and Migration Activating Apoptosis and Autophagy
Molecules doi: 10.3390/molecules27238335
Authors:
Maria Antonietta Oliva
Sabrina Staffieri
Massimo Sanchez
Antonietta Arcella
Isoginkgetin (Iso) is a natural bioflavonoid isolated from the leaves of Ginkgo biloba, this natural substance exhibits many healing properties, among which the antitumor effect stands out. Here we tested the effect of Iso on the growth of U87MG glioblastoma cells. Growth curves and MTT toxicity assays showed time and dose-...
Source: Molecules - November 29, 2022 Category: Chemistry Authors: Maria Antonietta Oliva Sabrina Staffieri Massimo Sanchez Antonietta Arcella Tags: Article Source Type: research
The modulatory effects of two bioflavonoids, quercetin and thymoquinone on the expression levels of DNA damage and repair genes in human breast, lung and prostate cancer cell lines
CONCLUSION: We concluded that quercetin and thymoquinone may exert their effects through modulation of DNA damage response, increasing DNA damage, and suppressing DNA repair genes.PMID:36347210 | DOI:10.1016/j.prp.2022.154143 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - November 8, 2022 Category: Pathology Authors: Ansar Karimian Maryam Majidinia Afshin Moliani Forough Alemi Zatollah Asemi Bahman Yousefi Andarz Fazlollahpour Naghibi Source Type: research
The modulatory effects of two bioflavonoids, quercetin and thymoquinone on the expression levels of DNA damage and repair genes in human breast, lung and prostate cancer cell lines
CONCLUSION: We concluded that quercetin and thymoquinone may exert their effects through modulation of DNA damage response, increasing DNA damage, and suppressing DNA repair genes.PMID:36347210 | DOI:10.1016/j.prp.2022.154143 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - November 8, 2022 Category: Pathology Authors: Ansar Karimian Maryam Majidinia Afshin Moliani Forough Alemi Zatollah Asemi Bahman Yousefi Andarz Fazlollahpour Naghibi Source Type: research
The modulatory effects of two bioflavonoids, quercetin and thymoquinone on the expression levels of DNA damage and repair genes in human breast, lung and prostate cancer cell lines
CONCLUSION: We concluded that quercetin and thymoquinone may exert their effects through modulation of DNA damage response, increasing DNA damage, and suppressing DNA repair genes.PMID:36347210 | DOI:10.1016/j.prp.2022.154143 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - November 8, 2022 Category: Pathology Authors: Ansar Karimian Maryam Majidinia Afshin Moliani Forough Alemi Zatollah Asemi Bahman Yousefi Andarz Fazlollahpour Naghibi Source Type: research
Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
In this study, we established an endotoxin-induced ALI mouse model with an in vitro LPS challenge. We demonstrated that the administration of quercetin could significantly reduce pulmonary injury and decrease the production of pro-inflammatory cytokines. Moreover, we found that quercetin could inhibit the activation of the NLRP3 inflammasome by suppressing the nuclear accumulation of PKM2 and increasing SIRT1 levels. Importantly, treatment with SRT1720 (a specific SIRT1 activator) could inhibit the nuclear accumulation of PKM2 and the activation of NLRP3. Besides, preventing PKM2 dimerization with ML265 yielded an anti-inf...
Source: European Journal of Pharmacology - October 29, 2022 Category: Drugs & Pharmacology Authors: Ling-Li Chen Chao Song Yan Zhang Yi Li Yu-Hao Zhao Feng-Yu Lin Duo-Duo Han Min-Hui Dai Wen Li Pin-Hua Pan Source Type: research
