Phytocorrection of Age-Related Changes in the Composition of Blood Plasma, Lymph, and Interstitial Fluid
We studied the effect of a new complex phytocomposition on age-related changes in the composition of biological fluids (blood, lymph, and interstitial fluid) in old (22-24-month-old) white Sprague-Dawley rats. A 3-month course of phytocomposition induced an increase in the volumes of interstitial fluid (IF) and plasma and stimulated lymph outflow and diuresis. In the blood and lymph, the clotting time increased, while the viscosity and all lipid indicators decreased. The phytocomposition increased the number of erythrocytes and leukocytes, the levels of immunoglobulins (except IgG) and lymphocyte subpopulations, which cont...
Source: Bulletin of Experimental Biology and Medicine - November 18, 2023 Category: Biology Source Type: research
Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats
This study investigated the protective activities of pinostrobin (PIN) against methotrexate (MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 weeks, while MTX was administered from weeks 2-4 of PIN treatment. Serum hormonal profiles, ovarian oxidative stress, inflammatory and apoptotic biomarkers as well as ovarian histomorphometry were evaluated. MTX administration elicited profound deficit in serum progesterone and estrogen (E2) levels, while luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly increased. Additionally, MTX administration was associated w...
Source: Tissue and Cell - October 22, 2023 Category: Cytology Authors: Ling-Ling Zhao Titilope John Jayeoye Tolulope Joshua Ashaolu Opeyemi Joshua Olatunji Source Type: research
Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats
This study investigated the protective activities of pinostrobin (PIN) against methotrexate (MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 weeks, while MTX was administered from weeks 2-4 of PIN treatment. Serum hormonal profiles, ovarian oxidative stress, inflammatory and apoptotic biomarkers as well as ovarian histomorphometry were evaluated. MTX administration elicited profound deficit in serum progesterone and estrogen (E2) levels, while luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly increased. Additionally, MTX administration was associated w...
Source: Tissue and Cell - October 22, 2023 Category: Cytology Authors: Ling-Ling Zhao Titilope John Jayeoye Tolulope Joshua Ashaolu Opeyemi Joshua Olatunji Source Type: research
Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats
This study investigated the protective activities of pinostrobin (PIN) against methotrexate (MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 weeks, while MTX was administered from weeks 2-4 of PIN treatment. Serum hormonal profiles, ovarian oxidative stress, inflammatory and apoptotic biomarkers as well as ovarian histomorphometry were evaluated. MTX administration elicited profound deficit in serum progesterone and estrogen (E2) levels, while luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly increased. Additionally, MTX administration was associated w...
Source: Tissue and Cell - October 22, 2023 Category: Cytology Authors: Ling-Ling Zhao Titilope John Jayeoye Tolulope Joshua Ashaolu Opeyemi Joshua Olatunji Source Type: research
Hesperidin: Enrichment, forced degradation, and structural elucidation of potential degradation products using spectral techniques
CONCLUSIONS: Hesperidin was labile under acidic and basic stress conditions. The potential DPs were characterized using LC-ESI-MS/MS and NMR spectral techniques. The proposed mechanism of formation was hypothesized. In addition, to identify and characterize the DPs, a SIAM, which has broad biomedical applications, was successfully developed.PMID:37706431 | DOI:10.1002/rcm.9615 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - September 14, 2023 Category: Chemistry Authors: Amol Chhatrapati Bisen Priyanka Rawat Gaurav Sharma Sachin Nashik Sanap Sristi Agrawal Shiv Kumar Ashok Kumar Abhijit Deb Choudhury Sakshi Kamboj Tadigoppula Narender Sanjeev K Shukla Sanjeev Kanojiya Rabi Sankar Bhatta Source Type: research
Hesperidin: Enrichment, forced degradation, and structural elucidation of potential degradation products using spectral techniques
CONCLUSIONS: Hesperidin was labile under acidic and basic stress conditions. The potential DPs were characterized using LC-ESI-MS/MS and NMR spectral techniques. The proposed mechanism of formation was hypothesized. In addition, to identify and characterize the DPs, a SIAM, which has broad biomedical applications, was successfully developed.PMID:37706431 | DOI:10.1002/rcm.9615 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - September 14, 2023 Category: Chemistry Authors: Amol Chhatrapati Bisen Priyanka Rawat Gaurav Sharma Sachin Nashik Sanap Sristi Agrawal Shiv Kumar Ashok Kumar Abhijit Deb Choudhury Sakshi Kamboj Tadigoppula Narender Sanjeev K Shukla Sanjeev Kanojiya Rabi Sankar Bhatta Source Type: research
Uncovering the anti-obesity constituents in Ginkgo biloba extract and deciphering their synergistic effects
This study demonstrated a case study for uncovering the anti-obesity constituents in an anti-obesity herbal medicine (Ginkgo biloba extract) and deciphering their synergistic effects via targeting human pancreatic lipase (hPL). Following screening the anti-hPL effects of eighty herbal medicines, Ginkgo biloba extract (GBE50) was found with the most potent anti-hPL activity. Global chemical profiling of herbal constituents coupling with hPL inhibition assay revealed that the bioflavonoids and several flavonoids in GBE50 were key anti-hPL constituents. Among all tested thirty-eight constituents, sciadopitysin, bilobetin, que...
Source: Fitoterapia - September 8, 2023 Category: Biochemistry Authors: Min Zhang Xu-Dong Hou Wei Liu Lu Wang Mei-Fang Jiang Jie Hou Hui Tang Guang-Bo Ge Source Type: research
Uncovering the anti-obesity constituents in Ginkgo biloba extract and deciphering their synergistic effects
This study demonstrated a case study for uncovering the anti-obesity constituents in an anti-obesity herbal medicine (Ginkgo biloba extract) and deciphering their synergistic effects via targeting human pancreatic lipase (hPL). Following screening the anti-hPL effects of eighty herbal medicines, Ginkgo biloba extract (GBE50) was found with the most potent anti-hPL activity. Global chemical profiling of herbal constituents coupling with hPL inhibition assay revealed that the bioflavonoids and several flavonoids in GBE50 were key anti-hPL constituents. Among all tested thirty-eight constituents, sciadopitysin, bilobetin, que...
Source: Fitoterapia - September 8, 2023 Category: Biochemistry Authors: Min Zhang Xu-Dong Hou Wei Liu Lu Wang Mei-Fang Jiang Jie Hou Hui Tang Guang-Bo Ge Source Type: research
Uncovering the anti-obesity constituents in Ginkgo biloba extract and deciphering their synergistic effects
This study demonstrated a case study for uncovering the anti-obesity constituents in an anti-obesity herbal medicine (Ginkgo biloba extract) and deciphering their synergistic effects via targeting human pancreatic lipase (hPL). Following screening the anti-hPL effects of eighty herbal medicines, Ginkgo biloba extract (GBE50) was found with the most potent anti-hPL activity. Global chemical profiling of herbal constituents coupling with hPL inhibition assay revealed that the bioflavonoids and several flavonoids in GBE50 were key anti-hPL constituents. Among all tested thirty-eight constituents, sciadopitysin, bilobetin, que...
Source: Fitoterapia - September 8, 2023 Category: Biochemistry Authors: Min Zhang Xu-Dong Hou Wei Liu Lu Wang Mei-Fang Jiang Jie Hou Hui Tang Guang-Bo Ge Source Type: research
N-acetylcysteine improves the inhibitory effect of Quercetin-rich onion extract on HT-29 and HCT-116 colorectal cancer migration and invasion through iNOS suppression
This study demonstrated that Quercetin has higher efficacy when used in combination with NAC, representing a potential combination agent for anti-cancer drug development.PMID:37575276 | PMC:PMC10416724 | DOI:10.7150/ijms.86573 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 14, 2023 Category: Biomedical Science Authors: Rataya Tanomrat Chonnapat Naktubtim Parichaya Aimvijarn Prasit Suwannalert Source Type: research
