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Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
In this study, we established an endotoxin-induced ALI mouse model with an in vitro LPS challenge. We demonstrated that the administration of quercetin could significantly reduce pulmonary injury and decrease the production of pro-inflammatory cytokines. Moreover, we found that quercetin could inhibit the activation of the NLRP3 inflammasome by suppressing the nuclear accumulation of PKM2 and increasing SIRT1 levels. Importantly, treatment with SRT1720 (a specific SIRT1 activator) could inhibit the nuclear accumulation of PKM2 and the activation of NLRP3. Besides, preventing PKM2 dimerization with ML265 yielded an anti-inf...
Source: European Journal of Pharmacology - October 29, 2022 Category: Drugs & Pharmacology Authors: Ling-Li Chen Chao Song Yan Zhang Yi Li Yu-Hao Zhao Feng-Yu Lin Duo-Duo Han Min-Hui Dai Wen Li Pin-Hua Pan Source Type: research

Engineering Saccharomyces cerevisiae for the production of dihydroquercetin from naringenin
Dihydroquercetin (DHQ), a powerful bioflavonoid, has a number of health-promoting qualities and shows potential as a treatment for a number of disorders. Dihydroquercetin biosynthesis is a promising solution t... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - October 15, 2022 Category: Microbiology Authors: Shiqin Yu, Mingjia Li, Song Gao and Jingwen Zhou Tags: Research Source Type: research

Influence of Quercetin Pretreatment on Pharmacokinetics of Warfarin in Rats
CONCLUSION: QUE alters the pharmacokinetics of WAR, warranting possibly WAR dose adjustment after confirmatory clinical investigations, specifically in patients with thrombotic disorders and a pre-treatment history of QUE or its product.PMID:36239716 | DOI:10.2174/1574886317666221014101201 (Source: Current Drug Safety)
Source: Current Drug Safety - October 14, 2022 Category: Drugs & Pharmacology Authors: Ejaz Ahmad Muhammad Jahangir Muhammad Akhter Ismail Hafsa Afzal Shehar Bano Rahat Shamim Nadeem Irfan Bukhari Source Type: research

Investigation of Potential In Vitro Anticancer and Antimicrobial Activities of < em > Balanites aegyptiaca < /em > (L.) Delile Fruit Extract and Its Phytochemical Components
Plants (Basel). 2022 Oct 5;11(19):2621. doi: 10.3390/plants11192621.ABSTRACTThe therapeutic importance of Balanites aegyptiaca in folk medicine for the treatment of several common human diseases has led researchers to conduct phytochemical and pharmacological studies on extracts from various parts of the plant. In the current study, the phytochemical composition of the B. aegyptiaca methanolic fruit extract was characterized, and its antimicrobial activity was evaluated together with the cytotoxic activity against MCF-7, PC-3, and Caco-2, compared with normal Vero cells. Further, its effects on cell cycle arrest, apoptosis...
Source: Cancer Control - October 14, 2022 Category: Cancer & Oncology Authors: Omer H M Ibrahim Adel D Al-Qurashi Khalid A Asiry Magdi A A Mousa Nabil A Alhakamy Kamal A M Abo-Elyousr Source Type: research