Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells
CONCLUSIONS: These results suggest that diosmetin exerts anti-osteosarcoma effects by suppressing cell proliferation and inducing apoptosis via inhibiting the activation of STAT3/c-Myc signaling pathway, which provide the possibility for diosmetin to be a chemotherapeutic candidate for osteosarcoma.PMID:34922636 | DOI:10.1186/s40659-021-00363-1 (Source: Cell Research)
Source: Cell Research - December 19, 2021 Category: Cytology Authors: Rende Ning Guang Chen Run Fang Yanhui Zhang Wenjuan Zhao Feng Qian Source Type: research
Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells
Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical tre... (Source: Biological Research)
Source: Biological Research - December 18, 2021 Category: Biomedical Science Authors: Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao and Feng Qian Tags: Research article Source Type: research
Molecules, Vol. 26, Pages 7497: Hepatoprotective Effects of Bioflavonoid Luteolin Using Self-Nanoemulsifying Drug Delivery System
brahim A. Alsarra
Luteolin (LUT) is a natural pharmaceutical compound that is weakly water soluble and has low bioavailability when taken orally. As a result, the goal of this research was to create self-nanoemulsifying drug delivery systems (SNEDDS) for LUT in an attempt to improve its in vitro dissolution and hepatoprotective effects, resulting in increased oral bioavailability. Using the aqueous phase titration approach and the creation of pseudo-ternary phase diagrams with Capryol-PGMC (oil phase), Tween-80 (surfactant), and Transcutol-HP (co-emulsifier), various SNEDDS of LUT were generated. SNEDDS were assessed f...
Source: Molecules - December 11, 2021 Category: Chemistry Authors: Faiyaz Shakeel Moad M. Alamer Prawez Alam Abdullah Alshetaili Nazrul Haq Fars K. Alanazi Sultan Alshehri Mohammed M. Ghoneim Ibrahim A. Alsarra Tags: Article Source Type: research
The genus < em > Schinus < /em > (Anacardiaceae): a review on phytochemicals and biological aspects
Nat Prod Res. 2021 Dec 9:1-19. doi: 10.1080/14786419.2021.2012772. Online ahead of print.ABSTRACTThe genus Schinus belongs to family 'Anacardiaceae' and includes about 29 species originating from South America, distributed to Peru, Chile, Argentina, Brazil and Paraguay and cultivated in Egypt. Traditionally, Schinus plants are used to alleviate several and diverse diseases including rheumatism, hypertension, ulcers, gastric distress, menstrual disorders, gonorrhea, bronchitis, gingivitis, conjunctivitis, dysentery, wounds, urinary tract, and eye infections. Several phytochemical studies on the Schinus plants revealed prese...
Source: Natural Product Research - December 10, 2021 Category: Biochemistry Authors: Heba A S El-Nashar Nada M Mostafa Eman A Abd El-Ghffar Omayma A Eldahshan Abdel Nasser B Singab Source Type: research
The genus < em > Schinus < /em > (Anacardiaceae): a review on phytochemicals and biological aspects
Nat Prod Res. 2021 Dec 9:1-19. doi: 10.1080/14786419.2021.2012772. Online ahead of print.ABSTRACTThe genus Schinus belongs to family 'Anacardiaceae' and includes about 29 species originating from South America, distributed to Peru, Chile, Argentina, Brazil and Paraguay and cultivated in Egypt. Traditionally, Schinus plants are used to alleviate several and diverse diseases including rheumatism, hypertension, ulcers, gastric distress, menstrual disorders, gonorrhea, bronchitis, gingivitis, conjunctivitis, dysentery, wounds, urinary tract, and eye infections. Several phytochemical studies on the Schinus plants revealed prese...
Source: Natural Product Research - December 10, 2021 Category: Biochemistry Authors: Heba A S El-Nashar Nada M Mostafa Eman A Abd El-Ghffar Omayma A Eldahshan Abdel Nasser B Singab Source Type: research
The genus < em > Schinus < /em > (Anacardiaceae): a review on phytochemicals and biological aspects
Nat Prod Res. 2021 Dec 9:1-19. doi: 10.1080/14786419.2021.2012772. Online ahead of print.ABSTRACTThe genus Schinus belongs to family 'Anacardiaceae' and includes about 29 species originating from South America, distributed to Peru, Chile, Argentina, Brazil and Paraguay and cultivated in Egypt. Traditionally, Schinus plants are used to alleviate several and diverse diseases including rheumatism, hypertension, ulcers, gastric distress, menstrual disorders, gonorrhea, bronchitis, gingivitis, conjunctivitis, dysentery, wounds, urinary tract, and eye infections. Several phytochemical studies on the Schinus plants revealed prese...
Source: Natural Product Research - December 10, 2021 Category: Biochemistry Authors: Heba A S El-Nashar Nada M Mostafa Eman A Abd El-Ghffar Omayma A Eldahshan Abdel Nasser B Singab Source Type: research
Ameliorative Effects of Dietary Ellagic Acid Against Severe Malaria Pathogenesis by Reducing Cytokine Storms and Oxidative Stress
Ellagic acid (EA), a fruit- and vegetable-derived flavonoid, has been reported for multiple pharmacological activities, which encouraged us to examine its useful effect in severe malaria pathogenesis, especially malaria-induced cytokine storms and oxidative stress linked to damage in major organs. Malaria was induced by injecting Plasmodium berghei–infected RBCs intraperitoneally into the mice. EA was given orally (5, 10, and 20 mg/kg) following Peter’s 4-day suppression test. EA exhibited the suppression of parasitemia, production of inflammatory cytokine storms and oxidative stress marker level quantified from vital...
Source: Frontiers in Pharmacology - December 9, 2021 Category: Drugs & Pharmacology Source Type: research
Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/ β-catenin pathway
Chem Biol Interact. 2021 Dec 2:109771. doi: 10.1016/j.cbi.2021.109771. Online ahead of print.ABSTRACTCigarette smoke exposure leads to upregulation of cyclooxygenase-2 (COX-2), an inducible enzyme that synthesizes prostaglandin E2 (PGE2) and promotes airway inflammation. COX-2 overexpression is frequently implicated in inflammation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). However, its detailed molecular mechanism in cigarette smoke induced EMT is not clear. Further, fisetin, a bioflavonoid, exhibits antioxidant and anti-inflammatory properties, but its effect in modulating COX-2-mediated inflamma...
Source: Chemico-Biological Interactions - December 5, 2021 Category: Molecular Biology Authors: Hina Agraval Jiten R Sharma Nutan Prakash Umesh C S Yadav Source Type: research
Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/ β-catenin pathway
Chem Biol Interact. 2021 Dec 2:109771. doi: 10.1016/j.cbi.2021.109771. Online ahead of print.ABSTRACTCigarette smoke exposure leads to upregulation of cyclooxygenase-2 (COX-2), an inducible enzyme that synthesizes prostaglandin E2 (PGE2) and promotes airway inflammation. COX-2 overexpression is frequently implicated in inflammation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). However, its detailed molecular mechanism in cigarette smoke induced EMT is not clear. Further, fisetin, a bioflavonoid, exhibits antioxidant and anti-inflammatory properties, but its effect in modulating COX-2-mediated inflamma...
Source: Chemico-Biological Interactions - December 5, 2021 Category: Molecular Biology Authors: Hina Agraval Jiten R Sharma Nutan Prakash Umesh C S Yadav Source Type: research
Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/ β-catenin pathway
Chem Biol Interact. 2021 Dec 2:109771. doi: 10.1016/j.cbi.2021.109771. Online ahead of print.ABSTRACTCigarette smoke exposure leads to upregulation of cyclooxygenase-2 (COX-2), an inducible enzyme that synthesizes prostaglandin E2 (PGE2) and promotes airway inflammation. COX-2 overexpression is frequently implicated in inflammation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). However, its detailed molecular mechanism in cigarette smoke induced EMT is not clear. Further, fisetin, a bioflavonoid, exhibits antioxidant and anti-inflammatory properties, but its effect in modulating COX-2-mediated inflamma...
Source: Chemico-Biological Interactions - December 5, 2021 Category: Molecular Biology Authors: Hina Agraval Jiten R Sharma Nutan Prakash Umesh C S Yadav Source Type: research
Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against < em > RNA-Dependent RNA Polymerase < /em > Complex (nsp7/nsp8/nsp12) of SARS-CoV-2
J Diet Suppl. 2021 Dec 1:1-30. doi: 10.1080/19390211.2021.2006387. Online ahead of print.ABSTRACTThe emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic domains on SARS-CoV-2 that are less prone to mutation. The nsp12, also known as the RNA-dependent RNA-polymerase (RdRp), the core component of 'SARS-CoV-2 replication-transcription complex', is a potential well-conserved druggable antiviral target. Several FDA-approved RdRp 'nucleotide analog inhibitors (NAIs)' such as remdesivir, have been repurposed to tre...
Source: Journal of Dietary Supplements - December 1, 2021 Category: Nutrition Authors: Sreus A G Naidu Ghulam Mustafa Roger A Clemens A Satyanarayan Naidu Source Type: research
