Recent developments in citrus bioflavonoid encapsulation to reinforce controlled antioxidant delivery and generate therapeutic uses: Review
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - March 25, 2023 Category: Nutrition Authors: Dadwal, Vikas Gupta, Mahesh Source Type: research
Role of NF- κB/IL-1β Pathway and Caspase 3 in mediating the hepatoprotective effect of rutin against paraquat-induced liver toxicity in male rats
Chem Biodivers. 2023 Mar 12:e202200248. doi: 10.1002/cbdv.202200248. Online ahead of print.ABSTRACT<p>One of the most common bipyridinium herbicides that can lead to liver toxicity is paraquat. Rutin is a bioflavonoid with antioxidant, anti-inflammatory, anti-hepatotoxic, and antimicrobial properties. The effect of rutin on paraquat-induced liver toxicity was examined in this study. 48 male rats were divided into six groups: the control group was given a normal diet; the non-treated group was given paraquat; the positive control group was given paraquat and silymarin and the treatment groups were given paraquat and r...
Source: Chemistry and Biodiversity - March 13, 2023 Category: Biochemistry Authors: Sahar Rafiee Ali Nouri Esfandiar Heidarian Source Type: research
Role of NF- κB/IL-1β Pathway and Caspase 3 in mediating the hepatoprotective effect of rutin against paraquat-induced liver toxicity in male rats
Chem Biodivers. 2023 Mar 12:e202200248. doi: 10.1002/cbdv.202200248. Online ahead of print.ABSTRACT<p>One of the most common bipyridinium herbicides that can lead to liver toxicity is paraquat. Rutin is a bioflavonoid with antioxidant, anti-inflammatory, anti-hepatotoxic, and antimicrobial properties. The effect of rutin on paraquat-induced liver toxicity was examined in this study. 48 male rats were divided into six groups: the control group was given a normal diet; the non-treated group was given paraquat; the positive control group was given paraquat and silymarin and the treatment groups were given paraquat and r...
Source: Chemistry and Biodiversity - March 13, 2023 Category: Biochemistry Authors: Sahar Rafiee Ali Nouri Esfandiar Heidarian Source Type: research
Kolaviron modulates angiogenesis, apoptosis and inflammatory signaling in rat model of testosterone propionate-induced benign prostate hyperplasia
In this study, we investigated the effect of Kolaviron on testosterone propionate (TP)-induced BPH in rats. Fifty male rats were assigned in 5 groups. Groups 1 and 2 were orally exposed to corn oil (2 ml/kg) and Kolaviron (200 mg/kg/day, p.o) for 28 days. Group 3 rats received TP (3 mg/kg/day, s.c) for 14 days while Groups 4 and 6 were treated with Kolaviron (200 mg/kg/day, p.o) and Finasteride (5 mg/kg/day, p.o), respectively, for 14 days prior to TP (3 mg/kg, s.c) co-exposure for the remaining 14 days. Administration of Kolaviron to TP-treated rats reverted histological alteration and significantly decreased p...
Source: Inflammopharmacology - March 7, 2023 Category: Drugs & Pharmacology Source Type: research
Pinosrtobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism
Antiviral Res. 2023 Feb 28;212:105570. doi: 10.1016/j.antiviral.2023.105570. Online ahead of print.ABSTRACTCoronaviruses, as enveloped positive-strand RNA viruses, manipulate host lipid compositions to enable robust viral replication. Temporal modulation of the host lipid metabolism is a potential novel strategy against coronaviruses. Here, the dihydroxyflavone pinostrobin (PSB) was identified through bioassay that inhibited the increment of human coronavirus OC43 (HCoV-OC43) in human ileocecal colorectal adenocarcinoma cells. Lipid metabolomic studies showed that PSB interfered with linoleic acid and arachidonic acid meta...
Source: Antiviral Research - March 2, 2023 Category: Virology Authors: Liyun Zhao Liyuan Yao Rui Chen Jiani He Tingting Lin Silin Qiu Guohua Chen Hongfeng Chen Sheng-Xiang Qiu Source Type: research
Pinosrtobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism
Antiviral Res. 2023 Feb 28:105570. doi: 10.1016/j.antiviral.2023.105570. Online ahead of print.ABSTRACTCoronaviruses, as enveloped positive-strand RNA viruses, manipulate host lipid compositions to enable robust viral replication. Temporal modulation of the host lipid metabolism is a potential novel strategy against coronaviruses. Here, the dihydroxyflavone pinostrobin (PSB) was identified through bioassay that inhibited the increment of human coronavirus OC43 (HCoV-OC43) in human ileocecal colorectal adenocarcinoma cells. Lipid metabolomic studies showed that PSB interfered with linoleic acid and arachidonic acid metaboli...
Source: Antiviral Research - March 2, 2023 Category: Virology Authors: Liyun Zhao Liyuan Yao Rui Chen Jiani He Tingting Lin Silin Qiu Guohua Chen Hongfeng Chen Sheng-Xiang Qiu Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Braz J Med Biol Res - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury
Braz J Med Biol Res. 2023 Feb 27;56:e12578. doi: 10.1590/1414-431X2023e12578. eCollection 2023.ABSTRACTOxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 group...
Source: Brazilian Journal of Medical and Biological Research - March 1, 2023 Category: Research Authors: R Kongsui S Surapinit T Promsrisuk S Thongrong Source Type: research
