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Influence of Quercetin Pretreatment on Pharmacokinetics of Warfarin in Rats
CONCLUSION: QUE alters the pharmacokinetics of WAR, warranting possibly WAR dose adjustment after confirmatory clinical investigations, specifically in patients with thrombotic disorders and a pre-treatment history of QUE or its product.PMID:36239716 | DOI:10.2174/1574886317666221014101201 (Source: Current Drug Safety)
Source: Current Drug Safety - October 14, 2022 Category: Drugs & Pharmacology Authors: Ejaz Ahmad Muhammad Jahangir Muhammad Akhter Ismail Hafsa Afzal Shehar Bano Rahat Shamim Nadeem Irfan Bukhari Source Type: research

Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF- κB and caspase-3 activities
Environ Sci Pollut Res Int. 2022 Oct 5. doi: 10.1007/s11356-022-23314-z. Online ahead of print.ABSTRACT5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities. This research aimed to assess the ameliorative effect of Qu against 5-FU-mediated cardiotoxicity. Thirty-five rats were allocated into five groups: control group (normal saline), 5-FU group (30 mg/kg, intraperitoneally), Qu group (50 mg/kg, oral), 25 mg/kg Qu+5-FU group, and 50 mg/kg Qu+5-FU. The experimental animals...
Source: Cell Research - October 5, 2022 Category: Cytology Authors: Maha S Lokman Hussam A Althagafi Fahad Alharthi Ola A Habotta Arwa A Hassan Mohamed A Elhefny Hassan Al Sberi Abdulrahman Theyab Ahmad Hasan Mufti Alaa Alhazmi Yousef M Hawsawi Asmaa F Khafaga Mahmoud S Gewaily Khalaf F Alsharif Ashraf Albrakati Rami B Ka Source Type: research

Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF- κB and caspase-3 activities
Environ Sci Pollut Res Int. 2022 Oct 5. doi: 10.1007/s11356-022-23314-z. Online ahead of print.ABSTRACT5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities. This research aimed to assess the ameliorative effect of Qu against 5-FU-mediated cardiotoxicity. Thirty-five rats were allocated into five groups: control group (normal saline), 5-FU group (30 mg/kg, intraperitoneally), Qu group (50 mg/kg, oral), 25 mg/kg Qu+5-FU group, and 50 mg/kg Qu+5-FU. The experimental animals...
Source: Cancer Control - October 5, 2022 Category: Cancer & Oncology Authors: Maha S Lokman Hussam A Althagafi Fahad Alharthi Ola A Habotta Arwa A Hassan Mohamed A Elhefny Hassan Al Sberi Abdulrahman Theyab Ahmad Hasan Mufti Alaa Alhazmi Yousef M Hawsawi Asmaa F Khafaga Mahmoud S Gewaily Khalaf F Alsharif Ashraf Albrakati Rami B Ka Source Type: research

Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF- κB and caspase-3 activities
Environ Sci Pollut Res Int. 2022 Oct 5. doi: 10.1007/s11356-022-23314-z. Online ahead of print.ABSTRACT5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities. This research aimed to assess the ameliorative effect of Qu against 5-FU-mediated cardiotoxicity. Thirty-five rats were allocated into five groups: control group (normal saline), 5-FU group (30 mg/kg, intraperitoneally), Qu group (50 mg/kg, oral), 25 mg/kg Qu+5-FU group, and 50 mg/kg Qu+5-FU. The experimental animals...
Source: Environmental Science and Pollution Research International - October 5, 2022 Category: Environmental Health Authors: Maha S Lokman Hussam A Althagafi Fahad Alharthi Ola A Habotta Arwa A Hassan Mohamed A Elhefny Hassan Al Sberi Abdulrahman Theyab Ahmad Hasan Mufti Alaa Alhazmi Yousef M Hawsawi Asmaa F Khafaga Mahmoud S Gewaily Khalaf F Alsharif Ashraf Albrakati Rami B Ka Source Type: research

Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats
In this study, we focused on the hypolipidemic proprieties of Chy in hypercholesterolemia-induced atherosclerosis. Male Wistar rats (150-220 g) were divided into four groups as follows: Group I control was fed with standard laboratory chow. Rats in Group II were fed a high-fat diet (HFD) for 60 days. After 60 days of HFD, Group III rats received Chy (100 mg/kg body weight); Group IV rats received Atorvastatin (Atv; 10 mg/kg body weight) for 30 days. Biochemical studies showed Chy, Atv treatment decreased the activities of liver marker enzymes and the levels of Reactive Oxygen Species (ROS) and lipid profile. Gene expressio...
Source: Atherosclerosis - July 27, 2022 Category: Cardiology Authors: Subramani Yuvaraj Sundrasen Sasikumar Shanavas Syed Mohamed Puhari Tharmarajan Ramprasath Nagarethinam Baskaran Varadaraj Vasudevan Govindan Sadasivam Selvam Source Type: research

Molecules, Vol. 27, Pages 4800: Hesperidin Exhibits Protective Effects against PM2.5-Mediated Mitochondrial Damage, Cell Cycle Arrest, and Cellular Senescence in Human HaCaT Keratinocytes
In conclusion, hesperidin ameliorates PM2.5-induced mitochondrial damage, cell cycle arrest, and cellular senescence in human HaCaT keratinocytes via the ROS/JNK pathway. (Source: Molecules)
Source: Molecules - July 27, 2022 Category: Chemistry Authors: Herath Mudiyanselage Udari Lakmini Herath Mei Jing Piao Kyoung Ah Kang Ao Xuan Zhen Pincha Devage Sameera Madushan Fernando Hee Kyoung Kang Joo Mi Yi Jin Won Hyun Tags: Article Source Type: research

Cancers, Vol. 14, Pages 3613: Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic Cancer
ton Yates Tomar Ghansah Pancreatic cancer (PC) is a deadly disease with a grim prognosis. Pancreatic tumor derived factors (TDF) contribute to the induction of an immunosuppressive tumor microenvironment (TME) that impedes the effectiveness of immunotherapy. PC-induced microRNA-155 (miRNA-155) represses expression of Src homology 2 (SH2) domain-containing Inositol 5&prime;-phosphatase-1 (SHIP-1), a regulator of myeloid cell development and function, thus impacting anti-tumor immunity. We recently reported that the bioflavonoid apigenin (API) increased SHIP-1 expression which correlated with the expansion of t...
Source: Cancers - July 25, 2022 Category: Cancer & Oncology Authors: Kazim Husain Krystal Villalobos-Ayala Valentina Laverde Oscar A. Vazquez Bradley Miller Samra Kazim George Blanck Margaret L. Hibbs Gerald Krystal Isra Elhussin Joakin Mori Clayton Yates Tomar Ghansah Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4741: Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements
n A. Jacobson Citrus bioflavonoids are polyphenolic plant-derived pigments found in high levels in oranges, lemons, grapefruits and other citrus fruits. The three most abundant types of citrus bioflavonoids are hesperidin, naringenin and eriocitrin. Citrus bioflavonoids have long been known to possess powerful free radical-scavenging properties and cardioprotective effects. The study involved the analysis of 10 commercially available citrus bioflavonoid supplements from three different countries: Australia, the United States and Canada. The supplements were tested for their citrus bioflavonoid content which varied from...
Source: Molecules - July 25, 2022 Category: Chemistry Authors: Ankit Gupta Hayder A. Al-Aubaidy Christian K. Narkowicz Herbert F. Jelinek David S. Nichols John R. Burgess Glenn A. Jacobson Tags: Article Source Type: research

The role of catechin in electroporation of pancreatic cancer cells - Effects on pore formation and multidrug resistance proteins
Bioelectrochemistry. 2022 Jun 30;147:108199. doi: 10.1016/j.bioelechem.2022.108199. Online ahead of print.ABSTRACTCatechin is a bioflavonoid known for its anti-cancer properties. In the present study, we combined theoretical and experimental approaches to reveal the potential of catechin application in the electroporation (EP) or electrochemotherapy (ECT) of pancreatic cancer cells. The molecular dynamics simulations were implemented to examine the interactions of catechin with a model of a membrane, its influence on the membrane's thickness, and the impact of the catechin-membrane interaction on the pore formation. The da...
Source: Bioelectrochemistry - July 16, 2022 Category: Biochemistry Authors: Olga Michel Wojciech Szlasa Dagmara Baczy ńska Jolanta Saczko Mounir Tarek Julita Kulbacka Source Type: research