Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats
In conclusion, genistein suppressed renin-angiotensin system-mediated sympathetic activation and oxidative stress in 2K1C rats. It alleviated renal atrophy in CK via modulation of AT1R/NADPH oxidase/Bcl-2/BAX pathways and hypertrophy in NCK via AT1R/TGF-β1/smad-dependent signalling pathways.PMID:35062067 | DOI:10.1016/j.biopha.2021.112601 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2022 Category: Drugs & Pharmacology Authors: Anuson Poasakate Putcharawipa Maneesai Prapassorn Potue Sarawoot Bunbupha Terdthai Tong-Un Wannapa Settheetham-Ishida Juthamas Khamseekaew Poungrat Pakdeechote Source Type: research
Sensors, Vol. 22, Pages 843: Fast and Sensitive Determination of Bioflavonoids Using a New Analytical System Based on Label-Free Silver Triangular Nanoplates
y Zolotov
Optical sensors based on silver triangular nanoplates (AgTNPs) are insufficiently studied as probes for the spectrophotometric determination of biologically active compounds. In the present article, an interaction between label-free AgTNPs and bioflavonoids in the presence of silver(I) ions was assessed to outline the possibilities of AgTNPs as a colorimetric probe for the fast and sensitive determination of bioflavonoids. It is shown that the interaction was accompanied by a bathochromic shift of the local surface plasmon resonance band of nanoparticles and an increase in its intensity. Seven bioflavonoids d...
Source: Sensors - January 22, 2022 Category: Biotechnology Authors: Aleksei Furletov Vladimir Apyari Alexey Garshev Stanislava Dmitrienko Yury Zolotov Tags: Article Source Type: research
Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3 β/Nrf2 pathway
In conclusion, vitexin ameliorated hepatic injury in EAH mice through activation of the AMPK/AKT/GSK-3β pathway and upregulation of the Nrf2 gene.PMID:34953801 | DOI:10.1016/j.ejphar.2021.174720 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 26, 2021 Category: Drugs & Pharmacology Authors: Lei Zhang Dazhi Chen Yulu Tu Tiantian Sang Tongtong Pan Hongwei Lin Chao Cai Xiaozhi Jin Faling Wu Lanman Xu Yongping Chen Source Type: research
Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3 β/Nrf2 pathway
In conclusion, vitexin ameliorated hepatic injury in EAH mice through activation of the AMPK/AKT/GSK-3β pathway and upregulation of the Nrf2 gene.PMID:34953801 | DOI:10.1016/j.ejphar.2021.174720 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 26, 2021 Category: Drugs & Pharmacology Authors: Lei Zhang Dazhi Chen Yulu Tu Tiantian Sang Tongtong Pan Hongwei Lin Chao Cai Xiaozhi Jin Faling Wu Lanman Xu Yongping Chen Source Type: research
Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3 β/Nrf2 pathway
In conclusion, vitexin ameliorated hepatic injury in EAH mice through activation of the AMPK/AKT/GSK-3β pathway and upregulation of the Nrf2 gene.PMID:34953801 | DOI:10.1016/j.ejphar.2021.174720 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 26, 2021 Category: Drugs & Pharmacology Authors: Lei Zhang Dazhi Chen Yulu Tu Tiantian Sang Tongtong Pan Hongwei Lin Chao Cai Xiaozhi Jin Faling Wu Lanman Xu Yongping Chen Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Cell Research)
Source: Cell Research - December 25, 2021 Category: Cytology Authors: R Dhanya Source Type: research
Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats
CONCLUSION: Troxerutin attenuated MTX-triggered renal injury via inhibition of inflammation and apoptosis alongside activation of autophagy. Thus, it may serve as an adjunct modality for the management of MTX-linked nephrotoxicity.PMID:34953450 | DOI:10.1016/j.intimp.2021.108284 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 25, 2021 Category: Allergy & Immunology Authors: Hany H Arab Sarah A Abd El-Aal Ahmed H Eid El-Shaimaa A Arafa Ayman M Mahmoud Ahmed M Ashour Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 25, 2021 Category: Drugs & Pharmacology Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomed Res)
Source: Biomed Res - December 25, 2021 Category: Research Authors: R Dhanya Source Type: research
Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats
CONCLUSION: Troxerutin attenuated MTX-triggered renal injury via inhibition of inflammation and apoptosis alongside activation of autophagy. Thus, it may serve as an adjunct modality for the management of MTX-linked nephrotoxicity.PMID:34953450 | DOI:10.1016/j.intimp.2021.108284 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 25, 2021 Category: Allergy & Immunology Authors: Hany H Arab Sarah A Abd El-Aal Ahmed H Eid El-Shaimaa A Arafa Ayman M Mahmoud Ahmed M Ashour Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 25, 2021 Category: Drugs & Pharmacology Authors: R Dhanya Source Type: research
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
CONCLUSION: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.PMID:34953390 | DOI:10.1016/j.biopha.2021.112560 (Source: Biomed Res)
Source: Biomed Res - December 25, 2021 Category: Research Authors: R Dhanya Source Type: research
