Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF- κB/Nrf2
In this study, we
evaluated the possible effect of isorhamnetin in prevention of APAP-induced ALI
and analyzed further the involvement of oxidative stress and
inflammation-associated factors. Male C57BL/6 mice were given
isorhamnetin (25 or 100 mg/kg b.w., p.o.) three times at
48, 24, and 1 h before APAP administration (300 mg/kg
b.w., i.p.). Functional indicators of liver injury were measured as well
as analysis of oxidative stress- and inflammation-associated indices and liver
histopathology was also conducted. Isorhamnetin at the higher dose of
100 mg/kg significantly lowered serum levels of ALT, ALP, and
AST in addition to reduction of ROS, TBARS, IL-6, TNFα, NF-kB, NLRP3,
caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity,
sirtuin 1, and Nrf2. Additionally, isorhamnetin alleviated pathological changes
of the liver tissue and suitably reversed NF-kB and Nrf2 immunoreactivity. These
findings show protective effect of isorhamnetin against acetaminophen-induced
liver injury through reducing oxidative stress, inflammation, and pyroptosis
which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Rousta, Ali-Mohammad Mirahmadi, Seyed-Mohamad-Sadegh Shahmohammadi, Alireza Mehrabi, Zhila Fallah, Soudabeh Baluchnejadmojarad, Tourandokht Roghani, Mehrdad Tags: Original Article Source Type: research
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