Septic arthritis due to Pasteurella multocida
Rev Esp Quimioter. 2024 Apr 17:pina17apr2024. doi: 10.37201/req/019.2024. Online ahead of print.NO ABSTRACTPMID:38627987 | DOI:10.37201/req/019.2024 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - April 17, 2024 Category: Drugs & Pharmacology Authors: C Pi ña Delgado M N Carmona Tello M Bola ños Rivero M C Lavilla Salgado I de Miguel Mart ínez Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
CONCLUSIONS: We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.PMID:38631220 | DOI:10.1016/j.intimp.2024.112040 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Chunmei Cai Yuye Huang Liyan Li Kai Kei Miu Zhangting Wang Yujie Deng Yanzhen Cai Jinxiu Li Liang Wu Hepeng Zhu Yang Gao Jun Chen Wende Xiao Li Lu Source Type: research
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period
CONCLUSIONS: Risk chart algorithms are very useful for discriminating PsA at low and high CV risk. An integrated model featuring QRISK3 and SCORE2 yielded the optimal synergy of QRISK3's discrimination ability and SCORE2's calibration accuracy.PMID:38631846 | DOI:10.1136/rmdopen-2024-004207 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Jessica Polo Y La Borda Santos Casta ñeda Elena Heras-Recuero Fernando S ánchez-Alonso Zulema Plaza Carmen Garc ía Gómez Ivan Ferraz-Amaro Jes ús Tomás Sanchez-Costa Olga Carmen S ánchez-González Ana Isabel Turri ón-Nieves Ana Perez-Alcal á Caro Source Type: research
Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis
This study underscores the shared pathogenic mechanisms, pivotal genes, and potential therapeutic interventions bridging RA and AS, offering valuable insights for future research and clinical management strategies.PMID:38628735 | PMC:PMC11019104 | DOI:10.1016/j.heliyon.2024.e28029 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng Source Type: research
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
In this study, the collagen-induced arthritis (CIA) rat model was established. Based on metabolomics analysis, the contents of β-indole-3-acetic acid (IAA), indolylpropionic acid, and indole-3-β-acrylic acid in the sera of CIA rats were significantly less compared with those of the normal rats. Under the condition of Treg or Th17 cell differentiation, IAA significantly promoted the differentiation and activation of Treg cells instead of Th17 cells. Intestinal tryptophan metabolites are well-known endogenic ligands of aryl hydrocarbon receptor (AhR). Not surprisingly, IAA increased the level of Foxp3 through activating th...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Xiaoran Su Xinliu Wang Xin Zhang Yajie Sun Yugai Jia Source Type: research
Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 17, 2024 Category: Rheumatology Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki Tags: Research Source Type: research
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 17, 2024 Category: Rheumatology Authors: Zhi-Jie Yang, Yuan Liu, Yan-Li Liu, Bin Qi, Xin Yuan, Wan-Xin Shi and Liu Miao Tags: Research Source Type: research
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
In this study, the collagen-induced arthritis (CIA) rat model was established. Based on metabolomics analysis, the contents of β-indole-3-acetic acid (IAA), indolylpropionic acid, and indole-3-β-acrylic acid in the sera of CIA rats were significantly less compared with those of the normal rats. Under the condition of Treg or Th17 cell differentiation, IAA significantly promoted the differentiation and activation of Treg c ells instead of Th17 cells. Intestinal tryptophan metabolites are well-known endogenic ligands of aryl hydrocarbon receptor (AhR). Not surprisingly, IAA increased the level of Foxp3 through activating t...
Source: Immunologic Research - April 17, 2024 Category: Allergy & Immunology Source Type: research
Drug Survival of IL-17 and IL-23 Inhibitors for Psoriasis: A Systematic Review and Meta-Analysis
ConclusionsThis meta-analysis showed that the investigated IL-17 and IL-23 inhibitors had high drug survival rates, with highest rates for guselkumab and risankizumab drug survival. We showed that effect modifiers such as biologic naivety, and the source of data used (registry/electronic health record data vs pharmacy/claims databases) is relevant when interpreting drug survival studies. (Source: Drugs)
Source: Drugs - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 1830: Onosma bracteatum Wall Aqueous & ndash;Ethanolic Extract Suppresses Complete Freund & rsquo;s Adjuvant-Induced Arthritis in Rats via Regulation of TNF- & alpha;, IL-6, and C-Reactive Protein
This study aimed to evaluate the anti-arthritic effects of the aqueous–ethanolic extract of O. bracteatum leaves (AeOB) in a rat model of complete Freund’s adjuvant (CFA)-induced arthritis. Rats were treated with AeOB (250, 500, and 750 mg/kg), indomethacin (10 mg/kg), or a vehicle control from days 8 to 28 post-CFA injection. Arthritic score, paw diameter, and body weight were monitored at regular intervals. X-ray radiographs and histopathological analysis were performed to assess arthritic severity. Inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6),...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Farah Zafar Ghazala Shaheen Hafiz Muhammad Asif Mohd Farhan Ghazala Muteeb Mohammad Aatif Tags: Article Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
ConclusionsFive literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA. (Source: Pediatric Drugs)
Source: Pediatric Drugs - April 17, 2024 Category: Pediatrics Source Type: research
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis
ConclusionIn biologic-na ïve patients with active PsA treated with guselkumab, achieving ER or DR was associated with durable improvements in selected PROs, including those of high importance to patients.Trial registrationClinicalTrials.gov (https://clinicaltrials.gov) NCT03158285; Registered: May 16, 2017.Key Points•At week 100, 65% and 76% of guselkumab-treated patients achieved enthesitis and dactylitis resolution (ER/DR).•Achieving ER was associated with achieving DR and vice versa through the end of study.•Achieving ER or DR was associated with durable and meaningful improvements in selected patient-reported ou...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
