Ultrasonographic and power doppler parameters of nails fail to differentiate between onychodystrophy in patients with psoriasis vulgaris or psoriatic arthritis
CONCLUSION: Greater nail bed thickness indicates early psoriatic nail disease, as confirmed in our study correlating NAPSI with nail bed thickness. Ultrasonography is a low-cost exam, promising in the evaluation, showing that the ultrasound grayscale is consistent with those who have dystrophic nails, but it can't distinguish psoriasis from psoriatic arthritis, even in those with nail dystrophy.PMID:38605415 | DOI:10.1186/s42358-024-00367-x (Source: Adv Data)
Source: Adv Data - April 11, 2024 Category: Epidemiology Authors: Anber Ancel Tanaka Betina Werner Annelise Correa Bueno Bragatto Thelma Larocca Skare B árbara Stadler Source Type: research
Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Pharmacological Reviews - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research
Detection of Haptoglobin and Serum Amyloid A as Biomarkers in Naturally Infected Mycoplasma bovis Calves
Acta Trop. 2024 Apr 10:107215. doi: 10.1016/j.actatropica.2024.107215. Online ahead of print.ABSTRACTThe livestock sector of Pakistan is increasing rapidly and it plays important role both for rural community and national economy. It is estimated that almost 8 million rural people are involved in livestock rearing and earning about 35-40% of their income from the livestock sector. Mycoplasma bovis (M. bovis) infection causes significant economic losses in dairy animals especially young calf in the form of clinical illnesses such as pneumonia, poly-arthritis, respiratory distress and mortality. M. bovis is hard to diagnose ...
Source: Acta Tropica - April 11, 2024 Category: Infectious Diseases Authors: Abdul Sameed Ali Raza Qiu Fuan Khalid Mehmood Riaz Hussain Abdul Qayyum Musadiq Idris Mikhlid H Almutairi Kun Li Source Type: research
Glycolysis, a driving force of rheumatoid arthritis
Int Immunopharmacol. 2024 Apr 9;132:111913. doi: 10.1016/j.intimp.2024.111913. Online ahead of print.ABSTRACTResident synoviocytes and synovial microvasculature, together with immune cells from circulation, contribute to pannus formation, the main pathological feature of rheumatoid arthritis (RA), leading to destruction of adjacent cartilage and bone. Seeds, fibroblast-like synoviocytes (FLSs), macrophages, dendritic cells (DCs), B cells, T cells and endothelial cells (ECs) seeds with high metabolic demands undergo metabolic reprogramming from oxidative phosphorylation to glycolysis in response to poor soil of RA synovium ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Pei-Rong Gan Hong Wu Yu-Long Zhu Yin Shu Yi Wei Source Type: research
The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Expert Review of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research
Radiocarpal Osteochondral Allografts for Wrist Pain Postproximal Row Carpectomy
We present an additional alternative to TWA, by resurfacing the radiocarpal joint affected by chondromalacia after a PRC. This option offers another treatment modality for recurrent wrist pain while still preserving some element of range of motion. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Wrist Surgery)
Source: Journal of Wrist Surgery - April 11, 2024 Category: Orthopaedics Authors: Bagdady, Kazimir R. Slovacek, Cedar Firouzbakht, Peter K. Mailey, Brian A. Tags: Case Report Source Type: research
Postoperative Wound Complications in Extensile Lateral Approach versus Sinus Tarsi Approach for Calcaneal Fractures: Are We Improving? Updated Meta-Analysis of Recent Literature
Calcaneal fractures account for approximately 65% of all tarsal bone fractures, often resulting from a high-energy axial load mechanism [1,2]. These fractures have a high incidence of intra-articular involvement, estimated to be 65.9%, which can lead to post-traumatic subtalar arthritis and long-term morbidity if not appropriately treated [3,4]. Historically, displaced intra-articular calcaneal fractures (DIACF) were often treated conservatively with sub-optimal outcomes; however, emerging evidence has shown superior outcomes after surgical treatment and is now the preferred management strategy in most populations [4 –6]. (Source: Injury)
Source: Injury - April 11, 2024 Category: Orthopaedics Authors: Andrea Attenasio, Erick Heiman, Ian S. Hong, Aditya Paul Bhalla, Jaclyn M. Jankowski, Richard S. Yoon, Frank A. Liporace, Daniel Dziadosz Tags: Review Source Type: research
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
Conclusions
TNF-α provoked the proinflammatory phenotype of B10 and B10pro cells by disturbing SHIP-1 in RA, contributing to the disease development. Reinstating the immunosuppressive property of B10 and B10pro cells might represent novel therapeutic approaches for RA. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Hu, F., Shi, L., Liu, X., Chen, Y., Zhang, X., Jia, Y., Liu, X., Guo, J., Zhu, H., Liu, H., Xu, L., Li, Y., Wang, P., Fang, X., Xue, J., Xie, Y., Wei, C., Song, J., Zheng, X., Liu, Y.-Y., Li, Y., Ren, L., Xu, D., Lu, L., Qiu, X., Mu, R., He, J., Wang, M., Tags: ARD, Rheumatoid arthritis Source Type: research
EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
Conclusion
EPO, as a proinflammatory factor, accelerates the process of RA through transcriptional upregulation of the expression of NEU3 by JAK2/STAT5 pathway. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Wu, G., Cao, B., Zhai, H., Liu, B., Huang, Y., Chen, X., Ling, H., Ling, S., Jin, S., Yang, X., Wang, J. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
Conclusions
More than 40% of patients with prevalent RA did not experience worse mortality than their peers without RA. The cluster with the worst prognosis (<10% of patients with prevalent RA) was older, had more comorbidities and had less disease-modifying antirheumatic drug and biological use compared with the other clusters. Comorbidity patterns may hold the key to moving beyond a one-size-fits-all perspective of RA prognosis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Crowson, C. S., Atkinson, E. J., Kronzer, V. L., Kimbrough, B. A., Arment, C. A., Peterson, L. S., Wright, K., Mason, T. G., Bekele, D. I., Davis, J. M., Myasoedova, E. Tags: ARD, Rheumatoid arthritis Source Type: research
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to the classification of the disease. These autoantibodies, mainly anti-citrullinated protein antibody (ACPA) and rheumatoid factor, have been assumed to be pathogenic and many attempts have been made to link them to the development of bone erosion, pain and arthritis. We and others have recently discovered that most cloned ACPA protect against experimental arthritis in the mouse. In addition, we have identified suppressor B cells in healthy individuals, selected in response to collagen type II, and these ...
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: He, Y., Aoun, M., Xu, Z., Holmdahl, R. Tags: ARD Reviews Source Type: research
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
The US Centers for Disease Control and Prevention (CDC) recommends three SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine doses, rather than two, to complete the initial vaccine series for immunosuppressed patients. However, they may remain at risk for breakthrough COVID-19 due to immunomodulators that blunt vaccine responses.1 Identifying patients at highest risk for breakthrough COVID-19 can prioritise resources for prevention. Therefore, we investigated the risk of breakthrough COVID-19 among fully vaccinated patients with rheumatoid arthritis (RA) using disease-modifying antirheumatic drugs (DMARDs) and/or glucocor...
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Schiff, A. E., Wang, X., Patel, N. J., Kawano, Y., Hanberg, J. L., Kowalski, E. N., Cook, C. E., Vanni, K. M., Qian, G., Bade, K. J., Saavedra, A. A., Srivatsan, S., Williams, Z. K., Venkat, R. K., Wallace, Z. S., Sparks, J. A. Tags: ARD, COVID-19 Letter Source Type: research
