From Psoriasis to Psoriatic Arthritis: Ultrasound Insights Connecting Psoriasis with Subclinical Musculoskeletal Inflammation and the Path to Psoriatic Arthritis
AbstractPurpose of ReviewThis review summarizes the literature about the transition from psoriasis to psoriatic arthritis (PsA), focusing on musculoskeletal ultrasound (MSUS) for detecting subclinical inflammation and its role in diagnosis and triage of high-risk patients.Recent FindingsMSUS effectively detects subclinical musculoskeletal inflammation in patients with psoriasis; however, some of these lesions are non-specific and can be found in healthy individuals. Preliminary evidence suggest that subclinical sonographic findings may predict progression to PsA in psoriasis patients. MSUS can also improve referrals ’ ac...
Source: Current Rheumatology Reports - March 21, 2024 Category: Rheumatology Source Type: research

High-Resolution Peripheral Quantitative Computed Tomography in Rheumatic Diseases
High-resolution peripheral quantitative computed tomography (HR-pQCT) provides a new opportunity for the noninvasive measurement of bone microarchitecture in patient research of rheumatic disease in joints of the extremities. Rheumatoid arthritis of the hand and osteoarthritis of the knee are highly prevalent and there are no cures, so an improved understanding of the etiology of these diseases, particularly when combining HR-pQCT with other imaging modalities, is important to develop new disease management strategies. Analysis of HR-pQCT data is challenging due to the large size of the datasets, but the field continues to...
Source: Radiologic Clinics of North America - March 21, 2024 Category: Radiology Authors: Steven K. Boyd Source Type: research

Rheumatoid Deformities of the Lesser Toes
Rheumatoid arthritis is a chronic heterogeneous autoimmune disease characterized by painful joint inflammation and causes destructive bone erosions. Most common deformities in the rheumatoid forefoot are hallux valgus and claw toes. Radiographs are helpful to show the deformity and the associated pathologies. Nonsurgical treatment is focused on pain reduction, function preservation, and prevention of further deformity, by relieving pressure and pain with shoe modification and use of insoles. Surgical procedures can address either soft tissue and bone deformities that can be performed by a percutaneous or open approach. (So...
Source: Foot and Ankle Clinics - March 21, 2024 Category: Orthopaedics Authors: Tania S. Mann, Gustavo Araujo Nunes Source Type: research

Extensor carpi ulnaris (ECU) tenosynovitis
History The patient is a 24-year-old right-handed amateur female tennis player who presented with a 4-week history of progressively worsening left ulnar-sided wrist pain (USWP). Onset of pain was gradual, with no inciting traumatic event. Specifically, her pain was most severe when hitting her two-handed backhand. Symptoms associated with instability such as wrist ‘clunking’ and neurological symptoms such as paresis or paresthesia were absent. Physical examination revealed point tenderness over the distal ulna. Imaging findings To assess the patient’s wrist pain, plain X-rays and ultrasound were obtained ...
Source: British Journal of Sports Medicine - March 21, 2024 Category: Sports Medicine Authors: Postle, R. D., Ahmad, G., Forster, B. B. Tags: BJSM Images in sports medicine Source Type: research

Massive Rotator Cuff Tears Benefit From Arthroscopic Repair Regardless of Advanced Goutallier or Hamada Changes
Massive rotator cuff tears (MRCTs) are a challenge to treat with options from arthroscopic rotator cuff repair to reverse shoulder arthroplasty. Arthroscopic repair may still be an option even in the setting of advanced Goutallier changes and Hamada grades and regardless of healing. As the lifetime risk of revision for a 55 year old patient having an RSA was approximately 1 in 3, arthroscopic surgical management of MRCTs should not be discounted. An individualized approach that should consider the patient ’s radiographs (severity of arthritis), function (i.e. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - March 21, 2024 Category: Surgery Authors: Patrick J. Denard Tags: Editorial Commentary Source Type: research

Judicious use of corticosteroid injections prior to shoulder arthroplasty does not compromise outcomes at a minimum of 2-year following surgery
The use of total shoulder arthroplasty is continuing to rise with its expanding indications. For patients with chronic conditions, such as glenohumeral arthritis and rotator cuff arthropathy, nonoperative treatment is typically done prior to arthroplasty and often includes corticosteroid injections. Recent studies in the shoulder arthroplasty literature as well as applied from the hip and knee literature have focused on the risk of periprosthetic infection. Literature is lacking as to whether the judicious use of corticosteroids in the year prior to arthroplasty influences patient reported outcomes. (Source: Journal of Sho...
Source: Journal of Shoulder and Elbow Surgery - March 21, 2024 Category: Orthopaedics Authors: Benjamin J. Cooper, Aaron Kesinger, Grace E. Welch, Jordyn M. Carroll, Adam Lutz, Ellen Shanley, Charles A. Thigpen, Stefan J. Tolan, Michael J. Kissenberth, Stephan G. Pill Tags: Original Article Source Type: research

Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from P. gingivalis in advanced periodontitis
Chronic periodontitis (CP), an inflammatory disease of periodontal tissues driven by a dysbiotic subgingival bacterial biofilm, is also associated with several systemic diseases, including rheumatoid arthritis (RA). Porphyromonas gingivalis, one of the bacterial species implicated in CP as a keystone pathogen produces peptidyl arginine deiminase (PPAD) that citrullinates C-terminal arginine residues in proteins and peptides. Autoimmunity to citrullinated epitopes is crucial in RA, hence PPAD activity is considered a possible mechanistic link between CP and RA. Here we determined the PPAD enzymatic activity produced by clin...
Source: Frontiers in Immunology - March 21, 2024 Category: Allergy & Immunology Source Type: research

Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets
Conclusion:Downregulation of HDAC6 may inhibit CMA and thereby ameliorate RA. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research

In silico identification of compounds from Piper sarmentosum Roxb leaf fractionated extract inhibit interleukin-6 to prevent rheumatoid arthritis
Discussion: Our findings reveal new strategies in which these phytochemicals are potential inhibitory agents that can be modified and further evaluated to develop more effective agents for the management of rheumatoid arthritis, thereby providing a better understanding and useful model for the reproduction and/or discovery of new drugs for the management of rheumatoid arthritis and its complications. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research

Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling
CONCLUSION: Reducing MIF to increase CORT and decrease TNF-α by moxibustion treatment in RA. MIF may be a factor for moxibustion to regulate the expression of CORT, but the expression of TNF-α is due to the incomplete regulation of the MIF. This study added to the body of evidence pointing to moxibustion's anti-inflammatory mechanism in the treatment of RA.PMID:38504541 | PMC:PMC10927400 | DOI:10.19852/j.cnki.jtcm.20220602.001 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Zhang Linlin Zhong Yumei L U Wenting Shang Yanan Guo Yanding Luo Xiaochao Chen Yang Luo Kun H U Danhui Y U Huiling Zhou Haiyan Source Type: research

Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling
CONCLUSION: Reducing MIF to increase CORT and decrease TNF-α by moxibustion treatment in RA. MIF may be a factor for moxibustion to regulate the expression of CORT, but the expression of TNF-α is due to the incomplete regulation of the MIF. This study added to the body of evidence pointing to moxibustion's anti-inflammatory mechanism in the treatment of RA.PMID:38504541 | PMC:PMC10927400 | DOI:10.19852/j.cnki.jtcm.20220602.001 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Zhang Linlin Zhong Yumei L U Wenting Shang Yanan Guo Yanding Luo Xiaochao Chen Yang Luo Kun H U Danhui Y U Huiling Zhou Haiyan Source Type: research

Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling
CONCLUSION: Reducing MIF to increase CORT and decrease TNF-α by moxibustion treatment in RA. MIF may be a factor for moxibustion to regulate the expression of CORT, but the expression of TNF-α is due to the incomplete regulation of the MIF. This study added to the body of evidence pointing to moxibustion's anti-inflammatory mechanism in the treatment of RA.PMID:38504541 | PMC:PMC10927400 | DOI:10.19852/j.cnki.jtcm.20220602.001 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Zhang Linlin Zhong Yumei L U Wenting Shang Yanan Guo Yanding Luo Xiaochao Chen Yang Luo Kun H U Danhui Y U Huiling Zhou Haiyan Source Type: research

Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling
CONCLUSION: Reducing MIF to increase CORT and decrease TNF-α by moxibustion treatment in RA. MIF may be a factor for moxibustion to regulate the expression of CORT, but the expression of TNF-α is due to the incomplete regulation of the MIF. This study added to the body of evidence pointing to moxibustion's anti-inflammatory mechanism in the treatment of RA.PMID:38504541 | PMC:PMC10927400 | DOI:10.19852/j.cnki.jtcm.20220602.001 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Zhang Linlin Zhong Yumei L U Wenting Shang Yanan Guo Yanding Luo Xiaochao Chen Yang Luo Kun H U Danhui Y U Huiling Zhou Haiyan Source Type: research

Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing
CONCLUSIONS: This study identified potential clinical diagnostic biomarkers for RA and provided novel insights into the diagnosis and subtyping of RA. The use of targeted deoxyribonucleic acid (DNA) methylation sequencing and machine learning methods for establishing diagnostic models for different clinical features and subtypes of RA is innovative and can improve the accuracy and efficiency of RA diagnosis.PMID:38508093 | DOI:10.1016/j.intimp.2024.111860 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 20, 2024 Category: Allergy & Immunology Authors: Jianan Zhao Lingxia Xu Kai Wei Ping Jiang Cen Chang Linshuai Xu Yiming Shi Yixin Zheng Yu Shan Yuejuan Zheng Yi Shen Jia Liu Shicheng Guo Rongsheng Wang Dongyi He Source Type: research

Rhizarthrosis: Resection Arthroplasty versus Resection Suspension Arthroplasty - Still the Gold Standard?
This study examined whether the traditional surgical methods continue to have their "right to exist" or whether they will be replaced by prostheses. In a retrospective study with prospective data collection, 48 hands of 45 patients diagnosed with rhizarthrosis in stages II and III according to Eaton and Littler were clinically examined 2.5 years after resection arthroplasty/resection-suspension-interposition arthroplasty using flexor carpi radialis (FCR) or abductor pollicis longus (APL) tendon strips in the years 2015-2018. The postoperative outcome was assessed using mobility, grip strength, two-point discrimination, pos...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - March 20, 2024 Category: Cosmetic Surgery Authors: Saskia Carolin Tosun Leonie Barbara Pietzsch Manuel Held Adrien Daigeler Wiebke Eisler Source Type: research