Janus kinase inhibitors and tumour necrosis factor inhibitors show a favourable safety profile and similar persistence in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: real-world data from the BIOBADASER registry
CONCLUSIONS: Infections, herpes zoster and gastrointestinal adverse events in patients with RA tended to be more frequent with JAKi. However, prognosis was poor in patients receiving JAKi. Persistence was similar for TNFi and JAKi, although factors associated with discontinuation differed by diagnostic group.PMID:38594056 | DOI:10.1136/ard-2023-225271 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: Blanca Hern ández-Cruz Luc ía Otero-Varela Mercedes Freire-Gonz ález Noem í Busquets-Pérez Alfredo Javier Garc ía González Manuel Moreno-Ramos Juan Maria Blanco-Madrigal Sara Manrique-Arija Eva Perez-Pampin Dolores Ruiz-Montesino Fernando S ánchez Source Type: research
A Review of the Current Status of Anesthetic Management of Patients with Rheumatoid Arthritis
This article aims to review the current status of anesthetic management of patients with rheumatoid arthritis.PMID:38590091 | DOI:10.12659/MSM.943829 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2024 Category: Research Authors: Pawe ł Radkowski Maciej Szewczyk Klaudia Sztaba Mariusz K ęska Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
CONCLUSIONS: Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute to tissue destruction and disease pathogenesis.PMID:38594612 | DOI:10.1186/s10020-024-00802-1 (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Dipabarna Bhattacharya Jason Theodoropoulos Katariina Nurmi Timo Juutilainen Kari K Eklund Riitta Koivuniemi Tiina Kelkka Satu Mustjoki Tapio L önnberg Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Vigeo attenuates cartilage and bone destruction in a collagen ‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines
Exp Ther Med. 2024 Mar 19;27(5):208. doi: 10.3892/etm.2024.12496. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease characterized by articular cartilage destruction, bone destruction and synovial hyperplasia. It has been suggested that Vigeo, a mixture of Eleutherococcus senticosus, Achyranthes japonica and Atractylodes japonica fermented with Korean nuruk, has an anti-osteoporotic effect in a mouse model of inflammation-mediated bone loss. The present study evaluated the therapeutic effects of Vigeo in RA using a collagen-induced arthritis (CIA) mouse model. DBA/1J mi...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yoon-Hee Cheon Chang Hoon Lee So Young Eun Gyeong Do Park Chong Hyuk Chung Ju-Young Kim Myeung Su Lee Source Type: research
A study of the molecular mechanism of action of Jiawei Guizhishaoyaozhimu Decoction during rheumatoid arthritis therapy based on basic of network pharmacology and experimental verification
Exp Ther Med. 2024 Mar 20;27(5):212. doi: 10.3892/etm.2024.12499. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease, which primarily affects the joints. The aim of the present study was to predict the main active ingredients of Jiawei Guizhishaoyaozhimu Decoction (JWGZSYZMD) and potential targets of this treatment during RA therapy by using molecular docking and network pharmacology methods. In addition, another aim was to investigate the therapeutic effects and mechanism of JWGZSYZMD on joint inflammation in rat models of collagen Ⅱ-induced arthritis (CIA). JWGZSYZMD ingredients and ...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yiji Cheng Yue Ji Kaidi Feng Xinyuan Zhang Yunming Xiao Weixia Jing Source Type: research
A Review of the Current Status of Anesthetic Management of Patients with Rheumatoid Arthritis
This article aims to review the current status of anesthetic management of patients with rheumatoid arthritis.PMID:38590091 | DOI:10.12659/MSM.943829 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2024 Category: Research Authors: Pawe ł Radkowski Maciej Szewczyk Klaudia Sztaba Mariusz K ęska Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Risk of Relapse of Antineutrophil Cytoplasmic Antibody –Associated Vasculitis in a Randomized Controlled Trial of Plasma Exchange and Glucocorticoids
ConclusionIn patients with severe ANCA-associated vasculitis, relapses remain common; neither the use of PLEX nor an initial glucocorticoid tapering regimen impacted relapse risk. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 9, 2024 Category: Rheumatology Authors: Mats L. Junek,
Peter A. Merkel,
Eswari Vilayur,
Ron Wald,
Nader Khalidi,
David Jayne,
Michael Walsh,
for the PEXIVAS Investigators,
Kathy Paizis,
Donna Reidlinger,
Alicia Morrish,
Sunil V Badve,
Elaine Pascoe,
Peta ‐Anne Paul‐Brent,
Laur Tags: Brief Report Source Type: research
Incidence and disease burden of autoimmune inflammatory rheumatic diseases after non ‐pharmaceutical interventions in the COVID‐19 era: A nationwide observational study in Korea
ConclusionImplementation of NPIs to contain the pandemic led to a reduction in the incidence of SLE and changed patterns of medical care utilization and treatment cost for most AIRDs. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 9, 2024 Category: Rheumatology Authors: Je Hee Shin,
Jung Yoon Pyo,
Minkyung Han,
Myeongjee Lee,
Sung Min Lim,
Jee Yeon Baek,
Ji Young Lee,
Ji ‐Man Kang,
InKyung Jung,
Jong Gyun Ahn Tags: ORIGINAL ARTICLE Source Type: research
