Total ankle replacement versus ankle fusion for end-stage ankle arthritis: A meta-analysis
CONCLUSION: Currently available evidence suggests no significant disparity in postoperative outcomes between TAR and AF. In the short term, TAR demonstrates better clinical scores than AF and lower complication rates. Conversely, in the long term, AF exhibits superior clinical scores and lower complication rates, although this difference is not statistically significant.PMID:38607239 | DOI:10.1177/10225536241244825 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - April 12, 2024 Category: Orthopaedics Authors: Taiyi Li Li Zhao Yan Liu Li Huang Jin Zhu Jie Xiong Junfeng Pang Lina Qin Zonggui Huang Yinglong Xu Hai Dai Source Type: research
Total ankle replacement versus ankle fusion for end-stage ankle arthritis: A meta-analysis
CONCLUSION: Currently available evidence suggests no significant disparity in postoperative outcomes between TAR and AF. In the short term, TAR demonstrates better clinical scores than AF and lower complication rates. Conversely, in the long term, AF exhibits superior clinical scores and lower complication rates, although this difference is not statistically significant.PMID:38607239 | DOI:10.1177/10225536241244825 (Source: Hand Surgery)
Source: Hand Surgery - April 12, 2024 Category: Surgery Authors: Taiyi Li Li Zhao Yan Liu Li Huang Jin Zhu Jie Xiong Junfeng Pang Lina Qin Zonggui Huang Yinglong Xu Hai Dai Source Type: research
Satellite Glial Cells in Human Disease
Cells. 2024 Mar 23;13(7):566. doi: 10.3390/cells13070566.ABSTRACTSatellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suf...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Menachem Hanani Source Type: research
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu Tags: Research Source Type: research
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestinal and renal involvement and thus contributing to higher mortality. Due to understudied ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Matija Baj želj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar and Katja Lakota Tags: Research Source Type: research
Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation
We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function f... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver and Jeffrey R. Curtis Tags: Research Source Type: research
Does arthroscopic or open washout in native knee septic arthritis result in superior post-operative function? A systematic review and meta-analysis of randomised controlled trials and observational studies
ConclusionsAW was associated with equivalent to superior post-operative function and lower requirement for further intervention compared with OW. Results need to be interpreted cautiously, taking into consideration the methodological and clinical heterogeneity of the included studies.Systematic review registrationPROSPERO 2022, CRD42022364062. (Source: Systematic Reviews)
Source: Systematic Reviews - April 12, 2024 Category: International Medicine & Public Health Source Type: research
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
This study investigated the hydroethanolic extract ofArtemisia herba-alba for its protective potential against arthritis hallmarks, oxidative stress, and lipid peroxidation in vitro. It also assessed its in vivo anti-arthritic activity. The phytochemical analysis identified various compounds within the extract, with high concentrations of polyphenols and flavonoids. These compounds are associated with numerous health benefits, makingA. herba-alba a potential source of valuable phytochemicals.A. herba-alba demonstrated a notable effect in body weight loss, paw edema, and arthritic severity. Histopathological examination rev...
Source: Inflammopharmacology - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
New | phs003417.v2.p1 | The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis
The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - April 11, 2024 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research
Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr;17(4):363-379. doi: 10.1080/17512433.2024.2340552. Epub 2024 Apr 11.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor ne...
Source: Pharmacological Reviews - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura Mateu-Arrom Lluis Puig Source Type: research
Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Expert Review of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research
Helminth-induced impairment of humoral immunity differently contribute to their anti-arthritic effects in mice: Comparison of Schistosoma mansoni and Trichinella spiralis
CONCLUSION: The down-modulations of anti-IIC IgG levels by the two parasitic infections and the correlation analyses suggest that the anti-arthritic activity of Sm was primarily attributed to the modulation of IgG-independent arthritogenic mechanisms and secondarily to the impairment of anti-IIC IgG production. In contrast, Ts could alleviate CIA mainly via reduction of antibody productions.PMID:38604301 | DOI:10.1016/j.exppara.2024.108752 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 11, 2024 Category: Parasitology Authors: Yoshio Osada Shoichi Shimizu Kentaro Morita Eman M Gaballah Zhiliang Wu Yoichi Maekawa Source Type: research
The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
