Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Expert Review of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research

A profile of azetukalner for the treatment of epilepsy: from pharmacology to potential for therapy
Expert Rev Clin Pharmacol. 2024 Apr 3:1-10. doi: 10.1080/17512433.2024.2337012. Online ahead of print.ABSTRACTINTRODUCTION: Epilepsies are a group of heterogeneous brain disorder, and antiseizure medications (ASMs) are the mainstay of treatment. Despite the availability of more than 30 drugs, at least one third of individuals with epilepsy are drug-resistant. This emphasizes the need for novel compounds that combine efficacy with improved tolerability.AREAS COVERED: A literature review on the pharmacology, efficacy, tolerability, and safety of azetukalner (XEN1101), a second-generation opener of neuronal potassium channels...
Source: Expert Review of Clinical Pharmacology - April 4, 2024 Category: Drugs & Pharmacology Authors: Simona Lattanzi Eugen Trinka Stefano Meletti Pasquale Striano Sara Matricardi Mauro Silvestrini Francesco Brigo Source Type: research

The thiazide-like diuretic chlorthalidone as an alternative evidence-based therapy for resistant hypertension in patients with stage 4 chronic kidney disease
Expert Rev Clin Pharmacol. 2024 Mar 22:1-4. doi: 10.1080/17512433.2024.2333776. Online ahead of print.NO ABSTRACTPMID:38511397 | DOI:10.1080/17512433.2024.2333776 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Panagiotis I Georgianos Vasilios Vaios Ioannis Kontogiorgos Maria Divani Vassilios Liakopoulos Source Type: research