Effect of laparoscopic sleeve gastrectomy on drug pharmacokinetics
Expert Rev Clin Pharmacol. 2021 Oct 25. doi: 10.1080/17512433.2021.1997585. Online ahead of print.ABSTRACTINTRODUCTION: Given its feasibility and efficacy, laparoscopic sleeve gastrectomy (LSG) has become a widely accepted bariatric surgery for patients with clinically diagnosed severe obesity. LSG induces anatomical changes and subsequent weight loss which may affect drug pharmacokinetics (PK) and consequently impact dosing regimens. This review aims to examine the effect of LSG on drug PK and identify relevant gastrointestinal physiological alterations.AREAS COVERED: PubMed, Embase, Scopus, and the Cochrane Library were ...
Source: Expert Review of Clinical Pharmacology - October 25, 2021 Category: Drugs & Pharmacology Authors: Kaifeng Chen Yaqi Lin Ping Luo Nan Yang Guoping Yang Liyong Zhu Qi Pei Source Type: research

Pharmacological and safety profile of a prolonged-release lanreotide formulation in acromegaly
CONCLUSIONS: The safety and tolerability profile was in-line with the known safety profile of lanreotide autogel. Lanreotide PRF was well tolerated and the pharmacokinetic profile suggests that a dosing interval of 12 weeks could be achievable.CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov identifier is NCT02396953; EudraCT 2014-002389-62.PMID:34664531 | DOI:10.1080/17512433.2021.1986004 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - October 19, 2021 Category: Drugs & Pharmacology Authors: Sebastian Neggers Corin Badiu Betina Biagetti Lucie Durand-Gasselin Anne Petit Patrick Petrossians Benjamin Regnault David Rich Zulfiya Shafigullina Sergey Shustov Anna Vydrych Source Type: research

Comparison of the registration process of the Medicines Control Authority of Zimbabwe with Australia, Canada, Singapore, and Switzerland: Benchmarking best practices
CONCLUSION: This study identified the MCAZ strengths and opportunities for improvement, which if implemented, will enable the achievement of its vision to be a leading regulatory authority in Africa.PMID:34645359 | DOI:10.1080/17512433.2022.1987883 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - October 14, 2021 Category: Drugs & Pharmacology Authors: Tariro Sithole Sam Salek Gugu Mahlangu Stuart Walker Source Type: research

Getting immunosuppression just right: the role of clinical biomarkers in predicting patient response post solid organ transplantation
Expert Rev Clin Pharmacol. 2021 Oct 7:1-13. doi: 10.1080/17512433.2021.1987882. Online ahead of print.ABSTRACTINTRODUCTION: Actually, immunosuppression selection isn't based on individual immune alloreactivity, and immunosuppressive drug dosing is mainly based on the development of toxicity and the achievement of specific target concentrations. Since a successful outcome requires optimal patient risk stratification and treatment, several groups have evaluated candidate biomarkers that have shown promise in the assessment of individual immune responses, the prediction of personal pharmacodynamic effects of immunosuppressive...
Source: Expert Review of Clinical Pharmacology - October 5, 2021 Category: Drugs & Pharmacology Authors: Merc è Brunet Olga Mill án Source Type: research

Getting immunosuppression just right: the role of clinical biomarkers in predicting patient response post solid organ transplantation
Expert Rev Clin Pharmacol. 2021 Oct 5. doi: 10.1080/17512433.2021.1987882. Online ahead of print.ABSTRACTINTRODUCTION: Immunosuppression selection is not based on individual immune alloreactivity, and immunosuppressive drug dosing is mainly based on the development of toxicity and the achievement of specific target concentrations. Since a successful outcome requires optimal patient risk stratification and treatment, several groups have evaluated candidate biomarkers that have shown promise in the assessment of individual immune responses, the prediction of personal pharmacodynamic effects of immunosuppressive drugs and the...
Source: Expert Review of Clinical Pharmacology - October 5, 2021 Category: Drugs & Pharmacology Authors: Merc è Brunet Olga Mill án Source Type: research

Selective FGFR/FGF pathway inhibitors: inhibition strategies, clinical activities, resistance mutations, and future directions
Expert Rev Clin Pharmacol. 2021 Oct;14(10):1233-1252. doi: 10.1080/17512433.2021.1947246.ABSTRACTIntroduction: Fibroblast growth factor receptor (FGFR)/fibroblast growth factor (FGF) is a pathway characterized by recurring alterations in cancer. Its dysregulations enhance cancer cell proliferation, survival, migration and invasion, as well as angiogenesis and immune evasion.Areas covered: FGFR/FGF selective inhibitors belong to a broad class of drugs with some being approved for specific indications and others under investigation in ongoing phase I and II clinical trials. In this review, all available clinical data from tr...
Source: Expert Review of Clinical Pharmacology - September 30, 2021 Category: Drugs & Pharmacology Authors: Matteo Repetto Edoardo Crimini Federica Giugliano Stefania Morganti Carmen Belli Giuseppe Curigliano Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.TRIAL REGISTRATION: The study protocol was posted on ClinicalTrials.gov with NCT number: NCT02407964.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis
CONCLUSION: Topical anti-inflammatory treatment after SLT for patients with glaucoma neither significantly affected IOP reduction nor remarkably relieved clinical discomfort and anterior chamber inflammation. Hence, regular use of post-SLT anti-inflammatory treatment may be unnecessary.PMID:34524035 | DOI:10.1080/17512433.2021.1981860 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Yu-Sheng Chen Hai-Ting Hung Siao-Pei Guo Hua-Ching Chang Source Type: research

Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database
CONCLUSIONS: Hugan tablets are safe and effective in DILI treatment. Large-scale randomized controlled studies are needed to explore the effects of Hugan tablets on DILI induced by different offending drugs.PMID:34521298 | DOI:10.1080/17512433.2021.1981859 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Jing Li Jianzhong Zhang Xiaorong Xu Weidong Fang Shilin Qu Feng Jin Jie Zhou Xian Han Hafiz Khuram Raza Xiaoyun Li Yimin Mao Source Type: research

Age and psoriatic arthritis are important predictors of biologic agent switch in psoriasis
Expert Rev Clin Pharmacol. 2021 Sep 14. doi: 10.1080/17512433.2021.1979394. Online ahead of print.ABSTRACTBACKGROUND: The demand of biologic switching is increasing for different reasons. We aimed to define reasons for switching biologics and possible predictors for switching risk, and to estimate data on drug survival.METHODS: One-hundred and fifteen patients treated with biologics for at least 12 consecutive months who switched to a second, third, and/or fourth biologic were eligible for this retrospective study. The data is extracted from the electronic medical records of the hospital. Patients were divided into 2 group...
Source: Expert Review of Clinical Pharmacology - September 14, 2021 Category: Drugs & Pharmacology Authors: Neslihan Akdogan Sibel Dogan Ecem Bostan Duygu Gulseren Basak Yalici-Armagan Gonca Elcin Sibel Evans Aysen Karaduman Nilgun Atakan Source Type: research

Recent advances in the pharmacological management of sepsis-associated acute kidney injury
Expert Rev Clin Pharmacol. 2021 Sep 14:1-11. doi: 10.1080/17512433.2021.1978287. Online ahead of print.ABSTRACTINTRODUCTION: Acute kidney injury is a common occurrence in patients with sepsis and portends a high mortality as well as increased morbidity with numerous sequelae including the development of chronic kidney disease. Currently, there are no specific therapies that either prevent AKI or hasten its recovery. Thus, clinicians typically rely on management of the underlying infection, optimization of hemodynamic parameters as well as avoidance of nephrotoxins to maximize outcomes.AREAS COVERED: Recent advances in unde...
Source: Expert Review of Clinical Pharmacology - September 8, 2021 Category: Drugs & Pharmacology Authors: Kambiz Kalantari Mitchell H Rosner Source Type: research

Recent advances in the pharmacological management of sepsis-associated acute kidney injury
Expert Rev Clin Pharmacol. 2021 Sep 8. doi: 10.1080/17512433.2021.1978287. Online ahead of print.ABSTRACTINTRODUCTION: : Acute kidney injury is a common occurrence in patients with sepsis and portends a high mortality as well as increased morbidity with numerous sequelae including the development of chronic kidney disease. Currently, there are no specific therapies that either prevent AKI or hasten its recovery. Thus, clinicians typically rely on management of the underlying infection, optimization of hemodynamic parameters as well as avoidance of nephrotoxins to maximize outcomes.AREAS COVERED: : Recent advances in unders...
Source: Expert Review of Clinical Pharmacology - September 8, 2021 Category: Drugs & Pharmacology Authors: Kambiz Kalantari Mitchell H Rosner Source Type: research