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Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research

Improvement of assessment in surrogate endpoint and safety outcome of single-arm trials for anticancer drugs
Expert Rev Clin Pharmacol. 2024 Apr 21:1-11. doi: 10.1080/17512433.2024.2344669. Online ahead of print.ABSTRACTINTRODUCTION: Single-arm trials (SATs) and surrogate endpoints were adopted as pivotal evidence for accelerated approval of anticancer drugs for more than 30 years. However, concerns regarding clinical evidence quality in trials, particularly in the SATs of anticancer drugs have increasingly been raised. SAT may not always provide strong evidence due to the lack of control and endpoint of overall survival that is typically present in randomized controlled trials.AREAS COVERED: Clinical trial endpoint adjudication ...
Source: Expert Review of Clinical Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Yafang Huang Jinqiu Yuan Source Type: research

Improvement of assessment in surrogate endpoint and safety outcome of single-arm trials for anticancer drugs
Expert Rev Clin Pharmacol. 2024 Apr 17. doi: 10.1080/17512433.2024.2344669. Online ahead of print.ABSTRACTINTRODUCTION: Single-arm trials (SATs) and surrogate endpoints were adopted as pivotal evidence for accelerated approval of anticancer drugs for more than 30 years. However, concerns regarding clinical evidence quality in trials, particularly in the SATs of anticancer drugs have increasingly been raised. SAT may not always provide strong evidence due to the lack of control and endpoint of overall survival that is typically present in randomized controlled trials.AREAS COVERED: Clinical trial endpoint adjudication is a ...
Source: Expert Review of Clinical Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Yafang Huang Jinqiu Yuan Source Type: research

Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research

Treatment adherence and adverse event management in chronic lymphocytic leukemia: challenges and strategies for the future
We describe how such a program can be designed and implemented.PMID:38629382 | DOI:10.1080/17512433.2024.2344665 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Maurlia D Upchurch Benyam Muluneh Source Type: research

Opioid use disorder in pediatric populations: considerations for perioperative pain management and precision opioid analgesia
Expert Rev Clin Pharmacol. 2024 Apr 16. doi: 10.1080/17512433.2024.2343915. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder.AREAS COVERED: Enhanced recovery after surgery (ERAS) protocols, are often inadequate in treating a child's severe surgical pain. Research suggests that 'older' and longer-acting opioids such as methad...
Source: Expert Review of Clinical Pharmacology - April 16, 2024 Category: Drugs & Pharmacology Authors: Yun Han Chen Anastasios Xenitidis Paul Hoffman Leslie Matthews Swathi G Padmanabhan Lakshmi Aravindan Ruth Ressler Inesh Sivam Sahana Sivam Chase F Gillispie Senthilkumar Sadhasivam Source Type: research

Engaging patients in conversations about deprescribing
Expert Rev Clin Pharmacol. 2024 Apr 15. doi: 10.1080/17512433.2024.2343913. Online ahead of print.NO ABSTRACTPMID:38618915 | DOI:10.1080/17512433.2024.2343913 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Barbara Farrell Source Type: research

Exploring the impact of co-exposure timing on drug-drug interactions in signal detection through spontaneous reporting system databases: a scoping review
Expert Rev Clin Pharmacol. 2024 Apr 15. doi: 10.1080/17512433.2024.2343875. Online ahead of print.ABSTRACTINTRODUCTION: Drug-drug interactions (DDIs) are defined as the pharmacological effects produced by the concomitant administration of two or more drugs. To minimize false positive signals and ensure their validity when analyzing Spontaneous Reporting System (SRS) databases, it has been suggested to incorporate key pharmacological principles, such as temporal plausibility.AREAS COVERED: the scoping review of the literature was completed using MEDLINE from inception to March 2023. Included studies had to provide detailed ...
Source: Expert Review of Clinical Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Marianna Cocco Carla Carnovale Emilio Clementi Maria Antonietta Barbieri Vera Battini Maurizio Sessa Source Type: research

Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Expert Review of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research