Optimization of secukinumab dose regimens in patients with moderate-to-severe plaque psoriasis via exposure-response modeling
CONCLUSIONS: Based on patient body weights, the exposure-response model recommends efficacious and economical dose regimens for patients with moderate-to-severe plaque psoriasis.PMID:37710355 | DOI:10.1080/17512433.2023.2259300 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Authors: Yixiao Liu Ling Xu Xinrui Wang Lijuan Wu Ruifen Cai Qingshan Zheng Lujin Li Source Type: research

Letermovir and new horizons in prevention of post-transplant CMV
Expert Rev Clin Pharmacol. 2023 Sep 14. doi: 10.1080/17512433.2023.2259308. Online ahead of print.NO ABSTRACTPMID:37706302 | DOI:10.1080/17512433.2023.2259308 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Authors: Emily A Siegrist Joseph Sassine Source Type: research

Optimization of secukinumab dose regimens in patients with moderate-to-severe plaque psoriasis via exposure-response modeling
CONCLUSIONS: Based on patient body weights, the exposure-response model recommends efficacious and economical dose regimens for patients with moderate-to-severe plaque psoriasis.PMID:37710355 | DOI:10.1080/17512433.2023.2259300 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Authors: Yixiao Liu Ling Xu Xinrui Wang Lijuan Wu Ruifen Cai Qingshan Zheng Lujin Li Source Type: research

Intravitreal immunotherapy in non-infectious uveitis: an update
Expert Rev Clin Pharmacol. 2023 Sep 12:1-18. doi: 10.1080/17512433.2023.2256660. Online ahead of print.ABSTRACTINTRODUCTION: In the past several years, there have been numerous advances in pharmacotherapeutics for the management of uveitis and other ocular inflammatory diseases, including newer therapeutic agents and ocular drug delivery systems. One of the most attractive modes of drug delivery is the intravitreal route since it has proven to be safe and efficacious and prevents unwanted systemic adverse events related to the agent.AREAS COVERED: In this review, intravitreal delivery of various pharmacotherapeutic agents ...
Source: Expert Review of Clinical Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Authors: Nitin Kumar Menia Sashwanthi Mohan Aniruddha Agarwal Source Type: research

Intravitreal immunotherapy in noninfectious uveitis: an update
Expert Rev Clin Pharmacol. 2023 Sep 6. doi: 10.1080/17512433.2023.2256660. Online ahead of print.ABSTRACTINTRODUCTION: In the past several years, there have been numerous advances in pharmacotherapeutics for the management of uveitis and other ocular inflammatory diseases, including newer therapeutic agents and ocular drug delivery systems. One of the most attractive modes of drug delivery is the intravitreal route since it has proven to be safe and efficacious and prevents unwanted systemic adverse events related to the agent.AREAS COVERED: In this review, intravitreal delivery of various pharmacotherapeutic agents for no...
Source: Expert Review of Clinical Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Authors: Nitin Kumar Menia Sashwanthi Mohan Aniruddha Agarwal Source Type: research

Quantitative effects of sodium-glucose cotransporter-2 inhibitors on liver functions in patients with nonalcoholic fatty liver disease
CONCLUSIONS: The present study exploredthe quantitative effects of SGLT-2inhibitors on liver functions and recommends a therapeutic regimen in patients with NAFLD.PMID:37669251 | DOI:10.1080/17512433.2023.2256224 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - September 5, 2023 Category: Drugs & Pharmacology Authors: Xiao Chen Chang Xu Ke Hu Yang Yang Yi-Jia Zhang Hao-Zhe Shi Qian Gu Su-Mei He Cun Zhang Dong-Dong Wang Source Type: research

< em > Clostridioides difficile < /em > resistance to antibiotics, including post-COVID-19 data
Expert Rev Clin Pharmacol. 2023 Aug 29:1-14. doi: 10.1080/17512433.2023.2252331. Online ahead of print.ABSTRACTINTRODUCTION: Updating data on Clostridioides difficile antibiotic resistance is important for treatment improvement of C. difficile infections (CDIs).AREAS COVERED: Results from 20 countries were included. The mean resistance to 2 mg/l vancomycin, 2 mg/l metronidazole, 4 mg/l moxifloxacin, and 4 mg/l clindamycin was 4.7% (0 to ≥ 26% in two studies), 2.6% (0 to ≥ 40% in 3 studies), 34.9% (6.6->80%), and 61.0% (30->90%), respectively. Resistance to erythromycin (>60-88%), rifampin (>23-55.0%), imipe...
Source: Expert Review of Clinical Pharmacology - August 29, 2023 Category: Drugs & Pharmacology Authors: Lyudmila Boyanova Georgi Dimitrov Raina Gergova Petyo Hadzhiyski Rumyana Markovska Source Type: research