Expert Review of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses
Expert Rev Clin Pharmacol. 2023 Jul-Dec;16(12):1201-1209. doi: 10.1080/17512433.2023.2288171. Epub 2023 Dec 9.ABSTRACTINTRODUCTION: Pharmacokinetic (PK)-Pharmacodynamic (PD) and exposure-response (E-R) modeling are critical parts of pediatric drug development. By integrating available knowledge and supportive data to support the design of future studies and pediatric dose selection, these techniques increase the efficiency of pediatric drug development and lowers the risk of exposing pediatric study participants to suboptimal or unsafe dose regimens.AREAS COVERED: The role of PK, PK-PD and E-R modeling within pediatric dru...
Source: Expert Review of Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: Sebastiaan C Goulooze Peter W Vis Elke H J Krekels Catherijne A J Knibbe Source Type: research

Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research

An overview of new and emerging antibody therapies for moderate-severe atopic dermatitis in adults
Expert Rev Clin Pharmacol. 2023 Dec 6. doi: 10.1080/17512433.2023.2292615. Online ahead of print.ABSTRACTINTRODUCTION: A comprehensive review of the English-language medical literature was performed searching for on-going and closed clinical trials concerning new and emerging monoclonal antibody therapies for moderate-to-severe atopic dermatitis in adults.AREAS COVERED: Atopic dermatitis is a chronic inflammatory cutaneous disease with a complex pathogenesis. In the last years, numerous advances in understanding the atopic dermatitis pathogenesis allowed to obtain several therapeutic options, such as numerous monoclonal an...
Source: Expert Review of Clinical Pharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Vincenzo Picone Ylenia Vallone Cataldo Patruno Maddelena Napolitano Source Type: research

Novel insights into molecular and cellular aspects of delayed drug hypersensitivity reactions
Expert Rev Clin Pharmacol. 2023 Nov 29:1-13. doi: 10.1080/17512433.2023.2289543. Online ahead of print.ABSTRACTINTRODUCTION: Delayed drug hypersensitivity reactions (DDHRs) represent a major health problem. They are unpredictable and can cause life-long disability or even death. The pathophysiology of DDHRs is complicated, multifactorial, and not well understood mainly due to the lack of validated animal models or in vitro systems. The role of the immune system is well demonstrated but its exact pathophysiology still a matter of debate.AREA COVERED: This review summarizes the current understanding of DDHRs pathophysiology ...
Source: Expert Review of Clinical Pharmacology - November 29, 2023 Category: Drugs & Pharmacology Authors: Abdelbaset A Elzagallaai Michael J Rieder Source Type: research

Novel insights into molecular and cellular aspects of delayed drug hypersensitivity reactions
Expert Rev Clin Pharmacol. 2023 Nov 29. doi: 10.1080/17512433.2023.2289543. Online ahead of print.ABSTRACTINTRODUCTION: Delayed drug hypersensitivity reactions (DDHRs) represent a major health problem. They are unpredictable and can cause life-long disability or even death. The pathophysiology of DDHRs is complicated, multifactorial, and not well understood mainly due to the lack of validated animal models or in vitro systems. The role of the immune system is well demonstrated but its exact pathophysiology still a matter of debate.AREA COVERED: This review summarizes the current understanding of DDHRs pathophysiology and a...
Source: Expert Review of Clinical Pharmacology - November 29, 2023 Category: Drugs & Pharmacology Authors: Abdelbaset A Elzagallaai Michael J Rieder Source Type: research

JAK inhibitors in vitiligo: what they hit and what they miss - an immunopathogenesis based exposition of existing evidence
Expert Rev Clin Pharmacol. 2023 Nov 20:1-7. doi: 10.1080/17512433.2023.2285011. Online ahead of print.ABSTRACTINTRODUCTION: Vitiligo is an autoimmune disorder which presents as depigmented macules due to selective loss of melanocytes. Heightened expression of Janus Kinase Signal transducers and activators of transcription (JAK STAT) pathway, which mediate cytokines action, suggest that targeting this signaling pathway may be an effective option.AREAS COVERED: A PubMed search was carried out with the broad key words 'JAK,' 'vitiligo' from 2016 to 2023. We also analyzed papers where tissue-based JAK expression was studied, w...
Source: Expert Review of Clinical Pharmacology - November 20, 2023 Category: Drugs & Pharmacology Authors: Kabir Sardana Aishwarya Muddebihal Ananta Khurana Source Type: research