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The outcomes of considering goals of care in medication reviews for older adults: a systematic review
CONCLUSIONS: There is evidence of positive impact on medication rationalization, quality of life and cost-effectiveness, supporting goal-directed medication reviews. Larger, longitudinal studies, exploring patient-focused outcomes may provide further insights into the ongoing impact of goal-directed medication reviews.PMID:38145414 | DOI:10.1080/17512433.2023.2286321 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 25, 2023 Category: Drugs & Pharmacology Authors: Nashwa Masnoon Cristen George Sarita Lo Edwin Tan Aagam Bordia Sarah Hilmer Source Type: research

Population pharmacokinetics of antibacterial agents in the older population: a literature review
Expert Rev Clin Pharmacol. 2023 Dec 22. doi: 10.1080/17512433.2023.2295009. Online ahead of print.ABSTRACTINTRODUCTION: Older individuals face an elevated risk of developing bacterial infections. The optimal use of antibacterial agents in this population is challenging because of age-related physiological alterations, changes in pharmacokinetics (PK) and pharmacodynamics (PD), and the presence of multiple underlying diseases. Therefore, population pharmacokinetics (PPK) studies are of great importance for optimizing individual treatments and prompt identification of potential risk factors.AREA COVERED: Our search involved ...
Source: Expert Review of Clinical Pharmacology - December 22, 2023 Category: Drugs & Pharmacology Authors: Hui-Xin Liu Bo-Hao Tang John van den Anker Guo-Xiang Hao Wei Zhao Yi Zheng Source Type: research

Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research