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Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research

Set and setting predict psychopathology, wellbeing and meaningfulness of psychedelic experiences: a correlational study
CONCLUSIONS: Based on these results, we suggest experimental hypotheses for future clinical trials and longitudinal studies with potential clinical implications.PMID:38108102 | DOI:10.1080/17512433.2023.2295997 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 18, 2023 Category: Drugs & Pharmacology Authors: Lucas F Borkel Jaime Rojas-Hern ández Luis Alberto Henr íquez-Hernández Ángelo Santana Del Pino Domingo J Quintana-Hern ández Source Type: research

Correction
Expert Rev Clin Pharmacol. 2023 Dec 14:1. doi: 10.1080/17512433.2023.2295153. Online ahead of print.NO ABSTRACTPMID:38098207 | DOI:10.1080/17512433.2023.2295153 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 15, 2023 Category: Drugs & Pharmacology Source Type: research

Challenges, unmet needs and future directions - a critical evaluation of the clinical trial landscape in schizophrenia research
Expert Rev Clin Pharmacol. 2023 Dec 12. doi: 10.1080/17512433.2023.2293996. Online ahead of print.ABSTRACTINTRODUCTION: Developing novel antipsychotic mechanisms of action and repurposing established compounds for the treatment of schizophrenia is of utmost importance to improve relevant symptom domains and to improve the risk/benefit ratio of antipsychotic compounds. Novel trial design concepts, pathophysiology-based targeted treatment approaches or even the return to old values may improve schizophrenia outcome in the future.AREAS COVERED: In this review of the clinical trial landscape in schizophrenia, we present an ove...
Source: Expert Review of Clinical Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Authors: Elias Wagner Jurjen J Luykx Wolfgang Strube Alkomiet Hasan Source Type: research

Response to letter to the editor: therapeutic importance of proteinuria classification in children with congenital anomalies of the kidney and urinary tract
Expert Rev Clin Pharmacol. 2023 Dec 13. doi: 10.1080/17512433.2023.2295005. Online ahead of print.NO ABSTRACTPMID:38087987 | DOI:10.1080/17512433.2023.2295005 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Authors: Giulio Rivetti Pietro Gizzone Anna Di Sessa Stefano Guarino Emanuele Miraglia Del Giudice Pierluigi Marzuillo Source Type: research

Implementing pharmacogenetics in clinical trials: considerations about current methodological, ethical, and regulatory challenges
Expert Rev Clin Pharmacol. 2023 Dec 13. doi: 10.1080/17512433.2023.2293999. Online ahead of print.ABSTRACTINTRODUCTION: The implementation of pharmacogenetic analysis within clinical trials faces methodological, ethical, and regulatory challenges, as well as tackling the difficulty in obtaining actionable information with a sufficient level of evidence to enable its integration into routine clinical practice.AREAS COVERED: we discuss the current status of pharmacogenetics integration in clinical trials, underscore the associated challenges, and make some suggestions on the aspects to address in any clinical trial including...
Source: Expert Review of Clinical Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Authors: Irene Garc ía Enrique Seco-Meseguer Alberto M Borobia Antonio J Carcas-Sansu án Source Type: research

Letter to the editor: type of proteinuria might be essential for RAAS-I treatment in children with CAKUT
Expert Rev Clin Pharmacol. 2023 Dec 12. doi: 10.1080/17512433.2023.2295004. Online ahead of print.NO ABSTRACTPMID:38086609 | DOI:10.1080/17512433.2023.2295004 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: Alessia Marcellino Riccardo Lubrano Source Type: research

Adverse clinical outcomes associated with drug-related hospitalizations in people with dementia
CONCLUSION: Safe prescribing and vigilant monitoring of ADRs is pivotal to mitigate adverse outcomes in people with dementia.PMID:38078438 | DOI:10.1080/17512433.2023.2294007 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Anum Saqib Zaidi Gregory M Peterson Colin M Curtain Mohammed S Salahudeen Source Type: research

The association between ACE inhibitors and psoriasis based on the drug-targeted Mendelian randomization and real-world pharmacovigilance analyses
CONCLUSIONS: Our integrative study verified that ACEIs, especially ramipril, trandolapril, perindopril, lisinopril, and enalapril, tended to increase the risk of psoriasis statistically.PMID:38078460 | DOI:10.1080/17512433.2023.2292605 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research