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Sodium-glucose cotransporter 2 inhibitors in frail, older people with type 2 diabetes and heart failure: do we have enough evidence to confidently support the use?
Expert Rev Clin Pharmacol. 2023 Aug 14. doi: 10.1080/17512433.2023.2247977. Online ahead of print.NO ABSTRACTPMID:37577977 | DOI:10.1080/17512433.2023.2247977 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 14, 2023 Category: Drugs & Pharmacology Authors: Theocharis Koufakis Michael N Doumas Alexandra Bargiota Kalliopi Kotsa Giuseppe Maltese Source Type: research

Renin angiotensin aldosterone inhibitors in the treatment of proteinuria in children with congenital anomalies of the kidney and urinary tract: more evidence needed
Expert Rev Clin Pharmacol. 2023 Aug 14. doi: 10.1080/17512433.2023.2247985. Online ahead of print.ABSTRACTINTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) can be associated with proteinuria, possibly leading to a decline of kidney function. The aim of this review is to evaluate evidence on the efficacy of renin-angiotensin-aldosterone system inhibitors (RAASi) in children affected by CAKUT with proteinuria or chronic kidney disease (CKD).AREAS COVERED: We conducted a bibliographic search between 1 December 2022 and 20 February 2023, including randomized controlled trials, case-control studies, obs...
Source: Expert Review of Clinical Pharmacology - August 14, 2023 Category: Drugs & Pharmacology Authors: Giulio Rivetti Pietro Gizzone Anna Di Sessa Stefano Guarino Emanuele Miraglia Del Giudice Pierluigi Marzuillo Source Type: research

Therapeutic effects of topical cetirizine in the treatment of female pattern hair loss: a randomized controlled noninferiority trial
CONCLUSION: Although inferior to topical minoxidil, topical cetirizine can provide favorable therapeutic effects for FPHL, specifically when patient incompatibility with Minoxidil is observed.TRIAL REGISTRATION: The study is registered in the Iranian Registry of Clinical Trials (IRCT) with the registration code IRCT20200521047536N1.PMID:37552615 | DOI:10.1080/17512433.2023.2243813 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 8, 2023 Category: Drugs & Pharmacology Authors: Seyed Mohammad Kazem Alavi Pouran Layegh Sadegh Vahabi-Amlashi Vahideh Sabeti Mehdi Forouzanfar Emadodin Darchini-Maragheh Source Type: research

Clinical pharmacology of emicizumab for the treatment of hemophilia A
Expert Rev Clin Pharmacol. 2023 Aug 2. doi: 10.1080/17512433.2023.2243213. Online ahead of print.ABSTRACTINTRODUCTION: Emicizumab is a humanized bispecific antibody approved for the routine prophylaxis of bleeding episodes in patients with hemophilia A (PwHA) regardless of the presence of factor VIII (FVIII) inhibitors. It mimics the cofactor function of missing activated FVIII by bridging activated factor IX and factor X, thereby restoring hemostasis.AREAS COVERED: This review covers the clinical pharmacology of emicizumab and the translation of its pharmacokinetics (PK) and pharmacodynamics (PD) to clinical efficacy and ...
Source: Expert Review of Clinical Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Authors: Koichiro Yoneyama Christophe Schmitt Agn ès Portron Anna Kiialainen Naoki Kotani Felix Jaminion Sylvie Retout Joanne I Adamkewicz Source Type: research

Short-acting versus long-acting opioids for pediatric postoperative pain management
Expert Rev Clin Pharmacol. 2023 Aug 7:1-11. doi: 10.1080/17512433.2023.2244417. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are potent analgesics commonly used to manage children's moderate to severe perioperative pain in children. A wide range of short and long-acting opioids are used to treat surgical pain and will be reviewed in this article.AREAS COVERED: Both short- and long-acting opioids contain unique therapeutic benefits and adverse effects; however, due to the side effect profile and safety concerns, lack of familiarity, and evidence with long-acting opioids to treat surgical pain, shorter-acting opioids ...
Source: Expert Review of Clinical Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Authors: Yun Han Chen Senthilkumar Sadhasivam Spencer DeMedal Mihaela Visoiu Source Type: research

Short-acting versus long-acting opioids for pediatric postoperative pain management
Expert Rev Clin Pharmacol. 2023 Aug 2. doi: 10.1080/17512433.2023.2244417. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are potent analgesics commonly used to manage children's moderate to severe perioperative pain in children. A wide range of short and long-acting opioids are used to treat surgical pain and will be reviewed in this article.AREAS COVERED: Both short- and long-acting opioids contain unique therapeutic benefits and adverse effects; however, due to the side effect profile and safety concerns, lack of familiarity, and evidence with long-acting opioids to treat surgical pain, shorter-acting opioids have ...
Source: Expert Review of Clinical Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Authors: Yun Han Chen Senthilkumar Sadhasivam Spencer DeMedal Mihaela Visoiu Source Type: research