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Emerging pharmacological strategies for treating and preventing mpox
Expert Rev Clin Pharmacol. 2023 Aug 22:1-12. doi: 10.1080/17512433.2023.2249820. Online ahead of print.ABSTRACTINTRODUCTION: Since May 2022, there have been nearly 87,000 documented cases of mpox worldwide, with 119 deaths. Pharmacological interventions for mpox include the MVA-BN smallpox vaccine, tecovirimat, cidofovir, its pro-drug brincidofovir, and vaccinia immune globulin intravenous (VIGIV).AREAS COVERED: The literature search and information gathering for this review included the PubMed database focusing on mpox and monkeypox, in combination with tecovirimat, brincidofovir, cidofovir, VIGIV, and smallpox vaccine. W...
Source: Expert Review of Clinical Pharmacology - August 18, 2023 Category: Drugs & Pharmacology Authors: Douglas W Grosenbach Andrew T Russo Emily D Blum Dennis E Hruby Source Type: research

Emerging pharmacological strategies for treating and preventing mpox
Expert Rev Clin Pharmacol. 2023 Aug 17. doi: 10.1080/17512433.2023.2249820. Online ahead of print.ABSTRACTINTRODUCTION: Since May 2022, there have been nearly 87,000 documented cases of mpox worldwide, with 119 deaths. Pharmacological interventions for mpox include the MVA-BN smallpox vaccine, tecovirimat, cidofovir or its pro-drug brincidofovir, and vaccinia immune globulin intravenous (VIGIV).AREAS COVERED: The literature search and information gathering for this review included the PubMed database focusing on mpox and monkeypox, in combination with tecovirimat, brincidofovir, cidofovir, VIGIV, and smallpox vaccine. WHO....
Source: Expert Review of Clinical Pharmacology - August 18, 2023 Category: Drugs & Pharmacology Authors: Douglas W Grosenbach Andrew T Russo Emily D Blum Dennis E Hruby Source Type: research

Pediatric attention deficit hyperactivity disorder (ADHD): 2022 updates on pharmacological management
This article offers an overview of ADHD, an overview of both stimulant and non-stimulant medication options as well an overview of stimulant misuse. It explores the medication mechanisms of action and side effect profiles, as well as offering an in-depth summary of the novel agents recently approved and soon to-be approved for use in youth. PubMed and Medline were utilized. Search terms included children, adolescents, ADHD and medication. FDA package inserts were reviewed for all medications.EXPERT OPINION: New formulations of medications include an evening administered, extended, and delayed-release form of methylphenidat...
Source: Expert Review of Clinical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Lisa O'Connor Stephanie Carbone Anthony Gobbo Hilary Gamble Stephen V Faraone Source Type: research

Correction
Expert Rev Clin Pharmacol. 2023 Aug 17:1. doi: 10.1080/17512433.2023.2247937. Online ahead of print.NO ABSTRACTPMID:37587854 | DOI:10.1080/17512433.2023.2247937 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Source Type: research

Sodium-glucose cotransporter 2 inhibitors in frail, older people with type 2 diabetes and heart failure: do we have enough evidence to confidently support the use?
Expert Rev Clin Pharmacol. 2023 Aug 14. doi: 10.1080/17512433.2023.2247977. Online ahead of print.NO ABSTRACTPMID:37577977 | DOI:10.1080/17512433.2023.2247977 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - August 14, 2023 Category: Drugs & Pharmacology Authors: Theocharis Koufakis Michael N Doumas Alexandra Bargiota Kalliopi Kotsa Giuseppe Maltese Source Type: research

Renin angiotensin aldosterone inhibitors in the treatment of proteinuria in children with congenital anomalies of the kidney and urinary tract: more evidence needed
Expert Rev Clin Pharmacol. 2023 Aug 14. doi: 10.1080/17512433.2023.2247985. Online ahead of print.ABSTRACTINTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) can be associated with proteinuria, possibly leading to a decline of kidney function. The aim of this review is to evaluate evidence on the efficacy of renin-angiotensin-aldosterone system inhibitors (RAASi) in children affected by CAKUT with proteinuria or chronic kidney disease (CKD).AREAS COVERED: We conducted a bibliographic search between 1 December 2022 and 20 February 2023, including randomized controlled trials, case-control studies, obs...
Source: Expert Review of Clinical Pharmacology - August 14, 2023 Category: Drugs & Pharmacology Authors: Giulio Rivetti Pietro Gizzone Anna Di Sessa Stefano Guarino Emanuele Miraglia Del Giudice Pierluigi Marzuillo Source Type: research